FI114397B - Menetelmä 16beta-metyylisteroidin ja uusien välituotteiden valmistamiseksi ja menetelmässä käytettävät välituotteet - Google Patents

Menetelmä 16beta-metyylisteroidin ja uusien välituotteiden valmistamiseksi ja menetelmässä käytettävät välituotteet Download PDF

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Publication number
FI114397B
FI114397B FI952718A FI952718A FI114397B FI 114397 B FI114397 B FI 114397B FI 952718 A FI952718 A FI 952718A FI 952718 A FI952718 A FI 952718A FI 114397 B FI114397 B FI 114397B
Authority
FI
Finland
Prior art keywords
formula
compound
methyl
give
process according
Prior art date
Application number
FI952718A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI952718A7 (fi
FI952718A0 (fi
Inventor
Michel Vivat
Catherine Geurts
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Publication of FI952718A0 publication Critical patent/FI952718A0/fi
Publication of FI952718A7 publication Critical patent/FI952718A7/fi
Application granted granted Critical
Publication of FI114397B publication Critical patent/FI114397B/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
    • C07J13/005—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 16 (17)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005—Ketals
    • C07J21/006—Ketals at position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
    • C07J7/004—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa
    • C07J7/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa substituted in position 16
    • C07J7/0055—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Steroid Compounds (AREA)
FI952718A 1994-06-02 1995-06-02 Menetelmä 16beta-metyylisteroidin ja uusien välituotteiden valmistamiseksi ja menetelmässä käytettävät välituotteet FI114397B (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9406743A FR2720747B1 (fr) 1994-06-02 1994-06-02 Nouveau procédé de préparation d'un stéroïde 16béta-méthyl et nouveaux intermédiaires.
FR9406743 1994-06-02

Publications (3)

Publication Number Publication Date
FI952718A0 FI952718A0 (fi) 1995-06-02
FI952718A7 FI952718A7 (fi) 1995-12-03
FI114397B true FI114397B (fi) 2004-10-15

Family

ID=9463797

Family Applications (1)

Application Number Title Priority Date Filing Date
FI952718A FI114397B (fi) 1994-06-02 1995-06-02 Menetelmä 16beta-metyylisteroidin ja uusien välituotteiden valmistamiseksi ja menetelmässä käytettävät välituotteet

Country Status (19)

Country Link
US (3) US5596108A (de)
EP (1) EP0685487B1 (de)
JP (1) JP3950489B2 (de)
KR (1) KR100369766B1 (de)
CN (3) CN1057303C (de)
AT (1) ATE157669T1 (de)
AU (1) AU689564B2 (de)
CA (1) CA2150738C (de)
DE (1) DE69500643T2 (de)
DK (1) DK0685487T3 (de)
ES (1) ES2106623T3 (de)
FI (1) FI114397B (de)
FR (1) FR2720747B1 (de)
GR (1) GR3024626T3 (de)
HU (1) HU219490B (de)
RU (1) RU2151774C1 (de)
TW (1) TW427997B (de)
UA (1) UA48107C2 (de)
ZA (1) ZA954453B (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10014847A1 (de) 2000-03-24 2001-10-04 Gsf Forschungszentrum Umwelt Verfahren und Vorrichtung zum Nachweis von Verbindungen in einem Gasstrom
CN100408025C (zh) * 2006-11-24 2008-08-06 上海医药(集团)有限公司 倍他米松β-11物的自乳化组合物及其制备方法和应用
US8362286B2 (en) * 2009-08-13 2013-01-29 Marinus Pharmaceuticals, Inc. Method for making 3α-hydroxy, 3β- substituted-5α-pregnan-20-ones
CN101851264B (zh) * 2010-03-12 2011-08-10 广西万德药业股份有限公司 一种具有16-β-甲基甾体类药物中间体的制备方法
CN103819495B (zh) * 2014-02-28 2016-08-17 上海新华联制药有限公司 倍他米松中间体的制备方法
CN107286216A (zh) * 2016-03-31 2017-10-24 天津金耀集团有限公司 具有多个烯烃甾体化合物的制备方法
CN105693802B (zh) * 2016-04-12 2017-08-25 湖南新合新生物医药有限公司 16β‑甲基甾族化合物的制备方法
CN106866777B (zh) * 2017-04-12 2019-05-24 杭州弘任医药科技有限公司 苯甲孕酮的制备方法
IT201800009683A1 (it) * 2018-10-22 2020-04-22 Ind Chimica Srl Processo per la preparazione di 3α-idrossi-5α-pregnan-20-one (brexanolone)

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2703799A (en) * 1954-05-12 1955-03-08 Searle & Co 9alpha-halo-11-oxo-16alpha, 17alpha-epoxyprogesterones
US2705711A (en) * 1954-09-24 1955-04-05 Searle & Co 9beta, 11beta; 16alpha, 17alpha-bisepoxyprogesterone
DE1041043B (de) * 1955-07-13 1958-10-16 Nat Res Dev Verfahren zur Herstellung von 17ª‡-Hydroxy-16-halogenallopregnanen
GB805497A (en) * 1955-07-13 1958-12-10 Glaxo Lab Ltd Steroid intermediates for the preparation of adreno-cortical hormones
US2951857A (en) * 1956-03-13 1960-09-06 Searle & Co 11-oxygenated 16-halo-17-hydroxy-progesterones
US3219674A (en) * 1959-03-11 1965-11-23 Syntex Corp 15-dehydro-16 methyl steroids and process for the production thereof
US3761498A (en) * 1971-06-05 1973-09-25 Plurichemie Anstalt New process of preparation of steroids
EP0263569B1 (de) * 1986-10-10 1992-12-09 Roussel-Uclaf 9-Alpha-Hydroxysteroide, Verfahren zu ihrer Herstellung und Verfahren zur Herstellung der entsprechenden 9(11)-Dehydro-Derivate.
HU198736B (en) * 1986-12-29 1989-11-28 Gyogyszerkutato Intezet Process for producing 16-dehydro-20-oxopregnane derivatives

Also Published As

Publication number Publication date
EP0685487B1 (de) 1997-09-03
FR2720747A1 (fr) 1995-12-08
RU2151774C1 (ru) 2000-06-27
FI952718A7 (fi) 1995-12-03
US5596108A (en) 1997-01-21
AU689564B2 (en) 1998-04-02
RU95108877A (ru) 1997-05-10
HK1098760A1 (en) 2007-07-27
TW427997B (en) 2001-04-01
CN1821263A (zh) 2006-08-23
CN100379753C (zh) 2008-04-09
UA48107C2 (uk) 2002-08-15
US6117994A (en) 2000-09-12
CA2150738C (fr) 2006-04-18
FR2720747B1 (fr) 1996-07-12
EP0685487A1 (de) 1995-12-06
ZA954453B (en) 1996-05-31
GR3024626T3 (en) 1997-12-31
HUT71801A (en) 1996-02-28
HU219490B (hu) 2001-04-28
ATE157669T1 (de) 1997-09-15
DK0685487T3 (da) 1998-04-20
KR100369766B1 (ko) 2003-12-11
CA2150738A1 (fr) 1995-12-03
KR960000915A (ko) 1996-01-25
CN1220996A (zh) 1999-06-30
FI952718A0 (fi) 1995-06-02
ES2106623T3 (es) 1997-11-01
JP3950489B2 (ja) 2007-08-01
HU9501595D0 (en) 1995-07-28
CN1252081C (zh) 2006-04-19
DE69500643T2 (de) 1998-01-08
US5795982A (en) 1998-08-18
CN1057303C (zh) 2000-10-11
CN1118351A (zh) 1996-03-13
JPH08169897A (ja) 1996-07-02
DE69500643D1 (de) 1997-10-09
AU2044295A (en) 1995-12-14

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Owner name: HOECHST MARION ROUSSEL

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Owner name: AVENTIS PHARMA S.A.

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