NO154116B - Fremgangsm¨te og lamellsepareringsapparat for tilf¯rsel og fordeling av en sammensatt v|ske til et lamellseparerings apparat. - Google Patents
Fremgangsm¨te og lamellsepareringsapparat for tilf¯rsel og fordeling av en sammensatt v|ske til et lamellseparerings apparat. Download PDFInfo
- Publication number
- NO154116B NO154116B NO803462A NO803462A NO154116B NO 154116 B NO154116 B NO 154116B NO 803462 A NO803462 A NO 803462A NO 803462 A NO803462 A NO 803462A NO 154116 B NO154116 B NO 154116B
- Authority
- NO
- Norway
- Prior art keywords
- methyl
- lamel
- dihydro
- preparation device
- lysergamine
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 8
- 238000002360 preparation method Methods 0.000 title claims description 5
- 150000003839 salts Chemical class 0.000 claims description 12
- 150000001875 compounds Chemical class 0.000 claims description 9
- 150000007524 organic acids Chemical class 0.000 claims description 5
- 150000007522 mineralic acids Chemical class 0.000 claims description 4
- HSDAJNMJOMSNEV-UHFFFAOYSA-N benzyl chloroformate Chemical compound ClC(=O)OCC1=CC=CC=C1 HSDAJNMJOMSNEV-UHFFFAOYSA-N 0.000 claims description 3
- 239000011541 reaction mixture Substances 0.000 claims description 3
- 150000003512 tertiary amines Chemical class 0.000 claims description 3
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 12
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 8
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 6
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 6
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 5
- HEMHJVSKTPXQMS-UHFFFAOYSA-M sodium hydroxide Inorganic materials [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 5
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 238000002560 therapeutic procedure Methods 0.000 description 4
- 238000006243 chemical reaction Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 3
- 239000003960 organic solvent Substances 0.000 description 3
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 2
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 2
- XTHFKEDIFFGKHM-UHFFFAOYSA-N Dimethoxyethane Chemical compound COCCOC XTHFKEDIFFGKHM-UHFFFAOYSA-N 0.000 description 2
- 206010020751 Hypersensitivity Diseases 0.000 description 2
- 229910019142 PO4 Inorganic materials 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 125000001931 aliphatic group Chemical group 0.000 description 2
- 230000007815 allergy Effects 0.000 description 2
- 239000003420 antiserotonin agent Substances 0.000 description 2
- 125000003118 aryl group Chemical group 0.000 description 2
- 229940072107 ascorbate Drugs 0.000 description 2
- 235000010323 ascorbic acid Nutrition 0.000 description 2
- 239000011668 ascorbic acid Substances 0.000 description 2
- 238000004587 chromatography analysis Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 2
- 231100000252 nontoxic Toxicity 0.000 description 2
- 230000003000 nontoxic effect Effects 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 2
- 239000010452 phosphate Substances 0.000 description 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-M salicylate Chemical compound OC1=CC=CC=C1C([O-])=O YGSDEFSMJLZEOE-UHFFFAOYSA-M 0.000 description 2
- 229960001860 salicylate Drugs 0.000 description 2
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 description 2
- 229940086735 succinate Drugs 0.000 description 2
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 2
- 229940095064 tartrate Drugs 0.000 description 2
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 2
- GETQZCLCWQTVFV-UHFFFAOYSA-N trimethylamine Chemical compound CN(C)C GETQZCLCWQTVFV-UHFFFAOYSA-N 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- UNELDXFWWQRODL-IUODEOHRSA-N (6ar,10ar)-4,7-dimethyl-6,6a,8,9,10,10a-hexahydroindolo[4,3-fg]quinoline Chemical class C1=CC([C@H]2CCCN([C@@H]2C2)C)=C3C2=CN(C)C3=C1 UNELDXFWWQRODL-IUODEOHRSA-N 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 208000001953 Hypotension Diseases 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 208000019695 Migraine disease Diseases 0.000 description 1
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 1
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical class [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 1
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 1
- 241001122767 Theaceae Species 0.000 description 1
- XSTXAVWGXDQKEL-UHFFFAOYSA-N Trichloroethylene Chemical group ClC=C(Cl)Cl XSTXAVWGXDQKEL-UHFFFAOYSA-N 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 230000002908 adrenolytic effect Effects 0.000 description 1
- 239000012670 alkaline solution Substances 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000000794 anti-serotonin Effects 0.000 description 1
- WPUJEWVVTKLMQI-UHFFFAOYSA-N benzene;ethoxyethane Chemical compound CCOCC.C1=CC=CC=C1 WPUJEWVVTKLMQI-UHFFFAOYSA-N 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- RNFNDJAIBTYOQL-UHFFFAOYSA-N chloral hydrate Chemical compound OC(O)C(Cl)(Cl)Cl RNFNDJAIBTYOQL-UHFFFAOYSA-N 0.000 description 1
- 229960002327 chloral hydrate Drugs 0.000 description 1
- 229940001468 citrate Drugs 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- GGSUCNLOZRCGPQ-UHFFFAOYSA-N diethylaniline Chemical compound CCN(CC)C1=CC=CC=C1 GGSUCNLOZRCGPQ-UHFFFAOYSA-N 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 150000008282 halocarbons Chemical class 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 208000021822 hypotensive Diseases 0.000 description 1
- 230000001077 hypotensive effect Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 239000012442 inert solvent Substances 0.000 description 1
- 208000027866 inflammatory disease Diseases 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 206010027599 migraine Diseases 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 description 1
- 229940124641 pain reliever Drugs 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 230000001624 sedative effect Effects 0.000 description 1
- 229940076279 serotonin Drugs 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 230000003033 spasmogenic effect Effects 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 229910021653 sulphate ion Inorganic materials 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 231100001274 therapeutic index Toxicity 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- UBOXGVDOUJQMTN-UHFFFAOYSA-N trichloroethylene Natural products ClCC(Cl)Cl UBOXGVDOUJQMTN-UHFFFAOYSA-N 0.000 description 1
- 206010044652 trigeminal neuralgia Diseases 0.000 description 1
- 210000004291 uterus Anatomy 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D17/00—Separation of liquids, not provided for elsewhere, e.g. by thermal diffusion
- B01D17/02—Separation of non-miscible liquids
- B01D17/0208—Separation of non-miscible liquids by sedimentation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D17/00—Separation of liquids, not provided for elsewhere, e.g. by thermal diffusion
- B01D17/02—Separation of non-miscible liquids
- B01D17/0208—Separation of non-miscible liquids by sedimentation
- B01D17/0211—Separation of non-miscible liquids by sedimentation with baffles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D21/00—Separation of suspended solid particles from liquids by sedimentation
- B01D21/0018—Separation of suspended solid particles from liquids by sedimentation provided with a pump mounted in or on a settling tank
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D21/00—Separation of suspended solid particles from liquids by sedimentation
- B01D21/0039—Settling tanks provided with contact surfaces, e.g. baffles, particles
- B01D21/0045—Plurality of essentially parallel plates
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D21/00—Separation of suspended solid particles from liquids by sedimentation
- B01D21/0039—Settling tanks provided with contact surfaces, e.g. baffles, particles
- B01D21/0063—Settling tanks provided with contact surfaces, e.g. baffles, particles with cross-flow flow direction of liquid and solid particles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D21/00—Separation of suspended solid particles from liquids by sedimentation
- B01D21/0039—Settling tanks provided with contact surfaces, e.g. baffles, particles
- B01D21/0069—Making of contact surfaces, structural details, materials therefor
- B01D21/0075—Contact surfaces having surface features
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D21/00—Separation of suspended solid particles from liquids by sedimentation
- B01D21/02—Settling tanks with single outlets for the separated liquid
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D21/00—Separation of suspended solid particles from liquids by sedimentation
- B01D21/24—Feed or discharge mechanisms for settling tanks
- B01D21/2427—The feed or discharge opening located at a distant position from the side walls
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S210/00—Liquid purification or separation
- Y10S210/05—Coalescer
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Thermal Sciences (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Separation Of Solids By Using Liquids Or Pneumatic Power (AREA)
Description
Analogifremgangsmåte for fremstilling av
den terapeutisk aktive forbindelse 1-methyl-,
N-carbobenzoxy-dihydro-lysergamin og salter
av denne.
Foreliggende oppfinnelse angår en analogifremgangsmåte for ; fremstilling av en terapeutisk aktiv forbindelse, 1-methyl-N-' carbobenzoxy-dihydrolysergamin, og i farmasøytisk henseende
. akseptable salter av denne.
I norsk patent nr. 108.020 er det beskrevet en fremgangs-måte for fremstilling av terapeutisk aktive 6-methyl- og 1,6-' < dimethyl-ergolinderivater av den generelle formel
i hvor R<*> er hydrogen eller en methylgruppe, og R er et radikal av jen syre valgt blant en rekke normere angitte alifatiske, aroma-!tiske og heterocykliake carboxylayrer og andre organiske syrer. i Forbindelsene som fremstilles i henhold til patent nr. 108.020 i l \ oppviser sterk oxytoksisk, antienteraminisk, (eller antisero- i itonisk), adrenolytisk, hypotensiv og sedatir virkning, både in i vitro og in vivo, samtidig som de er meget lite giftige. i Det har nu vist seg at et nytt, beslektet 1,6-dimethyl-ergo-jlinderivat, nemlig l-methyl-N-carbobenzoxy-dihydro-lysergamin <:>ar strukturformelen
og dettes i farmasb<y>tisk henseende akse<p>terbare salter har særlig sterk antiserotoninrirkning, samtidig som ds har lang virknlngs-j tid og liten giftighet. De egner seg derfor meget godt for i i
anvendelse i terapien som smertestillende midler og som midler mot allergi og betennelser.
Forbindelsene som fremstilles ved analogifremgangsmåten ifblje oppfinnelsen, representerer et bemerkelsesverdig fremskritt såvel overfor de i nevnte patent beskrevne forbindelser som overfor andre produkter som anvendes i terapien for de samme formål.
Det nye H-carbobenzoxy-l-methyl-dihydro-D-lysergamin ble sammenlignet med hensyn på antiserotoninvirkning med noen forbindelser fremstilt i henhold til patent nr.l08X)2CiSammenlignings-forsttkene ble utfort win vitro" etter metoden beskrevet av V. Erspamer (Arch. Exp. Path. Pharmak. 1940, 196, 343), som er basert på inhiberingen av den sammentrekkende virkning av serotonin på j livmoren hos rotter. Den folgende tabell viser verdiene som ble ! oppnådd for EC^0, dvs. konsentrasjonen i ug/ml som forårsaket ini-hibering av 50 j6 av de spasmogene virkninger som ble frembragt av Berotoninet. Tabellen gir ogBå toksisitetsverdiene for for- \ bindelsene, uttrykt ved LD^Q i mg/kg.
i Av tabellen vil det sees at den terapeutiske index for N-j carbobenroxy-l-methyl-dihydro-lysergamin er mer enn 1000 ganger • ! stiirre enn indexen for forbindelsene fremstilt i henhold til Lpatent nr. 108.020. J
Utgangsmaterialet som anvendes ved fremstillingen av de nye forbindelser, er det i nevnte patent beskrevne 1-methyl-dihydro-lysergamin.
Ved analogifremgangsmåten ifolge oppfinnelsen omsettes 1-metiyl-dihydro-lysergamin med carbobenzoxyklorid i nærvær av et tertiært amin, hvoretter det fra. reaksjonsblandingen isolerte 1-methyl-N-carbobenzoxy-dihydro-lysergamin om bnskes overfores på i og for seg kjent måte til et salt med en i farmasøytisk henseende aksep-terbar organisk eller uorganisk syre.
1-Methyl-dihydro-lysergaminet kan eventuelt være opplost i ét inert opplbsningsmiddel som kan være et alifatisk eller aromatisc, 'eventuelt halogenert.hydrocarbon, såsom hexan, kloroform, tri-klorethylen, benzen, toluen bg xylen eller en ether, såsom tetrai-hydrofuran og ethylenglycoldimethylether. Det tertiære amin kan ! f.eks. være pyridin, diethylanilin eller trimethylamin.
Det foretrekkes å utfore kondensasjonen ved en temperatur mellom -15 og +5°C og å utfore reaksjonen ved romtemperatur. Ettjer endt reaksjon tilsettes der en fortynnet, vandig alkalisk opp- i lbsning, såsom 5-10 #'ig vandig natrium- eller kaliumhydroxyd-i opplbsning, inntil det er oppnådd en alkalisk pH-verdi, og der ekstraheres med et opplbsningsmiddel av den ovennevnte gruppe, j som ikke er blandbart med vann. Den organiske ekstrakt inndampesj, .hvorpå 1-methyl-N-carbobenzoxy-dihydro-lyserganiinet utvinnes fra residuet etter kjente krystalliseringsmetoder fra et organisk opplbsningsmiddel eller ved kromatografering på aluminiumoxyd med påfblgende eluering med et organisk opplbsningsmiddel.
Dette produkt kan på kjent måte, ved tilsetning av en syre- j
i ekvivalent, overfores i sine ikke-giftige, i farmasøytisk henseende aksepterbare organiske eller uorganiske salter, såsom hydrokloridet, sulfatet, fosfatet, tartratet, maleatet, citratet, ascorbatet, succinatet, salicylatet og andre salter som er alminnelig brukt i terapien. Det erholdte produkt er et farve-lbst, krystallinsk produkt som er resistent såvel overfor inn-virkning av-lys- sonr overfor varme og som er opplbselig i vanlige organiske opplbsniirgsmidler og syrer.
På mennesker kan l-methyl-N-carbobenzoxy-dihydro-lysergaminet eller dettes salter anvendes oralt, rektalt eller paren-teralt. Dessuten finner det anvendelse ved de fblgende kliniske i : symptomer: migrene, hodepine, trigeminusneuralgi, allergi i sin ! alminnelighet og ved inflammasjonssykdommer. ]
De mest brukte terapeutiske preparater inneholder 1-methyl-
• N-carbobenzoxy-dihydro-lysergaminet eller et salt av dette samme i med en viss mengde av et fast eller flytende bindemiddel.
Det nedenstående eksempel vil ytterligere illustrere opp- | finnelsen.
Eksempel i
i 1- Methyl- N- carbobenzoxy- dihydro- lysergamin j
i 16 g forsiktig oppvarmet 1-methyl-dihydro-lysergamin opploses
j i 80 ml vannfritt pyridin. Den under omrbring til -10°C avkjbltej I opplbsning tilsettes dråpevis, men temmelig raskt, 18 ml 85 #-igj
i carbobenzoxyklorid (i toluen) fortynnet med 36 ml kloroform. Denl I godt omrbrte reaksjonsblanding holdes ved -10°C under tilsetningen i og derpå å ytterligere 10 minutter. Deretter avsluttes avkjblingen, i og temperaturen stiger i lbpet av ca. 10 minutter påny til romtemperatur. Det hele fortynnes med 240 ml kloroform og vaskes så; raskt med 80 ml 5#-ig natriumhydroxydopplbsning, deretter med mettet natriumbicarbonatopplbsning og til slutt med vann. Kloro-^ formopplbsningen tbrres i kort tid over vannfritt natriumsulfat og inndames til tbrrhet i vakuum ved 40°C. Det oljeaktige residuum opptas i 160 ml benzen og anbringes på en kromatografisk sbyle av AlgO^. Sbylen elueres så med ytterligere 160 ml benzen. De sammenslåtte eluater inndampes i vakuum ved 40°C, og det oljeaktige tykke residuum tilsettes en liten mengde vannfri ether. Etter noen tid fåes der en krystallmasse som vaskes med litt benzen og ethylether. Det erholdes 12 g hvite krystaller som smelter ved 146 - 148°C; [a]£<8>° = -7° + 2° i pyridin.
I stedet for at produktet renses ved kromatografering kan
i dette erholdes ved omkrystallisering fra benzenethylether. Produktet kan etter kjente fremgangsmåter overfores i sine salter med ikke-giftige organiske-' eller uorganiske syrer, såsom klor- I hydratet, sulfatet, fosfatet, tartratet, maleatet, citratet,
i ascorbatet, succinatet, salicylatet og andre salter som er vanlig ! . brukt i terapien. ji
Claims (1)
- Analogifremgangsmåte for fremstilling av den terapeutisk aktive forbindelse 1-methyl-N-carbobenzoxy-dihydro-lysergamin av formelenog dennes salter med i farmasoytisk henseende aksepterbare organiske og uorganiske syrer, karakterisert ved at 1-methyl-dihydro-lysergamin omsettes med carbobenzoxyklorid i nærvær av et tertiært amin, og det fra reaksjonsblandingen isolerte 1-methyl-N-carbobenzoxy-dihydro-lysergamin om onskes overfores på i og for seg kjent måte til et salt med en i farmasoytisk henseende aksep-terbar organisk eller uorganisk syre.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE7909609A SE437122B (sv) | 1979-11-20 | 1979-11-20 | Forfarande och anordning for fordelning och tillforsel av suspension till en lamellsedimenteringsapparats sedimenteringsutrymmen |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO803462L NO803462L (no) | 1981-05-21 |
| NO154116B true NO154116B (no) | 1986-04-14 |
| NO154116C NO154116C (no) | 1986-07-23 |
Family
ID=20339360
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO803462A NO154116C (no) | 1979-11-20 | 1980-11-18 | Fremgangsmaate og lamellsepareringsapparat for tilfoersel og fordeling av en sammensatt vaeske til et lamellsepareringsapparat. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US4400280A (no) |
| JP (1) | JPS5687408A (no) |
| CA (1) | CA1161370A (no) |
| DE (1) | DE3042316A1 (no) |
| FR (1) | FR2469948B1 (no) |
| GB (1) | GB2063090B (no) |
| IN (1) | IN163337B (no) |
| MY (1) | MY8600093A (no) |
| NO (1) | NO154116C (no) |
| SE (1) | SE437122B (no) |
| SG (1) | SG4785G (no) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE446211B (sv) * | 1984-01-23 | 1986-08-18 | Johnson Axel Eng Ab | Lamellpaket for lamellseparator |
| US4747948A (en) * | 1985-03-20 | 1988-05-31 | North Darryl L | Parallel plate extractor system and method for using same |
| JPS627409A (ja) * | 1985-07-03 | 1987-01-14 | Yoshitaka Ouchi | 懸濁粒子の沈降分離方法及びその装置 |
| NL8600032A (nl) * | 1986-01-09 | 1987-08-03 | Pielkenrood Vinitex Bv | Dwarsstroomafscheider voor het afscheiden van in een vloeistof gesuspendeerde bestanddelen. |
| US4643834A (en) * | 1986-02-03 | 1987-02-17 | Filter Plate Company | Separation system using coalescing techniques |
| JPH059109Y2 (no) * | 1988-06-30 | 1993-03-05 | ||
| JPH0382770U (no) * | 1989-12-15 | 1991-08-22 | ||
| DE4102776A1 (de) * | 1991-01-31 | 1992-08-06 | Winkelhorst Trenntechnik Gmbh | Ringkammerabscheider |
| US5246592A (en) * | 1992-05-14 | 1993-09-21 | Acs Industries, Inc. | Method and apparatus for recovering oil from the surface of a body of water |
| US5536409A (en) * | 1994-10-25 | 1996-07-16 | Citec International Incorporated | Water treatment system |
| US5547569A (en) * | 1995-01-25 | 1996-08-20 | Hinkle Contracting Corporation | Multiple stage water clarifier |
| US5670039A (en) * | 1995-05-26 | 1997-09-23 | Harris; Ronald B. | Linear solids removal unit |
| US5714068A (en) * | 1995-10-06 | 1998-02-03 | National Tank Company | Inlet device for large oil field separator |
| US5741426A (en) * | 1995-12-05 | 1998-04-21 | Mccabe; Derald L. | Method for treatment of contaminated water |
| US6056128A (en) * | 1998-08-04 | 2000-05-02 | Glasgow; James A. | Coalescer with removable cartridge |
| CN1314502A (zh) * | 2000-03-21 | 2001-09-26 | 亚洲电镀器材有限公司 | 混合设备 |
| GB2436303A (en) * | 2006-03-24 | 2007-09-26 | Zeta Dynamics Ltd | Vertical calming baffle |
| IT1402760B1 (it) * | 2010-11-16 | 2013-09-18 | Far Rubinetterie S P A | Dispositivo per separare impurita' da un fluido termico, e relativa cartuccia filtrante |
| US10214871B2 (en) * | 2011-05-27 | 2019-02-26 | Aqseptence Group, Inc. | Screen intake flow control and support device |
| US8985343B1 (en) | 2014-01-24 | 2015-03-24 | Kirby Smith Mohr | Method and apparatus for separating immiscible liquids and solids from liquids |
| CN106281522A (zh) * | 2015-06-04 | 2017-01-04 | 通用电气公司 | 用于重力分离的装置和方法及包含其的石油和天然气生产系统和方法 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE7120130U (de) * | 1972-02-03 | Pielkenrood-Vinitex Nv | Abscheidevorrichtung | |
| DE298758C (no) * | 1900-01-01 | |||
| GB229740A (en) * | 1923-11-21 | 1925-02-23 | Erwin Falkenthal | Improvements in separating and mixing apparatus for fluids or for fluids carrying suspended particles |
| BE363985A (no) * | 1929-09-23 | 1900-01-01 | ||
| US2060166A (en) * | 1934-11-12 | 1936-11-10 | Bowen William Spencer | Fluid treating mechanism and method |
| US2751998A (en) * | 1953-06-01 | 1956-06-26 | Nat Tank Co | Emulsion treaters and emulsion treating methods |
| FR316168A (no) * | 1954-02-11 | 1900-01-01 | ||
| DE969293C (de) * | 1954-02-11 | 1958-05-22 | Neyrpic Ets | Vorrichtung zum Abtrennen von Sand und anderen festen Stoffen aus stroemenden Fluessigkeiten mit einer Mehrzahl einzelner geneigter Zellen kleinen Querschnitts |
| US3521756A (en) * | 1968-06-17 | 1970-07-28 | Cities Service Athabasca Inc | Coalescing vessel |
| IL30304A (en) * | 1968-07-03 | 1971-12-29 | Israel Mining Ind Inst For Res | A gravitational settler vessel |
| SE330151B (no) * | 1968-09-20 | 1970-11-09 | Nordstjernan Rederi Ab | |
| US3460677A (en) * | 1968-10-22 | 1969-08-12 | Rolland L Fifer | Transportable sewage treating apparatus |
| AT300687B (de) * | 1970-07-13 | 1972-08-10 | Internat Pollution Control Sys | Vorrichtung zur Abtrennung von Öl aus verölten Flüssigkeiten, insbesondere Schiffsbilgen von Sportbooten od.dgl. |
| BE791202A (fr) * | 1971-11-12 | 1973-03-01 | Gustavsbergs Fabriker Ab | Separateur lamellaire |
| BE793060A (fr) * | 1971-12-24 | 1973-04-16 | Metallgesellschaft Ag | Dispositif pour separer des liquides |
| US4133771A (en) * | 1972-04-25 | 1979-01-09 | Pielkenrood-Vinitex B.V. | Apparatus for bringing about particle growth in a flowing liquid suspension |
| US3826740A (en) * | 1972-05-30 | 1974-07-30 | W Jewett | Method and apparatus for treating multi-phase systems |
| JPS49135874U (no) * | 1973-03-07 | 1974-11-22 | ||
| SU709115A1 (ru) * | 1973-03-13 | 1980-01-15 | Институт Гидромеханики Ан Украинской Сср | Вертикальный сгуститель |
| JPS5070964A (no) * | 1973-10-24 | 1975-06-12 | ||
| US4113629A (en) * | 1974-11-27 | 1978-09-12 | Pielkenrood-Vinitex B.V. | Separation device provided with a coalescence apparatus |
| SE387054B (sv) * | 1974-12-16 | 1976-08-30 | K O Wikholm | Sett och anordning for separation av emulsioner |
| US4132651A (en) * | 1976-02-19 | 1979-01-02 | Dejong Leendert W C | Separating device to separate two liquids of different specific gravity |
| NL7601702A (nl) * | 1976-02-19 | 1977-08-23 | Leendert Willem Cornelis De Jo | Afscheidingsinrichting voor het scheiden van twee vloeistoffen met een verschillend soorte- lijk gewicht. |
| FR2381550A1 (fr) * | 1977-02-23 | 1978-09-22 | Serep | Separateur fonctionnant par gravite et depression pour des melanges de deux liquides non miscibles |
| US4120796A (en) * | 1977-03-01 | 1978-10-17 | Huebner Werner P E | Vertical flow inclined plate clarifier |
| US4132652A (en) * | 1977-10-11 | 1979-01-02 | Chevron Research Company | Slotted baffle for use in separating oil-water mixtures |
| NL7711963A (nl) * | 1977-10-31 | 1979-05-02 | Ballast Nedam Groep Nv | Afscheidingsinrichting. |
| US4257895A (en) * | 1979-05-08 | 1981-03-24 | Murdock Forrest L | Low gravity crude oil and water separator |
-
1979
- 1979-11-20 SE SE7909609A patent/SE437122B/sv not_active IP Right Cessation
-
1980
- 1980-11-10 DE DE19803042316 patent/DE3042316A1/de active Granted
- 1980-11-18 FR FR8024402A patent/FR2469948B1/fr not_active Expired
- 1980-11-18 NO NO803462A patent/NO154116C/no unknown
- 1980-11-18 GB GB8036906A patent/GB2063090B/en not_active Expired
- 1980-11-19 CA CA000365018A patent/CA1161370A/en not_active Expired
- 1980-11-20 JP JP16401280A patent/JPS5687408A/ja active Granted
-
1982
- 1982-02-03 US US06/345,394 patent/US4400280A/en not_active Expired - Fee Related
-
1985
- 1985-01-19 SG SG47/85A patent/SG4785G/en unknown
- 1985-05-01 IN IN333/CAL/85A patent/IN163337B/en unknown
-
1986
- 1986-12-30 MY MY93/86A patent/MY8600093A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FR2469948B1 (fr) | 1988-09-09 |
| NO154116C (no) | 1986-07-23 |
| DE3042316A1 (de) | 1981-05-27 |
| DE3042316C2 (no) | 1991-12-19 |
| IN163337B (no) | 1988-09-10 |
| GB2063090B (en) | 1984-02-22 |
| US4400280A (en) | 1983-08-23 |
| SG4785G (en) | 1985-06-14 |
| GB2063090A (en) | 1981-06-03 |
| SE7909609L (sv) | 1981-05-21 |
| JPS5687408A (en) | 1981-07-16 |
| FR2469948A1 (fr) | 1981-05-29 |
| NO803462L (no) | 1981-05-21 |
| JPH0225645B2 (no) | 1990-06-05 |
| MY8600093A (en) | 1986-12-31 |
| SE437122B (sv) | 1985-02-11 |
| CA1161370A (en) | 1984-01-31 |
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