FI105916B - Menetelmä terapeuttisesti käyttökelpoisten 3R-3,7-difenyyli-1,8-diatsaspiro[5,5]undekaanijohdannaisten valmistamiseksi - Google Patents
Menetelmä terapeuttisesti käyttökelpoisten 3R-3,7-difenyyli-1,8-diatsaspiro[5,5]undekaanijohdannaisten valmistamiseksi Download PDFInfo
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- FI105916B FI105916B FI941022A FI941022A FI105916B FI 105916 B FI105916 B FI 105916B FI 941022 A FI941022 A FI 941022A FI 941022 A FI941022 A FI 941022A FI 105916 B FI105916 B FI 105916B
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- phenyl
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- diazaspiro
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- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
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- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/74—Oxygen atoms
- C07D211/76—Oxygen atoms attached in position 2 or 6
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2638293A | 1993-03-04 | 1993-03-04 | |
| US2638293 | 1993-03-04 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI941022A0 FI941022A0 (fi) | 1994-03-03 |
| FI941022A FI941022A (fi) | 1994-09-05 |
| FI105916B true FI105916B (fi) | 2000-10-31 |
Family
ID=21831515
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI941022A FI105916B (fi) | 1993-03-04 | 1994-03-03 | Menetelmä terapeuttisesti käyttökelpoisten 3R-3,7-difenyyli-1,8-diatsaspiro[5,5]undekaanijohdannaisten valmistamiseksi |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US5688806A (de) |
| EP (1) | EP0687268B1 (de) |
| JP (1) | JP2832754B2 (de) |
| CN (1) | CN1099035A (de) |
| AT (1) | ATE166650T1 (de) |
| AU (1) | AU6226494A (de) |
| CA (1) | CA2157117C (de) |
| DE (1) | DE69318854T2 (de) |
| DK (1) | DK0687268T3 (de) |
| ES (1) | ES2116587T3 (de) |
| FI (1) | FI105916B (de) |
| IL (1) | IL108769A0 (de) |
| WO (1) | WO1994020500A1 (de) |
Families Citing this family (65)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5393762A (en) * | 1993-06-04 | 1995-02-28 | Pfizer Inc. | Pharmaceutical agents for treatment of emesis |
| EP0655246A1 (de) * | 1993-11-30 | 1995-05-31 | Pfizer Inc. | Substanz P Antagonisten zur Behandlung von durch Helicobacter Pylori oder andere spirale Urease-positive Gram-negative Bakterien verursachten Krankheiten |
| US5696267A (en) * | 1995-05-02 | 1997-12-09 | Schering Corporation | Substituted oximes, hydrazones and olefins as neurokinin antagonists |
| US5688960A (en) * | 1995-05-02 | 1997-11-18 | Schering Corporation | Substituted oximes, hydrazones and olefins useful as neurokinin antagonists |
| TW458774B (en) | 1995-10-20 | 2001-10-11 | Pfizer | Antiemetic pharmaceutical compositions |
| WO1997019084A1 (en) * | 1995-11-23 | 1997-05-29 | Merck Sharp & Dohme Limited | Spiro-piperidine derivatives and their use as tachykinin antagonists |
| GB9603137D0 (en) * | 1996-02-15 | 1996-04-17 | Merck Sharp & Dohme | Therapeutic agents |
| GB9603136D0 (en) * | 1996-02-15 | 1996-04-17 | Merck Sharp & Dohme | Therapeutic agents |
| DK0888285T3 (da) * | 1996-03-14 | 2002-04-08 | Warner Lambert Co | Nye broforbundne cycliske aminosyrer som farmaceutiske midler |
| EA001574B1 (ru) * | 1996-06-21 | 2001-06-25 | Мерк Шарп Энд Домэ Лимитед | Производные спиропиперидина и их использование в качестве терапевтических агентов |
| GB9613969D0 (en) * | 1996-07-03 | 1996-09-04 | Merck Sharp & Dohme | Therapeutic agents |
| US6046195A (en) * | 1996-09-25 | 2000-04-04 | Merck Sharp & Dohme Ltd. | Spiro-azacyclic derivatives, their preparation and their use as tachykinin antagonists |
| US5929094A (en) * | 1996-10-25 | 1999-07-27 | Merck & Co., Inc. | Heteroaryl spiroethercycloalkyl tachykinin receptor antagonists |
| GB9625843D0 (en) * | 1996-12-12 | 1997-01-29 | Merck & Co Inc | Phenyl spiroethercycloalkyl tachykinn receptor antagonists |
| US5789422A (en) * | 1996-10-28 | 1998-08-04 | Schering Corporation | Substituted arylalkylamines as neurokinin antagonists |
| US5945428A (en) * | 1996-11-01 | 1999-08-31 | Schering Corporation | Substituted oximes, hydrazones and olefins as neurokinin antagonists |
| WO1998024444A1 (en) * | 1996-12-02 | 1998-06-11 | Merck Sharp & Dohme Limited | Use of nk-1 receptor antagonists for treating substance use disorders |
| GB9708484D0 (en) * | 1997-04-25 | 1997-06-18 | Merck Sharp & Dohme | Therapeutic agents |
| GB9711114D0 (en) * | 1997-05-29 | 1997-07-23 | Merck Sharp & Dohme | Therapeutic agents |
| US7101547B1 (en) | 1999-01-22 | 2006-09-05 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Method for the prevention and treatment of diseases caused by an inflammatory response mediated by endogenous substance P by using anti-substance P antibodies |
| GB9902881D0 (en) * | 1999-02-09 | 1999-03-31 | Merck Sharp & Dohme | Therapeutic agents |
| CA2324116A1 (en) * | 1999-10-25 | 2001-04-25 | Susan Beth Sobolov-Jaynes | Nk-1 receptor antagonists and eletriptan for the treatment of migraine |
| EP1241257A4 (de) | 1999-12-21 | 2005-03-16 | Takeda Pharmaceutical | Tachykinin-ähnliche polypeptide und deren anwendung |
| US20020049211A1 (en) * | 2000-09-06 | 2002-04-25 | Sobolov-Jaynes Susan Beth | Combination treatment for depression and anxiety |
| EP1192952A3 (de) * | 2000-09-28 | 2003-03-26 | Pfizer Products Inc. | Ein NK-3 rezeptorantagonisten und ein ZNS-penetrierende NK-1 rezeptorantagonisten enthaltende Zusammensetzung zur Behandlung von Depression und Angst |
| CN1529600A (zh) * | 2001-07-20 | 2004-09-15 | �Ʒ� | Nk-1受体拮抗剂在改变狗、猫和马的不需要行为中的用途 |
| CN101119969B (zh) | 2004-07-15 | 2014-04-09 | 阿尔巴尼分子研究公司 | 芳基和杂芳基取代的四氢异喹啉及其阻断去甲肾上腺素、多巴胺和血清素的重摄取的应用 |
| WO2006023630A2 (en) * | 2004-08-20 | 2006-03-02 | Targacept, Inc. | The use of n-aryl diazaspiracyclic compounds in the treatment of addiction |
| WO2006123182A2 (en) | 2005-05-17 | 2006-11-23 | Merck Sharp & Dohme Limited | Cyclohexyl sulphones for treatment of cancer |
| JP5258561B2 (ja) | 2005-07-15 | 2013-08-07 | アルバニー モレキュラー リサーチ， インコーポレイテッド | アリール置換およびヘテロアリール置換テトラヒドロベンズアゼピンならびにノルエピネフリン、ドーパミンおよびセロトニンの再取り込みを遮断するためのその使用 |
| EP1940842B1 (de) | 2005-09-29 | 2012-05-30 | Merck Sharp & Dohme Corp. | Acylierte spiropiperidinderivate als modulatoren des melanocortin-4-rezeptors |
| GB0603041D0 (en) | 2006-02-15 | 2006-03-29 | Angeletti P Ist Richerche Bio | Therapeutic compounds |
| EP2083831B1 (de) | 2006-09-22 | 2013-12-25 | Merck Sharp & Dohme Corp. | Verfahren zur behandlung von fettsäure-synthese-hemmern |
| US20110218176A1 (en) | 2006-11-01 | 2011-09-08 | Barbara Brooke Jennings-Spring | Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development |
| SI2805945T1 (sl) | 2007-01-10 | 2019-09-30 | Msd Italia S.R.L. | Amid substituirani indazoli, kot inhibitorji poli(ADP-riboza)polimeraze(PARP) |
| EP2145884B1 (de) | 2007-04-02 | 2014-08-06 | Msd K.K. | Indoledionderivat |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0273659A1 (de) * | 1986-12-27 | 1988-07-06 | Takeda Chemical Industries, Ltd. | Azaspiroverbindungen, ihre Herstellung und Verwendung |
| ATE122353T1 (de) * | 1987-10-05 | 1995-05-15 | Yamanouchi Pharma Co Ltd | Heterozyklische spiroverbindungen und ihre herstellung. |
| EP0360390A1 (de) * | 1988-07-25 | 1990-03-28 | Glaxo Group Limited | Spirolactamderivate |
| WO1990005525A1 (en) * | 1988-11-23 | 1990-05-31 | Pfizer Inc. | Quinuclidine derivatives as substance p antagonists |
| US5075317A (en) * | 1989-06-21 | 1991-12-24 | Fisons Corporation | Spirofurane derivatives |
| JPH082901B2 (ja) * | 1991-03-01 | 1996-01-17 | ファイザー・インコーポレーテッド | １−アザビシクロ［３．２．２ノナン−３−アミン誘導体類 |
| US5393762A (en) * | 1993-06-04 | 1995-02-28 | Pfizer Inc. | Pharmaceutical agents for treatment of emesis |
-
1993
- 1993-12-10 US US08/513,798 patent/US5688806A/en not_active Expired - Fee Related
- 1993-12-10 AT AT94909413T patent/ATE166650T1/de not_active IP Right Cessation
- 1993-12-10 DK DK94909413T patent/DK0687268T3/da active
- 1993-12-10 ES ES94909413T patent/ES2116587T3/es not_active Expired - Lifetime
- 1993-12-10 CA CA002157117A patent/CA2157117C/en not_active Expired - Fee Related
- 1993-12-10 AU AU62264/94A patent/AU6226494A/en not_active Abandoned
- 1993-12-10 WO PCT/US1993/011793 patent/WO1994020500A1/en active IP Right Grant
- 1993-12-10 JP JP6519951A patent/JP2832754B2/ja not_active Expired - Fee Related
- 1993-12-10 DE DE69318854T patent/DE69318854T2/de not_active Expired - Fee Related
- 1993-12-10 EP EP94909413A patent/EP0687268B1/de not_active Expired - Lifetime
-
1994
- 1994-02-24 IL IL10876994A patent/IL108769A0/xx unknown
- 1994-03-03 CN CN94102227A patent/CN1099035A/zh active Pending
- 1994-03-03 FI FI941022A patent/FI105916B/fi not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DK0687268T3 (da) | 1998-10-12 |
| DE69318854D1 (de) | 1998-07-02 |
| EP0687268B1 (de) | 1998-05-27 |
| ES2116587T3 (es) | 1998-07-16 |
| FI941022A (fi) | 1994-09-05 |
| WO1994020500A1 (en) | 1994-09-15 |
| EP0687268A1 (de) | 1995-12-20 |
| JPH08503226A (ja) | 1996-04-09 |
| US5688806A (en) | 1997-11-18 |
| CA2157117C (en) | 1999-01-05 |
| ATE166650T1 (de) | 1998-06-15 |
| CN1099035A (zh) | 1995-02-22 |
| JP2832754B2 (ja) | 1998-12-09 |
| FI941022A0 (fi) | 1994-03-03 |
| IL108769A0 (en) | 1994-06-24 |
| CA2157117A1 (en) | 1994-09-15 |
| DE69318854T2 (de) | 1998-10-08 |
| AU6226494A (en) | 1994-09-26 |
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| MA | Patent expired |