DE68921229D1 - Prozess zur Behandlung von unlöslichem heterogenem Fusionsprotein. - Google Patents

Prozess zur Behandlung von unlöslichem heterogenem Fusionsprotein.

Info

Publication number
DE68921229D1
DE68921229D1 DE68921229T DE68921229T DE68921229D1 DE 68921229 D1 DE68921229 D1 DE 68921229D1 DE 68921229 T DE68921229 T DE 68921229T DE 68921229 T DE68921229 T DE 68921229T DE 68921229 D1 DE68921229 D1 DE 68921229D1
Authority
DE
Germany
Prior art keywords
treatment
fusion protein
heterogeneous fusion
insoluble heterogeneous
insoluble
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE68921229T
Other languages
English (en)
Other versions
DE68921229T2 (de
Inventor
Kazuhide Yoshikawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tosoh Corp
Original Assignee
Tosoh Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tosoh Corp filed Critical Tosoh Corp
Publication of DE68921229D1 publication Critical patent/DE68921229D1/de
Application granted granted Critical
Publication of DE68921229T2 publication Critical patent/DE68921229T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1136—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by reversible modification of the secondary, tertiary or quarternary structure, e.g. using denaturating or stabilising agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE68921229T 1988-04-08 1989-03-31 Prozess zur Behandlung von unlöslichem heterogenem Fusionsprotein. Expired - Fee Related DE68921229T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP63085284A JPH01257491A (ja) 1988-04-08 1988-04-08 不溶性融合異種蛋白質の処理方法

Publications (2)

Publication Number Publication Date
DE68921229D1 true DE68921229D1 (de) 1995-03-30
DE68921229T2 DE68921229T2 (de) 1995-06-22

Family

ID=13854274

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68921229T Expired - Fee Related DE68921229T2 (de) 1988-04-08 1989-03-31 Prozess zur Behandlung von unlöslichem heterogenem Fusionsprotein.

Country Status (4)

Country Link
US (1) US5043430A (de)
EP (1) EP0336324B1 (de)
JP (1) JPH01257491A (de)
DE (1) DE68921229T2 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5171670A (en) * 1989-05-12 1992-12-15 The General Hospital Corporation Recombinant dna method for production of parathyroid hormone
USRE37919E1 (en) 1989-05-12 2002-12-03 The General Hospital Corporation Recombinant DNA method for production of parathyroid hormone
ATE113060T1 (de) * 1989-12-05 1994-11-15 American Cyanamid Co Methode zur auflösung und naturation von somatotropin unter verwendung von einer niedrigen harnstoffkonzentration.
US5182369A (en) * 1990-02-28 1993-01-26 Monsanto Company Method for purifying somatotropin monomers
US5606031A (en) * 1990-04-06 1997-02-25 Lile; Jack Production and purification of biologically active recombinant neurotrophic protein in bacteria
US5986070A (en) * 1990-04-06 1999-11-16 Amgen Inc. Production of biologically active NGF proteins
WO1992014832A1 (en) * 1991-02-26 1992-09-03 Ajinomoto Co., Inc. Processes for purifying human bcdf
JPH1123530A (ja) * 1996-03-28 1999-01-29 Fmc Corp 電気泳動技術に用いる安定な変性剤及びその使用方法
WO2000040706A1 (fr) * 1998-12-28 2000-07-13 Ajinomoto Co., Inc. Procede de production de transglutaminase
US9453251B2 (en) 2002-10-08 2016-09-27 Pfenex Inc. Expression of mammalian proteins in Pseudomonas fluorescens
JP2008507294A (ja) 2004-07-26 2008-03-13 ダウ グローバル テクノロジーズ インコーポレイティド 菌株遺伝子操作による改善されたタンパク質発現のための方法
AU2008245696B2 (en) 2007-04-27 2013-11-07 Pelican Technology Holdings, Inc. Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins
US9580719B2 (en) 2007-04-27 2017-02-28 Pfenex, Inc. Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins
JP2020097524A (ja) * 2017-03-07 2020-06-25 Ｓｐｉｂｅｒ株式会社 精製されたタンパク質を製造する方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR79124B (de) * 1982-12-22 1984-10-02 Genentech Inc
ES8800957A1 (es) * 1985-02-22 1987-12-01 Monsanto Co Un metodo para la solubilizacion y renaturalizacion de proteina somatotropina
FR2799185B1 (fr) * 1999-09-30 2002-01-18 Valois Sa Organe de fixation pour fixer un dispositif de distribution de produit fluide et distributeur de produit fluide comprenant un tel organe de fixation

Also Published As

Publication number Publication date
US5043430A (en) 1991-08-27
JPH01257491A (ja) 1989-10-13
EP0336324A1 (de) 1989-10-11
DE68921229T2 (de) 1995-06-22
EP0336324B1 (de) 1995-02-22

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee