FI118801B - Menetelmä valmistaa delta9,11-steroideja - Google Patents

Menetelmä valmistaa delta9,11-steroideja Download PDF

Info

Publication number
FI118801B
FI118801B FI964739A FI964739A FI118801B FI 118801 B FI118801 B FI 118801B FI 964739 A FI964739 A FI 964739A FI 964739 A FI964739 A FI 964739A FI 118801 B FI118801 B FI 118801B
Authority
FI
Finland
Prior art keywords
formula
tai
steroids
jossa
yes
Prior art date
Application number
FI964739A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI964739A0 (fi
FI964739A (fi
Inventor
Chou-Hong Tann
Tiruvettipuram K Thiruvengadam
Cesar Colon
Junning Lee
Xiaoyong Fu
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of FI964739A0 publication Critical patent/FI964739A0/fi
Publication of FI964739A publication Critical patent/FI964739A/fi
Application granted granted Critical
Publication of FI118801B publication Critical patent/FI118801B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
    • C07J7/0085—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21 by an halogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
    • C07J5/0069—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
    • C07J5/0076—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group by an alkyl group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
FI964739A 1994-06-01 1996-11-28 Menetelmä valmistaa delta9,11-steroideja FI118801B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US25230294 1994-06-01
US08/252,302 US5502222A (en) 1994-06-01 1994-06-01 Process for preparing delta 9,11 and 21-chloro corticosteroids
US9506600 1995-05-30
PCT/US1995/006600 WO1995032989A1 (fr) 1994-06-01 1995-05-30 Procede pour preparer des δ9,11 et 21-chloro corticosteroides

Publications (3)

Publication Number Publication Date
FI964739A0 FI964739A0 (fi) 1996-11-28
FI964739A FI964739A (fi) 1996-11-28
FI118801B true FI118801B (fi) 2008-03-31

Family

ID=22955451

Family Applications (3)

Application Number Title Priority Date Filing Date
FI964739A FI118801B (fi) 1994-06-01 1996-11-28 Menetelmä valmistaa delta9,11-steroideja
FI20050181A FI117600B (fi) 1994-06-01 2005-02-16 Menetelmä valmistaa 21-kloorikortikosteroideja
FI20050180A FI117599B (fi) 1994-06-01 2005-02-16 Menetelmä valmistaa delta 9,11 -kloorikortikosteroideja

Family Applications After (2)

Application Number Title Priority Date Filing Date
FI20050181A FI117600B (fi) 1994-06-01 2005-02-16 Menetelmä valmistaa 21-kloorikortikosteroideja
FI20050180A FI117599B (fi) 1994-06-01 2005-02-16 Menetelmä valmistaa delta 9,11 -kloorikortikosteroideja

Country Status (18)

Country Link
US (3) US5502222A (fr)
EP (3) EP0969011B1 (fr)
JP (1) JP2831472B2 (fr)
KR (4) KR100226568B1 (fr)
AT (3) ATE397008T1 (fr)
AU (1) AU696425B2 (fr)
CA (1) CA2191324C (fr)
DE (3) DE69535756D1 (fr)
DK (1) DK0063054T3 (fr)
ES (3) ES2306487T3 (fr)
FI (3) FI118801B (fr)
GR (1) GR3032714T3 (fr)
HU (3) HU227380B1 (fr)
IL (5) IL126598A (fr)
MX (1) MX9605893A (fr)
NZ (1) NZ287348A (fr)
PT (1) PT763054E (fr)
WO (1) WO1995032989A1 (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5502222A (en) * 1994-06-01 1996-03-26 Schering Corporation Process for preparing delta 9,11 and 21-chloro corticosteroids
ATE365171T1 (de) 1995-12-11 2007-07-15 Searle Llc Verfahren zur herstellung einer epoxyverbindung
US6887991B1 (en) * 1996-12-11 2005-05-03 G. D. Searle & Company Processes for preparation of 9, 11-epoxy steroids and intermediates useful therein
NZ336004A (en) 1996-12-11 2001-04-27 G Process for preparation of 3-keto-7-alpha-alkoxycarbonyl substituted delta-4,5-steroid by reacting 4,5-dihydro-5,7-lactone steroid substrate in the presence of a base
US7235655B2 (en) * 2002-03-22 2007-06-26 Pharmacia & Upjohn Company Processes to prepare eplerenone
PL372460A1 (en) * 2002-03-22 2005-07-25 Pharmacia Corporation C-17 spirolactonization and 6,7 oxidation of steroids
US20040023935A1 (en) * 2002-08-02 2004-02-05 Dey, L.P. Inhalation compositions, methods of use thereof, and process for preparation of same
US20040109826A1 (en) * 2002-12-06 2004-06-10 Dey, L.P. Stabilized albuterol compositions and method of preparation thereof
US7592348B2 (en) 2003-12-15 2009-09-22 Schering Corporation Heterocyclic aspartyl protease inhibitors
US7700603B2 (en) 2003-12-15 2010-04-20 Schering Corporation Heterocyclic aspartyl protease inhibitors
US7763609B2 (en) 2003-12-15 2010-07-27 Schering Corporation Heterocyclic aspartyl protease inhibitors
CN101668751A (zh) 2006-12-12 2010-03-10 先灵公司 天冬氨酰蛋白酶抑制剂
US8207151B2 (en) 2008-05-28 2012-06-26 Validus Biopharma Inc. Non-hormonal steroid modulators of NF-κB for treatment of disease
EP2556083A4 (fr) 2010-04-05 2013-12-04 Validus Biopharma Inc Modulateurs stéroïdes non hormonaux de nf- kappa b pour le traitement de maladies
CN102225959B (zh) * 2011-04-29 2012-11-07 中国科学院上海有机化学研究所 一种16β-甲基-17α-羟基孕甾-3,20-二酮化合物及其合成方法
WO2017004205A1 (fr) 2015-06-29 2017-01-05 Reveragen Biopharma, Inc. Modulateurs stéroïdiens non hormonaux de nf-κb pour le traitement de maladies
CN107840865A (zh) * 2016-09-20 2018-03-27 天津金耀集团有限公司 一种甲泼尼龙的制备方法
US11382922B2 (en) 2019-03-07 2022-07-12 Reveragen Biopharma, Inc. Aqueous oral pharmaceutical suspension compositions
US10953257B2 (en) 2019-04-19 2021-03-23 Kidde Technologies, Inc. Fire suppression composition
US11326998B2 (en) 2019-04-19 2022-05-10 Kidde Technologies, Inc. System and method for monitoring a fire suppression blend
EP4134373A1 (fr) 2021-08-12 2023-02-15 Santhera Pharmaceuticals (Schweiz) AG Synthèse de stéroïdes delta 9,11

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE28369E (en) * 1957-02-27 1975-03-18 Atcc-zxs
US3947409A (en) * 1958-06-19 1976-03-30 Merck & Co., Inc. 16-Alkyl-1,4,9(11)-pregnatrienes and 9,11-epoxides thereof
DE1127895B (de) * 1958-12-24 1962-04-19 Ciba Geigy Verfahren zur Herstellung von reinen 9 (11)-ungesaettigten Steroiden
US3284477A (en) * 1963-07-10 1966-11-08 Schering Corp Diuretic 1, 4, 9(11)-pregnatrienes
US3639434A (en) * 1967-02-02 1972-02-01 Boots Pure Drug Co Ltd 17-acyloxysteroids and their manufacture
US3933799A (en) * 1969-01-29 1976-01-20 Glaxo Laboratories Limited 11β-Halo-9,12-unsubstituted-C19 -steroids
GB1504133A (en) * 1975-02-24 1978-03-15 Palladino G 2-bromo-6beta-fluoro-pregnane compounds
GB1504134A (en) * 1975-02-25 1978-03-15 Palladino G 2-bromo-6beta-fluoro-pregnane compounds
BG33738A3 (en) * 1978-01-25 1983-04-15 Schering Ag,De Method for obtaining of substituated in 17- th position steroids from pregnan row
US4261984A (en) * 1978-04-05 1981-04-14 Syntex (U.S.A.) Inc. 17β-thiocarboxylic acid esters of 3-oxo-4-halo-16β-methylandrost-4-enes
DE3227312A1 (de) * 1982-07-19 1984-01-19 Schering AG, 1000 Berlin und 4709 Bergkamen Neue 6,16-dimethylkortikoide, ihre herstellung und verwendung
DE3640709A1 (de) * 1986-11-28 1988-06-09 Schering Ag Verfahren zur herstellung von 6(alpha),9(alpha)-difluor-11ss,17(alpha)-dihydroxy-16(alpha)-methyl-4-pregnen-3,20-dion und dessen derivate
US4920216A (en) * 1987-05-28 1990-04-24 The Trustees Of Columbia In The City Of New York Selective chlorination of steroids and other substrates directed by covalently linked pyridine derivatives acting as templates
US5502222A (en) * 1994-06-01 1996-03-26 Schering Corporation Process for preparing delta 9,11 and 21-chloro corticosteroids

Also Published As

Publication number Publication date
HU227379B1 (en) 2011-05-30
DE69535756D1 (de) 2008-06-26
KR100290225B1 (ko) 2001-05-15
ES2306487T3 (es) 2008-11-01
DE69514352T2 (de) 2000-08-24
EP0763054B1 (fr) 2000-01-05
US5616742A (en) 1997-04-01
FI20050181A (fi) 2005-02-16
FI117599B (fi) 2006-12-15
EP0969012A3 (fr) 2004-10-06
US5750745A (en) 1998-05-12
HU0302654D0 (en) 2003-10-28
GR3032714T3 (en) 2000-06-30
EP0969011A3 (fr) 2004-10-06
IL126597A0 (en) 1999-08-17
EP0969011B1 (fr) 2008-05-28
HU9603299D0 (en) 1997-01-28
FI964739A0 (fi) 1996-11-28
EP0969011A2 (fr) 2000-01-05
ES2306488T3 (es) 2008-11-01
JP2831472B2 (ja) 1998-12-02
DE69535765D1 (de) 2008-07-10
ES2140678T3 (es) 2000-03-01
HU227380B1 (en) 2011-05-30
CA2191324C (fr) 2001-08-28
DE69514352D1 (de) 2000-02-10
IL126597A (en) 2003-09-17
FI964739A (fi) 1996-11-28
FI20050180A (fi) 2005-02-16
IL113918A0 (en) 1995-08-31
ATE397008T1 (de) 2008-06-15
KR100290227B1 (ko) 2001-05-15
HU1000527D0 (en) 2010-11-29
KR100226568B1 (ko) 1999-10-15
PT763054E (pt) 2000-06-30
AU2603595A (en) 1995-12-21
US5502222A (en) 1996-03-26
DK0063054T3 (da) 2000-06-19
HUT75518A (en) 1997-05-28
AU696425B2 (en) 1998-09-10
MX9605893A (es) 1997-12-31
JPH09506113A (ja) 1997-06-17
IL126598A (en) 2003-07-31
CA2191324A1 (fr) 1995-12-07
ATE395353T1 (de) 2008-05-15
IL126598A0 (en) 1999-08-17
HU227378B1 (en) 2011-05-30
IL113918A (en) 1999-12-31
EP0763054A1 (fr) 1997-03-19
KR100290226B1 (ko) 2001-05-15
EP0969012B1 (fr) 2008-05-14
ATE188481T1 (de) 2000-01-15
FI117600B (fi) 2006-12-15
NZ287348A (en) 1998-12-23
WO1995032989A1 (fr) 1995-12-07
EP0969012A2 (fr) 2000-01-05

Similar Documents

Publication Publication Date Title
FI118801B (fi) Menetelmä valmistaa delta9,11-steroideja
FI80888C (fi) Foerfarande foer framstaellning av terapeutiskt verkande steroida karboxylsyraestrar.
JPS6354393A (ja) １７α−ヒドロキシステロイド及びその製法
US10112970B2 (en) Process for the preparation of 17-desoxy-corticosteroids
EP0061416B1 (fr) Procédé de préparation de Delta 9(11) et delta 16-21 chloro-20 céto stéroides des séries pregnane et D-homo pregnane et leur utilisation comme intermédiaires dans la synthèse de corticoides à forte activité
AU646342B2 (en) New substituted 16-methyl steroid derivatives of pregna-1,4-diene-3,20-dione, their preparation, their use in the preparation of 16-methylene steroids and new intermediates
JP2005530679A (ja) ６α−フルオロコルチコステロイドの調製方法
IE922042A1 (en) New substituted 16-methyl steroid derivatives of¹pregna-1,4-diene-3,20-dione, their preparation, their use in¹the preparation of 16-methylene steroids and new¹intermediates
CS252474B2 (en) Method of 17-halogenethinylsteroides production
KR800000556B1 (ko) 17 α-에스테르-21 할로 프레그난류의 제법

Legal Events

Date Code Title Description
MM Patent lapsed