FI20002042A - Polymeeripohjaisia, nopeasti liukenevia tabletteja ja menetelmiä niiden valmistamiseksi - Google Patents

Polymeeripohjaisia, nopeasti liukenevia tabletteja ja menetelmiä niiden valmistamiseksi Download PDF

Info

Publication number
FI20002042A
FI20002042A FI20002042A FI20002042A FI20002042A FI 20002042 A FI20002042 A FI 20002042A FI 20002042 A FI20002042 A FI 20002042A FI 20002042 A FI20002042 A FI 20002042A FI 20002042 A FI20002042 A FI 20002042A
Authority
FI
Finland
Prior art keywords
fast
polymer
preparation
methods
dissolving tablets
Prior art date
Application number
FI20002042A
Other languages
English (en)
Swedish (sv)
Inventor
Fang-Yu Liu
Min Michael He
Janaki Ram Nyshadham
Kuldeepak Sharma
James Shunnan Chu
Joseph A Fix
Original Assignee
Yamanouchi Pharma Tech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamanouchi Pharma Tech Inc filed Critical Yamanouchi Pharma Tech Inc
Publication of FI20002042A publication Critical patent/FI20002042A/fi

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/2027Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2013Organic compounds, e.g. phospholipids, fats
    • A61K9/2018Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1617Organic compounds, e.g. phospholipids, fats
    • A61K9/1623Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1635Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Nutrition Science (AREA)
  • Biophysics (AREA)
  • Endocrinology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Physiology (AREA)
  • Zoology (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Medicinal Preparation (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
FI20002042A 1998-03-18 2000-09-15 Polymeeripohjaisia, nopeasti liukenevia tabletteja ja menetelmiä niiden valmistamiseksi FI20002042A (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/044,302 US6465009B1 (en) 1998-03-18 1998-03-18 Water soluble polymer-based rapidly dissolving tablets and production processes thereof
PCT/US1999/006238 WO1999047126A1 (en) 1998-03-18 1999-03-18 Polymer based rapidly dissolving tablets and production processes thereof

Publications (1)

Publication Number Publication Date
FI20002042A true FI20002042A (fi) 2000-10-18

Family

ID=21931614

Family Applications (1)

Application Number Title Priority Date Filing Date
FI20002042A FI20002042A (fi) 1998-03-18 2000-09-15 Polymeeripohjaisia, nopeasti liukenevia tabletteja ja menetelmiä niiden valmistamiseksi

Country Status (14)

Country Link
US (2) US6465009B1 (fi)
EP (1) EP1063972A4 (fi)
JP (2) JP2002506811A (fi)
KR (2) KR100725833B1 (fi)
CN (2) CN1180769C (fi)
AU (1) AU763015B2 (fi)
CA (1) CA2325577C (fi)
FI (1) FI20002042A (fi)
HU (1) HUP0102862A3 (fi)
NO (1) NO20004643L (fi)
NZ (2) NZ525884A (fi)
PL (1) PL344105A1 (fi)
RU (1) RU2227020C2 (fi)
WO (1) WO1999047126A1 (fi)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8071128B2 (en) 1996-06-14 2011-12-06 Kyowa Hakko Kirin Co., Ltd. Intrabuccally rapidly disintegrating tablet and a production method of the tablets
US6319913B1 (en) 1997-11-10 2001-11-20 Cellegy Pharmaceuticals, Inc. Penetration enhancing and irritation reducing systems
US6743443B1 (en) * 1998-10-05 2004-06-01 Eisai Co., Ltd. Tablets immediately disintegrating in the oral cavity
FR2785538B1 (fr) * 1998-11-06 2004-04-09 Prographarm Laboratoires Comprime a delitement rapide perfectionne
FR2790387B1 (fr) * 1999-03-01 2001-05-18 Prographarm Laboratoires Comprime orodispersible presentant une faible friabilite et son procede de preparation
GB9910505D0 (en) * 1999-05-06 1999-07-07 Electrosols Ltd A method and apparatus for manufacturing consumable tablets
FR2798289B1 (fr) * 1999-09-15 2004-12-31 Cll Pharma Formes galeniques a delitement rapide en bouche et leur procede de preparation
KR100784659B1 (ko) * 2000-06-30 2007-12-12 아스텔라스세이야쿠 가부시키가이샤 구강내 속붕괴정
CN1638739A (zh) * 2000-08-18 2005-07-13 法玛西雅厄普约翰美国公司 治疗成瘾性障碍的化合物
AU2001286237A1 (en) * 2000-09-22 2002-04-02 Sumitomo Pharmaceuticals Company, Limited Oral preparations with favorable disintegration characteristics
US7799342B2 (en) * 2000-12-06 2010-09-21 Wyeth Llc Fast dissolving tablet
US6814978B2 (en) 2000-12-29 2004-11-09 Mcneil-Ppc, Inc. Process for preparing a soft tablet
ATE482692T1 (de) 2001-07-27 2010-10-15 Astellas Pharma Inc Zusammensetzung enthaltend feine körner mit verzögerter freisetzung für in der mundhöhle schnell zerfallende tabletten
GEP20063856B (en) * 2001-09-26 2006-06-26 Pharmacia Corp Organoleptically acceptable intraorally disintegrating compositions
US9358214B2 (en) 2001-10-04 2016-06-07 Adare Pharmaceuticals, Inc. Timed, sustained release systems for propranolol
US6811793B2 (en) * 2002-03-11 2004-11-02 Amerilab Technologies, Inc. Effervescent composition including stevia
AU2002255196A1 (en) * 2002-04-18 2003-10-27 Dr. Reddy's Laboratories Ltd. Rapidly dispersing solid oral compositions
US8367111B2 (en) 2002-12-31 2013-02-05 Aptalis Pharmatech, Inc. Extended release dosage forms of propranolol hydrochloride
US7749533B2 (en) * 2003-05-07 2010-07-06 Akina, Inc. Highly plastic granules for making fast melting tablets
ITRM20030288A1 (it) * 2003-06-10 2004-12-11 Valerio Cioli Somministrazione sublinguale di antinfiammatori non steroidei (fans)
US20050036977A1 (en) * 2003-08-11 2005-02-17 Dilip Gole Taste-masked resinate and preparation thereof
US8747895B2 (en) 2004-09-13 2014-06-10 Aptalis Pharmatech, Inc. Orally disintegrating tablets of atomoxetine
US8057820B2 (en) 2004-10-08 2011-11-15 Mcneil-Ppc, Inc. Enteric coated aspirin granules comingled with binder
US8758814B2 (en) 2004-10-08 2014-06-24 Mcneil-Ppc, Inc. Chewable enteric coated aspirin tablets
US9884014B2 (en) 2004-10-12 2018-02-06 Adare Pharmaceuticals, Inc. Taste-masked pharmaceutical compositions
ES2409347T3 (es) 2004-10-21 2013-06-26 Aptalis Pharmatech, Inc. Composiciones farmacéuticas de sabor enmascarado con agentes porogénicos gastrosolubles
US20060105038A1 (en) * 2004-11-12 2006-05-18 Eurand Pharmaceuticals Limited Taste-masked pharmaceutical compositions prepared by coacervation
ITMI20042356A1 (it) * 2004-12-10 2005-03-10 Acraf Composizione farmaceutica orodisperdibile e procedimento per prepararla
WO2006070735A1 (ja) * 2004-12-27 2006-07-06 Astellas Pharma Inc. ソリフェナシンまたはその塩の安定な粒子状医薬組成物
US9161918B2 (en) 2005-05-02 2015-10-20 Adare Pharmaceuticals, Inc. Timed, pulsatile release systems
CA2608690C (en) 2005-05-18 2016-07-05 Dainippon Sumitomo Pharma Co., Ltd. Stable tablet containing droxidopa
US20080085318A1 (en) * 2005-07-16 2008-04-10 Cherukuri S R Coated compositions and methods for preparing same
GB0516604D0 (en) * 2005-08-12 2005-09-21 Sandoz Ag Rapidly dispersing/disintegrating compositions
US7811604B1 (en) 2005-11-14 2010-10-12 Barr Laboratories, Inc. Non-effervescent, orally disintegrating solid pharmaceutical dosage forms comprising clozapine and methods of making and using the same
ITMI20061117A1 (it) * 2006-06-09 2007-12-10 Michele Bonanomi Una composizione farmaceutica per la somministrazione sublinguale di vaccini metodo per la sua preparazione e sui usi
US8202538B2 (en) * 2006-06-26 2012-06-19 Capricorn Pharma, Inc. Orally disintegrating layered compositions
EP2033643A4 (en) * 2006-06-27 2013-01-02 Daiichi Sankyo Co Ltd COMPRESSED PREPARATION
CN101686942B (zh) 2007-06-27 2012-09-26 韩美药品株式会社 用于快速制备用于口服的崩解剂的方法及其产品
JP5336483B2 (ja) * 2007-07-05 2013-11-06 ダウ グローバル テクノロジーズ エルエルシー その場液体活性化皮膜コーティング錠およびその製法
US20100055180A1 (en) * 2007-10-10 2010-03-04 Mallinckrodt Baker, Inc. Directly Compressible Granular Microcrystalline Cellulose Based Excipient, Manufacturing Process and Use Thereof
MX339320B (es) * 2007-10-10 2016-05-20 Avantor Performance Mat Inc Excipiente basado en celulosa microcristalina granular con alta funcionalidad y directamente comprimible, procedimiento de elaboracion y uso del mismo.
JP5583012B2 (ja) 2008-06-13 2014-09-03 大日本住友製薬株式会社 口腔内速崩壊錠及びその製造方法
KR101075556B1 (ko) 2008-11-21 2011-10-20 씨제이제일제당 (주) 구강내 속붕해정 및 그 제조방법
WO2010077878A1 (en) * 2008-12-15 2010-07-08 Fleming And Company, Pharmaceuticals Rapidly dissolving vitamin formulation and methods of using the same
EP2233134A1 (en) 2009-03-27 2010-09-29 McNeil AB Multi-portion intra-oral dosage form with organoleptic properties
JP5502358B2 (ja) * 2009-04-01 2014-05-28 テイカ製薬株式会社 口腔内速崩壊性錠剤およびその製造方法
CN102933207B (zh) * 2009-10-30 2018-02-02 Ix生物医药有限公司 快速溶解固体剂型
KR101765357B1 (ko) 2009-12-02 2017-08-04 아데어 파마수티컬스 에스.알.엘. 펙소페나딘 마이크로캡슐 및 그것을 함유하는 조성물
AR079862A1 (es) * 2010-01-08 2012-02-22 Eurand Inc Composicion de topiramato con sabor enmascarado, un comprimido desintegrable oralmente que comprende la misma y metodo de preparacion
EP2525783A1 (en) 2010-01-18 2012-11-28 Cephalon France Improved oral lysophilisates containing pvp/va
WO2013032310A1 (ko) * 2011-09-02 2013-03-07 재단법인 유타 인하 디디에스 및 신의료기술개발 공동연구소 메게스트롤 속붕해정 및 이의 제조 방법
US9925138B2 (en) 2015-01-20 2018-03-27 Handa Pharmaceuticals, Llc Stable solid fingolimod dosage forms
JP6411265B2 (ja) * 2015-03-30 2018-10-24 共和薬品工業株式会社 エンタカポン含有医薬組成物
WO2018217241A1 (en) 2017-05-22 2018-11-29 Johnson & Johnson Consumer Inc. Lozenge dosage form
CN110123634A (zh) 2018-02-09 2019-08-16 株式会社理光 颗粒的制造方法,颗粒的制造装置,以及颗粒

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1548022A (en) 1976-10-06 1979-07-04 Wyeth John & Brother Ltd Pharmaceutial dosage forms
CA1208558A (en) 1982-10-07 1986-07-29 Kazuo Kigasawa Soft buccal
US4684534A (en) 1985-02-19 1987-08-04 Dynagram Corporation Of America Quick-liquifying, chewable tablet
WO1987001936A1 (en) * 1985-09-25 1987-04-09 Gerhard Gergely Desintegration tablet and process for its manufacture
US4764378A (en) 1986-02-10 1988-08-16 Zetachron, Inc. Buccal drug dosage form
US4859704A (en) * 1987-10-15 1989-08-22 Oratech Pharmaceutical Development Corporation Water soluble ibuprofen compositions and methods of making them
YU183988A (en) * 1988-09-30 1990-08-31 Lek Tovarna Farmacevtskih Process for preparing dispersion pills of dihydroergotoxine
US5135752A (en) 1988-10-14 1992-08-04 Zetachron, Inc. Buccal dosage form
US5516763A (en) 1988-12-01 1996-05-14 Suomen Xyrofin Oy Crystalline lactitol monohydrate and a process for the preparation thereof, use thereof, and sweetening agent
US5039540A (en) 1989-08-14 1991-08-13 Neophore Technologies, Inc. Freeze dry composition and method for oral administration of drugs, biologicals, nutrients and foodstuffs
US5456919A (en) * 1989-12-29 1995-10-10 Bristol-Myers Squibb Company Capsule and caplet combination
US5464632C1 (en) 1991-07-22 2001-02-20 Prographarm Lab Rapidly disintegratable multiparticular tablet
US5262171A (en) 1991-11-25 1993-11-16 Isp Investments Inc. Pharmaceutical tablet with PVP having enhanced drug dissolution rate
JP3069458B2 (ja) 1992-01-29 2000-07-24 武田薬品工業株式会社 口腔内崩壊型錠剤およびその製造法
DE627218T1 (de) * 1992-02-18 1995-08-24 Nippon Shinyaku Co Ltd Schnelllösliche tablette.
IT1264517B1 (it) 1993-05-31 1996-09-24 Ekita Investments Nv Compressa farmaceutica atta al rilascio in tempi successivi dei principi attivi in essa veicolati
US5506248A (en) 1993-08-02 1996-04-09 Bristol-Myers Squibb Company Pharmaceutical compositions having good dissolution properties
CA2164344C (en) 1993-08-30 2004-06-29 Stanley Lech Tablet coating based on a melt-spun mixture of a saccharide and a polymer
US5622719A (en) 1993-09-10 1997-04-22 Fuisz Technologies Ltd. Process and apparatus for making rapidly dissolving dosage units and product therefrom
US5576014A (en) 1994-01-31 1996-11-19 Yamanouchi Pharmaceutical Co., Ltd Intrabuccally dissolving compressed moldings and production process thereof
ATE253899T1 (de) 1994-01-31 2003-11-15 Yamanouchi Pharma Co Ltd Intraoral löslicher formpressling und verfahren zu seiner herstellung
US5672364A (en) 1994-07-07 1997-09-30 Sankyo Seisakusho Co. & Eisai Co., Ltd. Apparatus for manufacturing tablets
US5684121A (en) 1994-12-06 1997-11-04 Isp Investments Inc. N-vinyl lactam polymer containing tablets of low friability and high rate of dissolution
JP2919771B2 (ja) 1995-04-17 1999-07-19 佐藤製薬株式会社 速溶解性錠剤の製造方法及び該製造方法により製造した速溶解性錠剤
US5560927A (en) 1995-07-28 1996-10-01 Isp Investments Inc. Co-processing method for making a free-flowing compressible powder and tablet therefrom
JPH0948726A (ja) 1995-08-07 1997-02-18 Tanabe Seiyaku Co Ltd 口腔内速崩壊性製剤およびその製法
DE19536394A1 (de) 1995-09-29 1997-04-03 Basf Ag Feste Arzneiformen, erhältlich durch Extrusion einer Isomalt enthaltenden Polymer-Wirkstoff-Schmelze
WO1997038679A2 (en) * 1996-04-16 1997-10-23 Novartis Consumer Health S.A. Fast disintegrating oral dosage form
WO1998006382A1 (en) * 1996-08-14 1998-02-19 Yamanouchi Europe B.V. Granulates comprising a water soluble compound and cellulose
EP0839526A3 (en) * 1996-10-31 1999-01-07 Takeda Chemical Industries, Ltd. Solid pharmaceutical preparation with fast buccal disintegration or dissolution
JPH10182436A (ja) * 1996-10-31 1998-07-07 Takeda Chem Ind Ltd 固形医薬製剤
US6024981A (en) 1997-04-16 2000-02-15 Cima Labs Inc. Rapidly dissolving robust dosage form
JP3296412B2 (ja) * 1997-04-25 2002-07-02 田辺製薬株式会社 成型製剤及びその製法
FR2766089B1 (fr) * 1997-07-21 2000-06-02 Prographarm Lab Comprime multiparticulaire perfectionne a delitement rapide
US6136833A (en) * 1998-01-16 2000-10-24 Dupont Pharmaceuticals Company Pharmaceutical formulations and process for their preparation

Also Published As

Publication number Publication date
CN1180769C (zh) 2004-12-22
JP2002506811A (ja) 2002-03-05
HUP0102862A3 (en) 2002-12-28
NZ507055A (en) 2003-08-29
NO20004643D0 (no) 2000-09-18
NZ525884A (en) 2004-09-24
CN1636551A (zh) 2005-07-13
CA2325577C (en) 2010-09-21
PL344105A1 (en) 2001-09-24
EP1063972A1 (en) 2001-01-03
KR100725833B1 (ko) 2007-06-08
AU3197399A (en) 1999-10-11
CN1303275A (zh) 2001-07-11
NO20004643L (no) 2000-11-17
RU2227020C2 (ru) 2004-04-20
KR20010074450A (ko) 2001-08-04
AU763015B2 (en) 2003-07-10
WO1999047126A1 (en) 1999-09-23
EP1063972A4 (en) 2004-08-04
US20030129226A1 (en) 2003-07-10
HUP0102862A2 (hu) 2002-03-28
US6465009B1 (en) 2002-10-15
CA2325577A1 (en) 1999-09-23
JP2006306891A (ja) 2006-11-09
KR20060093356A (ko) 2006-08-24

Similar Documents

Publication Publication Date Title
FI20002042A (fi) Polymeeripohjaisia, nopeasti liukenevia tabletteja ja menetelmiä niiden valmistamiseksi
EE04721B1 (et) Fenüülksantiini derivaadid, nende valmistamismeetodid ja kasutamine
EE200200175A (et) Asendatud 2-tio-3,5-ditsüano-4-arüül-6-aminopüridiinid ja nende kasutamine
EE04527B1 (et) Aromaatsed heterotsüklilised ühendid, nende kasutamine ja meetodid nende valmistamiseks
DK1180518T3 (da) 5-pyridyl-1,3-azolforbindelser, fremgangsmåde til fremstilling deraf og anvendelse deraf
PT1177178E (pt) Benzimidazois hetereciclicos substituidos, sua preparacao e aplicacao
PT1058538E (pt) Comprimidos de desintegracao rapida
PT1123274E (pt) Derivados de fenilo substituido, sua preparacao e utilizacao
EE200100431A (et) 16-halogenoepotilooni derivaadid, nende valmistamismeetod ja farmatseutiline kasutamine
NO20021379D0 (no) Benzodiazepin-derivater, fremstilling og anvendelse derav
EE04275B1 (et) Kinoliini derivaadid, nende valmistamismeetodid, kasutamine ja farmatseutilised kompositsioonid
EE04236B1 (et) Bensimidasoolid, nende valmistamine ja kasutamineravimitena
NO20005399L (no) Farmasöytisk preparat
DE60000854D1 (de) Schneidegerät
NO20006138D0 (no) Substituerte indolinoner, fremstilling og anvendelse derav som medikamenter
PT1073672E (pt) Compostos anti-picornavirus, sua preparacao e utilizacao
NO992692D0 (no) Nefadozon doseringsform
DK1466615T3 (da) Farmaceutisk præparat
EE200300245A (et) Bensotiofeeni derivaadid, nende valmistamise meetod ja kasutamine
EE04346B1 (et) Asoolid, nende valmistamismeetod, kasutamine ja farmatseutiline kompositsioon
PT1165495E (pt) Derivados de resorcinol
IT1292461B1 (it) Composti fotocromatici,procedimento per la loro preparazione e loro utilizzo in materiali polimerici
EE200100209A (et) Tritsüklilised 3-piperidiinid, nende valmistamismeetod, kasutamine, farmatseutiline kompositsioon ja selle valmistamismeetod
EE200100210A (et) Tritsüklilised 3-piperidiinid, nende valmistamismeetod, kasutamine, farmatseutiline kompositsioon ja selle valmistamismeetod
NO20006479D0 (no) Tienopyridinforbindelser, deres fremstilling og anvendelse

Legal Events

Date Code Title Description
MA Patent expired