FI110234B - Förfarande för framställning av en sammansättning för att åstadkomma ett immunsvar till en antigen - Google Patents
Förfarande för framställning av en sammansättning för att åstadkomma ett immunsvar till en antigen Download PDFInfo
- Publication number
- FI110234B FI110234B FI934013A FI934013A FI110234B FI 110234 B FI110234 B FI 110234B FI 934013 A FI934013 A FI 934013A FI 934013 A FI934013 A FI 934013A FI 110234 B FI110234 B FI 110234B
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- Finland
- Prior art keywords
- antigen
- physiochemical
- cells
- protein
- forms
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Links
- 102000036639 antigens Human genes 0.000 title claims abstract description 106
- 108091007433 antigens Proteins 0.000 title claims abstract description 106
- 239000000427 antigen Substances 0.000 title claims abstract description 105
- 230000028993 immune response Effects 0.000 title claims abstract description 31
- 239000000203 mixture Substances 0.000 title claims abstract description 13
- 238000000034 method Methods 0.000 title claims description 20
- 241001465754 Metazoa Species 0.000 claims abstract description 23
- 230000003612 virological effect Effects 0.000 claims abstract description 7
- 241000712461 unidentified influenza virus Species 0.000 claims abstract description 5
- 210000003719 b-lymphocyte Anatomy 0.000 claims description 22
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 20
- 241000700605 Viruses Species 0.000 claims description 16
- 108090000623 proteins and genes Proteins 0.000 claims description 15
- 102000004169 proteins and genes Human genes 0.000 claims description 13
- 210000004027 cell Anatomy 0.000 claims description 12
- 241000725303 Human immunodeficiency virus Species 0.000 claims description 7
- 229960005486 vaccine Drugs 0.000 claims description 6
- 230000002209 hydrophobic effect Effects 0.000 claims description 5
- 108700006640 OspA Proteins 0.000 claims description 3
- 230000001580 bacterial effect Effects 0.000 claims description 2
- 230000002538 fungal effect Effects 0.000 claims description 2
- 229940099789 ospa protein Drugs 0.000 claims description 2
- 230000003071 parasitic effect Effects 0.000 claims description 2
- 230000002163 immunogen Effects 0.000 abstract description 16
- 239000000126 substance Substances 0.000 abstract description 4
- 238000011260 co-administration Methods 0.000 description 19
- 230000004044 response Effects 0.000 description 11
- 101710105714 Outer surface protein A Proteins 0.000 description 9
- 241000700198 Cavia Species 0.000 description 8
- 241000699670 Mus sp. Species 0.000 description 6
- 230000005875 antibody response Effects 0.000 description 6
- 230000003993 interaction Effects 0.000 description 6
- 230000030741 antigen processing and presentation Effects 0.000 description 5
- 230000006870 function Effects 0.000 description 5
- 210000002443 helper t lymphocyte Anatomy 0.000 description 5
- 238000002474 experimental method Methods 0.000 description 4
- 230000006872 improvement Effects 0.000 description 4
- 210000002540 macrophage Anatomy 0.000 description 4
- 230000001681 protective effect Effects 0.000 description 4
- 241000700199 Cavia porcellus Species 0.000 description 3
- 241000282412 Homo Species 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 230000003053 immunization Effects 0.000 description 3
- 238000002649 immunization Methods 0.000 description 3
- 206010022000 influenza Diseases 0.000 description 3
- 238000002255 vaccination Methods 0.000 description 3
- 210000002845 virion Anatomy 0.000 description 3
- 238000002965 ELISA Methods 0.000 description 2
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 2
- 241000589970 Spirochaetales Species 0.000 description 2
- 230000006044 T cell activation Effects 0.000 description 2
- 101800000385 Transmembrane protein Proteins 0.000 description 2
- 108010067390 Viral Proteins Proteins 0.000 description 2
- 230000004913 activation Effects 0.000 description 2
- 230000001919 adrenal effect Effects 0.000 description 2
- 206010013023 diphtheria Diseases 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 230000006698 induction Effects 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 230000003389 potentiating effect Effects 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 230000016173 B cell antigen processing and presentation Effects 0.000 description 1
- 102000019260 B-Cell Antigen Receptors Human genes 0.000 description 1
- 108010012919 B-Cell Antigen Receptors Proteins 0.000 description 1
- 108010077805 Bacterial Proteins Proteins 0.000 description 1
- 241000606768 Haemophilus influenzae Species 0.000 description 1
- 108090001030 Lipoproteins Proteins 0.000 description 1
- 102000004895 Lipoproteins Human genes 0.000 description 1
- 230000006052 T cell proliferation Effects 0.000 description 1
- 230000004520 agglutination Effects 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 210000000612 antigen-presenting cell Anatomy 0.000 description 1
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- 230000008901 benefit Effects 0.000 description 1
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- 230000024245 cell differentiation Effects 0.000 description 1
- 230000008614 cellular interaction Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 231100000481 chemical toxicant Toxicity 0.000 description 1
- 210000004443 dendritic cell Anatomy 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 229940045808 haemophilus influenzae type b Drugs 0.000 description 1
- 230000028996 humoral immune response Effects 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 238000003018 immunoassay Methods 0.000 description 1
- 230000005847 immunogenicity Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 239000004816 latex Substances 0.000 description 1
- 229920000126 latex Polymers 0.000 description 1
- 125000003473 lipid group Chemical group 0.000 description 1
- 210000004698 lymphocyte Anatomy 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 230000001177 retroviral effect Effects 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 230000009870 specific binding Effects 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/0225—Spirochetes, e.g. Treponema, Leptospira, Borrelia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5252—Virus inactivated (killed)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55588—Adjuvants of undefined constitution
- A61K2039/55594—Adjuvants of undefined constitution from bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6018—Lipids, e.g. in lipopeptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Virology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Radar Systems Or Details Thereof (AREA)
- Jib Cranes (AREA)
- Medicines Containing Plant Substances (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Claims (9)
1. Förfarande for framställning av en sammansättning för att ästadkomma ett immunsvar tili en antigen i ett djur, k ä n n e t e c k n a t därav, att en samman-5 sättningen formuleras med en fysiologista acceptabel bärare i ett vaccin och första fysiokemisk form av nämnda antigen favoriserar presentation av antigenen med B-celler tili T-celler i djuret, och en andra fysiokemisk form av nämnda antigen befrämjar presentationen av antigenet med tilläggsceller tili T-celler i djuret. 10
2. Förfarande enligt patentkrav 1, kännetecknat därav, att nämnda första fysiokemiska form är en löslig form av nämnda antigen och nämnda andra fysio-| kemiska form är en olöslig form av nämnda antigen.
3. Förfarande enligt patentkrav 1 eller 2, kännetecknat därav, att den ena j 15 fysiokemiska fbrmen av antigenen är lipidiserad och den andra fysiokemiska formen är icke-lipidiserad. . V
4. Förfarande enligt patentkrav 1 eller 2, kännetecknat därav, att den ena ’ ' fysiokemiska formen av antigenen är ett protein med ett hydrofobiskt omräde och ’ · · · * 20 den andra är ett protein som saknar hydrofobiskt omräde.
• * · ; 5. Förfarande enligt patentkrav 1 eller 2, kännetecknat därav, att den ena • t ’ fysiokemiska formen av antigenen är ett protein som behandlats att innehälla en . . specifik epitop och/eller ett omräde och den andra är ett protein som saknar en 25 sadan specifik epitop och/eller omräde.
’;;;‘ 6. Förfarande enligt nägot av patentkraven 1-5, kännetecknat därav, att '; ‘ den ena fysiokemiska formen av antigenen är löslig och att den andra är olöslig '.:. ’ och/eller partikelformig. :.'·ί 30
7. Förfarande enligt nägot av patentkraven 1-6, kännetecknat därav, att 110234 nämnda antigen är ett virus, ett bakterie-, ett svamp-, ett protozan- eller ett para-sitprotein.
8. Förfarande enligt patentkrav 7, kännetecknat därav, att nämnda antigen 5 är HA-antigenen frän influenza-virus, gpl20-proteinet frän HIV-virus eller OspA-proteinet.
9. Förfarande enligt patentkrav 8, kännetecknat därav, att nämnda antigen är HA och de olika fysiokemiska formema av antigenen innefattar inaktiverat 10 helvirus och HA(p) eller antigenen är OspA och de olika fysiokemiska formema av nämnda antigen innefattar OspA-L och OspA-NL av R burgdorferi. • 1 • » ♦ · ♦ • · · • · · • i « · • 1 · • · ♦ • ♦ · • · · * · · • · • · · * ♦ ♦ » » * · ·
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US94317392A | 1992-09-14 | 1992-09-14 | |
| US94317392 | 1992-09-14 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI934013A0 FI934013A0 (fi) | 1993-09-14 |
| FI934013A FI934013A (fi) | 1994-03-15 |
| FI110234B true FI110234B (sv) | 2002-12-31 |
Family
ID=25479200
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI934013A FI110234B (sv) | 1992-09-14 | 1993-09-14 | Förfarande för framställning av en sammansättning för att åstadkomma ett immunsvar till en antigen |
Country Status (15)
| Country | Link |
|---|---|
| US (4) | US5662909A (sv) |
| EP (1) | EP0588578B2 (sv) |
| JP (1) | JP2512689B2 (sv) |
| AT (1) | ATE187338T1 (sv) |
| AU (1) | AU677592B2 (sv) |
| CA (1) | CA2105629A1 (sv) |
| DE (1) | DE69327214T3 (sv) |
| DK (1) | DK0588578T4 (sv) |
| ES (1) | ES2141750T5 (sv) |
| FI (1) | FI110234B (sv) |
| GR (1) | GR3032543T3 (sv) |
| IL (2) | IL106968A (sv) |
| NO (1) | NO313178B1 (sv) |
| PT (1) | PT588578E (sv) |
| ZA (1) | ZA936629B (sv) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6967088B1 (en) * | 1995-03-16 | 2005-11-22 | Allergan, Inc. | Soluble recombinant botulinum toxin proteins |
| ZA964896B (en) * | 1995-06-07 | 1997-01-08 | Connaught Lab | Expression of lipoproteins |
| US6251405B1 (en) * | 1995-06-07 | 2001-06-26 | Connaught Laboratories, Inc. | Immunological combination compositions and methods |
| AU2487300A (en) | 1998-12-31 | 2000-07-31 | Chiron Corporation | Polynucleotides encoding antigenic hiv type c polypeptides, polypeptides and uses thereof |
| WO2000039303A2 (en) * | 1998-12-31 | 2000-07-06 | Chiron Corporation | Modified hiv env polypeptides |
| EP1141313A2 (en) * | 1998-12-31 | 2001-10-10 | Chiron Corporation | Improved expression of hiv polypeptides and production of virus-like particles |
| US7935805B1 (en) * | 1998-12-31 | 2011-05-03 | Novartis Vaccines & Diagnostics, Inc | Polynucleotides encoding antigenic HIV Type C polypeptides, polypeptides and uses thereof |
| US20050106137A1 (en) * | 2000-05-05 | 2005-05-19 | Stephen Grimes | Chimeric peptide immunogens |
| ES2406405T3 (es) * | 2000-12-27 | 2013-06-06 | Gilead Sciences, Inc. | Aztreonam inhalable sin arginina para tratamiento y prevención de infecciones bacterianas pulmonares |
| AU2002320314A1 (en) * | 2001-07-05 | 2003-01-21 | Chiron, Corporation | Polynucleotides encoding antigenic hiv type c polypeptides, polypeptides and uses thereof |
| EP2292772A1 (en) * | 2001-07-05 | 2011-03-09 | Novartis Vaccines and Diagnostics, Inc. | HIV vaccination with a DNA encoding a HIV polypeptide and a HIV polypeptide |
| WO2003020876A2 (en) * | 2001-08-31 | 2003-03-13 | Chiron Corporation | Polynucleotides encoding antigenic hiv type b polypeptides, polypeptides and uses thereof |
| US20030170614A1 (en) * | 2001-08-31 | 2003-09-11 | Megede Jan Zur | Polynucleotides encoding antigenic HIV type B polypeptides, polypeptides and uses thereof |
| US7425331B2 (en) * | 2002-04-10 | 2008-09-16 | Protalex, Inc. | Protein A methods of use |
| US7211258B2 (en) * | 2002-04-10 | 2007-05-01 | Protalex, Inc. | Protein A compositions and methods of use |
| US6814729B2 (en) | 2002-06-27 | 2004-11-09 | Technovision Gmbh | Laser vision correction apparatus and control method |
| EP2550362B1 (en) | 2010-03-25 | 2017-01-04 | Oregon Health&Science University | Cmv glycoproteins and recombinant vectors |
| PT2691530T (pt) | 2011-06-10 | 2018-05-10 | Univ Oregon Health & Science | Glicoproteínas e vectores recombinantes cmv |
| US20130189754A1 (en) | 2011-09-12 | 2013-07-25 | International Aids Vaccine Initiative | Immunoselection of recombinant vesicular stomatitis virus expressing hiv-1 proteins by broadly neutralizing antibodies |
| US9402894B2 (en) | 2011-10-27 | 2016-08-02 | International Aids Vaccine Initiative | Viral particles derived from an enveloped virus |
| ES2631608T3 (es) | 2012-06-27 | 2017-09-01 | International Aids Vaccine Initiative | Variante de la glicoproteína Env del VIH-1 |
| US20150065381A1 (en) | 2013-09-05 | 2015-03-05 | International Aids Vaccine Initiative | Methods of identifying novel hiv-1 immunogens |
| EP2873423B1 (en) | 2013-10-07 | 2017-05-31 | International Aids Vaccine Initiative | Soluble hiv-1 envelope glycoprotein trimers |
| EP3069730A3 (en) | 2015-03-20 | 2017-03-15 | International Aids Vaccine Initiative | Soluble hiv-1 envelope glycoprotein trimers |
| EP3072901A1 (en) | 2015-03-23 | 2016-09-28 | International Aids Vaccine Initiative | Soluble hiv-1 envelope glycoprotein trimers |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4496538A (en) * | 1982-07-06 | 1985-01-29 | Connaught Laboratories, Inc. | Haemophilus influenzae b polysaccharide-diphtheria toxoid conjugate vaccine |
| US4619828A (en) * | 1982-07-06 | 1986-10-28 | Connaught Laboratories, Inc. | Polysaccharide exotoxoid conjugate vaccines |
| GB8610983D0 (en) * | 1986-05-06 | 1986-06-11 | Connaught Lab | Enhancement of antigen immunogenicity |
| US4946676A (en) * | 1986-08-27 | 1990-08-07 | De Staat Der Nederlanden | Vaccine comprising an immunogenic protein and, as an adjuvant, a substantially non-immunogenic, sequentially homologous peptide |
| EP0270295A3 (en) * | 1986-12-03 | 1989-08-02 | Connaught Laboratories Limited | Conjugate vaccine |
| DK425789A (da) * | 1988-08-31 | 1990-03-01 | Smithkline Beecham Corp | Vaccinale polypeptider |
| JPH0678245B2 (ja) * | 1989-07-04 | 1994-10-05 | 東興薬品工業株式会社 | 鼻腔内噴霧投与用インフルエンザワクチンゲル製剤 |
| WO1992000055A1 (en) * | 1990-06-15 | 1992-01-09 | Yale University | Compositions and methods for the prevention and diagnosis of lyme disease |
| JPH06511154A (ja) * | 1991-10-18 | 1994-12-15 | コノート ラボラトリーズ インコーポレイテッド | 組換えＢｏｒｒｅｌｉａタンパクの製造法 |
-
1993
- 1993-09-07 CA CA002105629A patent/CA2105629A1/en not_active Abandoned
- 1993-09-08 ZA ZA936629A patent/ZA936629B/xx unknown
- 1993-09-08 AU AU46226/93A patent/AU677592B2/en not_active Ceased
- 1993-09-10 IL IL10696893A patent/IL106968A/en not_active IP Right Cessation
- 1993-09-13 ES ES93307185T patent/ES2141750T5/es not_active Expired - Lifetime
- 1993-09-13 DK DK93307185T patent/DK0588578T4/da active
- 1993-09-13 PT PT93307185T patent/PT588578E/pt unknown
- 1993-09-13 AT AT93307185T patent/ATE187338T1/de not_active IP Right Cessation
- 1993-09-13 DE DE69327214T patent/DE69327214T3/de not_active Expired - Fee Related
- 1993-09-13 NO NO19933261A patent/NO313178B1/no unknown
- 1993-09-13 EP EP93307185A patent/EP0588578B2/en not_active Expired - Lifetime
- 1993-09-14 JP JP5229041A patent/JP2512689B2/ja not_active Expired - Lifetime
- 1993-09-14 FI FI934013A patent/FI110234B/sv not_active IP Right Cessation
-
1995
- 1995-02-08 US US08/385,587 patent/US5662909A/en not_active Expired - Fee Related
- 1995-06-06 US US08/470,278 patent/US5837264A/en not_active Expired - Lifetime
-
1997
- 1997-02-18 US US08/801,152 patent/US5853736A/en not_active Expired - Fee Related
-
1998
- 1998-11-17 US US09/193,682 patent/US6024963A/en not_active Expired - Lifetime
-
1999
- 1999-05-23 IL IL13007599A patent/IL130075A0/xx unknown
-
2000
- 2000-02-02 GR GR20000400239T patent/GR3032543T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2141750T5 (es) | 2005-12-01 |
| DE69327214T3 (de) | 2005-12-01 |
| EP0588578A1 (en) | 1994-03-23 |
| NO313178B1 (no) | 2002-08-26 |
| FI934013A0 (fi) | 1993-09-14 |
| CA2105629A1 (en) | 1994-03-15 |
| JPH06192125A (ja) | 1994-07-12 |
| US5662909A (en) | 1997-09-02 |
| GR3032543T3 (en) | 2000-05-31 |
| EP0588578B2 (en) | 2005-04-13 |
| IL106968A0 (en) | 1993-12-28 |
| NO933261L (no) | 1994-03-15 |
| DK0588578T3 (da) | 2000-03-27 |
| IL106968A (en) | 1999-10-28 |
| EP0588578B1 (en) | 1999-12-08 |
| DE69327214T2 (de) | 2000-09-07 |
| JP2512689B2 (ja) | 1996-07-03 |
| DE69327214D1 (de) | 2000-01-13 |
| ES2141750T3 (es) | 2000-04-01 |
| US6024963A (en) | 2000-02-15 |
| ATE187338T1 (de) | 1999-12-15 |
| AU4622693A (en) | 1994-03-24 |
| IL130075A0 (en) | 2000-02-29 |
| AU677592B2 (en) | 1997-05-01 |
| ZA936629B (en) | 1994-03-30 |
| DK0588578T4 (da) | 2005-07-25 |
| NO933261D0 (no) | 1993-09-13 |
| PT588578E (pt) | 2000-05-31 |
| US5853736A (en) | 1998-12-29 |
| FI934013A (fi) | 1994-03-15 |
| US5837264A (en) | 1998-11-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GB | Transfer or assigment of application |
Owner name: PHARMACIA & UPJOHN AKTIEBOLAG |
|
| HC | Name/ company changed in application |
Owner name: PHARMACIA & UPJOHN AKTIEBOLAG |
|
| MA | Patent expired |