FI112655B - Menetelmä uusien terapeuttisesti käyttökelpoisten fenyylisulfonamidijohdannaisten valmistamiseksi - Google Patents
Menetelmä uusien terapeuttisesti käyttökelpoisten fenyylisulfonamidijohdannaisten valmistamiseksi Download PDFInfo
- Publication number
- FI112655B FI112655B FI932052A FI932052A FI112655B FI 112655 B FI112655 B FI 112655B FI 932052 A FI932052 A FI 932052A FI 932052 A FI932052 A FI 932052A FI 112655 B FI112655 B FI 112655B
- Authority
- FI
- Finland
- Prior art keywords
- isoxazolyl
- dimethyl
- biphenyl
- sulfonamide
- compound
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/14—Nitrogen atoms
- C07D261/16—Benzene-sulfonamido isoxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Immunology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US87900092A | 1992-05-06 | 1992-05-06 | |
US87900092 | 1992-05-06 |
Publications (3)
Publication Number | Publication Date |
---|---|
FI932052A0 FI932052A0 (fi) | 1993-05-06 |
FI932052A FI932052A (fi) | 1993-11-07 |
FI112655B true FI112655B (fi) | 2003-12-31 |
Family
ID=25373236
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI932052A FI112655B (fi) | 1992-05-06 | 1993-05-06 | Menetelmä uusien terapeuttisesti käyttökelpoisten fenyylisulfonamidijohdannaisten valmistamiseksi |
Country Status (22)
Country | Link |
---|---|
EP (1) | EP0569193B1 (zh) |
JP (1) | JP3286391B2 (zh) |
KR (1) | KR100277454B1 (zh) |
CN (1) | CN1066441C (zh) |
AT (1) | ATE149155T1 (zh) |
AU (1) | AU659545B2 (zh) |
CA (1) | CA2095174A1 (zh) |
CY (1) | CY2016A (zh) |
DE (1) | DE69308229T2 (zh) |
DK (1) | DK0569193T3 (zh) |
ES (1) | ES2100459T3 (zh) |
FI (1) | FI112655B (zh) |
GR (1) | GR3023421T3 (zh) |
HK (1) | HK98197A (zh) |
HU (1) | HU218938B (zh) |
IL (1) | IL105481A (zh) |
MX (1) | MX9302618A (zh) |
NO (1) | NO303065B1 (zh) |
NZ (1) | NZ247440A (zh) |
PL (1) | PL178165B1 (zh) |
RU (1) | RU2133742C1 (zh) |
ZA (1) | ZA932914B (zh) |
Families Citing this family (74)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6124343A (en) * | 1919-01-27 | 2000-09-26 | Rhone-Poulenc Rorer Limited | Substituted phenyl compounds with a substituent having a thienyl ring |
WO1988005799A1 (en) * | 1987-02-09 | 1988-08-11 | Mitsui Petrochemical Industries, Ltd. | Sheet-like molding material and laminate for molding containing the material as one layer |
US5571821A (en) * | 1993-05-20 | 1996-11-05 | Texas Biotechnology Corporation | Sulfonamides and derivatives thereof that modulate the activity of endothelin |
US5591761A (en) * | 1993-05-20 | 1997-01-07 | Texas Biotechnology Corporation | Thiophenyl-, furyl-and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin |
US5962490A (en) | 1987-09-25 | 1999-10-05 | Texas Biotechnology Corporation | Thienyl-, furyl- and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin |
US5514691A (en) * | 1993-05-20 | 1996-05-07 | Immunopharmaceutics, Inc. | N-(4-halo-isoxazolyl)-sulfonamides and derivatives thereof that modulate the activity of endothelin |
US5594021A (en) * | 1993-05-20 | 1997-01-14 | Texas Biotechnology Corporation | Thienyl-, furyl- and pyrrolyl sulfonamides and derivatives thereof that modulate the activity of endothelin |
US5736509A (en) * | 1990-12-14 | 1998-04-07 | Texas Biotechnology Corporation | Cyclic peptide surface feature mimics of endothelin |
US5767310A (en) * | 1993-03-19 | 1998-06-16 | Merck & Co., Inc. | Phenoxyphenylacetic acid derivatives |
CA2121724A1 (en) | 1993-04-21 | 1994-10-22 | Toshifumi Watanabe | Methods and compositions for the prophylactic and/or therapeutic treatment of organ hypofunction |
US6613804B2 (en) | 1993-05-20 | 2003-09-02 | Encysive Pharmaceuticals, Inc. | Biphenylsulfonamides and derivatives thereof that modulate the activity of endothelin |
US6541498B2 (en) | 1993-05-20 | 2003-04-01 | Texas Biotechnology | Benzenesulfonamides and the use thereof to modulate the activity of endothelin |
US6342610B2 (en) | 1993-05-20 | 2002-01-29 | Texas Biotechnology Corp. | N-aryl thienyl-, furyl-, and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin |
US6030991A (en) * | 1993-05-20 | 2000-02-29 | Texas Biotechnology Corp. | Benzenesulfonamides and the use thereof to modulate the activity of endothelin |
US6376523B1 (en) | 1994-05-20 | 2002-04-23 | Texas Biotechnology Corporation | Benzenesulfonamides and the use thereof to modulate the activity of endothelin |
US5686478A (en) * | 1993-07-20 | 1997-11-11 | Merck & Co. Inc. | Endothelin antagonists |
ES2081250B1 (es) * | 1993-07-28 | 1996-10-16 | Squibb & Sons Inc | Antagonistas de endotelina a base de fenilsulfonamida. |
US5965732A (en) * | 1993-08-30 | 1999-10-12 | Bristol-Myers Squibb Co. | Sulfonamide endothelin antagonists |
BR9407933A (pt) * | 1993-11-01 | 1996-11-26 | Japat Ltd | Antagonistas de receptores de endotelina |
US5431842A (en) * | 1993-11-05 | 1995-07-11 | The Procter & Gamble Company | Liquid detergents with ortho-substituted phenylboronic acids for inhibition of proteolytic enzyme |
IL111959A (en) * | 1993-12-17 | 2000-07-16 | Tanabe Seiyaku Co | N-(polysubstituted pyrimidin-4-yl) benzenesulfonamide derivatives their preparation and pharmaceutical compositions containing them |
GB9504854D0 (en) * | 1994-03-31 | 1995-04-26 | Zeneca Ltd | Nitrogen derivatives |
GB9409618D0 (en) * | 1994-05-13 | 1994-07-06 | Zeneca Ltd | Pyridine derivatives |
US5612359A (en) * | 1994-08-26 | 1997-03-18 | Bristol-Myers Squibb Company | Substituted biphenyl isoxazole sulfonamides |
US5559135A (en) * | 1994-09-14 | 1996-09-24 | Merck & Co., Inc. | Endothelin antagonists bearing pyridyl amides |
US5538991A (en) * | 1994-09-14 | 1996-07-23 | Merck & Co., Inc. | Endothelin antagonists bearing 5-membered heterocyclic amides |
FR2724654B1 (fr) * | 1994-09-16 | 1997-12-12 | Roussel Uclaf | Nouveaux derives de l'acide gallique, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant |
FR2725988B1 (fr) * | 1994-10-24 | 1997-01-24 | Roussel Uclaf | Nouveaux derives de pyrazolones et pyrazoles acides, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant |
CZ289090B6 (cs) * | 1994-12-20 | 2001-10-17 | F. Hoffmann-La Roche Ag | Derivát arylsulfonamidu a heteroarylsulfonamidu, způsob jeho přípravy a jeho pouľití |
CA2168154A1 (en) * | 1995-02-06 | 1996-08-07 | Natesan Murugesan | Substituted biphenyl sulfonamide endothelin antagonists |
DE19509950A1 (de) * | 1995-03-18 | 1996-09-19 | Merck Patent Gmbh | Endothelin-Rezeptor-Antagonisten |
TR199701096T1 (xx) * | 1995-04-04 | 1998-02-21 | Texas Biotechnology Corporation | Tienil-, Furil-, Pirolil- ve Bifenils�lfonamidler ve Bunlar�n Endotelin Etkinli�ini D�zenleyen T�revleri. |
US5739333A (en) * | 1995-05-16 | 1998-04-14 | Tanabe Seiyaku Co., Ltd. | Sulfonamide derivative and process for preparing the same |
UA58494C2 (uk) * | 1995-06-07 | 2003-08-15 | Зенека Лімітед | Похідні n-гетероарилпіридинсульфонаміду, фармацевтична композиція, спосіб одержання та спосіб протидії впливам ендотеліну |
GB9512697D0 (en) * | 1995-06-22 | 1995-08-23 | Zeneca Ltd | Heterocyclic compounds |
US5846990A (en) * | 1995-07-24 | 1998-12-08 | Bristol-Myers Squibb Co. | Substituted biphenyl isoxazole sulfonamides |
AU7094996A (en) * | 1995-09-26 | 1997-04-17 | Shionogi & Co., Ltd. | Novel sulfonamide compounds and medicinal composition |
JPH09124620A (ja) * | 1995-10-11 | 1997-05-13 | Bristol Myers Squibb Co | 置換ビフェニルスルホンアミドエンドセリン拮抗剤 |
DE19540737A1 (de) | 1995-11-02 | 1997-05-07 | Bayer Ag | Substituierte Sulfonylamino(thio)carbonylverbindungen |
US5977117A (en) * | 1996-01-05 | 1999-11-02 | Texas Biotechnology Corporation | Substituted phenyl compounds and derivatives thereof that modulate the activity of endothelin |
US5856507A (en) * | 1997-01-21 | 1999-01-05 | Bristol-Myers Squibb Co. | Methods for the preparation of biphenyl isoxazole sulfonamides |
NZ330464A (en) * | 1996-02-20 | 2000-04-28 | Bristol Myers Squibb Co | Methods for the preparation of biphenyl isoxazole sulfonamides |
US5958905A (en) | 1996-03-26 | 1999-09-28 | Texas Biotechnology Corporation | Phosphoramidates, phosphinic amides and related compounds and the use thereof to modulate the activity of endothelin |
US5939446A (en) * | 1996-04-09 | 1999-08-17 | Bristol-Myers Squibb Co. | Heteroaryl substituted phenyl isoxazole sulfonamide endothelin antagonists |
US5804585A (en) | 1996-04-15 | 1998-09-08 | Texas Biotechnology Corporation | Thieno-pyridine sulfonamides derivatives thereof and related compounds that modulate the activity of endothelin |
US5877193A (en) * | 1996-07-19 | 1999-03-02 | Hoffmann-La Roche Inc. | Use of N-(4-aryl-thiazol-2-yl)-sulfonamides |
TW536540B (en) * | 1997-01-30 | 2003-06-11 | Bristol Myers Squibb Co | Endothelin antagonists: N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]-2-yl]methyl]-N,3,3-trimethylbutanamide and N-(4,5-dimethyl-3-isoxazolyl)-2'-[(3,3-dimethyl-2-oxo-1-pyrrolidinyl)methyl]-4'-(2-oxazolyl)[1,1'-biphe |
AU6187898A (en) * | 1997-01-30 | 1998-08-25 | Bristol-Myers Squibb Company | Method for preventing or treating low renin hypertension by administering an endothelin antagonist |
TR200101905T2 (tr) | 1997-04-28 | 2002-06-21 | Texas Biotechnology Corporation | Endotelin ile ilgili hastalıkların tedavisinde kullanılan sülfanoamidler. |
US5783705A (en) | 1997-04-28 | 1998-07-21 | Texas Biotechnology Corporation | Process of preparing alkali metal salys of hydrophobic sulfonamides |
AU3718900A (en) | 1999-03-19 | 2000-10-09 | Bristol-Myers Squibb Company | Methods for the preparation of biphenyl isoxazole sulfonamides |
US7566452B1 (en) | 1999-05-04 | 2009-07-28 | New York University | Cancer treatment with endothelin receptor antagonists |
ATE339417T1 (de) * | 1999-12-15 | 2006-10-15 | Bristol Myers Squibb Co | Biphenyl - sulfonamide als duale angiotensin - endothelin - rezeptor - antagonisten |
ATE286051T1 (de) * | 1999-12-31 | 2005-01-15 | Encysive Pharmaceuticals Inc | Sulfonamide und ihre derivate, die die aktivität des endothelins modulieren |
CA2348847A1 (en) * | 2000-05-31 | 2001-11-30 | Pfizer Inc. | New isoxazole-sulfonamide endothelin antagonists |
US6639082B2 (en) | 2000-10-17 | 2003-10-28 | Bristol-Myers Squibb Company | Methods for the preparation of biphenyl isoxazole sulfonamides |
GB0219660D0 (en) | 2002-08-23 | 2002-10-02 | Astrazeneca Ab | Therapeutic use |
GB0403744D0 (en) | 2004-02-20 | 2004-03-24 | Astrazeneca Ab | Chemical process |
CA2584413A1 (en) * | 2004-10-29 | 2006-05-04 | Astrazeneca Ab | Novel sulphonamide derivatives as glucocorticoid receptor modulators for the treatment of inflammatory diseases |
AU2006316867A1 (en) | 2005-11-22 | 2007-05-31 | Amgen Inc. | Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1 |
AU2007275301A1 (en) | 2006-07-20 | 2008-01-24 | Amgen Inc. | Substituted azole aromatic heterocycles as inhibitors of 11-beta-HSD-1 |
TW200829578A (en) | 2006-11-23 | 2008-07-16 | Astrazeneca Ab | Chemical compounds 537 |
JO2754B1 (en) | 2006-12-21 | 2014-03-15 | استرازينكا ايه بي | Amylendazoleil derivatives for the treatment of glucocorticoid-mediated disorders |
TWI445705B (zh) | 2008-05-20 | 2014-07-21 | Astrazeneca Ab | 經苯基及苯并二基取代之吲唑衍生物 |
HUE025013T2 (hu) | 2009-01-12 | 2016-04-28 | Pfizer Ltd | Szulfonamid-származékok |
EP2590972B1 (en) | 2010-07-09 | 2015-01-21 | Pfizer Limited | N-sulfonylbenzamides as inhibitors of voltage-gated sodium channels |
TW201512171A (zh) | 2013-04-19 | 2015-04-01 | Pfizer Ltd | 化學化合物 |
GB201721185D0 (en) | 2017-12-18 | 2018-01-31 | Nodthera Ltd | Sulphonyl urea derivatives |
GB201810581D0 (en) | 2018-06-28 | 2018-08-15 | Ctxt Pty Ltd | Compounds |
CN114761383A (zh) * | 2019-06-12 | 2022-07-15 | 诺瑟拉有限公司 | 磺酰胺衍生物及其用途 |
CN114641466A (zh) | 2019-06-12 | 2022-06-17 | 诺瑟拉有限公司 | 磺酰脲衍生物及其用途 |
EP3986890B1 (en) | 2019-06-18 | 2023-11-15 | Pfizer Inc. | Benzisoxazole sulfonamide derivatives |
WO2022270487A1 (ja) * | 2021-06-22 | 2022-12-29 | 株式会社アークメディスン | 化合物、エンドセリンa受容体拮抗剤及び医薬組成物 |
TW202423432A (zh) * | 2022-11-11 | 2024-06-16 | 日商亞克醫藥股份有限公司 | 化合物、內皮素a受體拮抗劑、血管收縮素ii第一型受體拮抗劑及醫藥組合物 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NO117180B (zh) * | 1963-12-23 | 1969-07-14 | Shionogi & Co | |
US4732519A (en) * | 1986-12-24 | 1988-03-22 | Illinois Tool Works Inc. | Fastener assembly with axial play |
TW270116B (zh) * | 1991-04-25 | 1996-02-11 | Hoffmann La Roche | |
RU2086544C1 (ru) * | 1991-06-13 | 1997-08-10 | Хоффманн-Ля Рош АГ | Бензолсульфонамидные производные пиримидина или их соли, фармацевтическая композиция для лечения заболеваний, связанных с активностью эндотелина |
US5305312A (en) * | 1992-02-07 | 1994-04-19 | At&T Bell Laboratories | Apparatus for interfacing analog telephones and digital data terminals to an ISDN line |
TW224462B (zh) * | 1992-02-24 | 1994-06-01 | Squibb & Sons Inc |
-
1993
- 1993-04-20 NZ NZ247440A patent/NZ247440A/en unknown
- 1993-04-21 IL IL10548193A patent/IL105481A/en not_active IP Right Cessation
- 1993-04-26 ZA ZA932914A patent/ZA932914B/xx unknown
- 1993-04-28 JP JP10235493A patent/JP3286391B2/ja not_active Expired - Fee Related
- 1993-04-29 AT AT93303373T patent/ATE149155T1/de not_active IP Right Cessation
- 1993-04-29 EP EP93303373A patent/EP0569193B1/en not_active Expired - Lifetime
- 1993-04-29 ES ES93303373T patent/ES2100459T3/es not_active Expired - Lifetime
- 1993-04-29 DK DK93303373.0T patent/DK0569193T3/da active
- 1993-04-29 CA CA002095174A patent/CA2095174A1/en not_active Abandoned
- 1993-04-29 DE DE69308229T patent/DE69308229T2/de not_active Expired - Fee Related
- 1993-05-04 MX MX9302618A patent/MX9302618A/es not_active IP Right Cessation
- 1993-05-04 KR KR1019930007628A patent/KR100277454B1/ko not_active IP Right Cessation
- 1993-05-05 HU HU9301305A patent/HU218938B/hu not_active IP Right Cessation
- 1993-05-05 AU AU38382/93A patent/AU659545B2/en not_active Ceased
- 1993-05-05 PL PL93298828A patent/PL178165B1/pl unknown
- 1993-05-05 RU RU93004992A patent/RU2133742C1/ru not_active IP Right Cessation
- 1993-05-05 NO NO931638A patent/NO303065B1/no not_active IP Right Cessation
- 1993-05-06 CN CN93107073A patent/CN1066441C/zh not_active Expired - Fee Related
- 1993-05-06 FI FI932052A patent/FI112655B/fi not_active IP Right Cessation
-
1997
- 1997-05-15 GR GR970401070T patent/GR3023421T3/el unknown
- 1997-06-26 HK HK98197A patent/HK98197A/xx not_active IP Right Cessation
-
1998
- 1998-02-20 CY CY201698A patent/CY2016A/xx unknown
Also Published As
Publication number | Publication date |
---|---|
CA2095174A1 (en) | 1993-11-07 |
HU218938B (hu) | 2001-01-29 |
NO931638L (no) | 1993-11-08 |
IL105481A (en) | 1996-12-05 |
PL178165B1 (pl) | 2000-03-31 |
ATE149155T1 (de) | 1997-03-15 |
DK0569193T3 (zh) | 1997-03-17 |
EP0569193B1 (en) | 1997-02-26 |
FI932052A0 (fi) | 1993-05-06 |
GR3023421T3 (en) | 1997-08-29 |
CN1084515A (zh) | 1994-03-30 |
JPH0649046A (ja) | 1994-02-22 |
JP3286391B2 (ja) | 2002-05-27 |
NO303065B1 (no) | 1998-05-25 |
MX9302618A (es) | 1994-05-31 |
KR100277454B1 (ko) | 2001-01-15 |
HK98197A (en) | 1997-08-08 |
HU9301305D0 (en) | 1993-09-28 |
DE69308229D1 (de) | 1997-04-03 |
IL105481A0 (en) | 1993-08-18 |
KR930023337A (ko) | 1993-12-18 |
EP0569193A1 (en) | 1993-11-10 |
DE69308229T2 (de) | 1997-07-17 |
AU659545B2 (en) | 1995-05-18 |
CY2016A (en) | 1998-02-20 |
PL298828A1 (en) | 1993-12-27 |
HUT65751A (en) | 1994-07-28 |
NZ247440A (en) | 1995-04-27 |
ZA932914B (en) | 1993-11-12 |
FI932052A (fi) | 1993-11-07 |
CN1066441C (zh) | 2001-05-30 |
ES2100459T3 (es) | 1997-06-16 |
NO931638D0 (no) | 1993-05-05 |
AU3838293A (en) | 1993-11-11 |
RU2133742C1 (ru) | 1999-07-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
FI112655B (fi) | Menetelmä uusien terapeuttisesti käyttökelpoisten fenyylisulfonamidijohdannaisten valmistamiseksi | |
US6107320A (en) | Phenyl sulfonamide endothelin antagonists | |
JP3273818B2 (ja) | スルホンアミドエンドセリンアンタゴニスト | |
NZ272812A (en) | N-oxazolyl azolyl(alkyl)biphenylsulphonamide derivatives; pharmaceutical compositions | |
IL110743A (en) | Heterocyclic compounds and pharmaceutical preparations containing them | |
JPH09124620A (ja) | 置換ビフェニルスルホンアミドエンドセリン拮抗剤 | |
KR20010083092A (ko) | 이중 안지오텐신 엔도텔린 수용체 길항제로서의 비페닐술폰아미드 | |
US6673824B1 (en) | Phenyl sulfonamide endothelin antagonists | |
AU717230B2 (en) | Methods for the preparation of biphenyl isoxazole sulfonamides | |
US5856507A (en) | Methods for the preparation of biphenyl isoxazole sulfonamides | |
US6639082B2 (en) | Methods for the preparation of biphenyl isoxazole sulfonamides | |
CA2367916A1 (en) | Methods for the preparation of biphenyl isoxazole sulfonamides | |
CA2239209A1 (en) | Methods for the preparation of biphenyl isoxazole sulfonamides |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
MA | Patent expired |