FI101476B1 - Menetelmä kalsiumista riippuvan proteiini C:n vastaisen monoklonaalisen vasta-aineen valmistamiseksi - Google Patents

Menetelmä kalsiumista riippuvan proteiini C:n vastaisen monoklonaalisen vasta-aineen valmistamiseksi

Info

Publication number
FI101476B1
FI101476B1 FI904262A FI904262A FI101476B1 FI 101476 B1 FI101476 B1 FI 101476B1 FI 904262 A FI904262 A FI 904262A FI 904262 A FI904262 A FI 904262A FI 101476 B1 FI101476 B1 FI 101476B1
Authority
FI
Finland
Prior art keywords
protein
antibody
activation
isolation
monoclonal antibody
Prior art date
Application number
FI904262A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI904262A0 (fi
FI101476B (fi
Inventor
Charles T Esmon
Naomi L Esmon
Original Assignee
Oklahoma Med Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oklahoma Med Res Found filed Critical Oklahoma Med Res Found
Publication of FI904262A0 publication Critical patent/FI904262A0/fi
Application granted granted Critical
Publication of FI101476B1 publication Critical patent/FI101476B1/fi
Publication of FI101476B publication Critical patent/FI101476B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6464—Protein C (3.4.21.69)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2405/00—Assays, e.g. immunoassays or enzyme assays, involving lipids
    • G01N2405/04—Phospholipids, i.e. phosphoglycerides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
FI904262A 1988-12-30 1990-08-29 Menetelmä kalsiumista riippuvan proteiini C:n vastaisen monoklonaalise n vasta-aineen valmistamiseksi FI101476B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US29244788A 1988-12-30 1988-12-30
US29244788 1988-12-30
PCT/US1989/005851 WO1990007524A1 (fr) 1988-12-30 1989-12-28 Anticorps monoclonal dirige contre la proteine c
US8905851 1989-12-28

Publications (3)

Publication Number Publication Date
FI904262A0 FI904262A0 (fi) 1990-08-29
FI101476B1 true FI101476B1 (fi) 1998-06-30
FI101476B FI101476B (fi) 1998-06-30

Family

ID=23124711

Family Applications (1)

Application Number Title Priority Date Filing Date
FI904262A FI101476B (fi) 1988-12-30 1990-08-29 Menetelmä kalsiumista riippuvan proteiini C:n vastaisen monoklonaalise n vasta-aineen valmistamiseksi

Country Status (11)

Country Link
EP (1) EP0407544B1 (fr)
JP (1) JP2559537B2 (fr)
KR (1) KR940002033B1 (fr)
AT (1) ATE122057T1 (fr)
AU (2) AU641634B2 (fr)
CA (1) CA2006684C (fr)
DE (1) DE68922491T2 (fr)
DK (1) DK171826B1 (fr)
ES (1) ES2074562T3 (fr)
FI (1) FI101476B (fr)
WO (1) WO1990007524A1 (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5298599A (en) * 1988-12-30 1994-03-29 Oklahoma Medical Research Foundation Expression and purification of recombinant soluble tissue factor
AT402262B (de) * 1991-06-20 1997-03-25 Immuno Ag Arzneimittel enthaltend aktiviertes protein c
EP0651655A4 (fr) * 1992-07-24 1996-05-29 Oklahoma Med Res Found Reduction d'hemorragie microvasculaire en cours de chirurgie par blocage d'activation de proteine c.
PT658168E (pt) * 1992-08-27 2001-04-30 Sanquin Bloedvoorziening Anticorpos especificos para uma proteina hemostatica sua utilizacao para isolamento da proteina intacta composicoes hemostaticas desprovidas de produtos de clivagem proteolitica da proteina
DE4320294A1 (de) * 1993-06-18 1994-12-22 Immuno Ag Verwendung von humanem Protein C zur Verhinderung und Behandlung von Thrombozytenablagerungen
US5532136A (en) * 1993-06-22 1996-07-02 Bionebraska, Inc. Monoclonal antibody assay and kit for detecting metal cations in body fluids
JPH08512323A (ja) * 1993-07-09 1996-12-24 スミスクライン・ビーチャム・コーポレイション タンパク精製方法
HRP940645A2 (en) * 1993-10-06 1996-12-31 Immuno Ag Process for virus deactivation in the presence of polyalkylene glycol and the pharmaceutical preparation thus obtained
DE69535855D1 (de) * 1994-06-10 2008-11-20 Oklahoma Med Res Found Calciumbindende rekombinante antikörper gegen protein c
TW200407335A (en) 2002-07-22 2004-05-16 Chugai Pharmaceutical Co Ltd Non-neutralizing antibody to inhibit the inactivation of activated protein C
DK2708559T3 (en) 2008-04-11 2018-06-14 Chugai Pharmaceutical Co Ltd Antigen-binding molecule capable of repeatedly binding two or more antigen molecules
JP6030452B2 (ja) 2010-11-30 2016-11-24 中外製薬株式会社 複数分子の抗原に繰り返し結合する抗原結合分子
CN103492565B (zh) 2011-02-25 2021-01-29 中外制药株式会社 FcγRIIb特异性Fc抗体
EP3939996A1 (fr) 2011-09-30 2022-01-19 Chugai Seiyaku Kabushiki Kaisha Molécule se liant à l'antigène favorisant la disparition des antigènes ayant une pluralité d'activités biologiques
US20160229922A1 (en) * 2013-09-20 2016-08-11 Chugai Seiyaku Kabushiki Kaisha Treatment for hemorrhagic diseases by anti-protein-c antibody
TW201809008A (zh) 2014-12-19 2018-03-16 日商中外製藥股份有限公司 抗ｃ５抗體及使用方法
US10000560B2 (en) 2014-12-19 2018-06-19 Chugai Seiyaku Kabushiki Kaisha Anti-myostatin antibodies, polypeptides containing variant Fc regions, and methods of use
WO2017110981A1 (fr) 2015-12-25 2017-06-29 Chugai Seiyaku Kabushiki Kaisha Anticorps anti-myostatine et procédés d'utilisation
CA3026050A1 (fr) 2016-08-05 2018-02-08 Chugai Seiyaku Kabushiki Kaisha Composition pour la prophylaxie ou le traitement de maladies liees a il-8
JP7191833B2 (ja) 2017-01-30 2022-12-19 中外製薬株式会社 抗スクレロスチン抗体およびその使用

Also Published As

Publication number Publication date
AU4968390A (en) 1990-08-01
KR940002033B1 (ko) 1994-03-14
DE68922491T2 (de) 1995-11-09
JPH03504332A (ja) 1991-09-26
CA2006684C (fr) 1996-12-17
AU641634B2 (en) 1993-09-30
WO1990007524A1 (fr) 1990-07-12
ES2074562T3 (es) 1995-09-16
CA2006684A1 (fr) 1990-06-30
AU4422893A (en) 1994-01-27
ATE122057T1 (de) 1995-05-15
EP0407544A1 (fr) 1991-01-16
FI904262A0 (fi) 1990-08-29
DK209090A (da) 1990-08-30
DE68922491D1 (de) 1995-06-08
FI101476B (fi) 1998-06-30
AU669540B2 (en) 1996-06-13
KR910700266A (ko) 1991-03-14
DK171826B1 (da) 1997-06-23
DK209090D0 (da) 1990-08-30
EP0407544B1 (fr) 1995-05-03
JP2559537B2 (ja) 1996-12-04

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Owner name: OKLAHOMA MEDICAL RESEARCH FOUNDATION