FI106454B - Förfarande för framställning av 4-[4-[4-(hydroxidifenylmetyl)-1-piperidinyl]-1-hydroxibutyl]- och 4-[4-[4-(hydroxidifenylmetyl)-1-piperidinyl]-1-oxobutyl]derivat - Google Patents

Förfarande för framställning av 4-[4-[4-(hydroxidifenylmetyl)-1-piperidinyl]-1-hydroxibutyl]- och 4-[4-[4-(hydroxidifenylmetyl)-1-piperidinyl]-1-oxobutyl]derivat Download PDF

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Publication number
FI106454B
FI106454B FI944713A FI944713A FI106454B FI 106454 B FI106454 B FI 106454B FI 944713 A FI944713 A FI 944713A FI 944713 A FI944713 A FI 944713A FI 106454 B FI106454 B FI 106454B
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FI
Finland
Prior art keywords
piperidinyl
hydroxydiphenylmethyl
oxobutyl
formula
acid
Prior art date
Application number
FI944713A
Other languages
English (en)
Finnish (fi)
Other versions
FI944713A (sv
FI944713A0 (sv
Inventor
Michele Ann Kaminski
Chi-Hsin Richard King
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of FI944713A0 publication Critical patent/FI944713A0/sv
Publication of FI944713A publication Critical patent/FI944713A/sv
Application granted granted Critical
Publication of FI106454B publication Critical patent/FI106454B/sv

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
FI944713A 1992-04-10 1994-10-07 Förfarande för framställning av 4-[4-[4-(hydroxidifenylmetyl)-1-piperidinyl]-1-hydroxibutyl]- och 4-[4-[4-(hydroxidifenylmetyl)-1-piperidinyl]-1-oxobutyl]derivat FI106454B (sv)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US86726192A 1992-04-10 1992-04-10
US86726192 1992-04-10
US1725193A 1993-02-25 1993-02-25
US1725193 1993-02-25
PCT/US1993/002103 WO1993021156A1 (en) 1992-04-10 1993-03-10 4-diphenylmethyl piperidine derivatives and process for their preparation
US9302103 1993-03-10

Publications (3)

Publication Number Publication Date
FI944713A0 FI944713A0 (sv) 1994-10-07
FI944713A FI944713A (sv) 1994-12-02
FI106454B true FI106454B (sv) 2001-02-15

Family

ID=26689638

Family Applications (2)

Application Number Title Priority Date Filing Date
FI944713A FI106454B (sv) 1992-04-10 1994-10-07 Förfarande för framställning av 4-[4-[4-(hydroxidifenylmetyl)-1-piperidinyl]-1-hydroxibutyl]- och 4-[4-[4-(hydroxidifenylmetyl)-1-piperidinyl]-1-oxobutyl]derivat
FI20002460A FI20002460A (sv) 1992-04-10 2000-11-09 4-difenylmetylpiperidinderivat

Family Applications After (1)

Application Number Title Priority Date Filing Date
FI20002460A FI20002460A (sv) 1992-04-10 2000-11-09 4-difenylmetylpiperidinderivat

Country Status (19)

Country Link
EP (1) EP0635004B1 (sv)
JP (3) JP3686950B2 (sv)
KR (1) KR100257805B1 (sv)
AR (1) AR253777A1 (sv)
AT (1) ATE220666T1 (sv)
AU (1) AU671822B2 (sv)
CA (1) CA2117892C (sv)
DE (1) DE69332117T2 (sv)
DK (1) DK0635004T3 (sv)
ES (1) ES2176201T3 (sv)
FI (2) FI106454B (sv)
HU (1) HU226561B1 (sv)
IL (1) IL105328A (sv)
MX (1) MX9302076A (sv)
NO (5) NO305076B1 (sv)
NZ (1) NZ251132A (sv)
PT (1) PT635004E (sv)
TW (1) TW362096B (sv)
WO (1) WO1993021156A1 (sv)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2284351B (en) * 1992-08-03 1996-11-27 Sepracor Inc Terfenadine metabolites and their optically pure isomers for treating allergic disorders
US20020007068A1 (en) 1999-07-16 2002-01-17 D'ambra Thomas E. Piperidine derivatives and process for their production
ES2261871T3 (es) 1993-06-24 2006-11-16 Amr Technology, Inc. Procedimiento para preparar compuestos utiles como intermediarios.
US6147216A (en) * 1993-06-25 2000-11-14 Merrell Pharmaceuticals Inc. Intermediates useful for the preparation of antihistaminic piperidine derivatives
ATE230395T1 (de) 1993-06-25 2003-01-15 Merrell Pharma Inc Neue zwischenprodukte für die herstellung von antihistaminschen 4- diphenylmethyl/diphenylmethoxypiperidin-derivat n
EP2354125A1 (en) * 1994-05-18 2011-08-10 Aventisub II Inc. Anhydrous and hydrate polymorphic forms of antihistaminic piperidine derivatives
PT812195E (pt) 1995-02-28 2003-03-31 Aventis Pharma Inc Composicao farmaceutica para compostos de piperidinoalcanol
US6153754A (en) * 1995-12-21 2000-11-28 Albany Molecular Research, Inc. Process for production of piperidine derivatives
US6201124B1 (en) 1995-12-21 2001-03-13 Albany Molecular Research, Inc. Process for production of piperidine derivatives
CA2336380C (en) * 1998-07-02 2007-04-10 Aventis Pharmaceuticals Inc. Novel antihistaminic piperidine derivatives and intermediates for the preparation thereof
EP1392303A4 (en) * 2001-04-09 2005-01-26 Teva Pharma FEXOFENADINE HYDROCHLORIDE POLYMORPHS
ITRM20010260A1 (it) 2001-05-17 2002-11-18 Dinamite Dipharma S P A In For Processo per la preparazione della fexofenadina o acido 4 1-idrossi-4-4- (idrossidifenilmetil)-1-piperidinil|-butil|-alfa,alfa-dimetilbenz
US6743941B2 (en) * 2001-06-15 2004-06-01 Aventis Pharma Deutschland Gmbh Process for the production of piperidine derivatives
WO2003104197A1 (en) 2002-06-10 2003-12-18 Teva Pharmaceutical Industries Ltd. Polymorphic form xvi of fexofenadine hydrochloride
GB0319935D0 (en) * 2003-08-26 2003-09-24 Cipla Ltd Polymorphs
ITMI20061492A1 (it) * 2006-07-27 2008-01-28 Archimica Srl Processo per la preparazione di fexofenadina.
ITMI20070987A1 (it) 2007-05-16 2008-11-17 Dipharma Francis Srl Procedimento per la preparazione di composti chetonici
EP2289867A3 (en) 2009-08-19 2012-04-25 Jubilant Organosys Limited A process for producing 4-(4-halo-1-oxybutyl)-alpha,alpha-dimethylbenzene acetic acid or alkyl esters thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4254129A (en) * 1979-04-10 1981-03-03 Richardson-Merrell Inc. Piperidine derivatives
US4254130A (en) * 1979-04-10 1981-03-03 Richardson-Merrell Inc. Piperidine derivatives

Also Published As

Publication number Publication date
NO305023B1 (no) 1999-03-22
JP3686950B2 (ja) 2005-08-24
FI20002460A (sv) 2000-11-09
CA2117892A1 (en) 1993-10-28
KR950700881A (ko) 1995-02-20
NO981433L (no) 1994-12-09
NO305076B1 (no) 1999-03-29
ATE220666T1 (de) 2002-08-15
ES2176201T3 (es) 2002-12-01
DK0635004T3 (da) 2002-11-11
NO305077B1 (no) 1999-03-29
JP4266184B2 (ja) 2009-05-20
IL105328A (en) 2007-03-08
JPH08502022A (ja) 1996-03-05
WO1993021156A1 (en) 1993-10-28
NO981432L (no) 1994-12-09
FI944713A (sv) 1994-12-02
NO981433D0 (no) 1998-03-30
PT635004E (pt) 2002-12-31
FI944713A0 (sv) 1994-10-07
HU226561B1 (en) 2009-04-28
NO943794D0 (no) 1994-10-07
NO981431L (no) 1994-12-09
NO305024B1 (no) 1999-03-22
AR253777A1 (es) 2001-10-08
NO981434D0 (no) 1998-03-30
KR100257805B1 (ko) 2000-07-01
TW362096B (en) 1999-06-21
EP0635004B1 (en) 2002-07-17
DE69332117T2 (de) 2003-01-30
CA2117892C (en) 2001-12-18
IL105328A0 (en) 1993-08-18
NO305025B1 (no) 1999-03-22
AU671822B2 (en) 1996-09-12
NO981432D0 (no) 1998-03-30
EP0635004A1 (en) 1995-01-25
HUT70517A (en) 1995-10-30
JP2004285072A (ja) 2004-10-14
HU9402913D0 (en) 1995-01-30
AU3797393A (en) 1993-11-18
NO981434L (no) 1994-12-09
DE69332117D1 (de) 2002-08-22
NO981431D0 (no) 1998-03-30
MX9302076A (es) 1994-03-31
NZ251132A (en) 1996-12-20
JP2005213268A (ja) 2005-08-11
NO943794L (no) 1994-12-09

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Owner name: AVENTIS INC.

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Owner name: AVENTISUB II INC.

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