RU2015103116A - Новый штамм lactobacillus crispatus - Google Patents
Новый штамм lactobacillus crispatus Download PDFInfo
- Publication number
- RU2015103116A RU2015103116A RU2015103116A RU2015103116A RU2015103116A RU 2015103116 A RU2015103116 A RU 2015103116A RU 2015103116 A RU2015103116 A RU 2015103116A RU 2015103116 A RU2015103116 A RU 2015103116A RU 2015103116 A RU2015103116 A RU 2015103116A
- Authority
- RU
- Russia
- Prior art keywords
- pharmaceutical composition
- composition according
- strain
- paragraphs
- lactobacillus crispatus
- Prior art date
Links
- 241000218492 Lactobacillus crispatus Species 0.000 title claims abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract 12
- 239000000203 mixture Substances 0.000 claims abstract 6
- 241000222122 Candida albicans Species 0.000 claims abstract 2
- 206010007134 Candida infections Diseases 0.000 claims abstract 2
- 239000004480 active ingredient Substances 0.000 claims abstract 2
- 230000009286 beneficial effect Effects 0.000 claims abstract 2
- 201000003984 candidiasis Diseases 0.000 claims abstract 2
- 210000004392 genitalia Anatomy 0.000 claims abstract 2
- 208000015181 infectious disease Diseases 0.000 claims abstract 2
- 239000011159 matrix material Substances 0.000 claims abstract 2
- 244000005706 microflora Species 0.000 claims abstract 2
- LWGJTAZLEJHCPA-UHFFFAOYSA-N n-(2-chloroethyl)-n-nitrosomorpholine-4-carboxamide Chemical compound ClCCN(N=O)C(=O)N1CCOCC1 LWGJTAZLEJHCPA-UHFFFAOYSA-N 0.000 claims abstract 2
- 239000002417 nutraceutical Substances 0.000 claims abstract 2
- 235000021436 nutraceutical agent Nutrition 0.000 claims abstract 2
- 230000002265 prevention Effects 0.000 claims abstract 2
- 230000001681 protective effect Effects 0.000 claims abstract 2
- AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 claims abstract 2
- 235000019345 sodium thiosulphate Nutrition 0.000 claims abstract 2
- 210000001215 vagina Anatomy 0.000 claims abstract 2
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/15—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators
- A61F13/20—Tampons, e.g. catamenial tampons; Accessories therefor
- A61F13/2074—Tampons, e.g. catamenial tampons; Accessories therefor impregnated with hydrophobic, hydrophilic, skin enhancers, medicinal etc. substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
- A61K9/0036—Devices retained in the vagina or cervix for a prolonged period, e.g. intravaginal rings, medicated tampons, medicated diaphragms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
- A23V2200/32—Foods, ingredients or supplements having a functional effect on health having an effect on the health of the digestive tract
- A23V2200/3204—Probiotics, living bacteria to be ingested for action in the digestive tract
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/11—Lactobacillus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/225—Lactobacillus
Abstract
1. Выделенный штамм Lactobacillus crispatus, идентифицированный как IP174178 и депонированный в CNCM под регистрационным номером I-4646.2. Фармацевтическая композиция, включающая штамм по п. 1.3. Фармацевтическая композиция по п. 2, включающая, по меньшей мере, 10KОЕ упомянутого штамма.4. Фармацевтическая композиция п. 2, дополнительно включающая защитную матрицу и, необязательно, другие активные ингредиенты.5. Фармацевтическая композиция по п. 2, дополнительно включающая тиосульфат натрия.6. Фармацевтическая композиция по п. 2, приготовленная для вагинального или перорального введения.7. Композиция по любому из пп. от 2 до 6 для применения в лечении и профилактике половых и урогенитальных инфекций, таких как вагиноз и кандидоз.8. Медицинское средство, в частности вагинальный тампон, содержащее композицию по п. 7.9. Нутрицевтическая композиция, включающая штамм по п. 1.10. Фармацевтическая композиция по любому из пп. от 2 до 6 для применения с целью поддержания или восстановления полезной микрофлоры влагалища.
Claims (10)
1. Выделенный штамм Lactobacillus crispatus, идентифицированный как IP174178 и депонированный в CNCM под регистрационным номером I-4646.
2. Фармацевтическая композиция, включающая штамм по п. 1.
3. Фармацевтическая композиция по п. 2, включающая, по меньшей мере, 109 KОЕ упомянутого штамма.
4. Фармацевтическая композиция п. 2, дополнительно включающая защитную матрицу и, необязательно, другие активные ингредиенты.
5. Фармацевтическая композиция по п. 2, дополнительно включающая тиосульфат натрия.
6. Фармацевтическая композиция по п. 2, приготовленная для вагинального или перорального введения.
7. Композиция по любому из пп. от 2 до 6 для применения в лечении и профилактике половых и урогенитальных инфекций, таких как вагиноз и кандидоз.
8. Медицинское средство, в частности вагинальный тампон, содержащее композицию по п. 7.
9. Нутрицевтическая композиция, включающая штамм по п. 1.
10. Фармацевтическая композиция по любому из пп. от 2 до 6 для применения с целью поддержания или восстановления полезной микрофлоры влагалища.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR1256569 | 2012-07-09 | ||
| FR1256569A FR2992973B1 (fr) | 2012-07-09 | 2012-07-09 | Nouvelle souche de lactobacillus crispatus |
| PCT/EP2013/064424 WO2014009330A1 (fr) | 2012-07-09 | 2013-07-09 | Nouvelle souche de lactobacillus crispatus |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2015103116A true RU2015103116A (ru) | 2016-08-27 |
| RU2661102C2 RU2661102C2 (ru) | 2018-07-11 |
Family
ID=47227918
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2015103116A RU2661102C2 (ru) | 2012-07-09 | 2013-07-09 | Штамм lactobacillus crispatus для лечения или профилактики половых и урогенитальных инфекций, таких как вагиноз и кандидоз, и его применение |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20150190438A1 (ru) |
| EP (1) | EP2870234B1 (ru) |
| KR (1) | KR20150036376A (ru) |
| CN (1) | CN104508117B (ru) |
| AU (1) | AU2013289309A1 (ru) |
| BR (1) | BR112014033026A2 (ru) |
| CA (1) | CA2878130A1 (ru) |
| ES (1) | ES2647833T3 (ru) |
| FR (1) | FR2992973B1 (ru) |
| HK (1) | HK1207116A1 (ru) |
| IN (1) | IN2014DN11142A (ru) |
| MX (1) | MX2015000338A (ru) |
| PT (1) | PT2870234T (ru) |
| RU (1) | RU2661102C2 (ru) |
| SA (1) | SA113340703B1 (ru) |
| TW (1) | TWI627276B (ru) |
| WO (1) | WO2014009330A1 (ru) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY172685A (en) * | 2013-11-08 | 2019-12-10 | Suzhou Osel Bio Pharm Co Ltd | A lactobacillus crispatus and application thereof |
| CN106562998A (zh) * | 2015-10-12 | 2017-04-19 | 深圳华大基因研究院 | 卷曲乳杆菌在治疗或预防子宫肌瘤相关疾病中的应用 |
| FR3048361B1 (fr) * | 2016-03-01 | 2020-12-18 | Biose | Compositions pour le traitement des candidoses |
| CA3068958A1 (en) * | 2017-07-07 | 2019-01-10 | Osel, Inc. | High potency stable formulations of vaginal lactobacillus |
| CN107794236B (zh) * | 2017-10-10 | 2022-10-18 | 内蒙古双奇药业股份有限公司 | 一种卷曲乳杆菌及其应用 |
| CN107937324B (zh) * | 2018-01-10 | 2020-01-21 | 中国科学院微生物研究所 | 一株卷曲乳杆菌及其应用 |
| GB201816425D0 (en) * | 2018-10-09 | 2018-11-28 | Tervisetehnoloogiate Arenduskeskus As | Probiotics |
| CN110960561B (zh) * | 2019-12-31 | 2020-10-16 | 江苏华庆农业发展有限公司 | 用于调节妇科菌群平衡的益生菌组合物 |
| CN111893057B (zh) * | 2020-06-29 | 2021-04-23 | 哈尔滨美华生物技术股份有限公司 | 一株用于防治妇女泌尿生殖道感染的卷曲乳杆菌及其应用 |
| CN112458007A (zh) * | 2020-11-10 | 2021-03-09 | 深圳华大生命科学研究院 | 用于预防和/或治疗生殖道菌群紊乱相关疾病的卷曲乳杆菌 |
| EP4301386A1 (en) * | 2021-03-03 | 2024-01-10 | Freya Biosciences ApS | Vaginal microbiota-associated methods, compositions, and devices |
| CN113512509B (zh) * | 2021-05-07 | 2022-02-22 | 南方医科大学珠江医院 | 卷曲乳杆菌及其用途 |
| WO2023075357A1 (ko) * | 2021-10-26 | 2023-05-04 | 일동제약(주) | 락토바실러스 크리스파투스 균주 및 이를 포함하는 질염의 예방 또는 치료용 조성물 |
| WO2024061444A1 (en) * | 2022-09-20 | 2024-03-28 | Uab "Avodes" | Sponge for the vaginal canal |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1426226A (fr) * | 1964-11-20 | 1966-01-28 | Ct De Lyophilisation Pharma | Perfectionnements à la conservation des germes microbiens et en particulier des bacilles lactiques par lyophilisation |
| DK242083D0 (da) | 1983-05-27 | 1983-05-27 | Hansens Chr Bio Syst | Vaginalkapsler |
| US6093394A (en) | 1997-04-11 | 2000-07-25 | Gynelogix, Inc. | Vaginal lactobacillus medicant |
| IT1299070B1 (it) * | 1998-04-10 | 2000-02-07 | Proge Farm Srl | Ceppi di lattobacilli capaci di inibire e/o avere azione microbicida nei confronti di microorganismi patogeni e metodo di induzione e |
| IL143632A0 (en) | 1998-12-11 | 2002-04-21 | Urex Biotech Inc | Pharmaceutical compositions containing lactobacillus |
| IT1306716B1 (it) * | 1999-06-21 | 2001-10-02 | Mendes S U R L | Associazione di batteri lattici e suo uso per la prevenzione e/o iltrattamento terapeutico di infezioni e di stati infiammatori. |
| US20020044926A1 (en) | 1999-12-10 | 2002-04-18 | Gregor Reid | Oral administration of lactobacillus for the treatment and prevention of urogenital infection |
| SE521022C2 (sv) * | 2001-09-20 | 2003-09-23 | Ellen Ab | Mjölksyraproducerande bakterier för användning som probiotiska organismer i vaginan hos människa |
| SE528382C2 (sv) * | 2004-10-05 | 2006-10-31 | Probi Ab | Probiotiska lactobacillusstammar för förbättrad vaginal hälsa |
| WO2006045347A1 (en) | 2004-10-22 | 2006-05-04 | Medinova Ag | Lactobacillus helveticus strain useful in the treatment or prevention of infections caused by urogenital pathogens |
| US7563758B2 (en) * | 2005-10-06 | 2009-07-21 | E. I. Du Pont De Nemours And Company | Enzymatic production of peracids using Lactobacilli having perhydrolysis activity |
| US8329447B2 (en) * | 2008-12-12 | 2012-12-11 | Osel, Inc. | Strain of Lactobacillus crispatus |
| EP2428214A1 (en) * | 2010-09-14 | 2012-03-14 | HSO Health Care GmbH | Compositions for the vaginal and oral administration of lactobacillus and uses thereof |
-
2012
- 2012-07-09 FR FR1256569A patent/FR2992973B1/fr active Active
-
2013
- 2013-07-08 TW TW102124318A patent/TWI627276B/zh not_active IP Right Cessation
- 2013-07-09 CA CA2878130A patent/CA2878130A1/fr not_active Abandoned
- 2013-07-09 WO PCT/EP2013/064424 patent/WO2014009330A1/fr active Application Filing
- 2013-07-09 KR KR1020157002981A patent/KR20150036376A/ko not_active Application Discontinuation
- 2013-07-09 ES ES13734435.4T patent/ES2647833T3/es active Active
- 2013-07-09 BR BR112014033026A patent/BR112014033026A2/pt not_active IP Right Cessation
- 2013-07-09 RU RU2015103116A patent/RU2661102C2/ru active
- 2013-07-09 CN CN201380036919.XA patent/CN104508117B/zh active Active
- 2013-07-09 US US14/413,303 patent/US20150190438A1/en not_active Abandoned
- 2013-07-09 EP EP13734435.4A patent/EP2870234B1/fr active Active
- 2013-07-09 MX MX2015000338A patent/MX2015000338A/es unknown
- 2013-07-09 PT PT137344354T patent/PT2870234T/pt unknown
- 2013-07-09 AU AU2013289309A patent/AU2013289309A1/en not_active Abandoned
- 2013-07-09 SA SA113340703A patent/SA113340703B1/ar unknown
-
2014
- 2014-12-26 IN IN11142DEN2014 patent/IN2014DN11142A/en unknown
-
2015
- 2015-08-10 HK HK15107711.6A patent/HK1207116A1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| TW201408773A (zh) | 2014-03-01 |
| KR20150036376A (ko) | 2015-04-07 |
| WO2014009330A1 (fr) | 2014-01-16 |
| FR2992973A1 (fr) | 2014-01-10 |
| AU2013289309A1 (en) | 2015-01-29 |
| US20150190438A1 (en) | 2015-07-09 |
| MX2015000338A (es) | 2015-09-25 |
| PT2870234T (pt) | 2017-11-30 |
| RU2661102C2 (ru) | 2018-07-11 |
| FR2992973B1 (fr) | 2015-12-18 |
| CN104508117A (zh) | 2015-04-08 |
| IN2014DN11142A (ru) | 2015-09-25 |
| CA2878130A1 (fr) | 2014-01-16 |
| EP2870234B1 (fr) | 2017-08-23 |
| EP2870234A1 (fr) | 2015-05-13 |
| TWI627276B (zh) | 2018-06-21 |
| CN104508117B (zh) | 2018-01-23 |
| ES2647833T3 (es) | 2017-12-26 |
| HK1207116A1 (en) | 2016-01-22 |
| BR112014033026A2 (pt) | 2017-06-27 |
| SA113340703B1 (ar) | 2015-10-11 |
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