FI116056B - N-(2-pyrrolidinyyli-1)-1-fenyylietyyli)asetamideja kappareseptoriantagonisteina - Google Patents
N-(2-pyrrolidinyyli-1)-1-fenyylietyyli)asetamideja kappareseptoriantagonisteina Download PDFInfo
- Publication number
- FI116056B FI116056B FI970746A FI970746A FI116056B FI 116056 B FI116056 B FI 116056B FI 970746 A FI970746 A FI 970746A FI 970746 A FI970746 A FI 970746A FI 116056 B FI116056 B FI 116056B
- Authority
- FI
- Finland
- Prior art keywords
- phenyl
- phenylethyl
- dichlorophenyl
- compound
- alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/335—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrrole Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP9401399 | 1994-08-24 | ||
| PCT/JP1994/001399 WO1996006078A1 (en) | 1994-08-24 | 1994-08-24 | N-(2-(pyrrolidinyl-1)-1-phenylethyl)acetamides as kappa receptor antagonists |
| IB9500374 | 1995-05-18 | ||
| PCT/IB1995/000374 WO1996006077A1 (en) | 1994-08-24 | 1995-05-18 | N-[2-(pyrrolidinyl-1)-1-phenylethyl]acetamides as kappa receptor antagonists |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI970746A0 FI970746A0 (fi) | 1997-02-21 |
| FI970746A FI970746A (fi) | 1997-02-21 |
| FI116056B true FI116056B (fi) | 2005-09-15 |
Family
ID=14098616
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI970746A FI116056B (fi) | 1994-08-24 | 1997-02-21 | N-(2-pyrrolidinyyli-1)-1-fenyylietyyli)asetamideja kappareseptoriantagonisteina |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US5837720A (pt) |
| EP (1) | EP0777649B1 (pt) |
| JP (1) | JP2935899B2 (pt) |
| AT (1) | ATE182138T1 (pt) |
| AU (1) | AU2350695A (pt) |
| BR (1) | BR9503775A (pt) |
| CA (1) | CA2196885C (pt) |
| CO (1) | CO4410322A1 (pt) |
| DE (1) | DE69510802T2 (pt) |
| DK (1) | DK0777649T3 (pt) |
| ES (1) | ES2133767T3 (pt) |
| FI (1) | FI116056B (pt) |
| GR (1) | GR3031133T3 (pt) |
| IL (1) | IL114969A0 (pt) |
| MX (1) | MX9701367A (pt) |
| TR (1) | TR199501055A2 (pt) |
| WO (2) | WO1996006078A1 (pt) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6239154B1 (en) | 1996-03-08 | 2001-05-29 | Adolor Corporation | Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith |
| US5763445A (en) | 1996-03-08 | 1998-06-09 | Adolor Corporation | Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith |
| WO1998049141A1 (en) * | 1997-04-30 | 1998-11-05 | Warner-Lambert Company | Kappa opioid agonists |
| US5760023A (en) * | 1997-07-14 | 1998-06-02 | Adolor Corporation | Kappa agonist anti-pruritic pharmaceutical formulations and method of treating pruritus therewith |
| JP2003526594A (ja) * | 1997-07-14 | 2003-09-09 | アドラー コーポレーション | カッパ・アゴニスト抗掻痒薬学的製剤およびそれにより掻痒を治療する方法 |
| US6284769B1 (en) | 1999-12-03 | 2001-09-04 | The Board Of Trustees Of The University Of Illinois | Nonpeptide kappa opioid receptor antagonists |
| WO2014148574A1 (ja) * | 2013-03-22 | 2014-09-25 | 参天製薬株式会社 | Ｉｌ－２産生抑制 |
| EP3013812B1 (en) | 2013-06-28 | 2019-10-16 | Nektar Therapeutics | Kappa opioid agonists and uses thereof |
| MX2016009624A (es) * | 2014-01-24 | 2016-11-08 | Cadila Healthcare Ltd | Compuestos heterobiciclicos novedosos como agonistas del opioide kappa. |
| BR112017023821A2 (pt) | 2015-05-06 | 2018-07-31 | Leidos Biomedical Res Inc | moduladores de k-ras |
| TW201900638A (zh) | 2017-04-20 | 2019-01-01 | 加州大學董事會 | Ｋ－ｒａｓ調節劑 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4034785A1 (de) * | 1990-11-02 | 1992-05-07 | Merck Patent Gmbh | 1-(2-arylethyl)-pyrrolidine |
| US5232978A (en) * | 1988-12-23 | 1993-08-03 | Merck Patent Gesellschaft Mit Beschrankter Haftung | 1-(2-arylethyl)-pyrrolidines |
| DE4215213A1 (de) * | 1992-05-09 | 1993-11-11 | Merck Patent Gmbh | Arylacetamide |
-
1994
- 1994-08-24 WO PCT/JP1994/001399 patent/WO1996006078A1/en unknown
-
1995
- 1995-05-18 ES ES95917437T patent/ES2133767T3/es not_active Expired - Lifetime
- 1995-05-18 DE DE69510802T patent/DE69510802T2/de not_active Expired - Fee Related
- 1995-05-18 US US08/793,225 patent/US5837720A/en not_active Expired - Fee Related
- 1995-05-18 DK DK95917437T patent/DK0777649T3/da active
- 1995-05-18 CA CA002196885A patent/CA2196885C/en not_active Expired - Fee Related
- 1995-05-18 AU AU23506/95A patent/AU2350695A/en not_active Abandoned
- 1995-05-18 JP JP7529926A patent/JP2935899B2/ja not_active Expired - Fee Related
- 1995-05-18 MX MX9701367A patent/MX9701367A/es not_active IP Right Cessation
- 1995-05-18 EP EP95917437A patent/EP0777649B1/en not_active Expired - Lifetime
- 1995-05-18 WO PCT/IB1995/000374 patent/WO1996006077A1/en active IP Right Grant
- 1995-05-18 AT AT95917437T patent/ATE182138T1/de not_active IP Right Cessation
- 1995-08-17 IL IL11496995A patent/IL114969A0/xx unknown
- 1995-08-23 CO CO95037814A patent/CO4410322A1/es unknown
- 1995-08-23 BR BR9503775A patent/BR9503775A/pt not_active IP Right Cessation
- 1995-08-24 TR TR95/01055A patent/TR199501055A2/xx unknown
-
1997
- 1997-02-21 FI FI970746A patent/FI116056B/fi not_active IP Right Cessation
-
1999
- 1999-09-01 GR GR990402218T patent/GR3031133T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2350695A (en) | 1996-03-14 |
| BR9503775A (pt) | 1996-04-16 |
| WO1996006077A1 (en) | 1996-02-29 |
| GR3031133T3 (en) | 1999-12-31 |
| ATE182138T1 (de) | 1999-07-15 |
| DE69510802T2 (de) | 1999-11-04 |
| US5837720A (en) | 1998-11-17 |
| JPH09510731A (ja) | 1997-10-28 |
| CO4410322A1 (es) | 1997-01-09 |
| JP2935899B2 (ja) | 1999-08-16 |
| WO1996006078A1 (en) | 1996-02-29 |
| FI970746A0 (fi) | 1997-02-21 |
| EP0777649A1 (en) | 1997-06-11 |
| DK0777649T3 (da) | 1999-11-29 |
| DE69510802D1 (de) | 1999-08-19 |
| MX9701367A (es) | 1997-05-31 |
| EP0777649B1 (en) | 1999-07-14 |
| CA2196885C (en) | 2001-01-23 |
| ES2133767T3 (es) | 1999-09-16 |
| CA2196885A1 (en) | 1996-02-29 |
| IL114969A0 (en) | 1995-12-08 |
| TR199501055A2 (tr) | 1996-07-21 |
| FI970746A (fi) | 1997-02-21 |
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| Date | Code | Title | Description |
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| FG | Patent granted |
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| MA | Patent expired |