FI3528830T3 - Polymyksiini-alginaattioligomeerikonjugaatteja - Google Patents
Polymyksiini-alginaattioligomeerikonjugaatteja Download PDFInfo
- Publication number
- FI3528830T3 FI3528830T3 FIEP17791037.9T FI17791037T FI3528830T3 FI 3528830 T3 FI3528830 T3 FI 3528830T3 FI 17791037 T FI17791037 T FI 17791037T FI 3528830 T3 FI3528830 T3 FI 3528830T3
- Authority
- FI
- Finland
- Prior art keywords
- polymyxin
- alginate oligomer
- alginate
- acid
- class antibiotic
- Prior art date
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- 229940072056 alginate Drugs 0.000 title claims 43
- 229920000615 alginic acid Polymers 0.000 title claims 43
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims 26
- 235000010443 alginic acid Nutrition 0.000 claims 26
- 108010040201 Polymyxins Proteins 0.000 claims 14
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- -1 carbonate ester Chemical class 0.000 claims 10
- 238000000034 method Methods 0.000 claims 6
- 239000000178 monomer Substances 0.000 claims 6
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 5
- 239000000243 solution Substances 0.000 claims 4
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- OGNSCSPNOLGXSM-UHFFFAOYSA-N 2,4-diaminobutyric acid Chemical group NCCC(N)C(O)=O OGNSCSPNOLGXSM-UHFFFAOYSA-N 0.000 claims 2
- GVJXGCIPWAVXJP-UHFFFAOYSA-N 2,5-dioxo-1-oxoniopyrrolidine-3-sulfonate Chemical compound ON1C(=O)CC(S(O)(=O)=O)C1=O GVJXGCIPWAVXJP-UHFFFAOYSA-N 0.000 claims 2
- PMNLUUOXGOOLSP-UHFFFAOYSA-N 2-mercaptopropanoic acid Chemical compound CC(S)C(O)=O PMNLUUOXGOOLSP-UHFFFAOYSA-N 0.000 claims 2
- VHYFNPMBLIVWCW-UHFFFAOYSA-N 4-Dimethylaminopyridine Chemical compound CN(C)C1=CC=NC=C1 VHYFNPMBLIVWCW-UHFFFAOYSA-N 0.000 claims 2
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- XDJYMJULXQKGMM-UHFFFAOYSA-N polymyxin E1 Natural products CCC(C)CCCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(C(C)O)NC(=O)C(CCN)NC(=O)C(CCN)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CCN)NC1=O XDJYMJULXQKGMM-UHFFFAOYSA-N 0.000 claims 2
- KNIWPHSUTGNZST-UHFFFAOYSA-N polymyxin E2 Natural products CC(C)CCCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(C(C)O)NC(=O)C(CCN)NC(=O)C(CCN)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CCN)NC1=O KNIWPHSUTGNZST-UHFFFAOYSA-N 0.000 claims 2
- 229940041153 polymyxins Drugs 0.000 claims 2
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- GMKMEZVLHJARHF-UHFFFAOYSA-N (2R,6R)-form-2.6-Diaminoheptanedioic acid Natural products OC(=O)C(N)CCCC(N)C(O)=O GMKMEZVLHJARHF-UHFFFAOYSA-N 0.000 claims 1
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims 1
- NMDDZEVVQDPECF-LURJTMIESA-N (2s)-2,7-diaminoheptanoic acid Chemical compound NCCCCC[C@H](N)C(O)=O NMDDZEVVQDPECF-LURJTMIESA-N 0.000 claims 1
- FYMNTAQFDTZISY-QMMMGPOBSA-N (2s)-2-amino-3-[4-(diaminomethylideneamino)phenyl]propanoic acid Chemical compound OC(=O)[C@@H](N)CC1=CC=C(N=C(N)N)C=C1 FYMNTAQFDTZISY-QMMMGPOBSA-N 0.000 claims 1
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- ABFYEILPZWAIBN-UHFFFAOYSA-N 3-(iminomethylideneamino)-n,n-dimethylpropan-1-amine;hydrochloride Chemical compound Cl.CN(C)CCCN=C=N ABFYEILPZWAIBN-UHFFFAOYSA-N 0.000 claims 1
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- BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
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- QUOGESRFPZDMMT-UHFFFAOYSA-N L-Homoarginine Natural products OC(=O)C(N)CCCCNC(N)=N QUOGESRFPZDMMT-UHFFFAOYSA-N 0.000 claims 1
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- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 claims 1
- UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 claims 1
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- UCKMPCXJQFINFW-UHFFFAOYSA-N Sulphide Chemical compound [S-2] UCKMPCXJQFINFW-UHFFFAOYSA-N 0.000 claims 1
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- YTGJWQPHMWSCST-UHFFFAOYSA-N Tiopronin Chemical compound CC(S)C(=O)NCC(O)=O YTGJWQPHMWSCST-UHFFFAOYSA-N 0.000 claims 1
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Classifications
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- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
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- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
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- A61P31/04—Antibacterial agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pulmonology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1617860.0A GB201617860D0 (en) | 2016-10-21 | 2016-10-21 | Polymyxin-alginate oligomer conjugates |
| GBGB1714710.9A GB201714710D0 (en) | 2017-09-13 | 2017-09-13 | Polymyxin-alginate oligomer conjugates |
| PCT/EP2017/076927 WO2018073449A1 (en) | 2016-10-21 | 2017-10-20 | Polymyxin-alginate oligomer conjugates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| FI3528830T3 true FI3528830T3 (fi) | 2023-01-13 |
Family
ID=60186268
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FIEP17791037.9T FI3528830T3 (fi) | 2016-10-21 | 2017-10-20 | Polymyksiini-alginaattioligomeerikonjugaatteja |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20190328833A1 (https=) |
| EP (1) | EP3528830B1 (https=) |
| JP (1) | JP2020503253A (https=) |
| KR (1) | KR20190072579A (https=) |
| CN (1) | CN109843315A (https=) |
| AU (1) | AU2017345295A1 (https=) |
| BR (1) | BR112019007927A2 (https=) |
| CA (1) | CA3040795A1 (https=) |
| DK (1) | DK3528830T3 (https=) |
| ES (1) | ES2933983T3 (https=) |
| FI (1) | FI3528830T3 (https=) |
| RU (1) | RU2019109719A (https=) |
| WO (1) | WO2018073449A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115003311B (zh) * | 2019-12-14 | 2024-04-19 | 乔杜里·马努 | 降低多器官毒性的多元药物制剂 |
| WO2021150792A1 (en) * | 2020-01-21 | 2021-07-29 | Micurx Pharmaceuticals, Inc. | Novel compounds and composition for targeted therapy of kidney-associated cancers |
| US12037631B2 (en) * | 2020-10-06 | 2024-07-16 | City University Of Hong Kong | System and method for detecting a target enzyme |
| CN113069556B (zh) * | 2021-04-12 | 2022-04-08 | 青岛大学附属医院 | 一种枝接那他霉素的氧化海藻酸纤维膜及其制备方法 |
| CN113081956A (zh) * | 2021-04-12 | 2021-07-09 | 青岛大学附属医院 | 一种氧化海藻酸钠改性的那他霉素滴眼液及其制备方法 |
| JP7755347B2 (ja) * | 2021-07-21 | 2025-10-16 | シャンハイ ミクウルク ファーマシューティカル シーオー．エルティーディー | 腎癌の標的治療のための新規化合物及び組成物 |
| US20250109171A1 (en) * | 2021-07-21 | 2025-04-03 | Shanghai MICURX Pharmaceuticals Co., Ltd. | Compounds and compositions for targeted therapy of renal diseases |
| CN114009731B (zh) * | 2021-11-05 | 2024-01-02 | 恒枫食品科技有限公司 | 一种茶风味基料及其制备方法、应用 |
| CN114752535A (zh) * | 2022-05-16 | 2022-07-15 | 北京昊峰节能环保科技有限公司 | 一种总石油烃污染地下水生物修复剂及其制备方法与应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB976301A (en) * | 1960-10-27 | 1964-11-25 | Calmic Ltd | Preparation and use of alginates |
| ES2063326T3 (es) * | 1989-11-15 | 1995-01-01 | Sandoz Ltd | Conjugados de polimixina. |
| US5177059A (en) * | 1989-11-15 | 1993-01-05 | Sandoz Ltd. | Polymyxin B conjugates |
| GB2270920B (en) * | 1992-09-25 | 1997-04-02 | Univ Keele | Alginate-bioactive agent conjugates |
| US6011008A (en) * | 1997-01-08 | 2000-01-04 | Yissum Research Developement Company Of The Hebrew University Of Jerusalem | Conjugates of biologically active substances |
| HUE034051T2 (en) * | 2007-11-27 | 2018-01-29 | Algipharma As | Use of alginate-containing oligomers to combat biofilms |
| ES2444541T3 (es) * | 2009-06-03 | 2014-02-25 | Algipharma As | Oligómeros de alginato para usar para superar la multirresistencia a fármacos en bacterias |
-
2017
- 2017-10-20 AU AU2017345295A patent/AU2017345295A1/en not_active Abandoned
- 2017-10-20 CN CN201780065109.5A patent/CN109843315A/zh active Pending
- 2017-10-20 BR BR112019007927A patent/BR112019007927A2/pt not_active IP Right Cessation
- 2017-10-20 DK DK17791037.9T patent/DK3528830T3/da active
- 2017-10-20 EP EP17791037.9A patent/EP3528830B1/en active Active
- 2017-10-20 FI FIEP17791037.9T patent/FI3528830T3/fi active
- 2017-10-20 JP JP2019521049A patent/JP2020503253A/ja active Pending
- 2017-10-20 ES ES17791037T patent/ES2933983T3/es active Active
- 2017-10-20 RU RU2019109719A patent/RU2019109719A/ru unknown
- 2017-10-20 KR KR1020197014050A patent/KR20190072579A/ko not_active Abandoned
- 2017-10-20 WO PCT/EP2017/076927 patent/WO2018073449A1/en not_active Ceased
- 2017-10-20 US US16/343,568 patent/US20190328833A1/en not_active Abandoned
- 2017-10-20 CA CA3040795A patent/CA3040795A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| KR20190072579A (ko) | 2019-06-25 |
| RU2019109719A (ru) | 2020-11-24 |
| DK3528830T3 (da) | 2022-12-19 |
| RU2019109719A3 (https=) | 2021-02-20 |
| BR112019007927A2 (pt) | 2019-07-02 |
| CA3040795A1 (en) | 2018-04-26 |
| ES2933983T3 (es) | 2023-02-15 |
| CN109843315A (zh) | 2019-06-04 |
| WO2018073449A1 (en) | 2018-04-26 |
| EP3528830A1 (en) | 2019-08-28 |
| JP2020503253A (ja) | 2020-01-30 |
| AU2017345295A1 (en) | 2019-05-02 |
| EP3528830B1 (en) | 2022-10-05 |
| US20190328833A1 (en) | 2019-10-31 |
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