FI3068216T3 - Menetelmä lisääntymiskyvyttömien kalojen ja munia tuottavien vesieläinten tuottamiseksi ja yhdisteiden toimittamikseksi muniin ja alkioihin - Google Patents
Menetelmä lisääntymiskyvyttömien kalojen ja munia tuottavien vesieläinten tuottamiseksi ja yhdisteiden toimittamikseksi muniin ja alkioihin Download PDFInfo
- Publication number
- FI3068216T3 FI3068216T3 FIEP14862081.8T FI14862081T FI3068216T3 FI 3068216 T3 FI3068216 T3 FI 3068216T3 FI 14862081 T FI14862081 T FI 14862081T FI 3068216 T3 FI3068216 T3 FI 3068216T3
- Authority
- FI
- Finland
- Prior art keywords
- eggs
- fish
- antisense morpholino
- morpholino oligomer
- seo
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims 14
- 235000013601 eggs Nutrition 0.000 title claims 12
- 241000251468 Actinopterygii Species 0.000 title claims 8
- 241001465754 Metazoa Species 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 210000002257 embryonic structure Anatomy 0.000 title 1
- 208000021267 infertility disease Diseases 0.000 title 1
- 230000000692 anti-sense effect Effects 0.000 claims 9
- 238000007654 immersion Methods 0.000 claims 9
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims 9
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 2
- 101150100366 end gene Proteins 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- 108010039627 Aprotinin Proteins 0.000 claims 1
- 241000276616 Cichlidae Species 0.000 claims 1
- 239000004471 Glycine Substances 0.000 claims 1
- GDBQQVLCIARPGH-UHFFFAOYSA-N Leupeptin Natural products CC(C)CC(NC(C)=O)C(=O)NC(CC(C)C)C(=O)NC(C=O)CCCN=C(N)N GDBQQVLCIARPGH-UHFFFAOYSA-N 0.000 claims 1
- 241000143387 Moronidae Species 0.000 claims 1
- 241000277331 Salmonidae Species 0.000 claims 1
- 239000007983 Tris buffer Substances 0.000 claims 1
- 229960004405 aprotinin Drugs 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 229940042399 direct acting antivirals protease inhibitors Drugs 0.000 claims 1
- 230000004720 fertilization Effects 0.000 claims 1
- 239000012530 fluid Substances 0.000 claims 1
- ZPNFWUPYTFPOJU-LPYSRVMUSA-N iniprol Chemical compound C([C@H]1C(=O)NCC(=O)NCC(=O)N[C@H]2CSSC[C@H]3C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(N[C@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC=4C=CC=CC=4)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC=4C=CC=CC=4)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC2=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]2N(CCC2)C(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N2[C@@H](CCC2)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N2[C@@H](CCC2)C(=O)N3)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@H](C(=O)N1)C(C)C)[C@@H](C)O)[C@@H](C)CC)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 ZPNFWUPYTFPOJU-LPYSRVMUSA-N 0.000 claims 1
- GDBQQVLCIARPGH-ULQDDVLXSA-N leupeptin Chemical compound CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C=O)CCCN=C(N)N GDBQQVLCIARPGH-ULQDDVLXSA-N 0.000 claims 1
- 108010052968 leupeptin Proteins 0.000 claims 1
- 238000012986 modification Methods 0.000 claims 1
- 230000004048 modification Effects 0.000 claims 1
- 230000002611 ovarian Effects 0.000 claims 1
- 125000000636 p-nitrophenyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)[N+]([O-])=O 0.000 claims 1
- 239000000137 peptide hydrolase inhibitor Substances 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 230000001850 reproductive effect Effects 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 230000001954 sterilising effect Effects 0.000 claims 1
- -1 trifluoroacetamidohexyl Chemical group 0.000 claims 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K61/00—Culture of aquatic animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0276—Knock-out vertebrates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/873—Techniques for producing new embryos, e.g. nuclear transfer, manipulation of totipotent cells or production of chimeric embryos
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/05—Animals modified by non-integrating nucleic acids, e.g. antisense, RNAi, morpholino, episomal vector, for non-therapeutic purpose
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/40—Fish
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/02—Animal zootechnically ameliorated
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/323—Chemical structure of the sugar modified ring structure
- C12N2310/3233—Morpholino-type ring
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/80—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in fisheries management
- Y02A40/81—Aquaculture, e.g. of fish
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
- Y02A90/40—Monitoring or fighting invasive species
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Environmental Sciences (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Marine Sciences & Fisheries (AREA)
- Farming Of Fish And Shellfish (AREA)
- Feed For Specific Animals (AREA)
- Fodder In General (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361904652P | 2013-11-15 | 2013-11-15 | |
| US201461968458P | 2014-03-21 | 2014-03-21 | |
| US201462050815P | 2014-09-16 | 2014-09-16 | |
| PCT/US2014/065698 WO2015073819A1 (en) | 2013-11-15 | 2014-11-14 | Method of producing infertile fish and egg-producing aquatic animals and of delivering compounds into eggs and embryos |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| FI3068216T3 true FI3068216T3 (fi) | 2024-07-10 |
Family
ID=53058068
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FIEP14862081.8T FI3068216T3 (fi) | 2013-11-15 | 2014-11-14 | Menetelmä lisääntymiskyvyttömien kalojen ja munia tuottavien vesieläinten tuottamiseksi ja yhdisteiden toimittamikseksi muniin ja alkioihin |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US9999208B2 (enExample) |
| EP (1) | EP3068216B1 (enExample) |
| JP (1) | JP6669650B2 (enExample) |
| CN (1) | CN105764333B (enExample) |
| AU (1) | AU2014348473B2 (enExample) |
| CA (1) | CA2929496C (enExample) |
| CL (1) | CL2016001113A1 (enExample) |
| DK (1) | DK180609B1 (enExample) |
| ES (1) | ES2981867T3 (enExample) |
| FI (1) | FI3068216T3 (enExample) |
| HR (1) | HRP20240918T1 (enExample) |
| IL (1) | IL245293B (enExample) |
| MX (1) | MX369329B (enExample) |
| NZ (1) | NZ719421A (enExample) |
| PL (1) | PL3068216T3 (enExample) |
| PT (1) | PT3068216T (enExample) |
| RU (1) | RU2723037C2 (enExample) |
| WO (1) | WO2015073819A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015073819A1 (en) | 2013-11-15 | 2015-05-21 | University Of Maryland Baltimore County | Method of producing infertile fish and egg-producing aquatic animals and of delivering compounds into eggs and embryos |
| BR112017000925B1 (pt) | 2014-07-14 | 2023-10-10 | Washington State University | Método de reprodução de porcos, método para gerar um porco sem nenhuma célula espermatogônica funcional, método de produção de um macho receptor e método de produção de porcos |
| RU2741645C2 (ru) * | 2015-05-19 | 2021-01-28 | Юниверсити Оф Мэрилэнд Балтимор Каунти | Способы доставки агента в икринки рыб |
| CN106614142B (zh) * | 2016-12-28 | 2019-12-03 | 浙江省海洋水产研究所 | 一种杂交不育黄姑鱼的生产方法 |
| CN109864017A (zh) * | 2017-12-05 | 2019-06-11 | 柳州市渔业技术推广站 | 山塘水库高产高效渔业养殖方法 |
| PL3723479T3 (pl) * | 2017-12-15 | 2024-10-07 | Acd Pharmaceuticals As | Sposoby produkcji sterylnych ryb |
| CN108668984B (zh) * | 2018-04-15 | 2021-02-12 | 广西壮族自治区水产科学研究院 | 一种罗非鱼苗种高密度运输方法 |
| CN108739537B (zh) * | 2018-06-06 | 2021-02-09 | 江苏省淡水水产研究所 | 一种粉白体色斑点叉尾鮰家系制种方法 |
| BR112021020349A2 (pt) * | 2019-04-09 | 2021-12-14 | Mayo Found Medical Education & Res | Peixe estéril |
| CN112553205B (zh) * | 2020-12-29 | 2022-09-13 | 中国水产科学研究院淡水渔业研究中心 | 一种抑制黄颡鱼性腺发育的反义rna序列组合和方法及应用 |
| CN114982678B (zh) * | 2022-07-21 | 2024-02-23 | 新疆额河生态养殖科技有限公司 | 一种北极茴鱼人工繁殖操作方法 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5780448A (en) * | 1995-11-07 | 1998-07-14 | Ottawa Civic Hospital Loeb Research | DNA-based vaccination of fish |
| US7115794B2 (en) * | 2003-05-19 | 2006-10-03 | University Of Hawaii | Method for direct nucleic acid uptake |
| US7194978B2 (en) * | 2003-08-22 | 2007-03-27 | University Of Maryland Biotechnology Institute | Inducing sterility in fish by disrupting the development of the GnRH system |
| CN1294808C (zh) * | 2003-09-26 | 2007-01-17 | 中国科学院水生生物研究所 | 不育转基因鱼的制备方法 |
| CN1274822C (zh) * | 2004-02-19 | 2006-09-13 | 武汉康祥科技发展有限公司 | 活体化学诱导鱼类雌核发育方法 |
| CN103898161A (zh) * | 2007-01-26 | 2014-07-02 | 辛那杰瓦生物制药股份有限公司 | 在禽类中进行转基因表达 |
| US7935816B2 (en) | 2007-10-25 | 2011-05-03 | Gene Tools, Llc | Molecular transporter compositions comprising dendrimeric oligoguanidine with a triazine core that facilitate delivery into cells in vivo |
| US8383880B2 (en) * | 2009-02-18 | 2013-02-26 | Academia Sinica | Infertility control of genetically modified fish |
| CA2789454A1 (en) * | 2010-02-09 | 2011-08-18 | National University Corporation Hokkaido University | Method for acquiring genetically identical gamete from lethal fish haploid-derived germ cell via germ line chimera |
| RU2422529C1 (ru) * | 2010-02-12 | 2011-06-27 | Учреждение Российской академии наук Институт цитологии и генетики Сибирского отделения РАН (ИЦиГ СО РАН) | ГЕННО-ИНЖЕНЕРНАЯ КОНСТРУКЦИЯ pGoatcasGCSF, ОБЕСПЕЧИВАЮЩАЯ ПРОДУКЦИЮ ГРАНУЛОЦИТ-КОЛОНИЕСТИМУЛИРУЮЩЕГО ФАКТОРА ЧЕЛОВЕКА В МОЛОКО ТРАНСГЕННЫХ ЖИВОТНЫХ |
| CA2825994A1 (en) * | 2011-02-01 | 2012-08-09 | Ten-Tsao WONG | Efficient sterilization of fish by disruption of germ cell development |
| GB201117538D0 (en) * | 2011-10-11 | 2011-11-23 | Royal Veterinary College The | Methods |
| US9538734B2 (en) | 2013-03-12 | 2017-01-10 | The General Hospital Corporation | Germ cell ablation compounds and uses thereof |
| WO2015073819A1 (en) | 2013-11-15 | 2015-05-21 | University Of Maryland Baltimore County | Method of producing infertile fish and egg-producing aquatic animals and of delivering compounds into eggs and embryos |
| RU2741645C2 (ru) * | 2015-05-19 | 2021-01-28 | Юниверсити Оф Мэрилэнд Балтимор Каунти | Способы доставки агента в икринки рыб |
-
2014
- 2014-11-14 WO PCT/US2014/065698 patent/WO2015073819A1/en not_active Ceased
- 2014-11-14 AU AU2014348473A patent/AU2014348473B2/en active Active
- 2014-11-14 FI FIEP14862081.8T patent/FI3068216T3/fi active
- 2014-11-14 RU RU2016123427A patent/RU2723037C2/ru active
- 2014-11-14 EP EP14862081.8A patent/EP3068216B1/en active Active
- 2014-11-14 PL PL14862081.8T patent/PL3068216T3/pl unknown
- 2014-11-14 US US15/035,342 patent/US9999208B2/en active Active
- 2014-11-14 ES ES14862081T patent/ES2981867T3/es active Active
- 2014-11-14 PT PT148620818T patent/PT3068216T/pt unknown
- 2014-11-14 HR HRP20240918TT patent/HRP20240918T1/hr unknown
- 2014-11-14 NZ NZ719421A patent/NZ719421A/en unknown
- 2014-11-14 MX MX2016006315A patent/MX369329B/es active IP Right Grant
- 2014-11-14 CA CA2929496A patent/CA2929496C/en active Active
- 2014-11-14 CN CN201480062691.6A patent/CN105764333B/zh active Active
- 2014-11-14 JP JP2016530195A patent/JP6669650B2/ja active Active
-
2016
- 2016-04-24 IL IL245293A patent/IL245293B/en active IP Right Grant
- 2016-05-10 CL CL2016001113A patent/CL2016001113A1/es unknown
- 2016-06-06 DK DKPA201670401A patent/DK180609B1/en active IP Right Grant
-
2018
- 2018-06-18 US US16/011,631 patent/US10136621B2/en active Active
- 2018-10-22 US US16/166,387 patent/US20190104710A1/en not_active Abandoned
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| EP3068216A1 (en) | 2016-09-21 |
| MX369329B (es) | 2019-11-05 |
| AU2014348473B2 (en) | 2018-06-14 |
| PL3068216T3 (pl) | 2024-10-14 |
| BR112016011080A2 (pt) | 2017-12-05 |
| CA2929496C (en) | 2022-08-23 |
| EP3068216B1 (en) | 2024-04-10 |
| ES2981867T3 (es) | 2024-10-10 |
| WO2015073819A1 (en) | 2015-05-21 |
| CN105764333A (zh) | 2016-07-13 |
| DK201670401A1 (en) | 2016-07-04 |
| RU2016123427A (ru) | 2017-12-20 |
| CA2929496A1 (en) | 2015-05-21 |
| US9999208B2 (en) | 2018-06-19 |
| PT3068216T (pt) | 2024-07-12 |
| DK180609B1 (en) | 2021-10-14 |
| US20160286768A1 (en) | 2016-10-06 |
| US20190104710A1 (en) | 2019-04-11 |
| HRP20240918T1 (hr) | 2024-10-11 |
| EP3068216A4 (en) | 2017-10-11 |
| IL245293A0 (en) | 2016-06-30 |
| JP2017502651A (ja) | 2017-01-26 |
| MX2016006315A (es) | 2017-01-19 |
| NZ719421A (en) | 2022-09-30 |
| US20180288984A1 (en) | 2018-10-11 |
| CL2016001113A1 (es) | 2017-01-06 |
| JP6669650B2 (ja) | 2020-03-18 |
| CN105764333B (zh) | 2021-09-03 |
| US10136621B2 (en) | 2018-11-27 |
| AU2014348473A1 (en) | 2016-05-19 |
| RU2723037C2 (ru) | 2020-06-08 |
| IL245293B (en) | 2020-04-30 |
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