FI113840B - Matriisi-metalloproteinaasi-inhibiittorien käyttö liposomien kohdentamisessa - Google Patents

Matriisi-metalloproteinaasi-inhibiittorien käyttö liposomien kohdentamisessa Download PDF

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Publication number
FI113840B
FI113840B FI20010620A FI20010620A FI113840B FI 113840 B FI113840 B FI 113840B FI 20010620 A FI20010620 A FI 20010620A FI 20010620 A FI20010620 A FI 20010620A FI 113840 B FI113840 B FI 113840B
Authority
FI
Finland
Prior art keywords
liposomes
peptides
ctt
cells
amino acid
Prior art date
Application number
FI20010620A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI20010620A0 (fi
FI20010620A (fi
Inventor
Paavo Kinnunen
Erkki Koivunen
Medina Oula Penate
Original Assignee
Ctt Cancer Targeting Tech Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ctt Cancer Targeting Tech Oy filed Critical Ctt Cancer Targeting Tech Oy
Publication of FI20010620A0 publication Critical patent/FI20010620A0/fi
Priority to FI20010620A priority Critical patent/FI113840B/fi
Priority to HU0303649A priority patent/HUP0303649A3/hu
Priority to BR0208681-6A priority patent/BR0208681A/pt
Priority to DK02706813T priority patent/DK1372694T3/da
Priority to US10/471,980 priority patent/US20040213833A1/en
Priority to KR10-2003-7012506A priority patent/KR20040000414A/ko
Priority to DE60212814T priority patent/DE60212814T2/de
Priority to RU2003131332/15A priority patent/RU2003131332A/ru
Priority to IL15811402A priority patent/IL158114A0/xx
Priority to EP02706813A priority patent/EP1372694B1/en
Priority to ES02706813T priority patent/ES2266458T3/es
Priority to NZ528043A priority patent/NZ528043A/en
Priority to CZ20032805A priority patent/CZ20032805A3/cs
Priority to AT02706813T priority patent/ATE331526T1/de
Priority to EEP200300467A priority patent/EE200300467A/xx
Priority to JP2002575004A priority patent/JP2004529127A/ja
Priority to YU74703A priority patent/YU74703A/sh
Priority to CA002441227A priority patent/CA2441227A1/en
Priority to SK1298-2003A priority patent/SK12982003A3/sk
Priority to CNB028073118A priority patent/CN1250279C/zh
Priority to PL02365248A priority patent/PL365248A1/xx
Priority to PCT/FI2002/000252 priority patent/WO2002076491A1/en
Publication of FI20010620A publication Critical patent/FI20010620A/fi
Priority to NO20034280A priority patent/NO20034280L/no
Application granted granted Critical
Publication of FI113840B publication Critical patent/FI113840B/fi
Priority to US11/125,186 priority patent/US20050271588A1/en

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08Peptides having 5 to 11 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/66Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid the modifying agent being a pre-targeting system involving a peptide or protein for targeting specific cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6905Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
    • A61K47/6911Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1217Dispersions, suspensions, colloids, emulsions, e.g. perfluorinated emulsion, sols
    • A61K51/1234Liposomes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1282Devices used in vivo and carrying the radioactive therapeutic or diagnostic agent, therapeutic or in vivo diagnostic kits, stents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dispersion Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nanotechnology (AREA)
  • Molecular Biology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Medical Informatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oncology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
FI20010620A 2001-03-26 2001-03-26 Matriisi-metalloproteinaasi-inhibiittorien käyttö liposomien kohdentamisessa FI113840B (fi)

Priority Applications (24)

Application Number Priority Date Filing Date Title
FI20010620A FI113840B (fi) 2001-03-26 2001-03-26 Matriisi-metalloproteinaasi-inhibiittorien käyttö liposomien kohdentamisessa
CZ20032805A CZ20032805A3 (cs) 2001-03-26 2002-03-26 Použití peptidových sloučenin, způsob zlepšení směrování a absorpce lipozómů, způsob léčby a diagnostiky pacientů, diagnostická nebo zobrazovací testovací sada a přípravek
EEP200300467A EE200300467A (et) 2001-03-26 2002-03-26 Liposoomide suunamine maatriksi metalloproteinaaside inhibiitorite abil
DK02706813T DK1372694T3 (da) 2001-03-26 2002-03-26 Liposom-målretning af matrix-metalloproteinase-hæmmere
US10/471,980 US20040213833A1 (en) 2001-03-26 2002-03-26 Liposomes targeting of matrix metalloproteinase inhibitors
KR10-2003-7012506A KR20040000414A (ko) 2001-03-26 2002-03-26 매트릭스 메탈로프로테이나제 저해제의 리포좀 표적화
DE60212814T DE60212814T2 (de) 2001-03-26 2002-03-26 Liposomen-targeting von matrix-metalloproteinase-hemmern
RU2003131332/15A RU2003131332A (ru) 2001-03-26 2002-03-26 Липосомное нацеливание ингибиторов матриксной металлопротеиназы
IL15811402A IL158114A0 (en) 2001-03-26 2002-03-26 Liposome targeting of matrix metalloproteinase inhibitors
EP02706813A EP1372694B1 (en) 2001-03-26 2002-03-26 Liposome targeting of matrix metalloproteinase inhibitors
ES02706813T ES2266458T3 (es) 2001-03-26 2002-03-26 Transporte dirigido de liposomas de inhibidores de metaloproteinasas de matriz.
NZ528043A NZ528043A (en) 2001-03-26 2002-03-26 Use of peptides CTTHWGFTLC, CLPGHWGFPSC and STTHWGFTLS in enhancing targeting and uptake of liposome containing chemotherapeutic agents to tumor cells to treat cancer and its use in diagnostics
HU0303649A HUP0303649A3 (en) 2001-03-26 2002-03-26 Liposome targeting of matrix metalloproteinase inhibitors
AT02706813T ATE331526T1 (de) 2001-03-26 2002-03-26 Liposomen-targeting von matrix-metalloproteinase- hemmern
BR0208681-6A BR0208681A (pt) 2001-03-26 2002-03-26 Compostos de peptìdeos e uso dos mesmos
JP2002575004A JP2004529127A (ja) 2001-03-26 2002-03-26 マトリックス金属プロティナーゼ阻害物質を用いたリポソームターゲッティング
YU74703A YU74703A (sh) 2001-03-26 2002-03-26 Lipozomsko ciljanje inhibitora mreže metaloproteinaze
CA002441227A CA2441227A1 (en) 2001-03-26 2002-03-26 Liposome targeting of matrix metalloproteinase inhibitors
SK1298-2003A SK12982003A3 (sk) 2001-03-26 2002-03-26 Použitie peptidových zlúčenín, spôsob zlepšenia smerovania a absorpcie lipozómov, spôsob liečby a diagnostiky pacientov, diagnostická alebo zobrazovacia súprava a prostriedok
CNB028073118A CN1250279C (zh) 2001-03-26 2002-03-26 基质金属蛋白酶抑制剂的脂质体靶向
PL02365248A PL365248A1 (en) 2001-03-26 2002-03-26 Liposome targeting of matrix metalloproteinase inhibitors
PCT/FI2002/000252 WO2002076491A1 (en) 2001-03-26 2002-03-26 Liposome targeting of matrix metalloproteinase inhibitors
NO20034280A NO20034280L (no) 2001-03-26 2003-09-25 Liposommålretting av matrise metallproteinasehemmere
US11/125,186 US20050271588A1 (en) 2001-03-26 2005-05-10 Liposome targeting of matrix metalloproteinase inhibitors

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FI20010620A FI113840B (fi) 2001-03-26 2001-03-26 Matriisi-metalloproteinaasi-inhibiittorien käyttö liposomien kohdentamisessa
FI20010620 2001-03-26

Publications (3)

Publication Number Publication Date
FI20010620A0 FI20010620A0 (fi) 2001-03-26
FI20010620A FI20010620A (fi) 2002-09-27
FI113840B true FI113840B (fi) 2004-06-30

Family

ID=8560842

Family Applications (1)

Application Number Title Priority Date Filing Date
FI20010620A FI113840B (fi) 2001-03-26 2001-03-26 Matriisi-metalloproteinaasi-inhibiittorien käyttö liposomien kohdentamisessa

Country Status (23)

Country Link
US (2) US20040213833A1 (ru)
EP (1) EP1372694B1 (ru)
JP (1) JP2004529127A (ru)
KR (1) KR20040000414A (ru)
CN (1) CN1250279C (ru)
AT (1) ATE331526T1 (ru)
BR (1) BR0208681A (ru)
CA (1) CA2441227A1 (ru)
CZ (1) CZ20032805A3 (ru)
DE (1) DE60212814T2 (ru)
DK (1) DK1372694T3 (ru)
EE (1) EE200300467A (ru)
ES (1) ES2266458T3 (ru)
FI (1) FI113840B (ru)
HU (1) HUP0303649A3 (ru)
IL (1) IL158114A0 (ru)
NO (1) NO20034280L (ru)
NZ (1) NZ528043A (ru)
PL (1) PL365248A1 (ru)
RU (1) RU2003131332A (ru)
SK (1) SK12982003A3 (ru)
WO (1) WO2002076491A1 (ru)
YU (1) YU74703A (ru)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7279150B2 (en) 2002-01-24 2007-10-09 Barnes-Jewish Hospital Chelating agents with lipophilic carriers
IL152609A0 (en) * 2002-11-03 2003-06-24 Hapto Biotech Inc Liposomal compositions comprising haptotactic peptides and uses thereof
CN1314704C (zh) * 2002-11-20 2007-05-09 中国人民解放军军事医学科学院放射与辐射医学研究所 基质金属蛋白酶2的小肽抑制剂
EP1594550A4 (en) * 2003-01-24 2007-07-11 Barnes Jewish Hospital CHELATBILDNER WITH LIPOPHILES
FI115035B (fi) * 2003-05-02 2005-02-28 Ctt Cancer Targeting Tech Oy In vivo -kuvantaminen käyttäen peptidijohdannaisia
FI20031528A0 (fi) * 2003-10-17 2003-10-17 Ctt Cancer Targeting Tech Oy Terapeuttinen liposomikoostumus ja menetelmä sen valmistamiseksi
FI20040572A0 (fi) * 2004-04-23 2004-04-23 Ctt Cancer Targeting Tech Oy Matriisi-metalloproteinaasin aktiviteetin inhibiittorit
FI20040682A0 (fi) * 2004-05-14 2004-05-14 Ctt Cancer Targeting Tech Oy Tuumorien ja mestastaasien kuvantaminen käyttäen gelatinaasiin targetoituvaa peptidiä
FR2870741B1 (fr) 2004-05-25 2008-03-14 Coletica Sa Phase lamellaires hydratees ou liposomes, contenant une monoamine grasse ou un polymere cationique favorisant la penetration intercellulaire, et composition cosmetique ou pharmaceutique la contenant.
JP2006248978A (ja) 2005-03-10 2006-09-21 Mebiopharm Co Ltd 新規なリポソーム製剤
WO2008005514A2 (en) * 2006-07-06 2008-01-10 The Trustees Of Columbia University In The City Of New York Polychromatic, diversely-sized particles for angiography
CN102114000B (zh) * 2009-12-31 2013-08-21 复旦大学 一种载药的共输送脂质纳米递药系统
US8871189B2 (en) * 2011-11-30 2014-10-28 Mallinckrodt Llc MMP-targeted therapeutic and/or diagnostic nanocarriers
EP3538546A1 (en) 2016-11-14 2019-09-18 Novartis AG Compositions, methods, and therapeutic uses related to fusogenic protein minion

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5158760A (en) * 1990-05-30 1992-10-27 Board Of Regents, The University Of Texas System 99m TC labeled liposomes
ATE244572T1 (de) * 1996-10-15 2003-07-15 Liposome Co Inc Peptid-lipid konjugate, liposomen und liposomale arzneimittelverabreichung
FI980604A0 (fi) * 1998-03-18 1998-03-18 Univ Helsinki Licensing Nya matrismetalloproteinasinhibitorer och -regulatorer

Also Published As

Publication number Publication date
JP2004529127A (ja) 2004-09-24
CZ20032805A3 (cs) 2004-06-16
PL365248A1 (en) 2004-12-27
NO20034280D0 (no) 2003-09-25
EP1372694B1 (en) 2006-06-28
RU2003131332A (ru) 2005-04-10
HUP0303649A3 (en) 2005-12-28
IL158114A0 (en) 2004-03-28
CN1250279C (zh) 2006-04-12
FI20010620A0 (fi) 2001-03-26
HUP0303649A2 (hu) 2004-01-28
ES2266458T3 (es) 2007-03-01
SK12982003A3 (sk) 2004-08-03
FI20010620A (fi) 2002-09-27
EE200300467A (et) 2003-12-15
DE60212814D1 (de) 2006-08-10
US20040213833A1 (en) 2004-10-28
NZ528043A (en) 2005-08-26
WO2002076491A1 (en) 2002-10-03
KR20040000414A (ko) 2004-01-03
YU74703A (sh) 2006-05-25
DE60212814T2 (de) 2007-02-08
BR0208681A (pt) 2004-03-30
DK1372694T3 (da) 2006-10-30
CN1531439A (zh) 2004-09-22
EP1372694A1 (en) 2004-01-02
US20050271588A1 (en) 2005-12-08
ATE331526T1 (de) 2006-07-15
CA2441227A1 (en) 2002-10-03
NO20034280L (no) 2003-11-25

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