FI56531C - Foerfarande foer framstaellning av isotiocyanobenstiazoler med anthelmintisk och mikrobicid verkan - Google Patents

Foerfarande foer framstaellning av isotiocyanobenstiazoler med anthelmintisk och mikrobicid verkan Download PDF

Info

Publication number
FI56531C
FI56531C FI3138/72A FI313872A FI56531C FI 56531 C FI56531 C FI 56531C FI 3138/72 A FI3138/72 A FI 3138/72A FI 313872 A FI313872 A FI 313872A FI 56531 C FI56531 C FI 56531C
Authority
FI
Finland
Prior art keywords
carbon atoms
alkyl
group
formula
halogen
Prior art date
Application number
FI3138/72A
Other languages
English (en)
Finnish (fi)
Other versions
FI56531B (fi
Inventor
Jean-Jacques Gallay
Rene Bosshard
Paul Brenneisen
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of FI56531B publication Critical patent/FI56531B/fi
Application granted granted Critical
Publication of FI56531C publication Critical patent/FI56531C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08—Radicals containing only hydrogen and carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/10—Radicals substituted by halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/14—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/16—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/26—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/28—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D263/57—Aryl or substituted aryl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
FI3138/72A 1971-12-07 1972-11-09 Foerfarande foer framstaellning av isotiocyanobenstiazoler med anthelmintisk och mikrobicid verkan FI56531C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH1787571 1971-12-07
CH1787571A CH566321A5 (pl) 1971-12-07 1971-12-07

Publications (2)

Publication Number Publication Date
FI56531B FI56531B (fi) 1979-10-31
FI56531C true FI56531C (fi) 1980-02-11

Family

ID=4428743

Family Applications (1)

Application Number Title Priority Date Filing Date
FI3138/72A FI56531C (fi) 1971-12-07 1972-11-09 Foerfarande foer framstaellning av isotiocyanobenstiazoler med anthelmintisk och mikrobicid verkan

Country Status (27)

Country Link
US (1) US3849431A (pl)
JP (1) JPS5754511B2 (pl)
AR (1) AR220663A1 (pl)
AT (2) AT322550B (pl)
BE (1) BE792402A (pl)
BG (1) BG21027A3 (pl)
BR (1) BR7208610D0 (pl)
CA (1) CA1014566A (pl)
CH (1) CH566321A5 (pl)
CS (2) CS177109B2 (pl)
DD (1) DD105230A5 (pl)
DE (1) DE2259220C2 (pl)
ES (1) ES409335A1 (pl)
FI (1) FI56531C (pl)
GB (1) GB1413519A (pl)
HU (1) HU167426B (pl)
IE (1) IE37194B1 (pl)
IL (1) IL40935A (pl)
IT (1) IT1048106B (pl)
NL (1) NL7216645A (pl)
NO (1) NO137234C (pl)
PL (2) PL86697B1 (pl)
RO (1) RO60572A (pl)
SE (1) SE402772B (pl)
SU (2) SU589915A3 (pl)
YU (1) YU36711B (pl)
ZA (1) ZA728643B (pl)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3894037A (en) * 1971-05-24 1975-07-08 Ciba Geigy Corp Certain isothiocyanobenzimidazoles
US3933841A (en) * 1971-05-24 1976-01-20 Ciba-Geigy Corporation 2-Phenoxy, -phenylthio-, and -phenyl-amino-benzoxazoles having an isothiocyano substituent
US3969351A (en) * 1974-05-17 1976-07-13 E. R. Squibb & Sons, Inc. Morpholine containing isothiocyanobenzoxazoles
LU75684A1 (pl) * 1976-08-27 1978-04-13
CH634306A5 (de) * 1977-04-12 1983-01-31 Ciba Geigy Ag Benzimidazolderivate, verfahren zu ihrer herstellung und anthelmintische mittel enthaltend diese verbindungen als wirkstoffe.
EP0007616B1 (de) 1978-07-27 1982-05-12 Ciba-Geigy Ag Isothiocyanobenzthiazolderivat, Verfahren zu seiner Herstellung und seine Anwendung in anthelmintischen Mitteln
US4287349A (en) * 1979-04-23 1981-09-01 Standard Oil Company (Indiana) Beta-alkyl (or aryl) beta-hydroxyethyl heterocyclic sulfoxides
FR2459239A1 (fr) * 1979-06-20 1981-01-09 Logeais Labor Jacques Nouveaux derives amines du benzothiazole, leur procede de preparation et leur application en therapeutique
DE2946524A1 (de) * 1979-11-17 1981-06-11 Bayer Ag, 5090 Leverkusen Azolyloxy-carbonsaeure-n-oxy-amide, verfahren zu ihrer herstellung und ihre verwendung als herbizide
US4267348A (en) * 1979-12-04 1981-05-12 The United States Of America As Represented By The Secretary Of The Air Force Fluorine-containing benzimidazoles
US4258188A (en) * 1980-02-04 1981-03-24 American Home Products Corporation 2-(1-Piperazinyl)-cycloheptimidazole derivatives
US4375470A (en) * 1980-02-04 1983-03-01 American Home Products Corporation 2(1-Piperazinyl)-cycloheptimidazole antihypertensive composition and methods
US4321363A (en) * 1980-02-21 1982-03-23 Nippon Soda Company Limited Adsorbent for urokinase containing agarose
MA19290A1 (fr) * 1980-05-22 1982-04-01 Ciba Geigy Ag Derives du benzole,leur preparaton et leur utilisations therapeutiques .
DE3027483A1 (de) * 1980-07-19 1982-02-25 Hoechst Ag, 6000 Frankfurt Verfahren zur herstellung heterocyclisch substituierter 4-oxiphenoxialkancarbonsaeurederivate
DE3039929A1 (de) * 1980-10-23 1982-06-03 Bayer Ag, 5090 Leverkusen Isocyanato-oxazolinone, ein verfahren zur herstellung von oxazolin-2-on-ringe aufweisenden kunststoffvorlaeufern und deren verwendung zur herstellung von hochmolekularen kunststoffen
FR2521141A1 (fr) * 1982-02-09 1983-08-12 Rhone Poulenc Agrochimie Nouveaux derives du cyano-2 benzimidazole, leur preparation et leur utilisation comme fongicides
DE3311285A1 (de) * 1983-03-28 1984-10-11 Cassella Ag, 6000 Frankfurt Verfahren zur herstellung heterocyclischer phenylether
GB8423697D0 (en) * 1984-09-19 1984-10-24 Ciba Geigy Ag Benzazole derivatives
US4873346A (en) * 1985-09-20 1989-10-10 The Upjohn Company Substituted benzothiazoles, benzimidazoles, and benzoxazoles
GB9205507D0 (en) * 1991-03-28 1992-04-29 Ici Plc Heterocyclic compounds
GB9219634D0 (en) * 1992-09-16 1992-10-28 Ici Plc Heterocyclic compounds
FR2708608B1 (fr) * 1993-07-30 1995-10-27 Sanofi Sa Dérivés de N-sulfonylbenzimidazolone, leur préparation, les compositions pharmaceutiques en contenant.
ID24372A (id) 1997-10-27 2000-07-13 Agouron Pharma SENYAWA-SENYAWA 4-AMINO-TIAZOL-2-IL SEBAGAI PENGHAMBAT-PENGHAMBAT CDKs
CA2553724A1 (en) * 2004-02-03 2005-08-18 Abbott Laboratories Aminobenzoxazoles as therapeutic agents
US9086416B2 (en) * 2011-07-12 2015-07-21 Academia Sinica Removable saccharide-benzimidazole (BIM) tags and conjugates thereof via 1H-position of the benzimidazoles

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH542853A (de) * 1967-07-26 1973-10-15 Agripat Sa Verfahren zur Herstellung neuer Isothiocyano-benzazol-Derivate
AT286292B (de) * 1969-01-10 1970-12-10 Agripat Sa Verfahren zur Herstellung von neuen Isothiocyano-benzimidazol- und -benzoxazolderivaten und ihren Salzen

Also Published As

Publication number Publication date
BR7208610D0 (pt) 1973-09-20
FI56531B (fi) 1979-10-31
IE37194L (en) 1973-06-07
AU4949472A (en) 1974-05-30
US3849431A (en) 1974-11-19
ZA728643B (en) 1973-08-29
DD105230A5 (pl) 1974-04-12
IE37194B1 (en) 1977-05-25
IL40935A (en) 1976-09-30
JPS5754511B2 (pl) 1982-11-18
ES409335A1 (es) 1976-04-16
NL7216645A (pl) 1973-06-12
YU36711B (en) 1984-08-31
AR220663A1 (es) 1980-11-28
IT1048106B (it) 1980-11-20
IL40935A0 (en) 1973-01-30
PL85278B1 (pl) 1976-04-30
GB1413519A (en) 1975-11-12
CH566321A5 (pl) 1975-09-15
AT322550B (de) 1975-05-26
AT324761B (de) 1975-09-25
RO60572A (pl) 1976-12-15
DE2259220C2 (de) 1984-05-17
NO137234B (no) 1977-10-17
HU167426B (pl) 1975-10-28
NO137234C (no) 1978-01-25
CS177109B2 (pl) 1977-07-29
BE792402A (fr) 1973-06-07
DE2259220A1 (de) 1973-06-14
SU589915A3 (ru) 1978-01-25
SU541433A3 (ru) 1976-12-30
JPS4864067A (pl) 1973-09-05
PL86697B1 (pl) 1976-06-30
YU298072A (en) 1982-06-18
SE402772B (sv) 1978-07-17
CA1014566A (en) 1977-07-26
BG21027A3 (pl) 1976-01-20
CS177148B2 (pl) 1977-07-29

Similar Documents

Publication Publication Date Title
FI56531C (fi) Foerfarande foer framstaellning av isotiocyanobenstiazoler med anthelmintisk och mikrobicid verkan
CN1035945C (zh) 5-烷基喹诺酮羧酸衍生物的制备方法
US3586670A (en) Isothiocyanobenzazoles and use thereof as anthelmintics
CS209450B2 (en) Method of making the new derivatives of the benzimidazole
NO311521B1 (no) Eventuelt substituerte 8-cyan-1-cyklopropyl-7-(2,8- diazabicyklo-[4.3.0]-nonan-8-yl)-6-fluor-1,4-dihydro-4-okso-3-kinolinkarboksylsyrer og deres derivater, fremgangsmåte forfremstilling derav, anvendelse av forbindelsene samt legemiddelinnehold
KR20010052236A (ko) 치환된 2-옥소-알칸산-[2-(인돌-3-일)-에틸]아미드
WO2017005018A1 (zh) 取代苯胍衍生物作为多粘菌素类抗生素增效剂的应用
US3676561A (en) Anthelmintic compositions containing new carbamates and thiocarbamates and method of use
US3840550A (en) Certain 6-isothiocyanobenzothiazoles
US3686110A (en) 1-oxybenzimidazoles
US4076824A (en) Anthelmintic oxadiazolinone derivatives
US4086336A (en) Phosphonothioureide anthelmintics
US4151298A (en) Anthelmintic compositions
HU183749B (en) Process for preparing new guanidine derivatives
US3755406A (en) Isothiocyano diphenylamines
US3934017A (en) Anthelmintic composition and method utilizing isothiocyanobenzazoles active ingredients
NO122373B (pl)
US3781290A (en) Phenoxyphenyl phenylthiophenyl and phenylaminophenyl piperazinylthio-ureas
US3803316A (en) Control of helminths with 4-(isothiocyanophenyl)-thiazoles
US3676450A (en) -4-(isothi ocyanophenyl)-thiazoles
US3933841A (en) 2-Phenoxy, -phenylthio-, and -phenyl-amino-benzoxazoles having an isothiocyano substituent
CS197255B2 (en) Method of producing basicly substituted 2-alkoxycarbonyl-amino-benzimidazol-5/6/-ylphenyl esters and ketones
US3894037A (en) Certain isothiocyanobenzimidazoles
US3822356A (en) Use of isothiocyanobenzoxazoles and isothiocyanobenzimidazoles as anthelmintics
IE48383B1 (en) Benzothiazole derivatives anthelmintics