FI113369B - Akridoni-johdetut bisinterkalaattorit kemoterapeuttisina aineina - Google Patents

Akridoni-johdetut bisinterkalaattorit kemoterapeuttisina aineina Download PDF

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Publication number
FI113369B
FI113369B FI963626A FI963626A FI113369B FI 113369 B FI113369 B FI 113369B FI 963626 A FI963626 A FI 963626A FI 963626 A FI963626 A FI 963626A FI 113369 B FI113369 B FI 113369B
Authority
FI
Finland
Prior art keywords
compound according
compound
double
compounds
mixture
Prior art date
Application number
FI963626A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI963626A0 (fi
FI963626A (fi
Inventor
Wieslaw M Cholody
Lidia Hernandez
Christopher J Michejda
Original Assignee
Us Gov Health & Human Serv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Us Gov Health & Human Serv filed Critical Us Gov Health & Human Serv
Publication of FI963626A0 publication Critical patent/FI963626A0/fi
Publication of FI963626A publication Critical patent/FI963626A/fi
Application granted granted Critical
Publication of FI113369B publication Critical patent/FI113369B/fi

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/001Preparation for luminescence or biological staining
    • A61K49/0013Luminescence
    • A61K49/0017Fluorescence in vivo
    • A61K49/0019Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0026Acridine dyes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D219/00Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C07D219/08Nitrogen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
FI963626A 1994-03-14 1996-09-13 Akridoni-johdetut bisinterkalaattorit kemoterapeuttisina aineina FI113369B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US08/213,315 US5508289A (en) 1994-03-14 1994-03-14 Bis-acridone chemotherapeutic derivatives
US21331594 1994-03-14
PCT/US1995/003079 WO1995025093A1 (en) 1994-03-14 1995-03-09 Acridone-derived bisintercalators as chemotherapeutic agents
US9503079 1995-03-09

Publications (3)

Publication Number Publication Date
FI963626A0 FI963626A0 (fi) 1996-09-13
FI963626A FI963626A (fi) 1996-11-08
FI113369B true FI113369B (fi) 2004-04-15

Family

ID=22794610

Family Applications (1)

Application Number Title Priority Date Filing Date
FI963626A FI113369B (fi) 1994-03-14 1996-09-13 Akridoni-johdetut bisinterkalaattorit kemoterapeuttisina aineina

Country Status (12)

Country Link
US (1) US5508289A (da)
EP (1) EP0750612B1 (da)
JP (1) JP3862747B2 (da)
AT (1) ATE187716T1 (da)
AU (1) AU684624B2 (da)
CA (1) CA2185350C (da)
DE (1) DE69513962T2 (da)
DK (1) DK0750612T3 (da)
ES (1) ES2140668T3 (da)
FI (1) FI113369B (da)
GR (1) GR3032836T3 (da)
WO (1) WO1995025093A1 (da)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU725629B2 (en) 1996-04-12 2000-10-19 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Acridone-derived compounds useful as antineoplastic and antiretroviral agents
WO1998048838A1 (en) * 1997-04-29 1998-11-05 Nycomed Imaging As Compounds
IT1293525B1 (it) * 1997-08-01 1999-03-01 Uni Degli Studi Camerino Bis-acridincarbossiammidi aventi attivita' antitumorale
EP1085846A2 (en) * 1998-06-08 2001-03-28 Advanced Medicine, Inc. Multibinding inhibitors of microsomal triglyceride transferase protein
JP5408829B2 (ja) 1999-12-28 2014-02-05 ゲットナー・ファンデーション・エルエルシー アクティブマトリックス基板の製造方法
US7144843B2 (en) * 2001-01-31 2006-12-05 Meiji Seika Kaisha, Ltd. Pest controllers
GB0208989D0 (en) 2002-04-19 2002-05-29 Amersham Biosciences Uk Ltd Methods for measuring enzyme activity
FR2879598B1 (fr) * 2004-12-17 2007-03-30 Sod Conseils Rech Applic Inhibiteurs de phosphatases cdc25
EP3070078B1 (en) * 2015-03-20 2017-10-04 Politechnika Gdanska Asymmetric bis-acridines with antitumor activity and use thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4626540A (en) * 1983-11-08 1986-12-02 Warner-Lambert Company Substituted 1-amino-4-nitro-acridinones and methods of treating bacterial infections and leukemia with them
IL91673A0 (en) * 1988-09-20 1990-04-29 Us Health Method for tagging an oligodeoxynucleotide
GB9104548D0 (en) * 1991-03-05 1991-04-17 Cholody Wienlaw M Antineoplastic modified imidazoacridines

Also Published As

Publication number Publication date
US5508289A (en) 1996-04-16
ATE187716T1 (de) 2000-01-15
ES2140668T3 (es) 2000-03-01
DE69513962T2 (de) 2000-06-21
DE69513962D1 (de) 2000-01-20
CA2185350A1 (en) 1995-09-21
JPH09510451A (ja) 1997-10-21
EP0750612A1 (en) 1997-01-02
FI963626A0 (fi) 1996-09-13
JP3862747B2 (ja) 2006-12-27
FI963626A (fi) 1996-11-08
CA2185350C (en) 2006-01-03
DK0750612T3 (da) 2000-05-01
WO1995025093A1 (en) 1995-09-21
EP0750612B1 (en) 1999-12-15
AU1990095A (en) 1995-10-03
AU684624B2 (en) 1997-12-18
GR3032836T3 (en) 2000-07-31

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