FI3294300T3 - Pitkävaikutteinen lääkkeenantolaite implantin tai kierukan muodossa, joka käsittää levonorgestreelia ja etinyyliestradiolia - Google Patents
Pitkävaikutteinen lääkkeenantolaite implantin tai kierukan muodossa, joka käsittää levonorgestreelia ja etinyyliestradiolia Download PDFInfo
- Publication number
- FI3294300T3 FI3294300T3 FIEP16720866.9T FI16720866T FI3294300T3 FI 3294300 T3 FI3294300 T3 FI 3294300T3 FI 16720866 T FI16720866 T FI 16720866T FI 3294300 T3 FI3294300 T3 FI 3294300T3
- Authority
- FI
- Finland
- Prior art keywords
- drug
- core segments
- silicon
- lng
- delivery device
- Prior art date
Links
- 238000012377 drug delivery Methods 0.000 title claims 3
- 239000007943 implant Substances 0.000 title claims 2
- ORKBYCQJWQBPFG-WOMZHKBXSA-N (8r,9s,10r,13s,14s,17r)-13-ethyl-17-ethynyl-17-hydroxy-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one;(8r,9s,13s,14s,17r)-17-ethynyl-13-methyl-7,8,9,11,12,14,15,16-octahydro-6h-cyclopenta[a]phenanthrene-3,17-diol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1.O=C1CC[C@@H]2[C@H]3CC[C@](CC)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 ORKBYCQJWQBPFG-WOMZHKBXSA-N 0.000 title 1
- 229960002826 levonorgestrel and ethinylestradiol Drugs 0.000 title 1
- 239000003509 long acting drug Substances 0.000 title 1
- 229940079593 drug Drugs 0.000 claims 10
- 239000003814 drug Substances 0.000 claims 10
- 238000000034 method Methods 0.000 claims 8
- WWYNJERNGUHSAO-XUDSTZEESA-N (+)-Norgestrel Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](CC)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 WWYNJERNGUHSAO-XUDSTZEESA-N 0.000 claims 7
- 229960004400 levonorgestrel Drugs 0.000 claims 7
- BFPYWIDHMRZLRN-UHFFFAOYSA-N 17alpha-ethynyl estradiol Natural products OC1=CC=C2C3CCC(C)(C(CC4)(O)C#C)C4C3CCC2=C1 BFPYWIDHMRZLRN-UHFFFAOYSA-N 0.000 claims 6
- BFPYWIDHMRZLRN-SLHNCBLASA-N Ethinyl estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 BFPYWIDHMRZLRN-SLHNCBLASA-N 0.000 claims 6
- 229960002568 ethinylestradiol Drugs 0.000 claims 6
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- -1 polysiloxanes Polymers 0.000 claims 3
- 229910052710 silicon Inorganic materials 0.000 claims 3
- 239000010703 silicon Substances 0.000 claims 3
- 239000004205 dimethyl polysiloxane Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000011159 matrix material Substances 0.000 claims 2
- 239000012528 membrane Substances 0.000 claims 2
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims 2
- 229920000642 polymer Polymers 0.000 claims 2
- 229920001296 polysiloxane Polymers 0.000 claims 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 1
- 125000002947 alkylene group Chemical group 0.000 claims 1
- 235000013870 dimethyl polysiloxane Nutrition 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- CXQXSVUQTKDNFP-UHFFFAOYSA-N octamethyltrisiloxane Chemical compound C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C CXQXSVUQTKDNFP-UHFFFAOYSA-N 0.000 claims 1
- 238000004987 plasma desorption mass spectroscopy Methods 0.000 claims 1
- 229920000233 poly(alkylene oxides) Polymers 0.000 claims 1
- 229920002379 silicone rubber Polymers 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
- A61K9/0036—Devices retained in the vagina or cervix for a prolonged period, e.g. intravaginal rings, medicated tampons, medicated diaphragms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
- A61K9/0039—Devices retained in the uterus for a prolonged period, e.g. intrauterine devices for contraception
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Reproductive Health (AREA)
- Epidemiology (AREA)
- Gynecology & Obstetrics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Orthopedics, Nursing, And Contraception (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15167521 | 2015-05-13 | ||
| PCT/EP2016/060298 WO2016180764A1 (en) | 2015-05-13 | 2016-05-09 | A long acting drug delivery device and its use in contraception |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| FI3294300T3 true FI3294300T3 (fi) | 2025-03-06 |
Family
ID=53174913
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FIEP16720866.9T FI3294300T3 (fi) | 2015-05-13 | 2016-05-09 | Pitkävaikutteinen lääkkeenantolaite implantin tai kierukan muodossa, joka käsittää levonorgestreelia ja etinyyliestradiolia |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US11096888B2 (cg-RX-API-DMAC10.html) |
| EP (1) | EP3294300B1 (cg-RX-API-DMAC10.html) |
| JP (1) | JP6898856B2 (cg-RX-API-DMAC10.html) |
| CN (1) | CN108135910B (cg-RX-API-DMAC10.html) |
| CA (1) | CA2985717A1 (cg-RX-API-DMAC10.html) |
| ES (1) | ES3009909T3 (cg-RX-API-DMAC10.html) |
| FI (1) | FI3294300T3 (cg-RX-API-DMAC10.html) |
| WO (1) | WO2016180764A1 (cg-RX-API-DMAC10.html) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20211195A1 (es) * | 2017-09-27 | 2021-07-01 | Bayer Oy | Un metodo para modificar la liberacion de un agente terapeuticamente activo de una matriz elastomerica |
| CA3087238A1 (en) | 2018-05-24 | 2019-11-28 | Celanese EVA Performance Polymers Corporation | Implantable device for sustained release of a macromolecular drug compound |
| EP3803866A4 (en) | 2018-05-24 | 2022-03-16 | Nureva Inc. | METHOD, APPARATUS, AND COMPUTER READABLE MATERIALS FOR MANAGING SEMI-CONSTANT (PERSISTENT) SOUND SOURCES IN MICROPHONE CATCH/HOME AREAS |
| CN111989068B (zh) | 2018-05-24 | 2024-10-25 | 塞拉尼斯伊娃高性能聚合物公司 | 用于持续释放大分子药物化合物的可植入器件 |
| US20240115490A1 (en) * | 2018-12-11 | 2024-04-11 | Lupin Inc. | Drug delivery system for ultra-low dose estrogen combinations and methods and uses thereof |
| WO2020123148A1 (en) * | 2018-12-11 | 2020-06-18 | Lupin Inc. | Drug delivery system for ultra-low dose estrogen combinations and methods and uses thereof |
| US20230404911A1 (en) * | 2018-12-11 | 2023-12-21 | Lupin Inc. | Drug delivery system for ultra-low dose estrogen combinations and methods and uses thereof |
| CN112315898B (zh) * | 2020-11-04 | 2021-08-13 | 国家卫生健康委科学技术研究所 | 含有芳香化酶抑制剂的阴道缓控释给药系统及其制备方法 |
| EP4329734A4 (en) | 2021-04-26 | 2025-04-02 | Celanese EVA Performance Polymers LLC | Implantable device for the delayed release of a macromolecular drug compound |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3920805A (en) | 1971-12-09 | 1975-11-18 | Upjohn Co | Pharmaceutical devices and method |
| US4215691A (en) | 1978-10-11 | 1980-08-05 | Alza Corporation | Vaginal contraceptive system made from block copolymer |
| US4292965A (en) | 1978-12-29 | 1981-10-06 | The Population Council, Inc. | Intravaginal ring |
| DE3040978A1 (de) | 1980-10-28 | 1982-05-27 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Vaginalring |
| FR2618329B1 (fr) | 1987-07-22 | 1997-03-28 | Dow Corning Sa | Procede de fabrication d'un anneau capable d'assurer la liberation d'un agent therapeutique, et anneau fabrique par ce procede |
| FI90627C (fi) | 1992-07-31 | 1994-03-10 | Leiras Oy | Laitteisto lääkeainesauvan varustamiseksi vaipalla |
| PH30867A (en) | 1992-07-31 | 1997-12-09 | Leiras Oy | Method and equipment for installing a medicine capsule on a support. |
| DK0836473T3 (da) | 1995-07-04 | 2002-02-11 | Akzo Nobel Nv | Ringformede indretninger |
| IL123813A0 (en) | 1997-04-11 | 1998-10-30 | Akzo Nobel Nv | Drug delivery system for two or more active substances |
| FI107339B (fi) | 1998-06-30 | 2001-07-13 | Leiras Oy | Lääkeaineiden läpäisynopeutta säätävä kalvo tai matriisi |
| US6056976A (en) | 1998-11-12 | 2000-05-02 | Leiras Oy | Elastomer, its preparation and use |
| US6063395A (en) * | 1998-11-12 | 2000-05-16 | Leiras Oy | Drug delivery device especially for the delivery of progestins and estrogens |
| US6476079B1 (en) * | 1999-12-23 | 2002-11-05 | Leiras Oy | Devices for the delivery of drugs having antiprogestinic properties |
| CN1289064C (zh) | 2001-08-31 | 2006-12-13 | 先灵有限责任公司 | 药物输送体系 |
| JP4898431B2 (ja) * | 2003-04-29 | 2012-03-14 | ザ ジェネラル ホスピタル コーポレイション | 複数薬物の持続放出のための方法およびデバイス |
| TW200927141A (en) * | 2007-11-22 | 2009-07-01 | Bayer Schering Pharma Oy | Vaginal delivery system |
| EP2062568A1 (en) | 2007-11-22 | 2009-05-27 | Bayer Schering Pharma Oy | Vaginal delivery system |
| EP2140860A1 (en) | 2008-07-03 | 2010-01-06 | Bayer Schering Pharma Oy | An improved method of contraception |
| FI121000B (fi) | 2008-11-19 | 2010-06-15 | Bayer Schering Pharma Oy | Intravaginaalinen antojärjestelmä ja menetelmä sen valmistamiseksi |
| US20140209100A1 (en) * | 2011-07-20 | 2014-07-31 | Patrick F. Kiser | Intravaginal devices for drug delivery |
| HUE049219T2 (hu) * | 2013-02-08 | 2020-09-28 | Qpharma Ab | Intravaginális eszköz, valamint eljárás az intravaginális eszközben lévõ hatóanyag diffúziós sebességének csökkentésére |
-
2016
- 2016-05-09 WO PCT/EP2016/060298 patent/WO2016180764A1/en not_active Ceased
- 2016-05-09 EP EP16720866.9A patent/EP3294300B1/en active Active
- 2016-05-09 US US15/573,187 patent/US11096888B2/en active Active
- 2016-05-09 CA CA2985717A patent/CA2985717A1/en active Pending
- 2016-05-09 CN CN201680041265.3A patent/CN108135910B/zh active Active
- 2016-05-09 FI FIEP16720866.9T patent/FI3294300T3/fi active
- 2016-05-09 ES ES16720866T patent/ES3009909T3/es active Active
- 2016-05-09 JP JP2017558678A patent/JP6898856B2/ja active Active
-
2021
- 2021-06-30 US US17/364,199 patent/US12357563B2/en active Active
-
2025
- 2025-06-18 US US19/242,221 patent/US20260053736A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP3294300A1 (en) | 2018-03-21 |
| US20260053736A1 (en) | 2026-02-26 |
| CN108135910B (zh) | 2022-12-02 |
| US12357563B2 (en) | 2025-07-15 |
| CN108135910A (zh) | 2018-06-08 |
| ES3009909T3 (en) | 2025-03-31 |
| US20210338573A1 (en) | 2021-11-04 |
| US20180104181A1 (en) | 2018-04-19 |
| WO2016180764A1 (en) | 2016-11-17 |
| JP6898856B2 (ja) | 2021-07-07 |
| CA2985717A1 (en) | 2016-11-17 |
| EP3294300B1 (en) | 2024-12-18 |
| JP2018516889A (ja) | 2018-06-28 |
| US11096888B2 (en) | 2021-08-24 |
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