FI110096B - Menetelmä terapeuttisesti käyttökelpoisen kiteisen Tiagabine-hydrokloridimonohydraatin valmistamiseksi - Google Patents

Menetelmä terapeuttisesti käyttökelpoisen kiteisen Tiagabine-hydrokloridimonohydraatin valmistamiseksi Download PDF

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Publication number
FI110096B
FI110096B FI934298A FI934298A FI110096B FI 110096 B FI110096 B FI 110096B FI 934298 A FI934298 A FI 934298A FI 934298 A FI934298 A FI 934298A FI 110096 B FI110096 B FI 110096B
Authority
FI
Finland
Prior art keywords
enyl
methylthien
nipecotinic
monohydrate
acid
Prior art date
Application number
FI934298A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI934298A (fi
FI934298A0 (fi
Inventor
Henning Petersen
Peter Nielsen
Michael Cain
R Subhash Patel
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Publication of FI934298A publication Critical patent/FI934298A/fi
Publication of FI934298A0 publication Critical patent/FI934298A0/fi
Application granted granted Critical
Publication of FI110096B publication Critical patent/FI110096B/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Mechanical Treatment Of Semiconductor (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Transceivers (AREA)
  • Mobile Radio Communication Systems (AREA)
FI934298A 1991-04-02 1993-09-30 Menetelmä terapeuttisesti käyttökelpoisen kiteisen Tiagabine-hydrokloridimonohydraatin valmistamiseksi FI110096B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DK58291 1991-04-02
DK91582A DK58291D0 (da) 1991-04-02 1991-04-02 Krystalinsk stof og dets fremstilling
DK9200093 1992-03-23
PCT/DK1992/000093 WO1992017473A1 (en) 1991-04-02 1992-03-23 Crystalline tiagabine hydrochloride monohydrate, its preparation and use

Publications (3)

Publication Number Publication Date
FI934298A FI934298A (fi) 1993-09-30
FI934298A0 FI934298A0 (fi) 1993-09-30
FI110096B true FI110096B (fi) 2002-11-29

Family

ID=8095193

Family Applications (1)

Application Number Title Priority Date Filing Date
FI934298A FI110096B (fi) 1991-04-02 1993-09-30 Menetelmä terapeuttisesti käyttökelpoisen kiteisen Tiagabine-hydrokloridimonohydraatin valmistamiseksi

Country Status (15)

Country Link
US (1) US5354760A (de)
EP (1) EP0579681B1 (de)
AT (1) ATE180781T1 (de)
AU (1) AU661483B2 (de)
CA (1) CA2107223C (de)
DE (1) DE69229339T2 (de)
DK (2) DK58291D0 (de)
ES (1) ES2134801T3 (de)
FI (1) FI110096B (de)
GR (1) GR3030919T3 (de)
IL (1) IL101358A (de)
NO (1) NO304113B1 (de)
NZ (1) NZ242191A (de)
WO (1) WO1992017473A1 (de)
ZA (1) ZA922297B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5750140A (en) * 1994-05-20 1998-05-12 Novo Nordisk A/S Transdermal delivery of tiagabine
JP3195360B2 (ja) * 1995-05-05 2001-08-06 ノボ ノルディスク アクティーゼルスカブ チアガビン塩酸塩を含有する医薬組成物およびその製法
AU736514B2 (en) * 1995-07-13 2001-07-26 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Non-allosteric gabaa agonists for treating sleep disorders
DE19525598C2 (de) * 1995-07-13 1997-09-25 Max Planck Gesellschaft Schlafmittel
UA52661C2 (uk) * 1996-06-14 2003-01-15 Ново Нордіск А/С Безводна кристалічна форма гідрохлориду r(-)-n-(4,4-ди(3-метилтієн-2-іл)бут-3-еніл) ніпекотинової кислоти
US5914333A (en) * 1996-07-31 1999-06-22 Novo Nordisk A/S Treatment of psychotic disorders
IE970588A1 (en) 1997-08-01 2000-08-23 Elan Corp Plc Controlled release pharmaceutical compositions containing tiagabine
FR2771292B1 (fr) * 1997-11-21 2000-02-18 Ethypharm Lab Prod Ethiques Spheroides contenant de la tiagabine, procede de preparation et compositions pharmaceutiques
US6562974B2 (en) 2000-02-01 2003-05-13 The Procter & Gamble Company Process for making geminal bisphosphonates
US6410520B2 (en) 2000-02-01 2002-06-25 The Procter & Gamble Company Selective crystallization of 3-pyridyl-1-hydroxyethylidene-1, 1-bisphosphonic acid sodium as the hemipentahydrate or monohydrate
EP2266590A3 (de) 2002-02-22 2011-04-20 Shire LLC Wirkstoff-Abgabesystem und Verfahren zum Schutz und zur Verabreichung von Wirkstoffen
CN1314684C (zh) * 2003-12-24 2007-05-09 中国科学院上海有机化学研究所 噻加宾及其消旋体和s－构型的合成方法及其无定形粉末的制法
US7667042B2 (en) * 2003-12-24 2010-02-23 Sun Pharma Advanced Research Company Ltd. Stable polymorphic forms of an anticonvulsant
WO2005092886A1 (en) * 2004-03-29 2005-10-06 Ranbaxy Laboratories Limited Process for the preparation of amorphous form of tiagabine
WO2006013550A2 (en) * 2004-08-04 2006-02-09 Ranbaxy Laboratories Limited Process for preparation of piperidine carboxylic acid
US20060105038A1 (en) * 2004-11-12 2006-05-18 Eurand Pharmaceuticals Limited Taste-masked pharmaceutical compositions prepared by coacervation
US20080064727A1 (en) * 2006-08-18 2008-03-13 Cephalon, Inc. Crystalline forms of tiagabine hydrochloride
US20080051435A1 (en) * 2006-08-18 2008-02-28 Cephalon, Inc. Crystalline and amorphous forms of tiagabine
CN101857591B (zh) * 2009-04-09 2013-06-05 北京京卫燕康药物研究所有限公司 盐酸噻加宾晶型及其制备方法
CN103554093B (zh) * 2013-11-12 2015-10-21 四川科瑞德凯华制药有限公司 噻加宾乙酯盐酸盐及其制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK288385D0 (da) * 1985-06-26 1985-06-26 Novo Industri As Aminosyrederivater
ES2058061T3 (es) * 1985-10-25 1994-11-01 Beecham Group Plc Derivado de piperidina, su preparacion y su uso como medicamento.
US4910312A (en) * 1985-11-08 1990-03-20 Warner-Lambert Company Various N-substituted 3-piperidine carboxylic acids or N-substituted 3-pyridinecarboxylic acids and derivatives thereof

Also Published As

Publication number Publication date
DK0579681T3 (da) 1999-11-15
FI934298A (fi) 1993-09-30
DE69229339D1 (de) 1999-07-08
AU1641592A (en) 1992-11-02
CA2107223C (en) 2005-02-15
NO933524L (no) 1993-10-01
ES2134801T3 (es) 1999-10-16
AU661483B2 (en) 1995-07-27
IL101358A (en) 1996-08-04
DK58291D0 (da) 1991-04-02
FI934298A0 (fi) 1993-09-30
IL101358A0 (en) 1992-11-15
ATE180781T1 (de) 1999-06-15
US5354760A (en) 1994-10-11
EP0579681A1 (de) 1994-01-26
JPH06506209A (ja) 1994-07-14
EP0579681B1 (de) 1999-06-02
NO933524D0 (no) 1993-10-01
NZ242191A (en) 1994-07-26
ZA922297B (en) 1992-12-30
DE69229339T2 (de) 1999-12-30
CA2107223A1 (en) 1992-10-03
WO1992017473A1 (en) 1992-10-15
NO304113B1 (no) 1998-10-26
GR3030919T3 (en) 1999-11-30

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