DE69535765D1 - Verfahren zur Herstellung von Delta 9,11 und 21-Chloro Corticosteroiden - Google Patents

Verfahren zur Herstellung von Delta 9,11 und 21-Chloro Corticosteroiden

Info

Publication number
DE69535765D1
DE69535765D1 DE69535765T DE69535765T DE69535765D1 DE 69535765 D1 DE69535765 D1 DE 69535765D1 DE 69535765 T DE69535765 T DE 69535765T DE 69535765 T DE69535765 T DE 69535765T DE 69535765 D1 DE69535765 D1 DE 69535765D1
Authority
DE
Germany
Prior art keywords
steroids
chloro
delta
corticosteroids
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69535765T
Other languages
English (en)
Inventor
Xiaoyong Fu
Tiruvettipuram K Thiruvengadam
Chou-Hong Tann
Junning Lee
Cesar Colon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme Corp
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of DE69535765D1 publication Critical patent/DE69535765D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
    • C07J7/0085—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21 by an halogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
    • C07J5/0069—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
    • C07J5/0076—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group by an alkyl group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
DE69535765T 1994-06-01 1995-05-30 Verfahren zur Herstellung von Delta 9,11 und 21-Chloro Corticosteroiden Expired - Lifetime DE69535765D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/252,302 US5502222A (en) 1994-06-01 1994-06-01 Process for preparing delta 9,11 and 21-chloro corticosteroids

Publications (1)

Publication Number Publication Date
DE69535765D1 true DE69535765D1 (de) 2008-07-10

Family

ID=22955451

Family Applications (3)

Application Number Title Priority Date Filing Date
DE69535756T Expired - Lifetime DE69535756D1 (de) 1994-06-01 1995-05-30 Verfahren zur Herstellung von delta 9,11 und 21-Chloro Corticosteroiden
DE69535765T Expired - Lifetime DE69535765D1 (de) 1994-06-01 1995-05-30 Verfahren zur Herstellung von Delta 9,11 und 21-Chloro Corticosteroiden
DE69514352T Expired - Lifetime DE69514352T2 (de) 1994-06-01 1995-05-30 Verfahren zur herstellung von delta-9,11 und 21-chloro-steroid-verbindungen

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69535756T Expired - Lifetime DE69535756D1 (de) 1994-06-01 1995-05-30 Verfahren zur Herstellung von delta 9,11 und 21-Chloro Corticosteroiden

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69514352T Expired - Lifetime DE69514352T2 (de) 1994-06-01 1995-05-30 Verfahren zur herstellung von delta-9,11 und 21-chloro-steroid-verbindungen

Country Status (18)

Country Link
US (3) US5502222A (de)
EP (3) EP0969011B1 (de)
JP (1) JP2831472B2 (de)
KR (4) KR100226568B1 (de)
AT (3) ATE397008T1 (de)
AU (1) AU696425B2 (de)
CA (1) CA2191324C (de)
DE (3) DE69535756D1 (de)
DK (1) DK0063054T3 (de)
ES (3) ES2306487T3 (de)
FI (3) FI118801B (de)
GR (1) GR3032714T3 (de)
HU (3) HU227380B1 (de)
IL (5) IL126598A (de)
MX (1) MX9605893A (de)
NZ (1) NZ287348A (de)
PT (1) PT763054E (de)
WO (1) WO1995032989A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5502222A (en) * 1994-06-01 1996-03-26 Schering Corporation Process for preparing delta 9,11 and 21-chloro corticosteroids
ATE365171T1 (de) 1995-12-11 2007-07-15 Searle Llc Verfahren zur herstellung einer epoxyverbindung
US6887991B1 (en) * 1996-12-11 2005-05-03 G. D. Searle & Company Processes for preparation of 9, 11-epoxy steroids and intermediates useful therein
NZ336004A (en) 1996-12-11 2001-04-27 G Process for preparation of 3-keto-7-alpha-alkoxycarbonyl substituted delta-4,5-steroid by reacting 4,5-dihydro-5,7-lactone steroid substrate in the presence of a base
US7235655B2 (en) * 2002-03-22 2007-06-26 Pharmacia & Upjohn Company Processes to prepare eplerenone
PL372460A1 (en) * 2002-03-22 2005-07-25 Pharmacia Corporation C-17 spirolactonization and 6,7 oxidation of steroids
US20040023935A1 (en) * 2002-08-02 2004-02-05 Dey, L.P. Inhalation compositions, methods of use thereof, and process for preparation of same
US20040109826A1 (en) * 2002-12-06 2004-06-10 Dey, L.P. Stabilized albuterol compositions and method of preparation thereof
US7592348B2 (en) 2003-12-15 2009-09-22 Schering Corporation Heterocyclic aspartyl protease inhibitors
US7700603B2 (en) 2003-12-15 2010-04-20 Schering Corporation Heterocyclic aspartyl protease inhibitors
US7763609B2 (en) 2003-12-15 2010-07-27 Schering Corporation Heterocyclic aspartyl protease inhibitors
CN101668751A (zh) 2006-12-12 2010-03-10 先灵公司 天冬氨酰蛋白酶抑制剂
US8207151B2 (en) 2008-05-28 2012-06-26 Validus Biopharma Inc. Non-hormonal steroid modulators of NF-κB for treatment of disease
EP2556083A4 (de) 2010-04-05 2013-12-04 Validus Biopharma Inc Nichthormonale steroide modulatoren von nf-kappa-b zur krankheitsbehandlung
CN102225959B (zh) * 2011-04-29 2012-11-07 中国科学院上海有机化学研究所 一种16β-甲基-17α-羟基孕甾-3,20-二酮化合物及其合成方法
WO2017004205A1 (en) 2015-06-29 2017-01-05 Reveragen Biopharma, Inc. NON-HORMONAL STEROID MODULATORS OF NF-κB FOR TREATMENT OF DISEASE
CN107840865A (zh) * 2016-09-20 2018-03-27 天津金耀集团有限公司 一种甲泼尼龙的制备方法
US11382922B2 (en) 2019-03-07 2022-07-12 Reveragen Biopharma, Inc. Aqueous oral pharmaceutical suspension compositions
US10953257B2 (en) 2019-04-19 2021-03-23 Kidde Technologies, Inc. Fire suppression composition
US11326998B2 (en) 2019-04-19 2022-05-10 Kidde Technologies, Inc. System and method for monitoring a fire suppression blend
EP4134373A1 (de) 2021-08-12 2023-02-15 Santhera Pharmaceuticals (Schweiz) AG Synthese von delta-9,11-steroiden

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE28369E (en) * 1957-02-27 1975-03-18 Atcc-zxs
US3947409A (en) * 1958-06-19 1976-03-30 Merck & Co., Inc. 16-Alkyl-1,4,9(11)-pregnatrienes and 9,11-epoxides thereof
DE1127895B (de) * 1958-12-24 1962-04-19 Ciba Geigy Verfahren zur Herstellung von reinen 9 (11)-ungesaettigten Steroiden
US3284477A (en) * 1963-07-10 1966-11-08 Schering Corp Diuretic 1, 4, 9(11)-pregnatrienes
US3639434A (en) * 1967-02-02 1972-02-01 Boots Pure Drug Co Ltd 17-acyloxysteroids and their manufacture
US3933799A (en) * 1969-01-29 1976-01-20 Glaxo Laboratories Limited 11β-Halo-9,12-unsubstituted-C19 -steroids
GB1504133A (en) * 1975-02-24 1978-03-15 Palladino G 2-bromo-6beta-fluoro-pregnane compounds
GB1504134A (en) * 1975-02-25 1978-03-15 Palladino G 2-bromo-6beta-fluoro-pregnane compounds
BG33738A3 (en) * 1978-01-25 1983-04-15 Schering Ag,De Method for obtaining of substituated in 17- th position steroids from pregnan row
US4261984A (en) * 1978-04-05 1981-04-14 Syntex (U.S.A.) Inc. 17β-thiocarboxylic acid esters of 3-oxo-4-halo-16β-methylandrost-4-enes
DE3227312A1 (de) * 1982-07-19 1984-01-19 Schering AG, 1000 Berlin und 4709 Bergkamen Neue 6,16-dimethylkortikoide, ihre herstellung und verwendung
DE3640709A1 (de) * 1986-11-28 1988-06-09 Schering Ag Verfahren zur herstellung von 6(alpha),9(alpha)-difluor-11ss,17(alpha)-dihydroxy-16(alpha)-methyl-4-pregnen-3,20-dion und dessen derivate
US4920216A (en) * 1987-05-28 1990-04-24 The Trustees Of Columbia In The City Of New York Selective chlorination of steroids and other substrates directed by covalently linked pyridine derivatives acting as templates
US5502222A (en) * 1994-06-01 1996-03-26 Schering Corporation Process for preparing delta 9,11 and 21-chloro corticosteroids

Also Published As

Publication number Publication date
HU227379B1 (en) 2011-05-30
DE69535756D1 (de) 2008-06-26
KR100290225B1 (ko) 2001-05-15
ES2306487T3 (es) 2008-11-01
DE69514352T2 (de) 2000-08-24
EP0763054B1 (de) 2000-01-05
US5616742A (en) 1997-04-01
FI20050181A (fi) 2005-02-16
FI117599B (fi) 2006-12-15
EP0969012A3 (de) 2004-10-06
US5750745A (en) 1998-05-12
HU0302654D0 (en) 2003-10-28
GR3032714T3 (en) 2000-06-30
EP0969011A3 (de) 2004-10-06
IL126597A0 (en) 1999-08-17
EP0969011B1 (de) 2008-05-28
HU9603299D0 (en) 1997-01-28
FI964739A0 (fi) 1996-11-28
FI118801B (fi) 2008-03-31
EP0969011A2 (de) 2000-01-05
ES2306488T3 (es) 2008-11-01
JP2831472B2 (ja) 1998-12-02
ES2140678T3 (es) 2000-03-01
HU227380B1 (en) 2011-05-30
CA2191324C (en) 2001-08-28
DE69514352D1 (de) 2000-02-10
IL126597A (en) 2003-09-17
FI964739A (fi) 1996-11-28
FI20050180A (fi) 2005-02-16
IL113918A0 (en) 1995-08-31
ATE397008T1 (de) 2008-06-15
KR100290227B1 (ko) 2001-05-15
HU1000527D0 (en) 2010-11-29
KR100226568B1 (ko) 1999-10-15
PT763054E (pt) 2000-06-30
AU2603595A (en) 1995-12-21
US5502222A (en) 1996-03-26
DK0063054T3 (da) 2000-06-19
HUT75518A (en) 1997-05-28
AU696425B2 (en) 1998-09-10
MX9605893A (es) 1997-12-31
JPH09506113A (ja) 1997-06-17
IL126598A (en) 2003-07-31
CA2191324A1 (en) 1995-12-07
ATE395353T1 (de) 2008-05-15
IL126598A0 (en) 1999-08-17
HU227378B1 (en) 2011-05-30
IL113918A (en) 1999-12-31
EP0763054A1 (de) 1997-03-19
KR100290226B1 (ko) 2001-05-15
EP0969012B1 (de) 2008-05-14
ATE188481T1 (de) 2000-01-15
FI117600B (fi) 2006-12-15
NZ287348A (en) 1998-12-23
WO1995032989A1 (en) 1995-12-07
EP0969012A2 (de) 2000-01-05

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Legal Events

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