FI117160B - Flytande kompositioner av HCG - Google Patents

Flytande kompositioner av HCG Download PDF

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Publication number
FI117160B
FI117160B FI973745A FI973745A FI117160B FI 117160 B FI117160 B FI 117160B FI 973745 A FI973745 A FI 973745A FI 973745 A FI973745 A FI 973745A FI 117160 B FI117160 B FI 117160B
Authority
FI
Finland
Prior art keywords
hcg
rec
liquid pharmaceutical
mannitol
buffer
Prior art date
Application number
FI973745A
Other languages
English (en)
Finnish (fi)
Other versions
FI973745A (sv
FI973745A0 (sv
Inventor
Fabrizio Samaritani
Patrizia Natale
Original Assignee
Applied Research Systems
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Research Systems filed Critical Applied Research Systems
Priority to FI973745A priority Critical patent/FI117160B/sv
Publication of FI973745A0 publication Critical patent/FI973745A0/sv
Publication of FI973745A publication Critical patent/FI973745A/sv
Application granted granted Critical
Publication of FI117160B publication Critical patent/FI117160B/sv

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis

Claims (9)

1. Stabil flytande farmaceutisk komposition innefattande rekombinant humant choriongonadotropin och en stabiliserande mängd mannitol. 5
2. Flytande farmaceutisk komposition enligt patentkrav 1, kännetecknad av att lösningen är en buffrad vattenlösning.
3. Flytande farmaceutisk komposition enligt patentkrav 2, kännetecknad av att 10 buffertlösningen väljs bland acetat-, succinat- och fosfatbuffert.
4. Flytande farmaceutisk komposition enligt patentkrav 3, kännetecknad av att buffetien är fosfatbuffert.
5. Flytande farmaceutisk förening enligt nägot av patentkraven 2-4, känneteck nad av att buffertlösningen häller pH 7,00.
6. Flytande farmaceutisk förening enligt nägot av patentkraven 2-5, kännetecknad av att buffertlösningen är 0,01 M. 20
7. Flytande farmaceutisk komposition enligt patentkrav 1, kännetecknad av att ; . den innefattar 1000 - 40 000 IU/ml hCG och 10-180 mg/1 mannitol i en 0,01 M fos- : fatbuffert vid pH 7,00. * 1 · ···· Φ m j ’1 25
8. Förfarande för framställning av en flytande farmaceutisk komposition enligt : 1.1 patentkrav 1, som innefattar utspädning av en bulklösning av hCG i en buffertlös- : "·· ning som innehäller excipientema. • ♦· • · · • mm 9
9. Presentationsform för en flytande farmaceutisk komposition enligt patentkrav . 30 1 som är hermetiskt försluten under sterila betingelser i en behällare som lämpar sig ·1· .1 · ·. för lagring före användning. mmm 9 • φ m 999 9 9 9 9 9 99 99 • ♦ • 2 · 9. m 9 99 2 9 9
FI973745A 1995-03-21 1997-09-22 Flytande kompositioner av HCG FI117160B (sv)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FI973745A FI117160B (sv) 1995-03-21 1997-09-22 Flytande kompositioner av HCG

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP9501055 1995-03-21
PCT/EP1995/001055 WO1996029095A1 (en) 1995-03-21 1995-03-21 Hcg liquid formulations
FI973745 1997-09-22
FI973745A FI117160B (sv) 1995-03-21 1997-09-22 Flytande kompositioner av HCG

Publications (3)

Publication Number Publication Date
FI973745A0 FI973745A0 (sv) 1997-09-22
FI973745A FI973745A (sv) 1997-11-11
FI117160B true FI117160B (sv) 2006-07-14

Family

ID=8165977

Family Applications (1)

Application Number Title Priority Date Filing Date
FI973745A FI117160B (sv) 1995-03-21 1997-09-22 Flytande kompositioner av HCG

Country Status (16)

Country Link
US (1) US6706681B1 (sv)
EP (1) EP0814841B1 (sv)
JP (1) JP4165718B2 (sv)
KR (1) KR100377967B1 (sv)
AT (1) ATE209930T1 (sv)
AU (1) AU707796B2 (sv)
BR (1) BR9510567A (sv)
DE (1) DE69524456T2 (sv)
DK (1) DK0814841T3 (sv)
ES (1) ES2166841T3 (sv)
FI (1) FI117160B (sv)
HK (1) HK1006365A1 (sv)
NO (1) NO318997B1 (sv)
PT (1) PT814841E (sv)
UA (1) UA61053C2 (sv)
WO (1) WO1996029095A1 (sv)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6319504B1 (en) 1996-06-24 2001-11-20 University Of Maryland Biotechnology Institute Treatment and prevention of HIV infection by administration of derivatives of human chorionic gonadotropin
IL122732A0 (en) * 1997-01-15 1998-08-16 Akzo Nobel Nv Liquid gonadotropin-containing formulation its preparation and a device containing same
KR100548107B1 (ko) * 1997-01-30 2006-02-02 바이오팜 게젤샤프트 쭈어 바이오테히놀로지셴 엔트비클룽 폰 파르마카 엠베하 뼈 유도 인자 인간 ｍｐ52 동결 건조 조성물
CN100482679C (zh) 2000-02-22 2009-04-29 雪兰诺实验室有限公司 人绒毛膜促性腺激素的纯化方法
WO2002011753A1 (fr) * 2000-08-04 2002-02-14 Chugai Seiyaku Kabushiki Kaisha Preparations proteiniques a injecter
FR2869979B1 (fr) * 2004-05-06 2006-08-04 Packinox Sa Echangeur thermique a plaques
KR101105871B1 (ko) * 2005-09-27 2012-01-16 주식회사 엘지생명과학 인 난포자극호르몬의 안정한 용액 제형
KR20080106636A (ko) * 2007-06-04 2008-12-09 동아제약주식회사 사람 융모성 성선자극호르몬 함유 즉시 사용형 주사 용액
MY153976A (en) * 2007-11-01 2015-04-30 Merck Serono Sa Lh liquid formulations
TWI532495B (zh) * 2009-10-05 2016-05-11 菲瑞茵國際中心股份有限公司 藥學製劑
WO2011108010A2 (en) * 2010-03-05 2011-09-09 Intas Biopharmaceuticals Limited A thermostable liquid formulation of gonadotropins
EP2417982A1 (en) 2010-07-30 2012-02-15 Ferring B.V. Stabilization of gonadotropins
US20120265129A1 (en) 2011-04-15 2012-10-18 Neuralight Hd, Llc Methods for Chronic Pain Management and Treatment using HCG
US8680086B2 (en) 2011-04-15 2014-03-25 Neuralight Hd, Llc Methods for chronic pain management and treatment using HCG
MX2015004940A (es) 2012-10-18 2015-12-09 Neuralight Hd Llc Tratamiento de depresion y ptsd.

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL88233A (en) * 1987-11-03 1993-08-18 Genentech Inc Gamma interferon formulation
IE64738B1 (en) * 1990-03-20 1995-09-06 Akzo Nv Stabilized gonadotropin containing preparations
US5385230A (en) * 1991-01-11 1995-01-31 Minnesota Mining And Manufacturing Company Adjustable tray assembly for use in desk drawers
JP2966592B2 (ja) * 1991-07-20 1999-10-25 萩原 義秀 安定化されたヒトモノクローナル抗体製剤
IT1250075B (it) * 1991-12-18 1995-03-30 Serono Cesare Ist Ricerca Composizioni farmaceutiche contenenti gonadotropine.

Also Published As

Publication number Publication date
US6706681B1 (en) 2004-03-16
KR19980702859A (ko) 1998-08-05
ATE209930T1 (de) 2001-12-15
HK1006365A1 (en) 1999-02-26
PT814841E (pt) 2002-03-28
WO1996029095A1 (en) 1996-09-26
DK0814841T3 (da) 2002-03-04
DE69524456D1 (de) 2002-01-17
NO974309L (no) 1997-10-14
NO318997B1 (no) 2005-05-30
EP0814841A2 (en) 1998-01-07
JP4165718B2 (ja) 2008-10-15
DE69524456T2 (de) 2002-08-01
AU707796B2 (en) 1999-07-22
JPH11502205A (ja) 1999-02-23
FI973745A (sv) 1997-11-11
NO974309D0 (no) 1997-09-18
EP0814841B1 (en) 2001-12-05
FI973745A0 (sv) 1997-09-22
UA61053C2 (en) 2003-11-17
ES2166841T3 (es) 2002-05-01
KR100377967B1 (ko) 2003-06-12
BR9510567A (pt) 1998-06-23
AU2110695A (en) 1996-10-08

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