FI103575B1 - Menetelmä terapeuttisesti vaikuttavien 6,9-bis(amino)bentso(g)isokinoliini-5,10-dionien valmistamiseksi - Google Patents

Menetelmä terapeuttisesti vaikuttavien 6,9-bis(amino)bentso(g)isokinoliini-5,10-dionien valmistamiseksi

Info

Publication number
FI103575B1
FI103575B1 FI933895A FI933895A FI103575B1 FI 103575 B1 FI103575 B1 FI 103575B1 FI 933895 A FI933895 A FI 933895A FI 933895 A FI933895 A FI 933895A FI 103575 B1 FI103575 B1 FI 103575B1
Authority
FI
Finland
Prior art keywords
alkyl
group
aralkyl
phenyl
nr2r3
Prior art date
Application number
FI933895A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI933895A (fi
FI933895A0 (fi
FI103575B (fi
Inventor
Paul A Krapcho
Original Assignee
Univ Vermont
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Vermont filed Critical Univ Vermont
Publication of FI933895A publication Critical patent/FI933895A/fi
Publication of FI933895A0 publication Critical patent/FI933895A0/fi
Application granted granted Critical
Publication of FI103575B1 publication Critical patent/FI103575B1/fi
Publication of FI103575B publication Critical patent/FI103575B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/08—Aza-anthracenes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Luminescent Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
FI933895A 1991-03-08 1993-09-07 Menetelmä terapeuttisesti vaikuttavien 6,9-bis(amino)bentso(g)isokinol iini-5,10-dionien valmistamiseksi FI103575B (fi)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US66595491A 1991-03-08 1991-03-08
US66595491 1991-03-08
US82730292A 1992-01-29 1992-01-29
US82730292 1992-01-29
PCT/US1992/001606 WO1992015300A1 (en) 1991-03-08 1992-03-09 6,9 BIS(SUBSTITUTED-AMINO)BENZO[g]ISOQUINOLINE-5,10-DIONES
US9201606 1992-03-09

Publications (4)

Publication Number Publication Date
FI933895A FI933895A (fi) 1993-09-07
FI933895A0 FI933895A0 (fi) 1993-09-07
FI103575B1 true FI103575B1 (fi) 1999-07-30
FI103575B FI103575B (fi) 1999-07-30

Family

ID=27099336

Family Applications (1)

Application Number Title Priority Date Filing Date
FI933895A FI103575B (fi) 1991-03-08 1993-09-07 Menetelmä terapeuttisesti vaikuttavien 6,9-bis(amino)bentso(g)isokinol iini-5,10-dionien valmistamiseksi

Country Status (22)

Country Link
EP (2) EP0575526A1 (de)
JP (1) JP3009465B2 (de)
KR (1) KR100193593B1 (de)
AT (1) ATE153018T1 (de)
AU (1) AU663494B2 (de)
BR (1) BR9205740A (de)
CA (1) CA2104582A1 (de)
CZ (1) CZ286180B6 (de)
DE (1) DE69219646T2 (de)
DK (1) DK0503537T3 (de)
ES (1) ES2104753T3 (de)
FI (1) FI103575B (de)
GR (1) GR3024436T3 (de)
HU (1) HU215967B (de)
IE (1) IE920754A1 (de)
IL (1) IL102087A (de)
MX (1) MX9201020A (de)
NZ (1) NZ241868A (de)
RU (1) RU2129546C1 (de)
SG (1) SG66252A1 (de)
TW (1) TW201735B (de)
WO (1) WO1992015300A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5519029A (en) * 1992-09-08 1996-05-21 Boehringer Mannheim Italia, S.P.A. 2-aminoalkyl-5-aminoalkylamino substituted-isoquinoindazole-6(2H)-ones
ZA936396B (en) * 1992-09-08 1994-06-13 Univ Vermont 4-Substituted 6,9-bis(substituted-amino)benzo[g] isoquinoline-5,10,diones
US5506232A (en) * 1994-03-28 1996-04-09 Boehringer Mannheim Italia S.P.A. 6,9-bis[(2-aminoethyl)amino]benzo[g]isoquinoline-5,10-dione and its dimaleate salt
US5587382A (en) * 1994-03-28 1996-12-24 Boehringer Mannheim Italia, Spa 6,9-bis[(2-aminoethyl) amino]benzo [g]isoquinoline-5,10- dione dimaleate; an aza-anthracenedione with reduced cardiotoxicity
US6747039B2 (en) 2002-03-12 2004-06-08 Albany Molecular Research, Inc. Aza-benzothiopyranoindazoles with antitumor activity
ITMI20021040A1 (it) 2002-05-16 2003-11-17 Novuspharma Spa Composizioni farmaceutiche iniettabili di un derivato antracenedionico ad attivita' antitumorale
WO2005097128A1 (en) * 2004-03-30 2005-10-20 Novacea, Inc. 1,4-bis-n-oxide azaanthracenediones and the use thereof
WO2008103320A1 (en) * 2007-02-16 2008-08-28 Novacea, Inc. Methods of treating ophthalmic disorders with anthraquinones
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
NZ593648A (en) 2008-12-23 2013-09-27 Gilead Pharmasset Llc Nucleoside phosphoramidates
CL2009002206A1 (es) 2008-12-23 2011-08-26 Gilead Pharmasset Llc Compuestos derivados de pirrolo -(2-3-d]-pirimidin-7(6h)-tetrahidrofuran-2-il fosfonamidato, composicion farmaceutica; y su uso en el tratamiento de enfermedades virales.
EP2376514A2 (de) 2008-12-23 2011-10-19 Pharmasset, Inc. Nukleosidanaloga
KR101715981B1 (ko) 2010-03-31 2017-03-13 길리애드 파마셋 엘엘씨 뉴클레오사이드 포스포르아미데이트
CN104513201B (zh) * 2013-09-28 2017-12-26 正大天晴药业集团股份有限公司 马来酸匹杉琼的结晶
CN104557704B (zh) * 2013-10-28 2017-05-10 北京凯莱天成医药科技有限公司 一种匹杉琼马来酸盐的制备方法
CN103787970A (zh) * 2014-01-14 2014-05-14 北京万全德众医药生物技术有限公司 一锅煮法制备6，9-二氟苯并异喹啉-5，10-二酮的工艺

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2051005A (en) * 1933-09-19 1936-08-11 Gen Aniline Works Inc Process of producing n-substitution products of 1, 4-diaminoanthraquinones
US2552263A (en) * 1947-09-27 1951-05-08 Eastman Kodak Co alpha-anthrapyridinequinone compounds
ZA774443B (en) * 1977-07-22 1978-06-28 Allied Chem Anthrquinone compounds as anti-cancer agents
US4197249A (en) * 1977-08-15 1980-04-08 American Cyanamid Company 1,4-Bis(substituted-amino)-5,8-dihydroxyanthraquinones and leuco bases thereof
DE3768922D1 (de) * 1986-12-01 1991-05-02 Sumitomo Chemical Co Anthrapyridon-verbindungen, ihre herstellung und ihre verwendung.

Also Published As

Publication number Publication date
MX9201020A (es) 1993-11-01
DE69219646T2 (de) 1997-10-02
BR9205740A (pt) 1994-09-27
CA2104582A1 (en) 1992-09-17
IE920754A1 (en) 1992-09-09
SG66252A1 (en) 1999-07-20
HU215967B (hu) 1999-03-29
JPH06511230A (ja) 1994-12-15
AU1580392A (en) 1992-10-06
DK0503537T3 (da) 1997-12-15
EP0503537B1 (de) 1997-05-14
ES2104753T3 (es) 1997-10-16
DE69219646D1 (de) 1997-06-19
HUT68649A (en) 1995-07-28
FI933895A (fi) 1993-09-07
TW201735B (de) 1993-03-11
EP0575526A4 (de) 1994-03-30
FI933895A0 (fi) 1993-09-07
JP3009465B2 (ja) 2000-02-14
AU663494B2 (en) 1995-10-12
ATE153018T1 (de) 1997-05-15
NZ241868A (en) 1995-05-26
IL102087A (en) 1996-09-12
CZ184793A3 (en) 1994-06-15
WO1992015300A1 (en) 1992-09-17
RU2129546C1 (ru) 1999-04-27
KR100193593B1 (ko) 1999-06-15
FI103575B (fi) 1999-07-30
GR3024436T3 (en) 1997-11-28
EP0575526A1 (de) 1993-12-29
CZ286180B6 (cs) 2000-02-16
EP0503537A1 (de) 1992-09-16

Similar Documents

Publication Publication Date Title
FI103575B1 (fi) Menetelmä terapeuttisesti vaikuttavien 6,9-bis(amino)bentso(g)isokinoliini-5,10-dionien valmistamiseksi
MX9200344A (es) Derivados de benzamida, proceso para su preparacion y composicion farmaceutica que los contiene.
NO941278D0 (no) Sykliske ureaer og analoger som er anvendbare som retrovirale proteaseinhibitorer
DK0673937T3 (da) Bicyclisk heterocyclisk sulfonamid og sulfonsyreesterderivater
HUT52059A (en) Process for producing pharmaceutical compositions and new quinoline derivatives as a group of active components
NO933147D0 (no) Imidazoakridiner og deres antieoplastiske anvendelse
NO950877L (no) Aminoalkylamino-substituerte isokinoindazoloner med antitumoraktivitet
FI93455B (fi) Menetelmä uusien terapeuttisesti käyttökelpoisten 1-oksa-2-okso-8-atsaspiro/4,5/dekaanijohdannaisten valmistamiseksi

Legal Events

Date Code Title Description
MA Patent expired