FI116220B - Rikki-substituoidut atsetidinoniyhdisteet, jotka ovat hyödyllisiä hypokolesteroleemisinä aineina - Google Patents

Rikki-substituoidut atsetidinoniyhdisteet, jotka ovat hyödyllisiä hypokolesteroleemisinä aineina Download PDF

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Publication number
FI116220B
FI116220B FI972099A FI972099A FI116220B FI 116220 B FI116220 B FI 116220B FI 972099 A FI972099 A FI 972099A FI 972099 A FI972099 A FI 972099A FI 116220 B FI116220 B FI 116220B
Authority
FI
Finland
Prior art keywords
phenyl
fluorophenyl
azetidinone
trans
thio
Prior art date
Application number
FI972099A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI972099A (fi
FI972099A0 (fi
Inventor
Sundeep Dugar
Duane A Burnett
Brian A Mckittrick
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/342,197 external-priority patent/US5624920A/en
Application filed by Schering Corp filed Critical Schering Corp
Publication of FI972099A publication Critical patent/FI972099A/fi
Publication of FI972099A0 publication Critical patent/FI972099A0/fi
Application granted granted Critical
Publication of FI116220B publication Critical patent/FI116220B/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pyridine Compounds (AREA)
FI972099A 1994-11-18 1997-05-16 Rikki-substituoidut atsetidinoniyhdisteet, jotka ovat hyödyllisiä hypokolesteroleemisinä aineina FI116220B (fi)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US34219794 1994-11-18
US08/342,197 US5624920A (en) 1994-11-18 1994-11-18 Sulfur-substituted azetidinone compounds useful as hypocholesterolemic agents
US08/463,619 US5633246A (en) 1994-11-18 1995-06-05 Sulfur-substituted azetidinone compounds useful as hypocholesterolemic agents
US46361995 1995-06-05
US9514134 1995-11-15
PCT/US1995/014134 WO1996016037A1 (en) 1994-11-18 1995-11-15 Sulfur-substituted azetidinone compounds useful as hypocholesterolemic agents

Publications (3)

Publication Number Publication Date
FI972099A FI972099A (fi) 1997-05-16
FI972099A0 FI972099A0 (fi) 1997-05-16
FI116220B true FI116220B (fi) 2005-10-14

Family

ID=26992866

Family Applications (1)

Application Number Title Priority Date Filing Date
FI972099A FI116220B (fi) 1994-11-18 1997-05-16 Rikki-substituoidut atsetidinoniyhdisteet, jotka ovat hyödyllisiä hypokolesteroleemisinä aineina

Country Status (25)

Country Link
US (2) US5633246A (ko)
EP (1) EP0792264B1 (ko)
JP (1) JP2908031B2 (ko)
KR (1) KR100235806B1 (ko)
CN (1) CN1083833C (ko)
AT (1) ATE213726T1 (ko)
AU (1) AU698750B2 (ko)
BR (1) BR9509669A (ko)
CA (1) CA2205202C (ko)
CZ (1) CZ289033B6 (ko)
DE (1) DE69525643T2 (ko)
DK (1) DK0792264T3 (ko)
ES (1) ES2169162T3 (ko)
FI (1) FI116220B (ko)
HK (1) HK1002558A1 (ko)
HU (1) HU227672B1 (ko)
MX (1) MX9703577A (ko)
NO (1) NO308468B1 (ko)
NZ (1) NZ296720A (ko)
PL (1) PL184310B1 (ko)
PT (1) PT792264E (ko)
RU (1) RU2159243C2 (ko)
SK (1) SK283860B6 (ko)
UA (1) UA54381C2 (ko)
WO (1) WO1996016037A1 (ko)

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US6982251B2 (en) 2000-12-20 2006-01-03 Schering Corporation Substituted 2-azetidinones useful as hypocholesterolemic agents
EP1510521A1 (en) * 2000-12-20 2005-03-02 Schering Corporation Sugar-substituted 2-Azetidinones useful as hypocholesterolemic agents
CZ302193B6 (cs) * 2000-12-20 2010-12-08 Schering Corporation 2-azetidinonové deriváty, substituované zbytkem cukru
US7071181B2 (en) * 2001-01-26 2006-07-04 Schering Corporation Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors
EP1911462A3 (en) 2001-01-26 2011-11-30 Schering Corporation Compositions comprising a sterol absorption inhibitor
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US20060287254A1 (en) * 2001-01-26 2006-12-21 Schering Corporation Use of substituted azetidinone compounds for the treatment of sitosterolemia
ES2290562T3 (es) * 2001-01-26 2008-02-16 Schering Corporation Combinaciones del activador del receptor activado por el proliferador de los peroxisomas (ppar) fenofibrato con el inhibidor de la absorcion de esteroles ezetimiba para indicaciones vasculares.
WO2002079174A2 (en) 2001-03-28 2002-10-10 Schering Corporation Enantioselective synthesis of azetidinone intermediate compounds
US7056906B2 (en) * 2001-09-21 2006-06-06 Schering Corporation Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women
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US7053080B2 (en) * 2001-09-21 2006-05-30 Schering Corporation Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors
EP1429756B1 (en) * 2001-09-21 2006-11-22 Schering Corporation Treatment of xanthoma with azetidinone derivatives as sterol absorption inhibitors
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US7135556B2 (en) * 2002-07-19 2006-11-14 Schering Corporation NPC1L1 (NPC3) and methods of use thereof
AR040588A1 (es) 2002-07-26 2005-04-13 Schering Corp Formulacion farmaceutica que comprende un inhibidor de la absorcion del colesterol y un inhibidor de una hmg- co a reductasa
US7208486B2 (en) 2003-03-07 2007-04-24 Schering Corporation Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
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ES2435790T3 (es) 2004-12-03 2013-12-23 Intervet International B.V. Piperazinas sustituidas como antagonistas de CB1
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AR057383A1 (es) * 2005-06-22 2007-12-05 Astrazeneca Ab Compuestos quimicos derivados de 2-azetidinona, formulacion farmaceutica y un proceso de preparacion del compuesto
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SA06270191B1 (ar) * 2005-06-22 2010-03-29 استرازينيكا ايه بي مشتقات من 2- أزيتيدينون جديدة باعتبارها مثبطات لامتصاص الكوليسترول لعلاج حالات فرط نسبة الدهون في الدم
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AU2006331770A1 (en) * 2005-12-21 2007-07-05 Schering Corporation Treatment of nonalcoholic fatty liver disease using cholesterol lowering agents and H3 receptor antagonist/inverse agonist
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Also Published As

Publication number Publication date
CN1083833C (zh) 2002-05-01
MX9703577A (es) 1997-08-30
NZ296720A (en) 1999-03-29
HK1002558A1 (en) 1998-09-04
BR9509669A (pt) 1997-10-28
ATE213726T1 (de) 2002-03-15
WO1996016037A1 (en) 1996-05-30
US5633246A (en) 1997-05-27
SK283860B6 (sk) 2004-03-02
CA2205202A1 (en) 1996-05-30
FI972099A (fi) 1997-05-16
JP2908031B2 (ja) 1999-06-21
DK0792264T3 (da) 2002-04-22
EP0792264A1 (en) 1997-09-03
HUT77088A (hu) 1998-03-02
KR970707092A (ko) 1997-12-01
DE69525643T2 (de) 2002-09-26
HU227672B1 (en) 2011-11-28
CZ148697A3 (en) 1997-11-12
PL184310B1 (pl) 2002-09-30
NO972272D0 (no) 1997-05-16
CN1174548A (zh) 1998-02-25
UA54381C2 (uk) 2003-03-17
PT792264E (pt) 2002-07-31
DE69525643D1 (de) 2002-04-04
AU698750B2 (en) 1998-11-05
US5744467A (en) 1998-04-28
AU4140196A (en) 1996-06-17
EP0792264B1 (en) 2002-02-27
ES2169162T3 (es) 2002-07-01
FI972099A0 (fi) 1997-05-16
SK61697A3 (en) 1997-12-10
NO308468B1 (no) 2000-09-18
CA2205202C (en) 2002-01-08
JPH09512833A (ja) 1997-12-22
KR100235806B1 (ko) 2000-02-01
RU2159243C2 (ru) 2000-11-20
NO972272L (no) 1997-05-16
PL320092A1 (en) 1997-09-15
CZ289033B6 (cs) 2001-10-17

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