FI3856151T3 - Treosulfaanin lyofilisaatti - Google Patents
Treosulfaanin lyofilisaatti Download PDFInfo
- Publication number
- FI3856151T3 FI3856151T3 FIEP19778493.7T FI19778493T FI3856151T3 FI 3856151 T3 FI3856151 T3 FI 3856151T3 FI 19778493 T FI19778493 T FI 19778493T FI 3856151 T3 FI3856151 T3 FI 3856151T3
- Authority
- FI
- Finland
- Prior art keywords
- weight
- lyophilisate
- mbar
- temperature
- process according
- Prior art date
Links
- YCPOZVAOBBQLRI-WDSKDSINSA-N Treosulfan Chemical compound CS(=O)(=O)OC[C@H](O)[C@@H](O)COS(C)(=O)=O YCPOZVAOBBQLRI-WDSKDSINSA-N 0.000 title claims 5
- 229960003181 treosulfan Drugs 0.000 title claims 5
- 238000000034 method Methods 0.000 claims 11
- 238000001035 drying Methods 0.000 claims 10
- 239000000243 solution Substances 0.000 claims 6
- 239000007864 aqueous solution Substances 0.000 claims 5
- 238000007710 freezing Methods 0.000 claims 4
- 230000008014 freezing Effects 0.000 claims 4
- 238000000634 powder X-ray diffraction Methods 0.000 claims 4
- 238000001816 cooling Methods 0.000 claims 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Natural products CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 2
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims 2
- 238000004108 freeze drying Methods 0.000 claims 2
- 239000003960 organic solvent Substances 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000001185 bone marrow Anatomy 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 239000002274 desiccant Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229940098779 methanesulfonic acid Drugs 0.000 claims 1
- 238000011476 stem cell transplantation Methods 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
- C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C309/07—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing oxygen atoms bound to the carbon skeleton
- C07C309/08—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing oxygen atoms bound to the carbon skeleton containing hydroxy groups bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18196967 | 2018-09-26 | ||
| PCT/EP2019/075832 WO2020064819A1 (en) | 2018-09-26 | 2019-09-25 | Lyophilisate of treosulfan |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| FI3856151T3 true FI3856151T3 (fi) | 2023-11-15 |
Family
ID=63685769
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FIEP19778493.7T FI3856151T3 (fi) | 2018-09-26 | 2019-09-25 | Treosulfaanin lyofilisaatti |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20220031620A1 (hu) |
| EP (2) | EP3856151B1 (hu) |
| JP (2) | JP2022509904A (hu) |
| CN (1) | CN112752569A (hu) |
| CA (1) | CA3113705A1 (hu) |
| DK (1) | DK3856151T3 (hu) |
| EA (1) | EA202190616A1 (hu) |
| ES (1) | ES2964602T3 (hu) |
| FI (1) | FI3856151T3 (hu) |
| HR (1) | HRP20231343T1 (hu) |
| HU (1) | HUE064508T2 (hu) |
| LT (1) | LT3856151T (hu) |
| PL (1) | PL3856151T3 (hu) |
| PT (1) | PT3856151T (hu) |
| WO (1) | WO2020064819A1 (hu) |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1188583B (de) | 1960-02-22 | 1965-03-11 | Leo Pharm Prod Ltd | Verfahren zur Herstellung der Steroisomeren und des Racemats von Butan-1, 2, 3, 4-tetrol-1, 4-di-(methansulfonat) |
| GB896052A (en) * | 1960-02-22 | 1962-05-09 | Knud Abildgaard | The stereo-isomers and the racemate of butane-1,2,3,4-tetrol-1,4-di-(methanesulphonate) |
| DE1193938B (de) | 1961-10-02 | 1965-06-03 | Leo Pharm Prod Ltd | Verfahren zur Herstellung des Racemats und der Stereoisomeren einschliesslich des Mesoisomeren von Butan-1, 2, 3, 4-tetrol-1, 4-di-(methansulfonat) |
| DE19936281C2 (de) * | 1999-08-02 | 2002-04-04 | Bayer Ag | Verfahren zur Gefriertrocknung |
| DE19953517C1 (de) | 1999-11-05 | 2001-08-09 | Medac Klinische Spezialpraep | Verwendung von Treosulfan zur Konditionierung von Patienten vor Knochemarktransplantation oder Blutstammzelltransplantation |
| US8793895B2 (en) * | 2006-02-10 | 2014-08-05 | Praxair Technology, Inc. | Lyophilization system and method |
| IN2013MU03491A (hu) * | 2013-11-04 | 2015-07-31 | Emcure Pharmaceuticals Ltd |
-
2019
- 2019-09-25 PL PL19778493.7T patent/PL3856151T3/pl unknown
- 2019-09-25 PT PT197784937T patent/PT3856151T/pt unknown
- 2019-09-25 EP EP19778493.7A patent/EP3856151B1/en active Active
- 2019-09-25 WO PCT/EP2019/075832 patent/WO2020064819A1/en unknown
- 2019-09-25 EA EA202190616A patent/EA202190616A1/ru unknown
- 2019-09-25 HR HRP20231343TT patent/HRP20231343T1/hr unknown
- 2019-09-25 LT LTEPPCT/EP2019/075832T patent/LT3856151T/lt unknown
- 2019-09-25 FI FIEP19778493.7T patent/FI3856151T3/fi active
- 2019-09-25 ES ES19778493T patent/ES2964602T3/es active Active
- 2019-09-25 DK DK19778493.7T patent/DK3856151T3/da active
- 2019-09-25 EP EP23192810.2A patent/EP4257122A3/en active Pending
- 2019-09-25 US US17/279,200 patent/US20220031620A1/en active Pending
- 2019-09-25 JP JP2021516733A patent/JP2022509904A/ja active Pending
- 2019-09-25 CN CN201980062324.9A patent/CN112752569A/zh active Pending
- 2019-09-25 CA CA3113705A patent/CA3113705A1/en active Pending
- 2019-09-25 HU HUE19778493A patent/HUE064508T2/hu unknown
-
2023
- 2023-08-24 JP JP2023136343A patent/JP2023153362A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2022509904A (ja) | 2022-01-25 |
| HUE064508T2 (hu) | 2024-03-28 |
| EP3856151B1 (en) | 2023-08-23 |
| EP3856151A1 (en) | 2021-08-04 |
| LT3856151T (lt) | 2023-11-27 |
| DK3856151T3 (da) | 2023-11-27 |
| CA3113705A1 (en) | 2020-04-02 |
| ES2964602T3 (es) | 2024-04-08 |
| EA202190616A1 (ru) | 2021-06-25 |
| US20220031620A1 (en) | 2022-02-03 |
| HRP20231343T1 (hr) | 2024-02-16 |
| JP2023153362A (ja) | 2023-10-17 |
| EP4257122A2 (en) | 2023-10-11 |
| EP4257122A3 (en) | 2024-01-10 |
| PL3856151T3 (pl) | 2024-02-19 |
| PT3856151T (pt) | 2023-10-27 |
| CN112752569A (zh) | 2021-05-04 |
| WO2020064819A1 (en) | 2020-04-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| TWI472515B (zh) | 苯達莫斯汀鹽酸鹽（ｂｅｎｄａｍｕｓｔｉｎｅ ｈｙｄｒｏｃｈｌｏｒｉｄｅ）之新穎固體型式 | |
| CN107207552B (zh) | N-乙酰神经氨酸铵盐无水物的晶体及其制造方法 | |
| WO2017203514A1 (en) | Polymorphs of crisaborole and production processes therefor | |
| US20160251387A1 (en) | Synthesis of 1-alkyl-2-amino-imidazol-5-carboxylic acid ester via calpha-substituted n-alkyl-glycine ester derivatives | |
| RU2016116274A (ru) | Твёрдые формы цефтолозана | |
| FI3856151T3 (fi) | Treosulfaanin lyofilisaatti | |
| AR113852A1 (es) | Procedimiento para la preparación de (3s)-3-(4-cloro-3-{[(2s,3r)-2-(4-clorofenil)-4,4,4-trifluor-3-metilbutanoil]amino}fenil)-3-ácido ciclopropilpropanoico y su forma cristalina para uso como principio activo farmacéutico | |
| CA2920080A1 (en) | A process for preparing rifaximin .kappa. | |
| CA3153888A1 (en) | Polymorphs of avapritinib and methods for preparing the polymorphs | |
| AU2019216615B2 (en) | New polymorphic forms of minocycline base and processes for their preparation | |
| US7507865B2 (en) | Method for obtaining calcipotriol hydrate | |
| US20190276399A1 (en) | Polymorph of nintedanib | |
| RU2425025C1 (ru) | Способ получения бета глицина | |
| KR102188689B1 (ko) | 세프메타졸 소듐의 제조 방법 | |
| WO2012066492A1 (en) | Processes for the preparation of carbapenem antibiotic composition | |
| RU2020124783A (ru) | Способ получения лиофилизированного препарата | |
| RU2616976C1 (ru) | Кристаллическая β-модификация 3-(4-амино-1-оксо-1,3-дигидро-2Н-изоиндол-2-ил)-пиперидин-2,6-диона, способ её получения и фармацевтическая композиция на её основе | |
| JPS63166813A (ja) | 殺微生物活性のあるピロ亜燐酸塩、その製法及び殺微生物剤 | |
| RU2020143018A (ru) | Солевая форма | |
| RU2567537C1 (ru) | Кристаллическая безводная дельта-модификация n-(2-хлор-6-метилфенил)-2-[[6-[4-(2-гидроксиэтил)-1-пиперазинил]-2-метил-4-пиримидинил]амино]-5-тиазолкарбоксамида, способ ее получения и фармацевтическая композиция на ее основе | |
| RU2022104700A (ru) | Твердые формы n-трет-бутил-4[[2-(5-хлор-2-гидроксифенил)ацетил]амино]пиридин-2-карбоксамида | |
| KR102355450B1 (ko) | 티아쿠미신의 제조를 위한 방법 | |
| SU945067A1 (ru) | Гидратированный двойной триполифосфат аммони -алюмини и способ его получени | |
| RU2010119780A (ru) | Способ получения кристаллов фуллерена с60 особой чистоты | |
| NZ738836A (en) | Solid forms of (z)-4-(5-((3-benzyl-4-oxo-2-thioxothiazolidin-5-ylidene)methyl)furan-2-yl)benzoic acid |