FI113475B - HIV-proteiinien geeniekspressioyksikkö ja HIV-proteiinien tuottaminen Drosophila-soluissa - Google Patents

HIV-proteiinien geeniekspressioyksikkö ja HIV-proteiinien tuottaminen Drosophila-soluissa

Info

Publication number
FI113475B
FI113475B FI912635A FI912635A FI113475B FI 113475 B FI113475 B FI 113475B FI 912635 A FI912635 A FI 912635A FI 912635 A FI912635 A FI 912635A FI 113475 B FI113475 B FI 113475B
Authority
FI
Finland
Prior art keywords
hiv proteins
production
gene expression
expression unit
drosophila cells
Prior art date
Application number
FI912635A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI912635A0 (fi
Inventor
Hanne Ranch Johansen
Martin Rosenberg
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of FI912635A0 publication Critical patent/FI912635A0/fi
Application granted granted Critical
Publication of FI113475B publication Critical patent/FI113475B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1036—Retroviridae, e.g. leukemia viruses
    • C07K16/1045—Lentiviridae, e.g. HIV, FIV, SIV
    • C07K16/1063—Lentiviridae, e.g. HIV, FIV, SIV env, e.g. gp41, gp110/120, gp160, V3, PND, CD4 binding site
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
    • C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/75—Vector systems having a special element relevant for transcription from invertebrates

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • AIDS & HIV (AREA)
  • Hematology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
FI912635A 1988-12-01 1991-05-31 HIV-proteiinien geeniekspressioyksikkö ja HIV-proteiinien tuottaminen Drosophila-soluissa FI113475B (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US27838688A 1988-12-01 1988-12-01
PCT/US1989/005155 WO1990006358A1 (en) 1988-12-01 1989-11-29 Expression of hiv proteins in drosophila cells

Publications (2)

Publication Number Publication Date
FI912635A0 FI912635A0 (fi) 1991-05-31
FI113475B true FI113475B (fi) 2004-04-30

Family

ID=23064787

Family Applications (1)

Application Number Title Priority Date Filing Date
FI912635A FI113475B (fi) 1988-12-01 1991-05-31 HIV-proteiinien geeniekspressioyksikkö ja HIV-proteiinien tuottaminen Drosophila-soluissa

Country Status (12)

Country Link
EP (1) EP0446272A4 (ja)
JP (1) JP3085704B2 (ja)
KR (1) KR0152525B1 (ja)
AU (1) AU630649B2 (ja)
CA (1) CA2003794C (ja)
DK (1) DK175461B1 (ja)
FI (1) FI113475B (ja)
IL (1) IL92470A (ja)
NO (1) NO314090B1 (ja)
PT (1) PT92477A (ja)
WO (1) WO1990006358A1 (ja)
ZA (1) ZA899150B (ja)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013006688A2 (en) * 2011-07-05 2013-01-10 Duke University N-terminal deleted gp120 immunogens
WO2013052095A2 (en) 2011-10-03 2013-04-11 Duke University Vaccine

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0272858A3 (en) * 1986-12-15 1989-07-12 Repligen Corporation Recombinant hiv envelope proteins produced in insect cells
CA1341345C (en) * 1987-05-08 2002-03-05 Hanne Ranch Johansen Expression of foreign genes in drosophila cells
AP129A (en) * 1988-06-03 1991-04-17 Smithkline Biologicals S A Expression of retrovirus gag protein eukaryotic cells
EP0409923A4 (en) * 1988-12-21 1993-01-20 Smithkline Biologicals Expression of the i(plasmodium) circumsporozoite protein in insect cells

Also Published As

Publication number Publication date
WO1990006358A1 (en) 1990-06-14
IL92470A0 (en) 1990-08-31
JPH04501954A (ja) 1992-04-09
KR910700344A (ko) 1991-03-14
DK104991A (da) 1991-05-31
DK104991D0 (da) 1991-05-31
NO912099D0 (no) 1991-05-31
AU630649B2 (en) 1992-11-05
NO912099L (no) 1991-07-31
AU4755290A (en) 1990-06-26
CA2003794A1 (en) 1990-06-01
FI912635A0 (fi) 1991-05-31
JP3085704B2 (ja) 2000-09-11
KR0152525B1 (ko) 1998-10-01
ZA899150B (en) 1991-04-24
DK175461B1 (da) 2004-11-01
EP0446272A1 (en) 1991-09-18
CA2003794C (en) 2000-02-08
EP0446272A4 (en) 1993-01-07
PT92477A (pt) 1990-06-29
NO314090B1 (no) 2003-01-27
IL92470A (en) 1997-01-10

Similar Documents

Publication Publication Date Title
FI893542A (fi) Entsyymielektrodit ja menetelmä niiden valmistamiseksi
DK40591A (da) Tredimensionalt celle- og vaevskultursystem
DE3752338D1 (de) Anti-Sense-Regulierung von Genexpression in Pflanzenzellen
AU3725689A (en) Expression of retrovirus gag protein in eukaryotic cells
FI885589A (fi) Proteiinituotteen valmistus ja käyttö
PT89121A (pt) Processo para a preparacao de interleuquina-2 imobilizada e interleuquina-2 contendo uma extensao no terminal-carboxilo com actividade de interleuquina-2 natural
DK299087D0 (da) Proteins and derivatives thereof
BR8902861A (pt) Processo de preparacao de copoliamidas amorfas e transparentes e sua aplicacao
PT84849A (pt) Enhanced expression of human interleukin-2 in mammalian cells
EP0295859A3 (en) Production of proteins in active forms
BR8600339A (pt) Processo de fabricacao de artigo poroso e artigo metalico poroso e respectivo artigo
FI113475B (fi) HIV-proteiinien geeniekspressioyksikkö ja HIV-proteiinien tuottaminen Drosophila-soluissa
DE69034051D1 (de) Stabil transformierte Hefezellen und ihre Verwendung zur Herstellung von Albumin
DK643188A (da) Ekspression af hiv-proteiner i e.coli og s.cerevisiae
AU2810089A (en) Production of proteins in plants
PT88556A (pt) Stable genomic integration and expression of a foreign coding sequence in yeast
IE893803L (en) Expression of hiv proteins in drosophila cells
PT86588A (pt) Kassetten-vektor-system zur expression offener leserahmen in eukaryotichen zellen
DE58901122D1 (de) Verwendung von tnf und lt zur herstellung von arzneimitteln.
ATE59407T1 (de) Expression von epa in saeugetierzellen.
ES550064A0 (es) Perfeccionamientos en la fabricacion de cuerpos ahuecados de carton y similares
JPS645492A (en) Production of b type hepatitis virus protein in yeast
BR8405786A (pt) Nivel de pedreiro com medicao em graus e percentual
PT88807A (pt) Processo para a amplificacao de genes e para a preparacao melhorada de proteinas em culturas de celulas animais
ATE74763T1 (de) Verwendung von tnf und lt zur herstellung von arzneimitteln.