FI60200C - Foerfarande foer framstaellning av farmakologiskt vaerdefulla n-arylalkylpiperidylsubstituerade bensamider - Google Patents

Foerfarande foer framstaellning av farmakologiskt vaerdefulla n-arylalkylpiperidylsubstituerade bensamider Download PDF

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Publication number
FI60200C
FI60200C FI750825A FI750825A FI60200C FI 60200 C FI60200 C FI 60200C FI 750825 A FI750825 A FI 750825A FI 750825 A FI750825 A FI 750825A FI 60200 C FI60200 C FI 60200C
Authority
FI
Finland
Prior art keywords
methoxy
amino
piperidyl
compounds
benzyl
Prior art date
Application number
FI750825A
Other languages
English (en)
Finnish (fi)
Other versions
FI60200B (fi
FI750825A (sv
Inventor
Robert Geoffrey W Spickett
Jacinto Moragues Mauri
Armando Vega Noverola
Jose Manuel Prieto Soto
Original Assignee
Anphar Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB12572/74A external-priority patent/GB1507462A/en
Application filed by Anphar Sa filed Critical Anphar Sa
Publication of FI750825A publication Critical patent/FI750825A/fi
Publication of FI60200B publication Critical patent/FI60200B/fi
Application granted granted Critical
Publication of FI60200C publication Critical patent/FI60200C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
    • C07D211/28—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms to which a second hetero atom is attached
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Otolaryngology (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyridine Compounds (AREA)

Claims (2)

1. Förfarande för framställning av farmakologiskt värdefulla N-arylalkylpiperidylsubstituerade bensamider med den allmänna forme In R2 R1 CONH - (CH)Z - Ar (I) OOH 3 i vilken är väte, amino, en acetylamino- eller halogenacetylamino-grupp, r2 är väte, halogen, sulfamoyl eller metylsulfonyl, under den förutsättningen att och R2 inte bäda är väte, r3 är väte, metyl eller fenyl, Ar är eventuellt substituerad fenyl eller bensoyl, eller tienyl, z är ett heltal 1-6, och varvid kedjan (CH) kan innehälla en z dubbelbindning, samt deras farmacuetiskt av acceptable syraadditionssalter, k ä n-netecknat därav, att a) en substituerad bensoesyra med den allmanna formeln 30 6 0 2 0 0 r2 R1 ^Q)~ C03H <ii) och3 eller dess syraklorid, syra-anhydrid/ ester eller dess med N-etyl-5-fenyl-isoxazolinium-3-sulfonat erhällna derivat/ omsättes med en 1-arylalkyl-4-amino-piperidin den allmänna formeln H2N \ - (CH)Z - Ar (III) i vilka formler , R2, R3, Ar och z betecknar detsamma som ovan, eller b) en förening med den allmänna formeln ri -{öy conh <iv) OCH 3 omsättes med en halogenid med den allmänna formeln X - (CH) - Ar (VII) i vilka R^, R2, R3, Ar och z betecknar detsamma som ovan och X betecknar halogen, och i erhillen förening med formeln I med en ace-tylamino- eller halogenacetylaminorgypp R.j, denna, om sk önskas, överföres i en fri aminogrupp R1, eller, om sk önskas, acyleras en fri aminogrupp R^ till en acetylamino- eller halogenacetylamino-grupp R.j , och/eller, om sä önskas, överföres en fri förening med formeln I tili ett sait med en oorganisk eller en organisk syra.
2. Förfarande enligt patentkravet 1 a) för framställning av
FI750825A 1974-03-21 1975-03-20 Foerfarande foer framstaellning av farmakologiskt vaerdefulla n-arylalkylpiperidylsubstituerade bensamider FI60200C (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB12572/74A GB1507462A (en) 1974-03-21 1974-03-21 N-heterocyclic substituted benzamides methods for their preparation and compositions containing them
GB1257274 1974-03-21
GB3540274 1974-08-12
GB3540274 1974-08-12

Publications (3)

Publication Number Publication Date
FI750825A FI750825A (sv) 1975-09-22
FI60200B FI60200B (fi) 1981-08-31
FI60200C true FI60200C (fi) 1981-12-10

Family

ID=26249107

Family Applications (1)

Application Number Title Priority Date Filing Date
FI750825A FI60200C (fi) 1974-03-21 1975-03-20 Foerfarande foer framstaellning av farmakologiskt vaerdefulla n-arylalkylpiperidylsubstituerade bensamider

Country Status (11)

Country Link
JP (1) JPS584019B2 (sv)
AR (1) AR216043A1 (sv)
CH (1) CH602641A5 (sv)
DK (1) DK147854C (sv)
ES (5) ES435753A1 (sv)
FI (1) FI60200C (sv)
FR (1) FR2264530A1 (sv)
KE (1) KE2900A (sv)
NL (1) NL159660B (sv)
NO (1) NO144108C (sv)
SE (1) SE427750B (sv)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1513631A (en) * 1976-02-17 1978-06-07 Gallardo Antonio Sa Piperidine derivatives
GB1561023A (en) * 1977-04-22 1980-02-13 Beecham Group Ltd 2-methoxy - 5 - chloro aniline derivatives
FR2446274A1 (fr) * 1979-01-15 1980-08-08 Delalande Sa Nouveaux derives de salicylamide, leur procede de preparation et leur application en therapeutique
EP0343307A1 (en) * 1988-05-26 1989-11-29 Fabrica Espanola De Productos Quimicos Y Farmaceuticos, S.A. 4-Piperidinealkanamine derivatives
FR2674849B1 (fr) * 1991-04-02 1994-12-23 Logeais Labor Jacques Nouveaux derives de n-cyclohexyl benzamides ou thiobenzamides, leurs preparations et leurs applications en therapeutique.
FR2766486B1 (fr) * 1997-07-25 1999-09-17 Logeais Labor Jacques Cycloalkyles benzamides stimulants de la motricite gastrointestinale haute et basse
FR2766484B1 (fr) * 1997-07-25 1999-09-17 Logeais Labor Jacques Nouveaux derives benzamides stimulants de la motricite gastrointestinale haute et basse
PT1893603E (pt) * 2005-06-02 2009-11-24 Hoffmann La Roche Derivados de piperidin-4-il-amida e a sua utilização como antagonistas do receptor de sst do subtipo 5
KR100976063B1 (ko) * 2007-03-16 2010-08-17 동아제약주식회사 신규한 벤즈아미드 유도체 화합물 및 그의 제조방법
CN103958477B (zh) * 2011-11-29 2017-03-29 (株)威沃尊 苯甲酰胺衍生物及其用途

Also Published As

Publication number Publication date
FR2264530B1 (sv) 1978-11-10
NO144108C (no) 1981-06-24
DK147854C (da) 1985-07-22
FI60200B (fi) 1981-08-31
FI750825A (sv) 1975-09-22
SE7503196L (sv) 1975-09-22
ES435754A1 (es) 1977-04-01
JPS50129573A (sv) 1975-10-13
DK117675A (sv) 1975-09-22
JPS584019B2 (ja) 1983-01-24
ES435753A1 (es) 1977-04-01
ES435757A1 (es) 1977-04-01
AR216043A1 (es) 1979-11-30
DK147854B (da) 1984-12-24
ES435755A1 (es) 1977-04-01
SE427750B (sv) 1983-05-02
ES435756A1 (es) 1977-04-01
NO750957L (sv) 1975-09-23
NO144108B (no) 1981-03-16
FR2264530A1 (en) 1975-10-17
NL7503417A (nl) 1975-09-23
KE2900A (en) 1978-12-01
NL159660B (nl) 1979-03-15
CH602641A5 (sv) 1978-07-31

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Owner name: FORDONAL S.A.