FI3373976T3 - Topikaalisia formulaatioita ja niiden käyttöjä - Google Patents
Topikaalisia formulaatioita ja niiden käyttöjä Download PDFInfo
- Publication number
- FI3373976T3 FI3373976T3 FIEP16864797.2T FI16864797T FI3373976T3 FI 3373976 T3 FI3373976 T3 FI 3373976T3 FI 16864797 T FI16864797 T FI 16864797T FI 3373976 T3 FI3373976 T3 FI 3373976T3
- Authority
- FI
- Finland
- Prior art keywords
- formulation
- hco
- polyoxyl
- weight
- ophthalmic
- Prior art date
Links
- 239000012049 topical pharmaceutical composition Substances 0.000 title 1
- 238000009472 formulation Methods 0.000 claims 29
- 239000000203 mixture Substances 0.000 claims 29
- 229920002675 Polyoxyl Polymers 0.000 claims 8
- 150000002632 lipids Chemical class 0.000 claims 8
- 239000000194 fatty acid Substances 0.000 claims 6
- 235000014113 dietary fatty acids Nutrition 0.000 claims 5
- 229930195729 fatty acid Natural products 0.000 claims 5
- 150000004665 fatty acids Chemical class 0.000 claims 5
- 150000001298 alcohols Polymers 0.000 claims 3
- 229920002701 Polyoxyl 40 Stearate Polymers 0.000 claims 2
- 229920004914 octoxynol-40 Polymers 0.000 claims 2
- 229940099429 polyoxyl 40 stearate Drugs 0.000 claims 2
- 208000003556 Dry Eye Syndromes Diseases 0.000 claims 1
- 206010013774 Dry eye Diseases 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 239000000227 bioadhesive Substances 0.000 claims 1
- 239000007853 buffer solution Substances 0.000 claims 1
- 239000004359 castor oil Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000003921 oil Substances 0.000 claims 1
- 239000003960 organic solvent Substances 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 239000003755 preservative agent Substances 0.000 claims 1
- 230000002335 preservative effect Effects 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Ophthalmology & Optometry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Dispersion Chemistry (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562253569P | 2015-11-10 | 2015-11-10 | |
| PCT/US2016/060391 WO2017083167A1 (en) | 2015-11-10 | 2016-11-03 | Topical formulations and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| FI3373976T3 true FI3373976T3 (fi) | 2024-03-25 |
Family
ID=58695926
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FIEP16864797.2T FI3373976T3 (fi) | 2015-11-10 | 2016-11-03 | Topikaalisia formulaatioita ja niiden käyttöjä |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US20190231885A1 (enExample) |
| EP (2) | EP3373976B1 (enExample) |
| JP (2) | JP7793283B2 (enExample) |
| AU (1) | AU2016351588A1 (enExample) |
| DK (1) | DK3373976T3 (enExample) |
| ES (1) | ES2974821T3 (enExample) |
| FI (1) | FI3373976T3 (enExample) |
| PL (1) | PL3373976T3 (enExample) |
| PT (1) | PT3373976T (enExample) |
| WO (1) | WO2017083167A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2948387T3 (es) | 2012-08-24 | 2023-09-11 | Sun Pharmaceutical Ind Ltd | Formulación oftálmica de ácidos grasos polioxílicos o lípidos polioxílicos y tratamiento de afecciones oculares |
| DK3373976T3 (da) | 2015-11-10 | 2024-04-02 | Sun Pharmaceutical Ind Ltd | Topiske formuleringer og anvendelser deraf |
| PT3423076T (pt) * | 2016-02-29 | 2024-07-01 | Sun Pharmaceutical Ind Ltd | Formulações tópicas contendo ciclosporina e respetivas utilizações |
| EP4387589A4 (en) * | 2021-08-20 | 2025-09-03 | Sun Pharmaceutical Ind Ltd | STABLE OPHTHALMIC FORMULATION OF CYCLOSPORINE AND PROCESS FOR ITS MANUFACTURE |
Family Cites Families (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG45449A1 (en) | 1992-05-13 | 1998-01-16 | Sandoz Ltd | Ophthalmic compositions |
| NZ247516A (en) | 1993-04-28 | 1995-02-24 | Bernard Charles Sherman | Water dispersible pharmaceutical compositions comprising drug dissolved in solvent system comprising at least one alcohol and at least one surfactant |
| US5484597A (en) * | 1993-07-30 | 1996-01-16 | Chesebrough-Pond's Usa Co. | Clear hydroalcholic cosmetic microemulsions |
| NZ280689A (en) | 1995-12-15 | 1997-08-22 | Bernard Charles Sherma Sherman | Pharmaceutical composition comprising a cyclosporipharmaceutical composition comprising a cyclosporin; a tocol, tocopherol or tocotrienol; and propylen; a tocol, tocopherol or tocotrienol; and propylene carbonate or polyethylene glycol ne carbonate or polyethylene glycol |
| MX9701946A (es) | 1997-03-14 | 1998-04-30 | Arturo Jimenez Bayardo | Solucion oftalmica transportadora. |
| US7678836B2 (en) | 1999-11-04 | 2010-03-16 | Fxs Ventures, Llc | Method for rendering a contact lens wettable |
| US7732404B2 (en) | 1999-12-30 | 2010-06-08 | Dexcel Ltd | Pro-nanodispersion for the delivery of cyclosporin |
| ATE504557T1 (de) | 2000-02-16 | 2011-04-15 | Brigham & Womens Hospital | Aspirin-ausgelöste lipidmediatoren |
| US20030176356A1 (en) | 2001-04-24 | 2003-09-18 | University Of North Texas Health Science Center | Endothelin antagonists and endothelin-converting enzyme inhibitors for the treatment of glaucoma |
| PT1435910E (pt) | 2001-10-19 | 2009-09-07 | Isotechnika Inc | Novos pré-concentrados de microemulsão de análogos da ciclosporina |
| AU2002365167A1 (en) | 2001-12-18 | 2003-07-09 | The Brigham And Women's Hospital | Inhibition or prevention of infection by bacteria with epa, dha or analogs |
| US7582785B2 (en) | 2002-04-01 | 2009-09-01 | University Of Southern California | Trihydroxy polyunsaturated eicosanoid derivatives |
| ES2527753T3 (es) | 2002-04-01 | 2015-01-29 | University Of Southern California | Eicosanoides trihidroxi poliinsaturados |
| US7759395B2 (en) | 2002-08-12 | 2010-07-20 | The Brigham And Women's Hospital, Inc. | Use of docosatrienes, resolvins and their stable analogs in the treatment of airway diseases and asthma |
| JP4845378B2 (ja) | 2002-08-12 | 2011-12-28 | ザ ブライハム アンド ウイメンズ ホスピタル，インコーポレイテッド | レソルビン：治療処置用のバイオテンプレート |
| WO2004069181A2 (en) | 2003-02-03 | 2004-08-19 | Pharmacia Corporation | Composition for the treatment of intraocular pressure |
| JP2004238346A (ja) | 2003-02-07 | 2004-08-26 | Shiono Chemical Co Ltd | トラニラストの安定な水溶液製剤 |
| WO2004078143A2 (en) | 2003-03-05 | 2004-09-16 | The Brigham And Women's Hospital Inc. | Methods for identification and uses of anti-inflammatory receptors for eicosapentaenoic acid analogs |
| AU2003228126A1 (en) | 2003-05-02 | 2004-11-23 | Arturo Jimenez Bayardo | Method of preparing an aqueous solution of cyclosporin-a and resulting aqueous solution |
| US7087237B2 (en) | 2003-09-19 | 2006-08-08 | Advanced Ocular Systems Limited | Ocular solutions |
| US20050238589A1 (en) | 2004-04-14 | 2005-10-27 | Van Dyke Thomas E | Methods and compositions for preventing or treating periodontal diseases |
| ES2314354T3 (es) | 2004-11-09 | 2009-03-16 | Novagali Pharma S.A. | Emulsion de tipo aceite en agua con baja concentracion de agente cationico y potencial zeta positivo. |
| EA010802B1 (ru) | 2004-11-19 | 2008-12-30 | Мартек Байосайенсиз Корпорейшн | Оксилипины из полиненасыщенных жирных кислот с длинной цепью и способы их получения и применения |
| US20090209599A1 (en) | 2005-06-09 | 2009-08-20 | Yoko Endo | Eye drop containing roflumilast |
| AU2006259261B2 (en) | 2005-06-16 | 2013-06-13 | Myrexis, Inc. | Pharmaceutical compositions and use thereof |
| US20070015691A1 (en) | 2005-07-13 | 2007-01-18 | Allergan, Inc. | Cyclosporin compositions |
| CA2615990A1 (en) | 2005-07-18 | 2007-01-25 | Minu, L.L.C. | Enhanced ocular neuroprotection/neurostimulation |
| EP1983977A4 (en) | 2006-01-31 | 2011-11-30 | Martek Biosciences Corp | OXYLIPINES FROM STEARIDONIC ACID AND GAMMA-LINOLIC ACID AND METHOD FOR THE PRODUCTION AND USE THEREOF |
| US10137083B2 (en) | 2006-03-07 | 2018-11-27 | SGN Nanopharma Inc | Ophthalmic preparations |
| CA2650422A1 (en) | 2006-04-24 | 2007-11-08 | Nanocarrier Co., Ltd. | Process for producing polymer micelles encapsulating low molecular weight drugs |
| JPWO2007136134A1 (ja) | 2006-05-23 | 2009-10-01 | ナノキャリア株式会社 | 疎水性薬物内包ポリマーミセルの製造方法 |
| US8147868B2 (en) * | 2006-07-18 | 2012-04-03 | Nanocarrier Co., Ltd. | Physiologically active polypeptide- or protein-encapsulating polymer micelles, and method for production of the same |
| US20110190389A1 (en) | 2007-02-20 | 2011-08-04 | Linda Arterburn | Oxylipins from long chain polyunsaturated fatty acids and methods of making and using the same |
| US20100310462A1 (en) | 2007-04-18 | 2010-12-09 | Biochromix Ab | Binding of pathological forms of proteins using conjugated polyelectrolytes |
| US8512687B2 (en) | 2007-07-09 | 2013-08-20 | Novagali Pharma Sa | Oil in water emulsion comprising NSAIDs and quaternary ammonium halides |
| WO2009028674A1 (ja) | 2007-08-29 | 2009-03-05 | Wakamoto Pharmaceutical Co., Ltd. | ラタノプロスト含有水性医薬組成物 |
| MX2007011165A (es) | 2007-09-12 | 2009-03-11 | Arturo Jimenez Bayardo | Composición farmacéutica estable de timolol, dorzolamida y brimonidina. |
| AU2008310956B2 (en) | 2007-10-08 | 2014-08-07 | Aurinia Pharmaceuticals Inc. | Ophthalmic compositions comprising calcineurin inhibitors or mTOR inhibitors |
| US20090286718A1 (en) | 2008-01-04 | 2009-11-19 | Sirion Therapeutics, Inc. | Stable Aqueous Cyclosporin Compositions |
| TWI544927B (zh) | 2008-03-17 | 2016-08-11 | 愛爾康研究有限公司 | 具有低濃度的表面活性劑以促進治療劑之生物可利用性的藥學組成物 |
| US20090298956A1 (en) | 2008-05-28 | 2009-12-03 | Chowhan Masood A | Self-preserved emulsions |
| EP2127638A1 (en) | 2008-05-30 | 2009-12-02 | Santen Pharmaceutical Co., Ltd | Method and composition for treating ocular hypertension and glaucoma |
| EP2437756A2 (en) | 2009-06-02 | 2012-04-11 | Wu, Nian | Pure peg-lipid conjugates |
| MX338355B (es) | 2009-06-09 | 2016-04-13 | Aurinia Pharmaceuticals Inc | Sistemas de suministro de farmaco topico para uso oftalmico. |
| RU2012115103A (ru) | 2009-09-17 | 2013-10-27 | Сэндзю Фармасьютикал Ко., Лтд. | Водные глазные капли, содержащие латанопрост, и способ ингибирования адсорбции латанопроста полимером |
| US8637569B2 (en) | 2009-10-22 | 2014-01-28 | Api Genesis, Llc | Methods of increasing solubility of poorly soluble compounds and methods of making and using formulations of such compounds |
| WO2011106697A1 (en) | 2010-02-25 | 2011-09-01 | Schepens Eye Research Institute | Therapeutic compositions for the treatment of dry eye disease |
| CA2798923A1 (en) | 2010-05-07 | 2011-11-10 | Sun Pharma Advanced Research Company Ltd. | Novel ophthalmic compositions |
| WO2013025696A1 (en) | 2011-08-15 | 2013-02-21 | Teva Pharmaceutical Industries Ltd. | Ophthalmic formulations and processes for their preparation |
| US9278132B2 (en) | 2012-02-13 | 2016-03-08 | Bausch & Lomb Incorporated | Ophthalmic pharmaceutical compositions and methods of making and using same |
| KR101211902B1 (ko) | 2012-04-30 | 2012-12-13 | 주식회사 휴온스 | 사이클로스포린 함유 무자극성 나노에멀젼 안약 조성물 |
| EP2846769A1 (en) | 2012-05-11 | 2015-03-18 | Cipla Limited | Pharmaceutical composition |
| ES2948387T3 (es) | 2012-08-24 | 2023-09-11 | Sun Pharmaceutical Ind Ltd | Formulación oftálmica de ácidos grasos polioxílicos o lípidos polioxílicos y tratamiento de afecciones oculares |
| US10946076B2 (en) | 2013-02-13 | 2021-03-16 | The Research Foundation For The State University Of New York | Glaucoma treatment |
| MX2016015211A (es) | 2014-05-23 | 2017-06-20 | Ocular Tech Sarl | Formulaciones topicas y usos de las mismas. |
| US20150352176A1 (en) | 2014-06-06 | 2015-12-10 | Newport Research, Inc. | Oil-free and fat-free aqueous suspensions of cyclosporin |
| US9421199B2 (en) | 2014-06-24 | 2016-08-23 | Sydnexis, Inc. | Ophthalmic composition |
| US20180133217A1 (en) | 2015-05-04 | 2018-05-17 | Ocular Technologies Sarl | Topical formulations and uses thereof |
| DK3373976T3 (da) | 2015-11-10 | 2024-04-02 | Sun Pharmaceutical Ind Ltd | Topiske formuleringer og anvendelser deraf |
| EP3373924A4 (en) | 2015-11-12 | 2019-06-19 | Sun Pharma Global FZE | Topical formulations and uses thereof |
| PT3423076T (pt) | 2016-02-29 | 2024-07-01 | Sun Pharmaceutical Ind Ltd | Formulações tópicas contendo ciclosporina e respetivas utilizações |
| WO2017152129A2 (en) | 2016-03-03 | 2017-09-08 | Ocular Technologies Sarl | Treatment of glaucoma and/or retinal diseases and formulations useful therefore |
-
2016
- 2016-11-03 DK DK16864797.2T patent/DK3373976T3/da active
- 2016-11-03 JP JP2018543272A patent/JP7793283B2/ja active Active
- 2016-11-03 PT PT168647972T patent/PT3373976T/pt unknown
- 2016-11-03 ES ES16864797T patent/ES2974821T3/es active Active
- 2016-11-03 EP EP16864797.2A patent/EP3373976B1/en active Active
- 2016-11-03 EP EP23219654.3A patent/EP4364810A3/en active Pending
- 2016-11-03 PL PL16864797.2T patent/PL3373976T3/pl unknown
- 2016-11-03 AU AU2016351588A patent/AU2016351588A1/en not_active Abandoned
- 2016-11-03 FI FIEP16864797.2T patent/FI3373976T3/fi active
- 2016-11-03 US US15/772,779 patent/US20190231885A1/en not_active Abandoned
- 2016-11-03 WO PCT/US2016/060391 patent/WO2017083167A1/en not_active Ceased
-
2021
- 2021-03-12 US US17/200,454 patent/US12053528B2/en active Active
-
2022
- 2022-11-04 JP JP2022177207A patent/JP7669326B2/ja active Active
-
2024
- 2024-07-02 US US18/762,112 patent/US20240358840A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| ES2974821T3 (es) | 2024-07-01 |
| JP7669326B2 (ja) | 2025-04-28 |
| EP3373976A1 (en) | 2018-09-19 |
| WO2017083167A1 (en) | 2017-05-18 |
| EP4364810A3 (en) | 2024-07-24 |
| JP2018532809A (ja) | 2018-11-08 |
| PT3373976T (pt) | 2024-04-02 |
| EP4364810A2 (en) | 2024-05-08 |
| EP3373976A4 (en) | 2019-05-22 |
| AU2016351588A1 (en) | 2018-05-24 |
| US20240358840A1 (en) | 2024-10-31 |
| PL3373976T3 (pl) | 2024-06-24 |
| JP7793283B2 (ja) | 2026-01-05 |
| US20210268114A1 (en) | 2021-09-02 |
| JP2023012533A (ja) | 2023-01-25 |
| EP3373976B1 (en) | 2024-01-03 |
| US20190231885A1 (en) | 2019-08-01 |
| US12053528B2 (en) | 2024-08-06 |
| DK3373976T3 (da) | 2024-04-02 |
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