FI106717B - Menetelmä terapeuttisesti aktiivisten 7-aminoasetyylimerkaptoasetyyliamidioktahydro-6-oksopyridiini[2,1a] [2] - bentsatsepiini- ja heksahydro-6-okso-1H- [1,4] -oksatsiini - [3,4-a] [2]bentsatsepiini-ja heksahydro-6-okso-1H-[1,4] - tiatsiini[3,4-a] [2]bentsatsepiini-4-karboksyylihappojen ja niiden farmaseuttisesti hyväksyttävien suolojen valmistamiseksi - Google Patents

Menetelmä terapeuttisesti aktiivisten 7-aminoasetyylimerkaptoasetyyliamidioktahydro-6-oksopyridiini[2,1a] [2] - bentsatsepiini- ja heksahydro-6-okso-1H- [1,4] -oksatsiini - [3,4-a] [2]bentsatsepiini-ja heksahydro-6-okso-1H-[1,4] - tiatsiini[3,4-a] [2]bentsatsepiini-4-karboksyylihappojen ja niiden farmaseuttisesti hyväksyttävien suolojen valmistamiseksi Download PDF

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Publication number
FI106717B
FI106717B FI943728A FI943728A FI106717B FI 106717 B FI106717 B FI 106717B FI 943728 A FI943728 A FI 943728A FI 943728 A FI943728 A FI 943728A FI 106717 B FI106717 B FI 106717B
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FI
Finland
Prior art keywords
oxo
mixture
benzazepine
amino
phenylpropyl
Prior art date
Application number
FI943728A
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English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI943728A (fi
FI943728A0 (fi
Inventor
Robert J Cregge
Shyam Sunder
Gary A Flynn
Patrick W Shum
Thomas L Fevig
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Merrell Dow Pharma
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Publication of FI943728A publication Critical patent/FI943728A/fi
Publication of FI943728A0 publication Critical patent/FI943728A0/fi
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Publication of FI106717B publication Critical patent/FI106717B/fi

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
FI943728A 1992-02-14 1994-08-12 Menetelmä terapeuttisesti aktiivisten 7-aminoasetyylimerkaptoasetyyliamidioktahydro-6-oksopyridiini[2,1a] [2] - bentsatsepiini- ja heksahydro-6-okso-1H- [1,4] -oksatsiini - [3,4-a] [2]bentsatsepiini-ja heksahydro-6-okso-1H-[1,4] - tiatsiini[3,4-a] [2]bentsatsepiini-4-karboksyylihappojen ja niiden farmaseuttisesti hyväksyttävien suolojen valmistamiseksi FI106717B (fi)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US83602892A 1992-02-14 1992-02-14
US83602892 1992-02-14
US98567892A 1992-12-11 1992-12-11
US98567892 1992-12-11
US9300153 1993-01-08
PCT/US1993/000153 WO1993016103A1 (en) 1992-02-14 1993-01-08 Aminoacetylmercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace

Publications (3)

Publication Number Publication Date
FI943728A FI943728A (fi) 1994-08-12
FI943728A0 FI943728A0 (fi) 1994-08-12
FI106717B true FI106717B (fi) 2001-03-30

Family

ID=27125838

Family Applications (1)

Application Number Title Priority Date Filing Date
FI943728A FI106717B (fi) 1992-02-14 1994-08-12 Menetelmä terapeuttisesti aktiivisten 7-aminoasetyylimerkaptoasetyyliamidioktahydro-6-oksopyridiini[2,1a] [2] - bentsatsepiini- ja heksahydro-6-okso-1H- [1,4] -oksatsiini - [3,4-a] [2]bentsatsepiini-ja heksahydro-6-okso-1H-[1,4] - tiatsiini[3,4-a] [2]bentsatsepiini-4-karboksyylihappojen ja niiden farmaseuttisesti hyväksyttävien suolojen valmistamiseksi

Country Status (18)

Country Link
US (3) US5424425A (xx)
EP (1) EP0625987B1 (xx)
JP (1) JP3460838B2 (xx)
KR (1) KR100276029B1 (xx)
AT (1) ATE164593T1 (xx)
AU (1) AU668707B2 (xx)
CA (1) CA2130116C (xx)
DE (1) DE69317764T2 (xx)
DK (1) DK0625987T3 (xx)
ES (1) ES2117123T3 (xx)
FI (1) FI106717B (xx)
HU (1) HU220596B1 (xx)
IL (1) IL104716A (xx)
MX (1) MX9300777A (xx)
NO (1) NO311524B1 (xx)
NZ (1) NZ246811A (xx)
TW (1) TW225534B (xx)
WO (1) WO1993016103A1 (xx)

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US5646276A (en) * 1992-05-13 1997-07-08 Bristol-Myers Squibb Co. Diazepine containing dual action inhibitors
US5552397A (en) * 1992-05-18 1996-09-03 E. R. Squibb & Sons, Inc. Substituted azepinone dual inhibitors of angiotensin converting enzyme and neutral exdopeptidase
HUT71494A (en) * 1993-06-11 1995-11-28 Eisai Co Ltd Pharmaceutical compositions containing of condensed heterocyclic amino acid derivatives
US5508272A (en) * 1993-06-15 1996-04-16 Bristol-Myers Squibb Company Compounds containing a fused bicycle ring and processes therefor
US5525723A (en) * 1993-11-18 1996-06-11 Bristol-Myers Squibb Co. Compounds containing a fused multiple ring lactam
EP0750631B1 (en) * 1994-02-14 2000-04-05 Merrell Pharmaceuticals Inc. Novel mercaptoacetylamido 1,3,4,5-tetrahydro-benzo(c)azepin-3-one disulfide derivatives useful as inhibitors of enkephalinase and ace
EP0746566A1 (en) * 1994-02-14 1996-12-11 Merrell Pharmaceuticals Inc. Novel 2-substituted indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and ace
ES2168355T3 (es) * 1994-02-14 2002-06-16 Merrell Pharma Inc Derivados de bisulfuro de indano-2-mercaptoacetilamida utiles como inhibidores de la encefalinasa.
ATE189392T1 (de) * 1994-03-24 2000-02-15 Merrell Pharma Inc Hypocholesterolemische, antiatherosklerotische und hypotriglyceridemische verwendung von aminoacetylmercapto derivaten
US5616775A (en) * 1994-05-05 1997-04-01 Bristol-Myers Squibb Co. Process for preparing homocystein analogs useful as intermediates for compounds containing a fused bicyclic ring
US5587375A (en) * 1995-02-17 1996-12-24 Bristol-Myers Squibb Company Azepinone compounds useful in the inhibition of ACE and NEP
US6699869B1 (en) 1995-03-24 2004-03-02 Myriad Genetics Inc. β-sheet mimetics and use thereof as inhibitors of biologically active peptides or proteins
US6245764B1 (en) 1995-03-24 2001-06-12 Molecumetics Ltd. β-sheet mimetics and use thereof as inhibitors of biologically active peptides or proteins
US6020331A (en) 1995-03-24 2000-02-01 Molecumetics, Ltd. β-sheet mimetics and use thereof as protease inhibitors
US5877313A (en) 1995-05-17 1999-03-02 Bristol-Myers Squibb Benzo-fused azepinone and piperidinone compounds useful in the inhibition of ACE and NEP
US5650408A (en) * 1995-06-07 1997-07-22 Karanewsky; Donald S. Thiazolo benzazepine containing dual action inhibitors
US5635504A (en) * 1995-06-07 1997-06-03 Bristol-Myers Squibb Co. Diazepine containing dual action inhibitors
US6117896A (en) * 1997-02-10 2000-09-12 Molecumetics Ltd. Methods for regulating transcription factors
US6953788B1 (en) 1996-09-19 2005-10-11 Aventis Pharmaceuticals Inc. 3-mercaptoacetylamino-1,5-substituted-2-oxo-azepan derivatives useful as inhibitors of matrix metalloproteinase
US6635632B1 (en) 1996-12-23 2003-10-21 Athena Neurosciences, Inc. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
JP2002503674A (ja) * 1998-02-12 2002-02-05 モレキュメティックス リミテッド βシート模倣物およびその使用に関する方法
EP1087775B1 (en) 1998-06-17 2005-08-17 Bristol-Myers Squibb Company Preventing cerebral infarction through administration of adp-receptor antiplatelet and antihypertensive drugs in combination
WO2000040564A1 (en) * 1998-12-31 2000-07-13 Aventis Pharmaceuticals Inc. N-carboxymethyl substituted benzolactams as inhibitors of matrix metalloproteinase
US6486193B2 (en) 1998-12-31 2002-11-26 Aventis Pharmaceuticals Inc. 3-substituted pyrrolidines useful as inhibitors of matrix metalloproteinases
CA2358939A1 (en) * 1998-12-31 2000-07-13 Joseph P. Burkhart 3-(thio-substituted amido)-lactams useful as inhibitors of matrix metalloproteinase
GB0119305D0 (en) 2001-04-12 2001-10-03 Aventis Pharma Gmbh Mercaptoacetylamide derivatives,a process for their preparation and their use
CN1642550A (zh) 2002-02-14 2005-07-20 美瑞德生物工程公司 β－折叠模拟物和组合物及其有关方法
DE10229180A1 (de) * 2002-06-28 2004-01-29 Aventis Pharma Deutschland Gmbh Verwendung von Vasopeptidase-Inhibitoren bei der Behandlung von metabolischen Erkrankungen, Nephropathie und mit AGE assoziierten Erkrankungen

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Also Published As

Publication number Publication date
JP3460838B2 (ja) 2003-10-27
TW225534B (xx) 1994-06-21
CA2130116A1 (en) 1993-08-19
WO1993016103A1 (en) 1993-08-19
FI943728A (fi) 1994-08-12
DK0625987T3 (da) 1999-01-11
ATE164593T1 (de) 1998-04-15
AU3439193A (en) 1993-09-03
EP0625987B1 (en) 1998-04-01
US5424425A (en) 1995-06-13
AU668707B2 (en) 1996-05-16
KR950700323A (ko) 1995-01-16
IL104716A0 (en) 1993-06-10
MX9300777A (es) 1993-08-01
EP0625987A1 (en) 1994-11-30
NO942994D0 (no) 1994-08-12
NO942994L (no) 1994-10-13
NZ246811A (en) 1996-02-27
HU220596B1 (hu) 2002-03-28
NO311524B1 (no) 2001-12-03
DE69317764T2 (de) 1998-07-30
CA2130116C (en) 1998-04-07
HU9402355D0 (en) 1994-10-28
US5529995A (en) 1996-06-25
FI943728A0 (fi) 1994-08-12
DE69317764D1 (de) 1998-05-07
US5488048A (en) 1996-01-30
JPH07503955A (ja) 1995-04-27
ES2117123T3 (es) 1998-08-01
HUT71105A (en) 1995-11-28
KR100276029B1 (ko) 2000-12-15
IL104716A (en) 1997-09-30

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