FI110263B - Menetelmä uusien terapeuttisesti käyttökelpoisten 6-[amino]oktahydro-5-okso-tiatsolo- tai oksatsolo[3,2-a]-atsepiini-, [1,4]tiatsepiini- tai [1,4]oksatsepiini-3-karboksyylihappojohdannaisten valmistamiseksi - Google Patents

Menetelmä uusien terapeuttisesti käyttökelpoisten 6-[amino]oktahydro-5-okso-tiatsolo- tai oksatsolo[3,2-a]-atsepiini-, [1,4]tiatsepiini- tai [1,4]oksatsepiini-3-karboksyylihappojohdannaisten valmistamiseksi Download PDF

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Publication number
FI110263B
FI110263B FI952014A FI952014A FI110263B FI 110263 B FI110263 B FI 110263B FI 952014 A FI952014 A FI 952014A FI 952014 A FI952014 A FI 952014A FI 110263 B FI110263 B FI 110263B
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FI
Finland
Prior art keywords
oxo
octahydro
amino
carboxylic acid
phenylpropyl
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FI952014A
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English (en)
Finnish (fi)
Swedish (sv)
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FI952014A0 (fi
FI952014A (fi
Inventor
Gary Alan Flynn
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Merrell Dow Pharma
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Publication of FI952014A publication Critical patent/FI952014A/fi
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Transplantation (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
FI952014A 1992-10-30 1995-04-27 Menetelmä uusien terapeuttisesti käyttökelpoisten 6-[amino]oktahydro-5-okso-tiatsolo- tai oksatsolo[3,2-a]-atsepiini-, [1,4]tiatsepiini- tai [1,4]oksatsepiini-3-karboksyylihappojohdannaisten valmistamiseksi FI110263B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US96877092A 1992-10-30 1992-10-30
US96877092 1992-10-30
PCT/US1993/009001 WO1994010193A1 (en) 1992-10-30 1993-09-23 Novel mercaptoacetylamide bicyclic lactam derivatives useful as inhibitors of enkephalinase and ace
US9309001 1993-09-23

Publications (3)

Publication Number Publication Date
FI952014A0 FI952014A0 (fi) 1995-04-27
FI952014A FI952014A (fi) 1995-04-27
FI110263B true FI110263B (fi) 2002-12-31

Family

ID=25514751

Family Applications (1)

Application Number Title Priority Date Filing Date
FI952014A FI110263B (fi) 1992-10-30 1995-04-27 Menetelmä uusien terapeuttisesti käyttökelpoisten 6-[amino]oktahydro-5-okso-tiatsolo- tai oksatsolo[3,2-a]-atsepiini-, [1,4]tiatsepiini- tai [1,4]oksatsepiini-3-karboksyylihappojohdannaisten valmistamiseksi

Country Status (21)

Country Link
US (1) US5635502A (el)
EP (1) EP0669936B1 (el)
JP (1) JP3420766B2 (el)
KR (1) KR100311166B1 (el)
AT (1) ATE197714T1 (el)
AU (1) AU673857B2 (el)
CA (1) CA2146238C (el)
DE (1) DE69329701T2 (el)
DK (1) DK0669936T3 (el)
ES (1) ES2155852T3 (el)
FI (1) FI110263B (el)
GR (1) GR3035416T3 (el)
HU (1) HUT71243A (el)
IL (1) IL107413A (el)
MX (1) MX9306758A (el)
NO (1) NO951646L (el)
NZ (1) NZ256589A (el)
PT (1) PT669936E (el)
TW (1) TW327172B (el)
WO (1) WO1994010193A1 (el)
ZA (1) ZA937912B (el)

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US5552397A (en) * 1992-05-18 1996-09-03 E. R. Squibb & Sons, Inc. Substituted azepinone dual inhibitors of angiotensin converting enzyme and neutral exdopeptidase
US5504080A (en) * 1992-10-28 1996-04-02 Bristol-Myers Squibb Co. Benzo-fused lactams
US5654294A (en) * 1993-05-13 1997-08-05 Bristol-Myers Squibb Spiro lactam dual action inhibitors
WO1994028901A1 (fr) * 1993-06-11 1994-12-22 Eisai Co., Ltd. Derive aminoacide
US5508272A (en) * 1993-06-15 1996-04-16 Bristol-Myers Squibb Company Compounds containing a fused bicycle ring and processes therefor
US5525723A (en) * 1993-11-18 1996-06-11 Bristol-Myers Squibb Co. Compounds containing a fused multiple ring lactam
PT750631E (pt) * 1994-02-14 2000-07-31 Merrell Pharma Inc Novos derivados de dissulfureto de mercapto-aacetilamido-1,3,4,5-tetra-hidro-benzo¬c)azepin-3-ona uteis como inibidores de encefalinase e ace
AU689192B2 (en) * 1994-02-14 1998-03-26 Merrell Pharmaceuticals Inc. Novel 2-substituted indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and ace
CA2183313C (en) * 1994-02-14 2001-01-02 Gary A. Flynn Novel indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase
WO1996002549A1 (fr) * 1994-07-18 1996-02-01 Eisai Co., Ltd. DERIVE DE THIAZOLO[3,2-α]AZEPINE A SUBSTITUTION
US5587375A (en) * 1995-02-17 1996-12-24 Bristol-Myers Squibb Company Azepinone compounds useful in the inhibition of ACE and NEP
US6245764B1 (en) 1995-03-24 2001-06-12 Molecumetics Ltd. β-sheet mimetics and use thereof as inhibitors of biologically active peptides or proteins
US6020331A (en) * 1995-03-24 2000-02-01 Molecumetics, Ltd. β-sheet mimetics and use thereof as protease inhibitors
US6699869B1 (en) 1995-03-24 2004-03-02 Myriad Genetics Inc. β-sheet mimetics and use thereof as inhibitors of biologically active peptides or proteins
US5877313A (en) 1995-05-17 1999-03-02 Bristol-Myers Squibb Benzo-fused azepinone and piperidinone compounds useful in the inhibition of ACE and NEP
US5650408A (en) * 1995-06-07 1997-07-22 Karanewsky; Donald S. Thiazolo benzazepine containing dual action inhibitors
US5635504A (en) * 1995-06-07 1997-06-03 Bristol-Myers Squibb Co. Diazepine containing dual action inhibitors
JP4588877B2 (ja) 1998-06-17 2010-12-01 ブリストル−マイヤーズ スクイブ カンパニー Ａｄｐ−受容体抗血小板物質と抗高血圧薬の組合せ投与による脳梗塞の予防
CA2368026A1 (en) * 1999-03-22 2000-09-28 Bi-Huang Hu Oxazole and thiazole combinatorial libraries
US7015212B1 (en) 1999-05-12 2006-03-21 The United States Of America As Represented By The Department Of Health And Human Services Thiazepine inhibitors of HIV-1 integrase
WO2003068237A1 (en) 2002-02-14 2003-08-21 Myriad Genetics, Inc. Beta-sheet mimetics and composition and methods relating thereto
FR2984716B1 (fr) 2011-12-22 2013-12-27 Essilor Int Dispositif et procede de determination d'au moins un parametre de refraction oculaire objective d'un sujet en fonction d'une pluralite de directions de regard
EP2925764B1 (en) 2012-11-30 2023-03-01 Sanford-Burnham Medical Research Institute Inhibitor of apoptosis protein (iap) antagonists
US10300074B2 (en) 2014-06-04 2019-05-28 Sanford Burnham Prebys Medical Discovery Institute Use of inhibitor of apoptosis protein (IAP) antagonists in HIV therapy
US10513515B2 (en) 2017-08-25 2019-12-24 Biotheryx, Inc. Ether compounds and uses thereof
WO2020023782A1 (en) 2018-07-27 2020-01-30 Biotheryx, Inc. Bifunctional compounds as cdk modulators
WO2021222150A2 (en) 2020-04-28 2021-11-04 Anwita Biosciences, Inc. Interleukin-2 polypeptides and fusion proteins thereof, and their pharmaceutical compositions and therapeutic applications

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Also Published As

Publication number Publication date
DE69329701T2 (de) 2001-05-10
PT669936E (pt) 2001-04-30
NO951646L (no) 1995-06-23
IL107413A (en) 1999-08-17
DE69329701D1 (de) 2000-12-28
FI952014A0 (fi) 1995-04-27
EP0669936B1 (en) 2000-11-22
EP0669936A1 (en) 1995-09-06
JPH08502746A (ja) 1996-03-26
HU9501239D0 (en) 1995-06-28
NZ256589A (en) 1996-05-28
KR950704349A (ko) 1995-11-20
KR100311166B1 (ko) 2002-02-28
GR3035416T3 (en) 2001-05-31
ZA937912B (en) 1994-06-01
CA2146238C (en) 2001-03-13
HUT71243A (en) 1995-11-28
US5635502A (en) 1997-06-03
FI952014A (fi) 1995-04-27
CA2146238A1 (en) 1994-05-11
MX9306758A (es) 1994-07-29
IL107413A0 (en) 1994-01-25
AU673857B2 (en) 1996-11-28
TW327172B (en) 1998-02-21
JP3420766B2 (ja) 2003-06-30
ATE197714T1 (de) 2000-12-15
DK0669936T3 (da) 2001-02-05
NO951646D0 (no) 1995-04-28
AU5136293A (en) 1994-05-24
WO1994010193A1 (en) 1994-05-11
ES2155852T3 (es) 2001-06-01

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