FI106463B - Menetelmä terapeuttisesti käyttökelpoisten rapamysiinikarbamaattijohdannaisten valmistamiseksi - Google Patents

Menetelmä terapeuttisesti käyttökelpoisten rapamysiinikarbamaattijohdannaisten valmistamiseksi Download PDF

Info

Publication number
FI106463B
FI106463B FI934501A FI934501A FI106463B FI 106463 B FI106463 B FI 106463B FI 934501 A FI934501 A FI 934501A FI 934501 A FI934501 A FI 934501A FI 106463 B FI106463 B FI 106463B
Authority
FI
Finland
Prior art keywords
carbon atoms
rapamycin
ester
acid
compound
Prior art date
Application number
FI934501A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI934501A0 (fi
FI934501A (fi
Inventor
Robert Lewis Vogel
Kao Wenling
Magid Abdel Abou-Gharbia
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/054,655 external-priority patent/US5302584A/en
Priority claimed from GB939317596A external-priority patent/GB9317596D0/en
Application filed by American Home Prod filed Critical American Home Prod
Publication of FI934501A0 publication Critical patent/FI934501A0/fi
Publication of FI934501A publication Critical patent/FI934501A/fi
Application granted granted Critical
Publication of FI106463B publication Critical patent/FI106463B/fi

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
FI934501A 1992-10-13 1993-10-12 Menetelmä terapeuttisesti käyttökelpoisten rapamysiinikarbamaattijohdannaisten valmistamiseksi FI106463B (fi)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US96059792A 1992-10-13 1992-10-13
US96059792 1992-10-13
US5465593 1993-04-23
US08/054,655 US5302584A (en) 1992-10-13 1993-04-23 Carbamates of rapamycin
GB9317596 1993-08-24
GB939317596A GB9317596D0 (en) 1993-08-24 1993-08-24 Carbamates of rapamycin

Publications (3)

Publication Number Publication Date
FI934501A0 FI934501A0 (fi) 1993-10-12
FI934501A FI934501A (fi) 1994-04-14
FI106463B true FI106463B (fi) 2001-02-15

Family

ID=27266825

Family Applications (1)

Application Number Title Priority Date Filing Date
FI934501A FI106463B (fi) 1992-10-13 1993-10-12 Menetelmä terapeuttisesti käyttökelpoisten rapamysiinikarbamaattijohdannaisten valmistamiseksi

Country Status (12)

Country Link
EP (2) EP1266900A1 (de)
AT (1) ATE321053T1 (de)
AU (1) AU679931B2 (de)
BR (1) BR9304211A (de)
DE (1) DE69333995T2 (de)
DK (1) DK0593227T3 (de)
ES (1) ES2258763T3 (de)
FI (1) FI106463B (de)
HK (1) HK1048809A1 (de)
HU (1) HU222575B1 (de)
NZ (1) NZ248909A (de)
SG (1) SG47580A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9315914D0 (en) * 1993-07-31 1993-09-15 Smithkline Beecham Plc Novel compound
CA2175215C (en) * 1993-11-19 2008-06-03 Yat Sun Or Semisynthetic analogs of rapamycin (macrolides) being immunomodulators
US5527907A (en) * 1993-11-19 1996-06-18 Abbott Laboratories Macrolide immunomodulators
US5385908A (en) * 1993-11-22 1995-01-31 American Home Products Corporation Hindered esters of rapamycin
US5385909A (en) * 1993-11-22 1995-01-31 American Home Products Corporation Heterocyclic esters of rapamycin
GB9826882D0 (en) 1998-12-07 1999-01-27 Novartis Ag Organic compounds
US20050026868A1 (en) * 2003-07-11 2005-02-03 Metcalf Chester A. Phosphorus-containing macrocycles
US8021849B2 (en) 2004-11-05 2011-09-20 Siemens Healthcare Diagnostics Inc. Methods and kits for the determination of sirolimus in a sample
US7189582B2 (en) 2005-04-27 2007-03-13 Dade Behring Inc. Compositions and methods for detection of sirolimus
MX2009010683A (es) * 2007-04-05 2010-01-20 Wyeth Corp Conjugado de wortmanina-rapamicina y usos del mismo.
TW200845960A (en) * 2007-04-05 2008-12-01 Wyeth Corp Wortmannin-rapalog conjugate and uses thereof
US20090253733A1 (en) * 2008-04-02 2009-10-08 Biointeractions, Ltd. Rapamycin carbonate esters
AU2016278040B2 (en) * 2015-06-16 2019-07-04 Nanophagix LLC Drug delivery and imaging chemical conjugate, formulations and methods of use thereof
CR20230103A (es) 2018-05-01 2023-04-11 Revolution Medicines Inc Análogos de rapamicina ligados a c40, c28 y c32 como inhibidores de mtor

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4650803A (en) * 1985-12-06 1987-03-17 University Of Kansas Prodrugs of rapamycin
PT98990A (pt) * 1990-09-19 1992-08-31 American Home Prod Processo para a preparacao de esteres de acidos carboxilicos de rapamicina
US5118678A (en) * 1991-04-17 1992-06-02 American Home Products Corporation Carbamates of rapamycin
US5118677A (en) * 1991-05-20 1992-06-02 American Home Products Corporation Amide esters of rapamycin
JPH06502659A (ja) * 1991-05-31 1994-03-24 ファイザー　インク 免疫抑制剤としてのラパマイシンプロドラッグの使用

Also Published As

Publication number Publication date
HUT70199A (en) 1995-09-28
ATE321053T1 (de) 2006-04-15
FI934501A0 (fi) 1993-10-12
AU4894293A (en) 1994-04-28
SG47580A1 (en) 1998-04-17
NZ248909A (en) 1995-11-27
DE69333995T2 (de) 2006-10-19
DE69333995D1 (de) 2006-05-11
EP0593227B1 (de) 2006-03-22
HU9302880D0 (en) 1993-12-28
EP1266900A1 (de) 2002-12-18
HU222575B1 (hu) 2003-08-28
DK0593227T3 (da) 2006-05-01
AU679931B2 (en) 1997-07-17
EP0593227A1 (de) 1994-04-20
HK1048809A1 (zh) 2003-04-17
BR9304211A (pt) 1994-06-07
FI934501A (fi) 1994-04-14
ES2258763T3 (es) 2006-09-01

Similar Documents

Publication Publication Date Title
JP3909870B2 (ja) ラパマイシンのカルバメート
FI106463B (fi) Menetelmä terapeuttisesti käyttökelpoisten rapamysiinikarbamaattijohdannaisten valmistamiseksi
US5411967A (en) Carbamates of rapamycin
US5550133A (en) Carbamates of rapamycin
US5508399A (en) Carbamates of rapamycin
US5489595A (en) Carbamates of rapamycin
DE69426831T2 (de) Heterocyclische ester von rapamycin und sie enthaltende pharmazeutische zusammensetzungen
DE69522225T2 (de) Rapamycinamidinocarbamate und diese enthaltende pharmazeutische zubereitungen
US5385910A (en) Gem-distributed esters of rapamycin
DE69430586T2 (de) Aminoalkanester von rapamycin
JPH06293774A (ja) 大環状免疫調節剤
US20070149526A1 (en) Diuretic and diuretic-like compound analogs
RU2005106846A (ru) Производные бензотиазола, характеризующиеся агонистической активностью к бета-2-адренорецепторам
JP2008540659A (ja) 心血管障害の処置および／または予防のためのラパマイシン誘導体の使用
HU211329A9 (hu) Rapamicin-karbamátok Az átmeneti oltalom az 1-27. és 31-33. igénypontra vonatkozik.
WO2004024149A1 (de) Arzneimittel enthaltend disorale und ihre derivate und deren anwendung zur behandlung gutartiger und bosärtiger tumorerkrankungen
NZ784118B2 (en) 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives
NZ784118A (en) 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives

Legal Events

Date Code Title Description
FD Application lapsed
MA Patent expired