FI103577B1 - Menetelmä, DNA ja mikro-organismi trombolyyttisen aineen valmistamiseksi - Google Patents

Menetelmä, DNA ja mikro-organismi trombolyyttisen aineen valmistamiseksi

Info

Publication number
FI103577B1
FI103577B1 FI913818A FI913818A FI103577B1 FI 103577 B1 FI103577 B1 FI 103577B1 FI 913818 A FI913818 A FI 913818A FI 913818 A FI913818 A FI 913818A FI 103577 B1 FI103577 B1 FI 103577B1
Authority
FI
Finland
Prior art keywords
microorganism
dna
thrombolytic substance
producing
producing thrombolytic
Prior art date
Application number
FI913818A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI103577B (fi
FI913818A0 (fi
Inventor
Bertholf Baldus
Peter Donner
Wolf-Dieter Schleuning
Alejandro Alagon
Werner Boidol
Joern Reiner Kraetzschmar
Bernard Jacques Haendler
Gernot Langer
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE3904580A external-priority patent/DE3904580A1/de
Priority claimed from DE19893917949 external-priority patent/DE3917949A1/de
Application filed by Schering Ag filed Critical Schering Ag
Publication of FI913818A0 publication Critical patent/FI913818A0/fi
Application granted granted Critical
Publication of FI103577B1 publication Critical patent/FI103577B1/fi
Publication of FI103577B publication Critical patent/FI103577B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
FI913818A 1989-02-13 1991-08-12 Menetelmä, DNA ja mikro-organismi trombolyyttisen aineen valmistamisek si FI103577B (fi)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
DE3904580 1989-02-13
DE3904580A DE3904580A1 (de) 1989-02-13 1989-02-13 Neues thrombolytikum
DE3917949 1989-05-30
DE19893917949 DE3917949A1 (de) 1989-05-30 1989-05-30 Neues thrombolytikum
PCT/EP1990/000242 WO1990009438A1 (en) 1989-02-13 1990-02-13 Novel thrombolytic
EP9000242 1990-02-13

Publications (3)

Publication Number Publication Date
FI913818A0 FI913818A0 (fi) 1991-08-12
FI103577B1 true FI103577B1 (fi) 1999-07-30
FI103577B FI103577B (fi) 1999-07-30

Family

ID=25877826

Family Applications (1)

Application Number Title Priority Date Filing Date
FI913818A FI103577B (fi) 1989-02-13 1991-08-12 Menetelmä, DNA ja mikro-organismi trombolyyttisen aineen valmistamisek si

Country Status (16)

Country Link
EP (1) EP0383417B1 (de)
JP (1) JP2904918B2 (de)
AT (1) ATE132187T1 (de)
AU (1) AU642404B2 (de)
BR (1) BR9007115A (de)
CA (1) CA2046632C (de)
DE (1) DE69024382T2 (de)
DK (1) DK0383417T3 (de)
ES (1) ES2085326T3 (de)
FI (1) FI103577B (de)
GR (1) GR3019328T3 (de)
HU (1) HU217219B (de)
IE (1) IE73229B1 (de)
NO (1) NO308708B1 (de)
UA (1) UA34415C2 (de)
WO (1) WO1990009438A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE69054B1 (en) * 1988-07-20 1996-08-07 Schering Ag Vampire bat salivary plasminogen activators
DE3943241A1 (de) * 1989-12-22 1991-06-27 Schering Ag Thrombolytisch wirkendes kombinationspraeparat
DE4442665A1 (de) * 1994-11-30 1996-06-05 Gruenenthal Gmbh Chimäre Proteine mit fibrinolytischen und thrombinhemmenden Eigenschaften
US5731186A (en) * 1996-02-05 1998-03-24 Schering Aktiengesellschaft Method for the production of rDSPA α1
DE10016139A1 (de) * 2000-03-27 2001-10-18 Schleuning Wolf Dieter Verfahren zur Bestimmung von löslichem Fibrin
DE10153601A1 (de) * 2001-11-02 2003-05-22 Paion Gmbh DSPA zur Behandlung von Schlaganfall
DE602004011505T2 (de) * 2003-05-21 2008-05-21 Ares Trading S.A. Verfahren zur chromatographischen analyse einer proteinlösung
DE10342518A1 (de) * 2003-09-12 2005-05-12 Paion Gmbh Plasminogen-Aktivatoren mit verringerter Lysin-Bindungskapazität
GB0321997D0 (en) 2003-09-19 2003-10-22 Novartis Ag Organic compound
WO2007134617A1 (en) * 2006-05-19 2007-11-29 Paion Deutschland Gmbh Use of desmodus salivary plasminogen activator (dspa) for treating venous thromboembolism
BRPI0718406A2 (pt) 2006-11-17 2013-12-17 Novartis Ag Moléculas de ligação de lingo e uso farmacêutico das mesmas
SI2207808T1 (sl) 2007-11-02 2013-09-30 Novartis Ag Izboljšane Nogo-A vezavne molekule in njihova farmacevtska uporaba
WO2011107299A2 (en) 2010-04-16 2011-09-09 Paion Deutschland Gmbh Method for the manufacture of recombinant dspa alpha1
WO2021079002A2 (en) 2019-10-24 2021-04-29 Novago Therapeutics Ag Novel anti-nogo-a antibodies

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE69054B1 (en) * 1988-07-20 1996-08-07 Schering Ag Vampire bat salivary plasminogen activators

Also Published As

Publication number Publication date
NO308708B1 (no) 2000-10-16
DE69024382D1 (de) 1996-02-08
WO1990009438A1 (en) 1990-08-23
IE900506L (en) 1990-08-13
GR3019328T3 (en) 1996-06-30
HU217219B (hu) 1999-12-28
DK0383417T3 (da) 1996-05-13
AU5080790A (en) 1990-09-05
NO913129L (no) 1991-10-11
NO913129D0 (no) 1991-08-12
ATE132187T1 (de) 1996-01-15
FI103577B (fi) 1999-07-30
BR9007115A (pt) 1991-11-26
DE69024382T2 (de) 1996-08-14
HUT59724A (en) 1992-06-29
UA34415C2 (uk) 2001-03-15
IE73229B1 (en) 1997-05-21
JP2904918B2 (ja) 1999-06-14
JPH04504799A (ja) 1992-08-27
HU902004D0 (en) 1991-11-28
FI913818A0 (fi) 1991-08-12
EP0383417A1 (de) 1990-08-22
AU642404B2 (en) 1993-10-21
CA2046632C (en) 1999-05-11
EP0383417B1 (de) 1995-12-27
ES2085326T3 (es) 1996-06-01
CA2046632A1 (en) 1990-08-14

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Owner name: BAYER SCHERING PHARMA AKTIENGESELLSCHAFT

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