FI118918B - Användningen av en CD40-reseptorbindar vid framställning av ett läkemedel - Google Patents
Användningen av en CD40-reseptorbindar vid framställning av ett läkemedel Download PDFInfo
- Publication number
- FI118918B FI118918B FI972484A FI972484A FI118918B FI 118918 B FI118918 B FI 118918B FI 972484 A FI972484 A FI 972484A FI 972484 A FI972484 A FI 972484A FI 118918 B FI118918 B FI 118918B
- Authority
- FI
- Finland
- Prior art keywords
- cell
- cells
- mab
- cd40l
- effect
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Claims (6)
1. Användningen av en CD40-reseptorbindare för framställning av ett läkeme-del för förebyggande av epitelcellers förökning eller för behandling av kancer i 5 epitelcellssystemen.
2. Användningen av en CD40-reseptorbindare för framställning av ett läkeme-del för förstärkning av neoplastiska epitelcellers mottaglighet för anti-neoplas-tisk läkemedelsinducerad apoptos. 10
3. Användningen av en CD40-reseptorbindare enligt patentkravet 1 tillsam-mans med ett CD40-induktionsmedel.
4. Användningen av en CD40-reseptorbindare enligt patentkravet 1 tillsam-15 mans med anti-neoplastiskt läkemedel.
5. Användningen enligt nägot av patentkraven 1-4, kännetecknad därav, att CD40-reseptorbindaren är vald bland ligandliknande monoklonala anti-kroppar och naturligt förekommande eller konstruerade former av CD40-ligander. »·»· 20 • · « • * 4t;j·
6. Användningen enligt nägot av patentkraven 1-4, kännetecknad därav, att !/.{ CD40-reseptorbindaren är vald bland G28.5 (deponeringsnummer HB-9110 (ATTC)) och CD40L. ··· • ♦ « ·.· · ·♦ • · • ·* ··· • · • · ··« ··· : : ··« • · ·» · • · e • * • · · ·♦·
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9425060 | 1994-12-13 | ||
GBGB9425060.2A GB9425060D0 (en) | 1994-12-13 | 1994-12-13 | Carcinoma treatment |
PCT/GB1995/002807 WO1996018413A1 (en) | 1994-12-13 | 1995-12-01 | Carcinoma treatment |
GB9502807 | 1995-12-01 |
Publications (3)
Publication Number | Publication Date |
---|---|
FI972484A0 FI972484A0 (sv) | 1997-06-12 |
FI972484A FI972484A (sv) | 1997-06-12 |
FI118918B true FI118918B (sv) | 2008-05-15 |
Family
ID=10765814
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI972484A FI118918B (sv) | 1994-12-13 | 1997-06-12 | Användningen av en CD40-reseptorbindar vid framställning av ett läkemedel |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP0806963B1 (sv) |
JP (1) | JP4076230B2 (sv) |
AT (1) | ATE203676T1 (sv) |
AU (1) | AU691996B2 (sv) |
CA (1) | CA2207779C (sv) |
DE (1) | DE69522012T2 (sv) |
FI (1) | FI118918B (sv) |
GB (1) | GB9425060D0 (sv) |
MX (1) | MX9704372A (sv) |
NO (1) | NO318587B1 (sv) |
NZ (1) | NZ296161A (sv) |
WO (1) | WO1996018413A1 (sv) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH09507074A (ja) * | 1993-12-23 | 1997-07-15 | イミュネックス・コーポレーション | Cd40を発現する腫瘍細胞を特徴とする疾患の予防又は治療方法 |
US7070771B1 (en) * | 1996-12-09 | 2006-07-04 | Regents Of The University Of California | Methods of expressing chimeric mouse and human CD40 ligand in human CD40+ cells |
EP1946775A3 (en) * | 1998-08-11 | 2008-08-06 | Biogen Idec Inc. | Combination therapies for B-cell lymphomas comprising administration of anti-CD20 antibody |
US6946129B1 (en) | 1999-06-08 | 2005-09-20 | Seattle Genetics, Inc. | Recombinant anti-CD40 antibody and uses thereof |
US8557244B1 (en) | 1999-08-11 | 2013-10-15 | Biogen Idec Inc. | Treatment of aggressive non-Hodgkins lymphoma with anti-CD20 antibody |
US7138379B2 (en) * | 2000-07-26 | 2006-11-21 | Schering Aktiengesellschaft | Use of the interferon receptor 2c polypeptide chain to enhance the anti-growth effects of type I interferons |
GB0025132D0 (en) * | 2000-10-13 | 2000-11-29 | Medical Res Council | Method |
AR039067A1 (es) | 2001-11-09 | 2005-02-09 | Pfizer Prod Inc | Anticuerpos para cd40 |
US7786282B2 (en) | 2001-12-06 | 2010-08-31 | The Regents Of The University Of California | Nucleic acid molecules encoding TNF-α ligand polypeptides having a CD154 domain |
US7495090B2 (en) | 2002-05-23 | 2009-02-24 | The Regents Of The University Of California | Nucleic acids encoding chimeric CD154 polypeptides |
EP1680141B8 (en) * | 2003-11-04 | 2011-01-12 | Novartis Vaccines and Diagnostics, Inc. | Methods of therapy for solid tumors expressing the cd40 cell-surface antigen |
US8277810B2 (en) | 2003-11-04 | 2012-10-02 | Novartis Vaccines & Diagnostics, Inc. | Antagonist anti-CD40 antibodies |
US20050136055A1 (en) | 2003-12-22 | 2005-06-23 | Pfizer Inc | CD40 antibody formulation and methods |
AU2006249305B2 (en) | 2005-05-26 | 2012-10-18 | Genentech, Inc. | Humanized anti-CD40 antibodies and their methods of use |
AU2006308606C1 (en) | 2005-11-01 | 2013-07-25 | Novartis Ag | Uses of anti-CD40 antibodies |
WO2007067032A1 (en) | 2005-12-09 | 2007-06-14 | Academisch Medisch Cemtrum Bij De Universiteit Van Amsterdam | Means and methods for influencing the stability of cells |
CA2633157C (en) | 2005-12-09 | 2018-10-09 | Academisch Medisch Centrum Bij De Universiteit Van Amsterdam | Means and methods for influencing the stability of antibody producing cells |
NZ571757A (en) | 2006-04-21 | 2012-01-12 | Novartis Ag | Antagonist anti-CD40 antibody pharmaceutical compositions comprising arginine-HCl and a citrate or citric acid buffer |
WO2009062125A1 (en) | 2007-11-07 | 2009-05-14 | Genentech, Inc. | Methods and compositions for assessing responsiveness of b-cell lymphoma to treatment with anti-cd40 antibodies |
AU2010236168B2 (en) | 2009-04-18 | 2015-08-13 | Genentech, Inc. | Methods for assessing responsiveness of B-cell lymphoma to treatment with anti-CD40 antibodies |
EP2454283B1 (en) | 2009-07-15 | 2018-03-14 | AIMM Therapeutics B.V. | Means and methods for producing high affinity antibodies |
AR083847A1 (es) | 2010-11-15 | 2013-03-27 | Novartis Ag | Variantes de fc (fragmento constante) silenciosas de los anticuerpos anti-cd40 |
NZ611600A (en) | 2010-12-02 | 2015-02-27 | Aimm Therapeutics Bv | Means and methods for producing high affinity antibodies |
WO2012149356A2 (en) | 2011-04-29 | 2012-11-01 | Apexigen, Inc. | Anti-cd40 antibodies and methods of use |
EP3925977A1 (en) | 2012-10-30 | 2021-12-22 | Apexigen, Inc. | Anti-cd40 antibodies and methods of use |
DK3099709T3 (da) | 2014-01-31 | 2020-02-03 | Aimm Therapeutics Bv | Midler og fremgangsmåder til fremstilling af stabile antistoffer |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5540926A (en) * | 1992-09-04 | 1996-07-30 | Bristol-Myers Squibb Company | Soluble and its use in B cell stimulation |
-
1994
- 1994-12-13 GB GBGB9425060.2A patent/GB9425060D0/en active Pending
-
1995
- 1995-12-01 JP JP51844696A patent/JP4076230B2/ja not_active Expired - Fee Related
- 1995-12-01 MX MX9704372A patent/MX9704372A/es not_active IP Right Cessation
- 1995-12-01 CA CA002207779A patent/CA2207779C/en not_active Expired - Fee Related
- 1995-12-01 EP EP95938518A patent/EP0806963B1/en not_active Expired - Lifetime
- 1995-12-01 NZ NZ296161A patent/NZ296161A/en not_active IP Right Cessation
- 1995-12-01 DE DE69522012T patent/DE69522012T2/de not_active Expired - Lifetime
- 1995-12-01 AT AT95938518T patent/ATE203676T1/de active
- 1995-12-01 WO PCT/GB1995/002807 patent/WO1996018413A1/en active IP Right Grant
- 1995-12-01 AU AU39884/95A patent/AU691996B2/en not_active Ceased
-
1997
- 1997-06-12 FI FI972484A patent/FI118918B/sv active IP Right Grant
- 1997-06-13 NO NO19972732A patent/NO318587B1/no not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
WO1996018413A1 (en) | 1996-06-20 |
CA2207779C (en) | 2009-10-06 |
JPH10510526A (ja) | 1998-10-13 |
NO972732L (no) | 1997-06-13 |
DE69522012T2 (de) | 2002-04-25 |
NO318587B1 (no) | 2005-04-11 |
DE69522012D1 (de) | 2001-09-06 |
JP4076230B2 (ja) | 2008-04-16 |
AU691996B2 (en) | 1998-05-28 |
EP0806963B1 (en) | 2001-08-01 |
CA2207779A1 (en) | 1996-06-20 |
FI972484A0 (sv) | 1997-06-12 |
MX9704372A (es) | 1998-02-28 |
FI972484A (sv) | 1997-06-12 |
ATE203676T1 (de) | 2001-08-15 |
GB9425060D0 (en) | 1995-02-08 |
AU3988495A (en) | 1996-07-03 |
EP0806963A1 (en) | 1997-11-19 |
NO972732D0 (no) | 1997-06-13 |
NZ296161A (en) | 2001-10-26 |
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