ES2140668T3 - Intercaladores bifuncionales derivados de acridona que se utilizan como agentes quimioterapeuticos. - Google Patents
Intercaladores bifuncionales derivados de acridona que se utilizan como agentes quimioterapeuticos.Info
- Publication number
- ES2140668T3 ES2140668T3 ES95912887T ES95912887T ES2140668T3 ES 2140668 T3 ES2140668 T3 ES 2140668T3 ES 95912887 T ES95912887 T ES 95912887T ES 95912887 T ES95912887 T ES 95912887T ES 2140668 T3 ES2140668 T3 ES 2140668T3
- Authority
- ES
- Spain
- Prior art keywords
- acridone
- derived
- double
- bond
- chemotherapeutical agents
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- GDALETGZDYOOGB-UHFFFAOYSA-N Acridone Natural products C1=C(O)C=C2N(C)C3=CC=CC=C3C(=O)C2=C1O GDALETGZDYOOGB-UHFFFAOYSA-N 0.000 title 1
- FZEYVTFCMJSGMP-UHFFFAOYSA-N acridone Chemical compound C1=CC=C2C(=O)C3=CC=CC=C3NC2=C1 FZEYVTFCMJSGMP-UHFFFAOYSA-N 0.000 title 1
- 230000001588 bifunctional effect Effects 0.000 title 1
- 230000000973 chemotherapeutic effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000001093 anti-cancer Effects 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
- A61K49/0026—Acridine dyes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
- C07D219/08—Nitrogen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
LA PRESENTE INVENCION SUMINISTRA UN COMPUESTO DE ESTRUCTURA (I) EN DONDE R ES -H, -CH{SUB,3}, O -C{SUB,2}H{SUB,5}; R1 Y R2 SON INDEPENDIENTEMENTE -H, -OH, -NH{SUB,2}, -OCH{SUB,3}, C(CH{SUB,3}){SUB,3}, O UN ATOMO DE HALOGENO; N ES DE 2 A 6; X Y X'' SON INDEPENDIENTEMENTE -N O -NO{SUB,2}; Y E Y'' SON INDEPENDIENTEMENTE -N, -CH O -H; Y EL DOBLE PUNTEADO REPRESENTA UN ENLACE DOBLE O NINGUN ENLACE; ASI QUE CUANDO X O X'' ES -N, Y E Y'' ES -CH O -N, Y EL DOBLE PUNTEADO ES UN ENLACE DOBLE, Y CUANDO X O X'' ES -NO{SUB,2}, Y E Y'' ES -H, Y EL DOBLE PUNTEADO NO ES UN ENLACE. LA PRESENTE INVENCION TAMBIEN SUMINISTRA UNA COMPOSICION FARMACEUTICA QUE COMPRENDE EL COMPUESTO ANTERIOR Y UN PORTADOR FARMACEUTICAMENTE ACEPTABLE. LA PRESENTE INVENCION ADEMAS SUMINISTRA UN METODO PARA TRATAR UN CRECIMIENTO CELULAR NEOPLASTICO EN UN PACIENTE QUE NECESITE TAL TRATAMIENTO QUE COMPRENDE ADMINISTRAR AL PACIENTE UNA CANTIDAD DE LA COMPOSICION FARMACEUTICA EFICAZ PARA TRATAR EL CRECIMIENTO CELULAR NEOPLASTICO. POR ULTIMO,LA PRESENTE INVENCION SUMINISTRA ACIDO NUCLEICO MARCADO CON EL COMPUESTO, ASI COMO UN METODO PARA DETECTAR ACIDO NUCLEICO EN UNA MUESTRA.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/213,315 US5508289A (en) | 1994-03-14 | 1994-03-14 | Bis-acridone chemotherapeutic derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2140668T3 true ES2140668T3 (es) | 2000-03-01 |
Family
ID=22794610
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES95912887T Expired - Lifetime ES2140668T3 (es) | 1994-03-14 | 1995-03-09 | Intercaladores bifuncionales derivados de acridona que se utilizan como agentes quimioterapeuticos. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5508289A (es) |
| EP (1) | EP0750612B1 (es) |
| JP (1) | JP3862747B2 (es) |
| AT (1) | ATE187716T1 (es) |
| AU (1) | AU684624B2 (es) |
| CA (1) | CA2185350C (es) |
| DE (1) | DE69513962T2 (es) |
| DK (1) | DK0750612T3 (es) |
| ES (1) | ES2140668T3 (es) |
| FI (1) | FI113369B (es) |
| GR (1) | GR3032836T3 (es) |
| WO (1) | WO1995025093A1 (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0892801B1 (en) * | 1996-04-12 | 2002-01-02 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | Acridone-derived compounds useful as antineoplastic and antiretroviral agents |
| WO1998048845A1 (en) * | 1997-04-29 | 1998-11-05 | Nycomed Imaging As | Method of demarcating tissue |
| IT1293525B1 (it) * | 1997-08-01 | 1999-03-01 | Uni Degli Studi Camerino | Bis-acridincarbossiammidi aventi attivita' antitumorale |
| US6288234B1 (en) * | 1998-06-08 | 2001-09-11 | Advanced Medicine, Inc. | Multibinding inhibitors of microsomal triglyceride transferase protein |
| JP5408829B2 (ja) | 1999-12-28 | 2014-02-05 | ゲットナー・ファンデーション・エルエルシー | アクティブマトリックス基板の製造方法 |
| US7144843B2 (en) * | 2001-01-31 | 2006-12-05 | Meiji Seika Kaisha, Ltd. | Pest controllers |
| GB0208989D0 (en) * | 2002-04-19 | 2002-05-29 | Amersham Biosciences Uk Ltd | Methods for measuring enzyme activity |
| FR2879598B1 (fr) * | 2004-12-17 | 2007-03-30 | Sod Conseils Rech Applic | Inhibiteurs de phosphatases cdc25 |
| EP3070078B1 (en) * | 2015-03-20 | 2017-10-04 | Politechnika Gdanska | Asymmetric bis-acridines with antitumor activity and use thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4626540A (en) * | 1983-11-08 | 1986-12-02 | Warner-Lambert Company | Substituted 1-amino-4-nitro-acridinones and methods of treating bacterial infections and leukemia with them |
| IL91673A0 (en) * | 1988-09-20 | 1990-04-29 | Us Health | Method for tagging an oligodeoxynucleotide |
| GB9104548D0 (en) * | 1991-03-05 | 1991-04-17 | Cholody Wienlaw M | Antineoplastic modified imidazoacridines |
-
1994
- 1994-03-14 US US08/213,315 patent/US5508289A/en not_active Expired - Lifetime
-
1995
- 1995-03-09 JP JP52411295A patent/JP3862747B2/ja not_active Expired - Fee Related
- 1995-03-09 WO PCT/US1995/003079 patent/WO1995025093A1/en active IP Right Grant
- 1995-03-09 CA CA002185350A patent/CA2185350C/en not_active Expired - Fee Related
- 1995-03-09 AT AT95912887T patent/ATE187716T1/de not_active IP Right Cessation
- 1995-03-09 ES ES95912887T patent/ES2140668T3/es not_active Expired - Lifetime
- 1995-03-09 DE DE69513962T patent/DE69513962T2/de not_active Expired - Fee Related
- 1995-03-09 EP EP95912887A patent/EP0750612B1/en not_active Expired - Lifetime
- 1995-03-09 DK DK95912887T patent/DK0750612T3/da active
- 1995-03-09 AU AU19900/95A patent/AU684624B2/en not_active Ceased
-
1996
- 1996-09-13 FI FI963626A patent/FI113369B/fi active
-
2000
- 2000-02-29 GR GR20000400528T patent/GR3032836T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| WO1995025093A1 (en) | 1995-09-21 |
| ATE187716T1 (de) | 2000-01-15 |
| CA2185350A1 (en) | 1995-09-21 |
| EP0750612B1 (en) | 1999-12-15 |
| EP0750612A1 (en) | 1997-01-02 |
| US5508289A (en) | 1996-04-16 |
| JP3862747B2 (ja) | 2006-12-27 |
| DE69513962T2 (de) | 2000-06-21 |
| CA2185350C (en) | 2006-01-03 |
| JPH09510451A (ja) | 1997-10-21 |
| FI113369B (fi) | 2004-04-15 |
| DK0750612T3 (da) | 2000-05-01 |
| FI963626A0 (fi) | 1996-09-13 |
| AU684624B2 (en) | 1997-12-18 |
| DE69513962D1 (de) | 2000-01-20 |
| FI963626A (fi) | 1996-11-08 |
| GR3032836T3 (en) | 2000-07-31 |
| AU1990095A (en) | 1995-10-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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