FR2264530A1 - N-(heterocyclyl)substd benzamides - with antiemetic activity, also useful in treating psychic disorders and migraine - Google Patents

N-(heterocyclyl)substd benzamides - with antiemetic activity, also useful in treating psychic disorders and migraine

Info

Publication number
FR2264530A1
FR2264530A1 FR7509371A FR7509371A FR2264530A1 FR 2264530 A1 FR2264530 A1 FR 2264530A1 FR 7509371 A FR7509371 A FR 7509371A FR 7509371 A FR7509371 A FR 7509371A FR 2264530 A1 FR2264530 A1 FR 2264530A1
Authority
FR
France
Prior art keywords
substd
benzamides
migraine
heterocyclyl
useful
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7509371A
Other languages
French (fr)
Other versions
FR2264530B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Antonio Gallardo SA
Original Assignee
Antonio Gallardo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB12572/74A external-priority patent/GB1507462A/en
Application filed by Antonio Gallardo SA filed Critical Antonio Gallardo SA
Publication of FR2264530A1 publication Critical patent/FR2264530A1/en
Application granted granted Critical
Publication of FR2264530B1 publication Critical patent/FR2264530B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
    • C07D211/28—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms to which a second hetero atom is attached
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Otolaryngology (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyridine Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

N-(Heterocyclyl) substd. benzamides of formula (I), (where R is 1-6C alkoxy or 2-60C alkenyloxy; R1, R2 are H, halogen, -SO2NH2, NH2, 1-6C alkyl, dialkylamino, alkylsulphonyl, alkylsulphonamido, acylamino, r1 being in the 3- or 4-position; R3 is H, alkyl, aryl; AR is aryl, aroyl, or a monocyclic heterocyclic aryl group; x is 0 or 1; y is 2 or 3; z is 1 to 6); also their acid-addition salts are used in the treatment of nausea, vomiting as a result of congestive cardiac failure, post-operative condition, gastrointestinal disorders; dyspepsia, flatulence, hiatus hernia, peptic ulcer, gastritis, Gallstones, psychic disorders, migraine.
FR7509371A 1974-03-21 1975-03-20 N-(heterocyclyl)substd benzamides - with antiemetic activity, also useful in treating psychic disorders and migraine Granted FR2264530A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB12572/74A GB1507462A (en) 1974-03-21 1974-03-21 N-heterocyclic substituted benzamides methods for their preparation and compositions containing them
GB3540274 1974-08-12

Publications (2)

Publication Number Publication Date
FR2264530A1 true FR2264530A1 (en) 1975-10-17
FR2264530B1 FR2264530B1 (en) 1978-11-10

Family

ID=26249107

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7509371A Granted FR2264530A1 (en) 1974-03-21 1975-03-20 N-(heterocyclyl)substd benzamides - with antiemetic activity, also useful in treating psychic disorders and migraine

Country Status (11)

Country Link
JP (1) JPS584019B2 (en)
AR (1) AR216043A1 (en)
CH (1) CH602641A5 (en)
DK (1) DK147854C (en)
ES (5) ES435753A1 (en)
FI (1) FI60200C (en)
FR (1) FR2264530A1 (en)
KE (1) KE2900A (en)
NL (1) NL159660B (en)
NO (1) NO144108C (en)
SE (1) SE427750B (en)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2705949A1 (en) * 1976-02-17 1977-08-25 Gallardo Antonio Sa NEW PIPERIDINE BASED THERAPEUTICS
FR2387955A1 (en) * 1977-04-22 1978-11-17 Beecham Group Ltd ANILINE DERIVATIVES FOR USE AS A MEDICINAL PRODUCT
FR2446274A1 (en) * 1979-01-15 1980-08-08 Delalande Sa 5-Acetoxy:methyl and 5-chloro:methyl 2-methoxy benzamide(s) - and related cpds. have neuroleptic activity and are used for psychic disorders
EP0343307A1 (en) * 1988-05-26 1989-11-29 Fabrica Espanola De Productos Quimicos Y Farmaceuticos, S.A. 4-Piperidinealkanamine derivatives
EP0507672A1 (en) * 1991-04-02 1992-10-07 LABORATOIRES JACQUES LOGEAIS Société dite: N-cyclohexyl benzamides derivatives, preparations and therapeutic applications thereof
FR2766486A1 (en) * 1997-07-25 1999-01-29 Logeais Labor Jacques CYMLOALKYLES BENZAMIDES STIMULATING HIGH AND LOW GASTROINTESTINAL MOTRICITY
FR2766484A1 (en) * 1997-07-25 1999-01-29 Logeais Labor Jacques New piperidino benzamide derivatives and their salts
EP2786986A2 (en) * 2011-11-29 2014-10-08 Vivozon Inc. Novel benzamide derivative and use thereof

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1893603E (en) * 2005-06-02 2009-11-24 Hoffmann La Roche Piperidin-4-yl-amide derivatives and their use as sst receptor subtype 5 antagonists
KR100976063B1 (en) * 2007-03-16 2010-08-17 동아제약주식회사 Novel benzamide derivatives and process for the preparation thereof

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2705949A1 (en) * 1976-02-17 1977-08-25 Gallardo Antonio Sa NEW PIPERIDINE BASED THERAPEUTICS
FR2387955A1 (en) * 1977-04-22 1978-11-17 Beecham Group Ltd ANILINE DERIVATIVES FOR USE AS A MEDICINAL PRODUCT
FR2446274A1 (en) * 1979-01-15 1980-08-08 Delalande Sa 5-Acetoxy:methyl and 5-chloro:methyl 2-methoxy benzamide(s) - and related cpds. have neuroleptic activity and are used for psychic disorders
EP0343307A1 (en) * 1988-05-26 1989-11-29 Fabrica Espanola De Productos Quimicos Y Farmaceuticos, S.A. 4-Piperidinealkanamine derivatives
EP0507672A1 (en) * 1991-04-02 1992-10-07 LABORATOIRES JACQUES LOGEAIS Société dite: N-cyclohexyl benzamides derivatives, preparations and therapeutic applications thereof
FR2674849A1 (en) * 1991-04-02 1992-10-09 Logeais Labor Jacques NOVEL N-CYCLOHEXYL BENZAMIDE OR THIOBENZAMIDE DERIVATIVES, THEIR PREPARATIONS AND THEIR THERAPEUTIC APPLICATIONS
US5273983A (en) * 1991-04-02 1993-12-28 Laboratories Jacques Logeais Cyclohexylbenzamide derivatives, their preparations and their use as gastrointestinal stimulants
FR2766486A1 (en) * 1997-07-25 1999-01-29 Logeais Labor Jacques CYMLOALKYLES BENZAMIDES STIMULATING HIGH AND LOW GASTROINTESTINAL MOTRICITY
FR2766484A1 (en) * 1997-07-25 1999-01-29 Logeais Labor Jacques New piperidino benzamide derivatives and their salts
WO1999005133A1 (en) * 1997-07-25 1999-02-04 Laboratoires Jacques Logeais Benzamide cycloalkyl stimulating high and low gastrointestinal motricity
EP2786986A2 (en) * 2011-11-29 2014-10-08 Vivozon Inc. Novel benzamide derivative and use thereof
EP2786986A4 (en) * 2011-11-29 2015-01-14 Vivozon Inc Novel benzamide derivative and use thereof
US9359346B2 (en) 2011-11-29 2016-06-07 Vivozon, Inc. Benzamide derivative and use thereof

Also Published As

Publication number Publication date
JPS50129573A (en) 1975-10-13
KE2900A (en) 1978-12-01
FI750825A (en) 1975-09-22
NL7503417A (en) 1975-09-23
ES435754A1 (en) 1977-04-01
DK117675A (en) 1975-09-22
DK147854C (en) 1985-07-22
JPS584019B2 (en) 1983-01-24
AR216043A1 (en) 1979-11-30
FI60200C (en) 1981-12-10
CH602641A5 (en) 1978-07-31
NL159660B (en) 1979-03-15
SE427750B (en) 1983-05-02
FR2264530B1 (en) 1978-11-10
SE7503196L (en) 1975-09-22
NO144108B (en) 1981-03-16
ES435757A1 (en) 1977-04-01
ES435756A1 (en) 1977-04-01
ES435755A1 (en) 1977-04-01
ES435753A1 (en) 1977-04-01
NO144108C (en) 1981-06-24
NO750957L (en) 1975-09-23
FI60200B (en) 1981-08-31
DK147854B (en) 1984-12-24

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