ATE187716T1 - Acridonderivate von diinterkalatoren als chemotherapeutische wirkstoffe - Google Patents

Acridonderivate von diinterkalatoren als chemotherapeutische wirkstoffe

Info

Publication number
ATE187716T1
ATE187716T1 AT95912887T AT95912887T ATE187716T1 AT E187716 T1 ATE187716 T1 AT E187716T1 AT 95912887 T AT95912887 T AT 95912887T AT 95912887 T AT95912887 T AT 95912887T AT E187716 T1 ATE187716 T1 AT E187716T1
Authority
AT
Austria
Prior art keywords
double
diintercalators
chemotherapeutic agents
bond
acridone derivatives
Prior art date
Application number
AT95912887T
Other languages
English (en)
Inventor
Christopher J Michejda
Wieslaw M Cholody
Lidia Hernandez
Original Assignee
Us Health
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Us Health filed Critical Us Health
Application granted granted Critical
Publication of ATE187716T1 publication Critical patent/ATE187716T1/de

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/001Preparation for luminescence or biological staining
    • A61K49/0013Luminescence
    • A61K49/0017Fluorescence in vivo
    • A61K49/0019Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0026Acridine dyes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D219/00Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C07D219/08Nitrogen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT95912887T 1994-03-14 1995-03-09 Acridonderivate von diinterkalatoren als chemotherapeutische wirkstoffe ATE187716T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/213,315 US5508289A (en) 1994-03-14 1994-03-14 Bis-acridone chemotherapeutic derivatives
PCT/US1995/003079 WO1995025093A1 (en) 1994-03-14 1995-03-09 Acridone-derived bisintercalators as chemotherapeutic agents

Publications (1)

Publication Number Publication Date
ATE187716T1 true ATE187716T1 (de) 2000-01-15

Family

ID=22794610

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95912887T ATE187716T1 (de) 1994-03-14 1995-03-09 Acridonderivate von diinterkalatoren als chemotherapeutische wirkstoffe

Country Status (12)

Country Link
US (1) US5508289A (de)
EP (1) EP0750612B1 (de)
JP (1) JP3862747B2 (de)
AT (1) ATE187716T1 (de)
AU (1) AU684624B2 (de)
CA (1) CA2185350C (de)
DE (1) DE69513962T2 (de)
DK (1) DK0750612T3 (de)
ES (1) ES2140668T3 (de)
FI (1) FI113369B (de)
GR (1) GR3032836T3 (de)
WO (1) WO1995025093A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6187775B1 (en) * 1996-04-12 2001-02-13 The United States Of America As Represented By The Department Of Health And Human Services Acridone-derived compounds useful as antineoplastic and antiretroviral agents
WO1998048845A1 (en) 1997-04-29 1998-11-05 Nycomed Imaging As Method of demarcating tissue
IT1293525B1 (it) * 1997-08-01 1999-03-01 Uni Degli Studi Camerino Bis-acridincarbossiammidi aventi attivita' antitumorale
US6288234B1 (en) * 1998-06-08 2001-09-11 Advanced Medicine, Inc. Multibinding inhibitors of microsomal triglyceride transferase protein
JP5408829B2 (ja) 1999-12-28 2014-02-05 ゲットナー・ファンデーション・エルエルシー アクティブマトリックス基板の製造方法
ATE556075T1 (de) * 2001-01-31 2012-05-15 Meiji Seika Pharma Co Ltd Triazoquinolone-derivate als pestizide
GB0208989D0 (en) * 2002-04-19 2002-05-29 Amersham Biosciences Uk Ltd Methods for measuring enzyme activity
FR2879598B1 (fr) * 2004-12-17 2007-03-30 Sod Conseils Rech Applic Inhibiteurs de phosphatases cdc25
EP3070078B1 (de) * 2015-03-20 2017-10-04 Politechnika Gdanska Unsymmetrische bisacridine und ihre verwendung zur behandlung von tumoren

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4626540A (en) * 1983-11-08 1986-12-02 Warner-Lambert Company Substituted 1-amino-4-nitro-acridinones and methods of treating bacterial infections and leukemia with them
IL91673A0 (en) * 1988-09-20 1990-04-29 Us Health Method for tagging an oligodeoxynucleotide
GB9104548D0 (en) * 1991-03-05 1991-04-17 Cholody Wienlaw M Antineoplastic modified imidazoacridines

Also Published As

Publication number Publication date
CA2185350A1 (en) 1995-09-21
FI113369B (fi) 2004-04-15
DE69513962D1 (de) 2000-01-20
FI963626A (fi) 1996-11-08
FI963626A0 (fi) 1996-09-13
AU1990095A (en) 1995-10-03
EP0750612B1 (de) 1999-12-15
EP0750612A1 (de) 1997-01-02
DE69513962T2 (de) 2000-06-21
WO1995025093A1 (en) 1995-09-21
JP3862747B2 (ja) 2006-12-27
JPH09510451A (ja) 1997-10-21
DK0750612T3 (da) 2000-05-01
GR3032836T3 (en) 2000-07-31
CA2185350C (en) 2006-01-03
US5508289A (en) 1996-04-16
ES2140668T3 (es) 2000-03-01
AU684624B2 (en) 1997-12-18

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee