FI118918B - Användningen av en CD40-reseptorbindar vid framställning av ett läkemedel - Google Patents

Användningen av en CD40-reseptorbindar vid framställning av ett läkemedel Download PDF

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Publication number
FI118918B
FI118918B FI972484A FI972484A FI118918B FI 118918 B FI118918 B FI 118918B FI 972484 A FI972484 A FI 972484A FI 972484 A FI972484 A FI 972484A FI 118918 B FI118918 B FI 118918B
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FI
Finland
Prior art keywords
cell
cells
mab
cd40l
effect
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Application number
FI972484A
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English (en)
Finnish (fi)
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FI972484A0 (sv
FI972484A (sv
Inventor
Lawrence Sterling Young
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Univ Birmingham
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Publication date
Application filed by Univ Birmingham filed Critical Univ Birmingham
Publication of FI972484A0 publication Critical patent/FI972484A0/sv
Publication of FI972484A publication Critical patent/FI972484A/sv
Application granted granted Critical
Publication of FI118918B publication Critical patent/FI118918B/sv

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)

Claims (6)

1. Användningen av en CD40-reseptorbindare för framställning av ett läkeme-del för förebyggande av epitelcellers förökning eller för behandling av kancer i 5 epitelcellssystemen.
2. Användningen av en CD40-reseptorbindare för framställning av ett läkeme-del för förstärkning av neoplastiska epitelcellers mottaglighet för anti-neoplas-tisk läkemedelsinducerad apoptos. 10
3. Användningen av en CD40-reseptorbindare enligt patentkravet 1 tillsam-mans med ett CD40-induktionsmedel.
4. Användningen av en CD40-reseptorbindare enligt patentkravet 1 tillsam-15 mans med anti-neoplastiskt läkemedel.
5. Användningen enligt nägot av patentkraven 1-4, kännetecknad därav, att CD40-reseptorbindaren är vald bland ligandliknande monoklonala anti-kroppar och naturligt förekommande eller konstruerade former av CD40-ligander. »·»· 20 • · « • * 4t;j·
6. Användningen enligt nägot av patentkraven 1-4, kännetecknad därav, att !/.{ CD40-reseptorbindaren är vald bland G28.5 (deponeringsnummer HB-9110 (ATTC)) och CD40L. ··· • ♦ « ·.· · ·♦ • · • ·* ··· • · • · ··« ··· : : ··« • · ·» · • · e • * • · · ·♦·
FI972484A 1994-12-13 1997-06-12 Användningen av en CD40-reseptorbindar vid framställning av ett läkemedel FI118918B (sv)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9425060.2A GB9425060D0 (en) 1994-12-13 1994-12-13 Carcinoma treatment
GB9425060 1994-12-13
GB9502807 1995-12-01
PCT/GB1995/002807 WO1996018413A1 (en) 1994-12-13 1995-12-01 Carcinoma treatment

Publications (3)

Publication Number Publication Date
FI972484A0 FI972484A0 (sv) 1997-06-12
FI972484A FI972484A (sv) 1997-06-12
FI118918B true FI118918B (sv) 2008-05-15

Family

ID=10765814

Family Applications (1)

Application Number Title Priority Date Filing Date
FI972484A FI118918B (sv) 1994-12-13 1997-06-12 Användningen av en CD40-reseptorbindar vid framställning av ett läkemedel

Country Status (12)

Country Link
EP (1) EP0806963B1 (sv)
JP (1) JP4076230B2 (sv)
AT (1) ATE203676T1 (sv)
AU (1) AU691996B2 (sv)
CA (1) CA2207779C (sv)
DE (1) DE69522012T2 (sv)
FI (1) FI118918B (sv)
GB (1) GB9425060D0 (sv)
MX (1) MX9704372A (sv)
NO (1) NO318587B1 (sv)
NZ (1) NZ296161A (sv)
WO (1) WO1996018413A1 (sv)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09507074A (ja) * 1993-12-23 1997-07-15 イミュネックス・コーポレーション Ｃｄ４０を発現する腫瘍細胞を特徴とする疾患の予防又は治療方法
US7070771B1 (en) 1996-12-09 2006-07-04 Regents Of The University Of California Methods of expressing chimeric mouse and human CD40 ligand in human CD40+ cells
EA004107B1 (ru) 1998-08-11 2003-12-25 Айдек Фармацевтикалс Корпорэйшн Комбинированная терапия в-клеточных лимфом, предусматривающая введение антитела против cd20
US6946129B1 (en) 1999-06-08 2005-09-20 Seattle Genetics, Inc. Recombinant anti-CD40 antibody and uses thereof
US8557244B1 (en) 1999-08-11 2013-10-15 Biogen Idec Inc. Treatment of aggressive non-Hodgkins lymphoma with anti-CD20 antibody
US7138379B2 (en) * 2000-07-26 2006-11-21 Schering Aktiengesellschaft Use of the interferon receptor 2c polypeptide chain to enhance the anti-growth effects of type I interferons
GB0025132D0 (en) * 2000-10-13 2000-11-29 Medical Res Council Method
AR039067A1 (es) * 2001-11-09 2005-02-09 Pfizer Prod Inc Anticuerpos para cd40
US7786282B2 (en) 2001-12-06 2010-08-31 The Regents Of The University Of California Nucleic acid molecules encoding TNF-α ligand polypeptides having a CD154 domain
US7495090B2 (en) 2002-05-23 2009-02-24 The Regents Of The University Of California Nucleic acids encoding chimeric CD154 polypeptides
US8277810B2 (en) 2003-11-04 2012-10-02 Novartis Vaccines & Diagnostics, Inc. Antagonist anti-CD40 antibodies
CA2544852A1 (en) * 2003-11-04 2005-05-19 Chiron Corporation Methods of therapy for solid tumors expressing the cd40 cell-surface antigen
US20050136055A1 (en) 2003-12-22 2005-06-23 Pfizer Inc CD40 antibody formulation and methods
CA2609269C (en) 2005-05-26 2014-08-05 Seattle Genetics, Inc. Humanized anti-cd40 antibodies and their methods of use
KR20080073725A (ko) 2005-11-01 2008-08-11 노파르티스 아게 항-ｃｄ40 항체의 용도
PT2540820T (pt) 2005-12-09 2018-03-02 Academisch Medisch Centrum Bij De Univ Van Amsterdam Meios e métodos para influenciar a establidade de células produtoras de anticorpos
WO2007067032A1 (en) 2005-12-09 2007-06-14 Academisch Medisch Cemtrum Bij De Universiteit Van Amsterdam Means and methods for influencing the stability of cells
WO2007124299A2 (en) 2006-04-21 2007-11-01 Novartis Ag Antagonist anti-cd40 antibody pharmaceutical compositions
MX2010005080A (es) 2007-11-07 2010-07-28 Genentech Inc Metodos y composiciones para determinar la sensibilidad de linfoma de celula b al tratamiento con anticuerpos anti-cd40.
CN102459639A (zh) 2009-04-18 2012-05-16 健泰科生物技术公司 用于评估b细胞淋巴瘤对抗cd40抗体治疗的响应性的方法
JP5781508B2 (ja) 2009-07-15 2015-09-24 アイム・セラピューティクス・べー・フェー 高親和性抗体を産生させるための手段および方法
AR083847A1 (es) 2010-11-15 2013-03-27 Novartis Ag Variantes de fc (fragmento constante) silenciosas de los anticuerpos anti-cd40
CN103429615B (zh) 2010-12-02 2018-03-16 埃姆医疗有限公司 用于生产高亲和力抗体的方式和方法
JP6125489B2 (ja) 2011-04-29 2017-05-10 アペクシジェン， インコーポレイテッド 抗ｃｄ４０抗体および使用方法
AU2013337903B2 (en) 2012-10-30 2018-08-16 Apexigen, Inc. Anti-CD40 antibodies and methods of use
EP3099709B1 (en) 2014-01-31 2019-12-25 AIMM Therapeutics B.V. Means and methods for producing stable antibodies

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5540926A (en) * 1992-09-04 1996-07-30 Bristol-Myers Squibb Company Soluble and its use in B cell stimulation

Also Published As

Publication number Publication date
DE69522012T2 (de) 2002-04-25
CA2207779A1 (en) 1996-06-20
JPH10510526A (ja) 1998-10-13
CA2207779C (en) 2009-10-06
ATE203676T1 (de) 2001-08-15
NO972732D0 (no) 1997-06-13
MX9704372A (es) 1998-02-28
WO1996018413A1 (en) 1996-06-20
AU691996B2 (en) 1998-05-28
NO318587B1 (no) 2005-04-11
EP0806963B1 (en) 2001-08-01
DE69522012D1 (de) 2001-09-06
GB9425060D0 (en) 1995-02-08
AU3988495A (en) 1996-07-03
FI972484A0 (sv) 1997-06-12
NZ296161A (en) 2001-10-26
FI972484A (sv) 1997-06-12
EP0806963A1 (en) 1997-11-19
JP4076230B2 (ja) 2008-04-16
NO972732L (no) 1997-06-13

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