DE69333995D1 - Carbamate von Rapamycin - Google Patents

Carbamate von Rapamycin

Info

Publication number
DE69333995D1
DE69333995D1 DE69333995T DE69333995T DE69333995D1 DE 69333995 D1 DE69333995 D1 DE 69333995D1 DE 69333995 T DE69333995 T DE 69333995T DE 69333995 T DE69333995 T DE 69333995T DE 69333995 D1 DE69333995 D1 DE 69333995D1
Authority
DE
Germany
Prior art keywords
carbon atoms
chem
hydrogen
po3h
co2h
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69333995T
Other languages
English (en)
Other versions
DE69333995T2 (de
Inventor
Wenling Kao
Magid Abdel Abou-Gharbia
Robert Lewis Vogel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
Wyeth LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/054,655 external-priority patent/US5302584A/en
Priority claimed from GB939317596A external-priority patent/GB9317596D0/en
Application filed by Wyeth LLC filed Critical Wyeth LLC
Application granted granted Critical
Publication of DE69333995D1 publication Critical patent/DE69333995D1/de
Publication of DE69333995T2 publication Critical patent/DE69333995T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
DE69333995T 1992-10-13 1993-10-08 Carbamate von Rapamycin Expired - Fee Related DE69333995T2 (de)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US96059792A 1992-10-13 1992-10-13
US960597 1992-10-13
US08/054,655 US5302584A (en) 1992-10-13 1993-04-23 Carbamates of rapamycin
US54655 1993-04-23
GB9317596 1993-08-24
GB939317596A GB9317596D0 (en) 1993-08-24 1993-08-24 Carbamates of rapamycin

Publications (2)

Publication Number Publication Date
DE69333995D1 true DE69333995D1 (de) 2006-05-11
DE69333995T2 DE69333995T2 (de) 2006-10-19

Family

ID=27266825

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69333995T Expired - Fee Related DE69333995T2 (de) 1992-10-13 1993-10-08 Carbamate von Rapamycin

Country Status (12)

Country Link
EP (2) EP0593227B1 (de)
AT (1) ATE321053T1 (de)
AU (1) AU679931B2 (de)
BR (1) BR9304211A (de)
DE (1) DE69333995T2 (de)
DK (1) DK0593227T3 (de)
ES (1) ES2258763T3 (de)
FI (1) FI106463B (de)
HK (1) HK1048809A1 (de)
HU (1) HU222575B1 (de)
NZ (1) NZ248909A (de)
SG (1) SG47580A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9315914D0 (en) * 1993-07-31 1993-09-15 Smithkline Beecham Plc Novel compound
EP0729471A1 (de) * 1993-11-19 1996-09-04 Abbott Laboratories Semisynthetische rapamycin analoge mit immunomodulatorischer wirkung
US5527907A (en) * 1993-11-19 1996-06-18 Abbott Laboratories Macrolide immunomodulators
US5385909A (en) * 1993-11-22 1995-01-31 American Home Products Corporation Heterocyclic esters of rapamycin
US5385908A (en) * 1993-11-22 1995-01-31 American Home Products Corporation Hindered esters of rapamycin
GB9826882D0 (en) 1998-12-07 1999-01-27 Novartis Ag Organic compounds
EP1648900A4 (de) * 2003-07-11 2010-02-10 Ariad Pharma Inc Phosphorhaltige makrocyclen
US8021849B2 (en) 2004-11-05 2011-09-20 Siemens Healthcare Diagnostics Inc. Methods and kits for the determination of sirolimus in a sample
US7189582B2 (en) 2005-04-27 2007-03-13 Dade Behring Inc. Compositions and methods for detection of sirolimus
TW200845960A (en) * 2007-04-05 2008-12-01 Wyeth Corp Wortmannin-rapalog conjugate and uses thereof
CA2678415A1 (en) * 2007-04-05 2008-10-16 Wyeth Wortmannin-rapamycin conjugate and uses thereof
US20090253733A1 (en) * 2008-04-02 2009-10-08 Biointeractions, Ltd. Rapamycin carbonate esters
US11034701B2 (en) 2015-06-16 2021-06-15 Nanophagix LLC Drug delivery and imaging chemical conjugate, formulations and methods of use thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4650803A (en) * 1985-12-06 1987-03-17 University Of Kansas Prodrugs of rapamycin
PT98990A (pt) * 1990-09-19 1992-08-31 American Home Prod Processo para a preparacao de esteres de acidos carboxilicos de rapamicina
US5118678A (en) * 1991-04-17 1992-06-02 American Home Products Corporation Carbamates of rapamycin
US5118677A (en) * 1991-05-20 1992-06-02 American Home Products Corporation Amide esters of rapamycin
JPH06502659A (ja) * 1991-05-31 1994-03-24 ファイザー　インク 免疫抑制剤としてのラパマイシンプロドラッグの使用

Also Published As

Publication number Publication date
FI934501A (fi) 1994-04-14
FI106463B (fi) 2001-02-15
ATE321053T1 (de) 2006-04-15
HUT70199A (en) 1995-09-28
EP0593227A1 (de) 1994-04-20
HK1048809A1 (zh) 2003-04-17
SG47580A1 (en) 1998-04-17
DK0593227T3 (da) 2006-05-01
ES2258763T3 (es) 2006-09-01
AU679931B2 (en) 1997-07-17
HU222575B1 (hu) 2003-08-28
EP1266900A1 (de) 2002-12-18
DE69333995T2 (de) 2006-10-19
AU4894293A (en) 1994-04-28
NZ248909A (en) 1995-11-27
FI934501A0 (fi) 1993-10-12
HU9302880D0 (en) 1993-12-28
EP0593227B1 (de) 2006-03-22
BR9304211A (pt) 1994-06-07

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee