FI113369B - Akridoni-johdetut bisinterkalaattorit kemoterapeuttisina aineina - Google Patents
Akridoni-johdetut bisinterkalaattorit kemoterapeuttisina aineina Download PDFInfo
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- FI113369B FI113369B FI963626A FI963626A FI113369B FI 113369 B FI113369 B FI 113369B FI 963626 A FI963626 A FI 963626A FI 963626 A FI963626 A FI 963626A FI 113369 B FI113369 B FI 113369B
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- 230000001472 cytotoxic effect Effects 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 125000001891 dimethoxy group Chemical group [H]C([H])([H])O* 0.000 description 1
- 238000009510 drug design Methods 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 230000001804 emulsifying effect Effects 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 239000012894 fetal calf serum Substances 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 239000007850 fluorescent dye Substances 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 239000012737 fresh medium Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 125000005456 glyceride group Chemical group 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 description 1
- 229910000041 hydrogen chloride Inorganic materials 0.000 description 1
- 238000000099 in vitro assay Methods 0.000 description 1
- 238000009830 intercalation Methods 0.000 description 1
- 230000002687 intercalation Effects 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 238000007912 intraperitoneal administration Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 208000032839 leukemia Diseases 0.000 description 1
- XGZVUEUWXADBQD-UHFFFAOYSA-L lithium carbonate Chemical compound [Li+].[Li+].[O-]C([O-])=O XGZVUEUWXADBQD-UHFFFAOYSA-L 0.000 description 1
- 229910052808 lithium carbonate Inorganic materials 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 239000011976 maleic acid Substances 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- AFVFQIVMOAPDHO-UHFFFAOYSA-M methanesulfonate group Chemical class CS(=O)(=O)[O-] AFVFQIVMOAPDHO-UHFFFAOYSA-M 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 description 1
- 238000004452 microanalysis Methods 0.000 description 1
- 239000007758 minimum essential medium Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- KMBPCQSCMCEPMU-UHFFFAOYSA-N n'-(3-aminopropyl)-n'-methylpropane-1,3-diamine Chemical compound NCCCN(C)CCCN KMBPCQSCMCEPMU-UHFFFAOYSA-N 0.000 description 1
- 230000035407 negative regulation of cell proliferation Effects 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- RLOWWWKZYUNIDI-UHFFFAOYSA-N phosphinic chloride Chemical compound ClP=O RLOWWWKZYUNIDI-UHFFFAOYSA-N 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 230000004962 physiological condition Effects 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 239000000651 prodrug Substances 0.000 description 1
- 229940002612 prodrug Drugs 0.000 description 1
- 230000002062 proliferating effect Effects 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- WGYKZJWCGVVSQN-UHFFFAOYSA-N propylamine Chemical group CCCN WGYKZJWCGVVSQN-UHFFFAOYSA-N 0.000 description 1
- 238000010839 reverse transcription Methods 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- CZDYPVPMEAXLPK-UHFFFAOYSA-N tetramethylsilane Chemical compound C[Si](C)(C)C CZDYPVPMEAXLPK-UHFFFAOYSA-N 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- FGWARXSCGJFBCM-UHFFFAOYSA-N wmc-42 Chemical compound C12=C3C(=O)C4=CC=CC=C4N1N=NC2=CC=C3NCCCN(C)CCCNC1=CC=C2C3=C1C(=O)C1=CC=CC=C1N3C=N2 FGWARXSCGJFBCM-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
- A61K49/0026—Acridine dyes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
- C07D219/08—Nitrogen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/213,315 US5508289A (en) | 1994-03-14 | 1994-03-14 | Bis-acridone chemotherapeutic derivatives |
| US21331594 | 1994-03-14 | ||
| PCT/US1995/003079 WO1995025093A1 (en) | 1994-03-14 | 1995-03-09 | Acridone-derived bisintercalators as chemotherapeutic agents |
| US9503079 | 1995-03-09 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI963626A0 FI963626A0 (fi) | 1996-09-13 |
| FI963626A FI963626A (fi) | 1996-11-08 |
| FI113369B true FI113369B (fi) | 2004-04-15 |
Family
ID=22794610
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI963626A FI113369B (fi) | 1994-03-14 | 1996-09-13 | Akridoni-johdetut bisinterkalaattorit kemoterapeuttisina aineina |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5508289A (da) |
| EP (1) | EP0750612B1 (da) |
| JP (1) | JP3862747B2 (da) |
| AT (1) | ATE187716T1 (da) |
| AU (1) | AU684624B2 (da) |
| CA (1) | CA2185350C (da) |
| DE (1) | DE69513962T2 (da) |
| DK (1) | DK0750612T3 (da) |
| ES (1) | ES2140668T3 (da) |
| FI (1) | FI113369B (da) |
| GR (1) | GR3032836T3 (da) |
| WO (1) | WO1995025093A1 (da) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU725629B2 (en) | 1996-04-12 | 2000-10-19 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Acridone-derived compounds useful as antineoplastic and antiretroviral agents |
| WO1998048838A1 (en) * | 1997-04-29 | 1998-11-05 | Nycomed Imaging As | Compounds |
| IT1293525B1 (it) * | 1997-08-01 | 1999-03-01 | Uni Degli Studi Camerino | Bis-acridincarbossiammidi aventi attivita' antitumorale |
| EP1085846A2 (en) * | 1998-06-08 | 2001-03-28 | Advanced Medicine, Inc. | Multibinding inhibitors of microsomal triglyceride transferase protein |
| JP5408829B2 (ja) | 1999-12-28 | 2014-02-05 | ゲットナー・ファンデーション・エルエルシー | アクティブマトリックス基板の製造方法 |
| US7144843B2 (en) * | 2001-01-31 | 2006-12-05 | Meiji Seika Kaisha, Ltd. | Pest controllers |
| GB0208989D0 (en) | 2002-04-19 | 2002-05-29 | Amersham Biosciences Uk Ltd | Methods for measuring enzyme activity |
| FR2879598B1 (fr) * | 2004-12-17 | 2007-03-30 | Sod Conseils Rech Applic | Inhibiteurs de phosphatases cdc25 |
| EP3070078B1 (en) * | 2015-03-20 | 2017-10-04 | Politechnika Gdanska | Asymmetric bis-acridines with antitumor activity and use thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4626540A (en) * | 1983-11-08 | 1986-12-02 | Warner-Lambert Company | Substituted 1-amino-4-nitro-acridinones and methods of treating bacterial infections and leukemia with them |
| IL91673A0 (en) * | 1988-09-20 | 1990-04-29 | Us Health | Method for tagging an oligodeoxynucleotide |
| GB9104548D0 (en) * | 1991-03-05 | 1991-04-17 | Cholody Wienlaw M | Antineoplastic modified imidazoacridines |
-
1994
- 1994-03-14 US US08/213,315 patent/US5508289A/en not_active Expired - Lifetime
-
1995
- 1995-03-09 CA CA002185350A patent/CA2185350C/en not_active Expired - Fee Related
- 1995-03-09 ES ES95912887T patent/ES2140668T3/es not_active Expired - Lifetime
- 1995-03-09 AT AT95912887T patent/ATE187716T1/de not_active IP Right Cessation
- 1995-03-09 DK DK95912887T patent/DK0750612T3/da active
- 1995-03-09 AU AU19900/95A patent/AU684624B2/en not_active Ceased
- 1995-03-09 JP JP52411295A patent/JP3862747B2/ja not_active Expired - Fee Related
- 1995-03-09 EP EP95912887A patent/EP0750612B1/en not_active Expired - Lifetime
- 1995-03-09 DE DE69513962T patent/DE69513962T2/de not_active Expired - Fee Related
- 1995-03-09 WO PCT/US1995/003079 patent/WO1995025093A1/en active IP Right Grant
-
1996
- 1996-09-13 FI FI963626A patent/FI113369B/fi active
-
2000
- 2000-02-29 GR GR20000400528T patent/GR3032836T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| US5508289A (en) | 1996-04-16 |
| ATE187716T1 (de) | 2000-01-15 |
| ES2140668T3 (es) | 2000-03-01 |
| DE69513962T2 (de) | 2000-06-21 |
| DE69513962D1 (de) | 2000-01-20 |
| CA2185350A1 (en) | 1995-09-21 |
| JPH09510451A (ja) | 1997-10-21 |
| EP0750612A1 (en) | 1997-01-02 |
| FI963626A0 (fi) | 1996-09-13 |
| JP3862747B2 (ja) | 2006-12-27 |
| FI963626A (fi) | 1996-11-08 |
| CA2185350C (en) | 2006-01-03 |
| DK0750612T3 (da) | 2000-05-01 |
| WO1995025093A1 (en) | 1995-09-21 |
| EP0750612B1 (en) | 1999-12-15 |
| AU1990095A (en) | 1995-10-03 |
| AU684624B2 (en) | 1997-12-18 |
| GR3032836T3 (en) | 2000-07-31 |
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