FI107698B - Fasta, ej-porösa mikrosfärer - Google Patents
Fasta, ej-porösa mikrosfärer Download PDFInfo
- Publication number
- FI107698B FI107698B FI925661A FI925661A FI107698B FI 107698 B FI107698 B FI 107698B FI 925661 A FI925661 A FI 925661A FI 925661 A FI925661 A FI 925661A FI 107698 B FI107698 B FI 107698B
- Authority
- FI
- Finland
- Prior art keywords
- microspheres
- contraceptive
- diameter
- progesterone
- estradiol
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nutrition Science (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Claims (15)
1. Fasta, ej-porösa mikrosfärer, vilkas diameter är 1 - 300 μm, kännetecknade därav, att de bildas av ätminstone ett injicerbart preventiv- 5 medel och kolesterol.
2. Mikrosfärer enligt patentkrav 1, kännetecknade därav, att mikrosfärernas diameter är 5 - 100 μπκ
3. Mikrosfärer enligt patentkrav 2, k ä n -10 netecknade därav, att mikrosf ärernas smält- punkt är over 60 °C.
4. Mikrosfärer enligt patentkrav 3, kännetecknade därav, att de ytterligare innehäl-ler fysiologiskt godtagbara tillsatsämnen.
5. Mikrosfärer enligt patentkrav 1, kän netecknade därav, att prevent ivmedlet är en steroid.
6. Mikrosfärer enligt patentkrav 1, kännetecknade därav, att preventivmedlet är pro- 20 gesteron.
7. Mikrosfärer enligt patentkrav 1, kännetecknade därav, att preventivmedlet är 17-β-estradiol.
8. Mikrosfärer enligt patentkrav 1, k ä n -25 netecknade därav, att mikrosfärerna är i form «· · • av ett pulver, vilket är klart att vid användnings-··· · .·. : ögonblicket suspenderas i en fysiologiskt godtagbar .···. flytande bärare, vilken utgörs av en vattenlösning, • · · foreträdesvis en saltlösning eller oija. . 3 0
9. Mikrosfärer enligt patentkrav 1, k ä n - [ / netecknade därav, att mikrosfärerna suspende ras i en fysiologiskt godtagbar flytande bärare, i ··· vilken mikrosfärerna är väsentligen olösliga.
···· ’.···. 10. Mikrosfärer enligt patentkrav 1, k ä n - ··· ^ 35 netecknade därav, att preparatet innehällande • · · • ·' mikrosfärer innehäller en kombination av kalibrerade • · • · · • ·· ♦ · 107698 progesteronmikrosfärer och kalibrerade 17-P~estradiol-mikrosfärer.
11. Mikrosfärer enligt patentkrav 1, k ä n -netecknade därav, att sammansättningen inne- 5 hallande mikrosfärer innehäller kalibrerade 17-β-estradiolmikrosfärer i en kolesterolstruktur.
12. Förfarande för framställning av fasta, ej-porösa mikrosiärers, vilkas diameter är 1 - 300 μτη, för förbättrande av kontrollen av ett inj icerbart äm- 10 nes, vilket utgörs av ett preventivmedel, fysiokine-tiska och fysiologiska egenskaper, känneteck-n a t därav, att mikrosfärer, vilka bildas av ätmin-stone ett injicerbart preventivmedel och kolesterol, framställs pä följande sätt: 15 a. preventivmedlet smälts i en inert atmo- sf är, b. sprutas tili ett droppmoln i den inerta atmosfären, c. kyls i kali inert atmosfär, och 20 d. separeras i fraktioner enligt storlek.
13. Förfarande enligt patentkrav 12, k ä n -netecknat därav, att separeringen av fraktio-nerna fortsätts, tills over 70 % av mikrosfärerna har • · . .·. en diameter, som är 70 - 130 % av den specificerade « · · *" 25 diametern. t i t • 1 2 · .3
14. Förfarande enligt patentkrav 12, k ä n - • · « ··· j netecknat därav, att sprutningen tili ett • · · ’· '· droppmoln görs under tryck.
• · · *.· · 15. Användning av mikrosfärerna enligt nägot 30 av patentkraven 1-7 för f ramställning av ett prepa- *:··: rat avsett för parenteral administration som en injek- ····. tion. • » · • · · • Ml • · · • · • · • · · ·· · • « · • · • · · 2 • · · • · 1 3 • ·
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9007416A FR2663223B1 (fr) | 1990-06-14 | 1990-06-14 | Forme galenique parenterale. |
| FR9007416 | 1990-06-14 | ||
| EP9101096 | 1991-06-12 | ||
| PCT/EP1991/001096 WO1991019484A1 (fr) | 1990-06-14 | 1991-06-12 | Composition pharmaceutique injectable |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI925661A FI925661A (fi) | 1992-12-11 |
| FI925661A0 FI925661A0 (fi) | 1992-12-11 |
| FI107698B true FI107698B (sv) | 2001-09-28 |
Family
ID=9397598
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI925661A FI107698B (sv) | 1990-06-14 | 1992-12-11 | Fasta, ej-porösa mikrosfärer |
Country Status (30)
| Country | Link |
|---|---|
| US (3) | US5360616A (sv) |
| EP (1) | EP0533739B1 (sv) |
| JP (1) | JP2675675B2 (sv) |
| KR (1) | KR0157439B1 (sv) |
| CN (1) | CN1057442C (sv) |
| AT (1) | ATE109658T1 (sv) |
| AU (1) | AU661275B2 (sv) |
| BG (1) | BG61179B1 (sv) |
| BR (1) | BR9106545A (sv) |
| CA (1) | CA2085344C (sv) |
| CZ (1) | CZ286793B6 (sv) |
| DE (1) | DE69103419T2 (sv) |
| DK (1) | DK0533739T3 (sv) |
| ES (1) | ES2059142T3 (sv) |
| FI (1) | FI107698B (sv) |
| FR (1) | FR2663223B1 (sv) |
| HU (1) | HUT68709A (sv) |
| IE (1) | IE62679B1 (sv) |
| IL (1) | IL98459A (sv) |
| NO (1) | NO302998B1 (sv) |
| NZ (1) | NZ238542A (sv) |
| PL (1) | PL167234B1 (sv) |
| PT (1) | PT97975B (sv) |
| RU (1) | RU2104692C1 (sv) |
| SK (1) | SK280564B6 (sv) |
| TN (1) | TNSN91048A1 (sv) |
| UA (1) | UA27043C2 (sv) |
| UY (1) | UY23240A1 (sv) |
| WO (1) | WO1991019484A1 (sv) |
| ZA (1) | ZA914550B (sv) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2663224B1 (fr) * | 1990-06-14 | 1995-01-20 | Applicationes Farmaceuticas Sa | Forme galenique parenterale. |
| GB9313642D0 (en) * | 1993-07-01 | 1993-08-18 | Glaxo Group Ltd | Method and apparatus for the formation of particles |
| FR2732621B1 (fr) * | 1995-04-10 | 1997-06-06 | Rhone Poulenc Chimie | Perles d'un produit presentant le phenomene de surfusion et leur procede d'obtention |
| US5904935A (en) * | 1995-06-07 | 1999-05-18 | Alza Corporation | Peptide/protein suspending formulations |
| US6028057A (en) * | 1998-02-19 | 2000-02-22 | Thorn Bioscience, Llc | Regulation of estrus and ovulation in gilts |
| ATE265846T1 (de) * | 1998-02-25 | 2004-05-15 | Abbott Lab | Butorphanol enthaltende formulierungen mit verzögerter freisetzung |
| US6287693B1 (en) | 1998-02-25 | 2001-09-11 | John Claude Savoir | Stable shaped particles of crystalline organic compounds |
| CA2382216A1 (en) * | 1999-08-20 | 2001-03-01 | Xian Ming Zeng | Method to produce powders for pulmonary or nasal administration |
| US20030055075A1 (en) * | 2001-07-13 | 2003-03-20 | Rubsamen Reid M. | Programmable controlled release injectable opioid formulation |
| US20070254008A1 (en) * | 2001-07-13 | 2007-11-01 | Flow Focusing, Inc. | Antibiotic formulation and method of treatment |
| US20070254009A1 (en) * | 2001-07-13 | 2007-11-01 | Flow Focusing, Inc. | Antibiotic/bone morphogenic protein formulation and method of treatment |
| GB0117696D0 (en) * | 2001-07-20 | 2001-09-12 | Bradford Particle Design Plc | Particle information |
| AU2004246870B2 (en) | 2003-06-13 | 2009-07-23 | Skendi Finance Ltd | Slow release estradiol-progesterone formulation for contraception and hormone replacement therapy |
| US20050032811A1 (en) | 2003-08-06 | 2005-02-10 | Josiah Brown | Methods for administering aripiprazole |
| US9532995B2 (en) | 2003-09-03 | 2017-01-03 | Miscon Trading S.A. | Methods for the treatment of endometriosis |
| US7205281B2 (en) | 2003-10-03 | 2007-04-17 | Thorn Bioscience, Llc | Process for the synchronization of ovulation for timed breeding without heat detection |
| BRPI0415531B8 (pt) | 2003-10-23 | 2021-05-25 | Otsuka Pharma Co Ltd | formulação de aripiprazol injetável estéril de liberação controlada e método para a sua preparação |
| US7413690B1 (en) | 2003-10-29 | 2008-08-19 | The University Of Mississippi | Process and apparatus for producing spherical pellets using molten solid matrices |
| US7491263B2 (en) * | 2004-04-05 | 2009-02-17 | Technology Innovation, Llc | Storage assembly |
| US7392635B2 (en) * | 2005-06-09 | 2008-07-01 | Tipper Tie, Inc. | Breech loader packaging systems and associated breech loading chutes and methods |
| US20070197435A1 (en) * | 2006-02-17 | 2007-08-23 | Webel Stephen K | Process for the synchronization of ovulation for timed breeding without heat detection |
| ATE475686T1 (de) | 2006-10-31 | 2010-08-15 | Surmodics Pharmaceuticals Inc | Kugelförmige polymer-teilchen |
| AR067747A1 (es) | 2007-07-31 | 2009-10-21 | Otsuka Pharma Co Ltd | Metodos para producir suspension de aripiprazol y formulacion liofilizada |
| CN102056611A (zh) * | 2008-04-14 | 2011-05-11 | Posi维森纳里解决方案有限责任公司 | 用于获得不同的治疗适应症所需要的血浆孕酮水平的方法和药物组合物 |
| WO2010124220A1 (en) | 2009-04-23 | 2010-10-28 | Pennatek, Llc | Method and composition for synchronizing time of insemination |
| UY33103A (es) * | 2009-12-15 | 2011-07-29 | Techsphere S A De C V | Formulacion farmaceutica parenteral en suspension, de liberacion sostenida, en dosis baja y ultra baja, en terapia hormonal en el sindrome climaterico |
| CN113398243A (zh) | 2012-11-28 | 2021-09-17 | 联合动物健康第二有限责任公司 | 用于同步小母猪的授精时间的方法 |
| WO2017105512A1 (en) | 2015-12-18 | 2017-06-22 | Proinvet Innovations S.A. | Formulations and methods for controlling the reproductive cycle and ovulation |
| CA3015781C (en) * | 2016-02-24 | 2024-04-23 | Eastern Virginia Medical School | An improved formulation of long-acting levonorgestrel butanoate injectable depot suspension |
| CN106063783B (zh) * | 2016-06-16 | 2019-03-12 | 浙江爱生药业有限公司 | 一种黄体酮缓释微囊制剂及其制备方法 |
| US11376220B2 (en) | 2017-06-30 | 2022-07-05 | Therio, LLC | Single-injection methods and formulations to induce and control multiple ovarian follicles in bovine, caprine, ovine, camelid and other female animals |
| CN115212170B (zh) * | 2021-04-19 | 2024-01-26 | 中国人民解放军军事科学院军事医学研究院 | 一种致密圆整的药物球形微晶及其制备方法和其应用 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE670438A (sv) * | 1964-10-06 | 1966-01-31 | ||
| US3773919A (en) * | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| US3928566A (en) * | 1970-08-14 | 1975-12-23 | Du Pont | Lyophilized biological products |
| JPS5017525A (sv) * | 1973-06-14 | 1975-02-24 | ||
| CA1077842A (en) * | 1975-10-09 | 1980-05-20 | Minnesota Mining And Manufacturing Company | Albumin medicament carrier system |
| US4244949A (en) * | 1978-04-06 | 1981-01-13 | The Population Council, Inc. | Manufacture of long term contraceptive implant |
| US4349580A (en) * | 1978-08-18 | 1982-09-14 | Queen's University At Kingston | Process and solution for preserving green plant tissues |
| US4384975A (en) * | 1980-06-13 | 1983-05-24 | Sandoz, Inc. | Process for preparation of microspheres |
| US4349530A (en) * | 1980-12-11 | 1982-09-14 | The Ohio State University | Implants, microbeads, microcapsules, preparation thereof and method of administering a biologically-active substance to an animal |
| US4963367A (en) * | 1984-04-27 | 1990-10-16 | Medaphore, Inc. | Drug delivery compositions and methods |
| IL79407A (en) * | 1985-08-01 | 1991-03-10 | Theragenics Corp | System and method for delivering insoluble material into a living body |
| US4837381A (en) * | 1986-08-11 | 1989-06-06 | American Cyanamid Company | Compositions for parenteral administration and their use |
| ES2039219T3 (es) * | 1986-08-11 | 1993-09-16 | American Cyanamid Company | Composiciones para administracion parenteral y su uso. |
| US4892734A (en) * | 1987-04-06 | 1990-01-09 | Endocon, Inc. | Dispensing paste for forming medicinal pellets |
| ATE109941T1 (de) * | 1987-04-06 | 1994-09-15 | Endocon Inc | Durch schnellschmelzen hergestellte medizinische implantate. |
| US4748024A (en) * | 1987-04-06 | 1988-05-31 | Endocon, Inc. | Flash flow fused medicinal implants |
| CA2030551C (en) * | 1989-05-01 | 1998-08-25 | Wayne Gombotz | Process for producing small particles of biologically active molecules |
| US5019400A (en) * | 1989-05-01 | 1991-05-28 | Enzytech, Inc. | Very low temperature casting of controlled release microspheres |
-
1990
- 1990-06-14 FR FR9007416A patent/FR2663223B1/fr not_active Expired - Fee Related
-
1991
- 1991-06-11 IL IL9845991A patent/IL98459A/en not_active IP Right Cessation
- 1991-06-12 JP JP3510331A patent/JP2675675B2/ja not_active Expired - Lifetime
- 1991-06-12 AT AT91910762T patent/ATE109658T1/de not_active IP Right Cessation
- 1991-06-12 AU AU80847/91A patent/AU661275B2/en not_active Ceased
- 1991-06-12 ES ES91910762T patent/ES2059142T3/es not_active Expired - Lifetime
- 1991-06-12 RU RU92016471A patent/RU2104692C1/ru active
- 1991-06-12 CA CA002085344A patent/CA2085344C/en not_active Expired - Fee Related
- 1991-06-12 DE DE69103419T patent/DE69103419T2/de not_active Expired - Fee Related
- 1991-06-12 EP EP91910762A patent/EP0533739B1/fr not_active Expired - Lifetime
- 1991-06-12 DK DK91910762.3T patent/DK0533739T3/da active
- 1991-06-12 HU HU9203958A patent/HUT68709A/hu unknown
- 1991-06-12 WO PCT/EP1991/001096 patent/WO1991019484A1/fr active IP Right Grant
- 1991-06-12 UA UA93004686A patent/UA27043C2/uk unknown
- 1991-06-12 KR KR1019920703205A patent/KR0157439B1/ko not_active IP Right Cessation
- 1991-06-12 BR BR919106545A patent/BR9106545A/pt not_active Application Discontinuation
- 1991-06-13 CZ CS19911816A patent/CZ286793B6/cs not_active IP Right Cessation
- 1991-06-13 IE IE201791A patent/IE62679B1/en not_active IP Right Cessation
- 1991-06-13 US US07/714,583 patent/US5360616A/en not_active Expired - Lifetime
- 1991-06-13 UY UY23240A patent/UY23240A1/es not_active IP Right Cessation
- 1991-06-13 SK SK1816-91A patent/SK280564B6/sk unknown
- 1991-06-14 PL PL91290677A patent/PL167234B1/pl not_active IP Right Cessation
- 1991-06-14 PT PT97975A patent/PT97975B/pt not_active IP Right Cessation
- 1991-06-14 TN TNTNSN91048A patent/TNSN91048A1/fr unknown
- 1991-06-14 CN CN91104859A patent/CN1057442C/zh not_active Expired - Fee Related
- 1991-06-14 NZ NZ238542A patent/NZ238542A/xx not_active IP Right Cessation
- 1991-06-14 ZA ZA914550A patent/ZA914550B/xx unknown
-
1992
- 1992-12-11 FI FI925661A patent/FI107698B/sv active
- 1992-12-11 NO NO924792A patent/NO302998B1/no not_active IP Right Cessation
- 1992-12-14 BG BG97166A patent/BG61179B1/bg unknown
-
1994
- 1994-05-17 US US08/243,823 patent/US5512303A/en not_active Expired - Lifetime
-
1996
- 1996-04-15 US US08/632,616 patent/US5633014A/en not_active Expired - Lifetime
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| FI107698B (sv) | Fasta, ej-porösa mikrosfärer | |
| FI107697B (sv) | Förfarande för framställning av fasta, ej-porösa mikrosfärer | |
| Qushawy et al. | Solid lipid nanoparticles (SLNs) as nano drug delivery carriers: Preparation, characterization and application | |
| JP2002524411A (ja) | 微粒子 | |
| US7862751B2 (en) | Formulation of fine particles using liquefield or dense gases | |
| US20200197311A1 (en) | Amorphous nanostructured pharmaceutical materials | |
| Solanki | Solid dispersion a promising tool for drug solubility improvement |