ES8900214A1 - Proceso para la fabricacion de compuestos de espiro-hidantoina. - Google Patents

Proceso para la fabricacion de compuestos de espiro-hidantoina.

Info

Publication number
ES8900214A1
ES8900214A1 ES535798A ES535798A ES8900214A1 ES 8900214 A1 ES8900214 A1 ES 8900214A1 ES 535798 A ES535798 A ES 535798A ES 535798 A ES535798 A ES 535798A ES 8900214 A1 ES8900214 A1 ES 8900214A1
Authority
ES
Spain
Prior art keywords
compounds
spiro
inhibitors
aldose reductase
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES535798A
Other languages
English (en)
Other versions
ES535798A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alcon Vision LLC
Original Assignee
Alcon Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcon Laboratories Inc filed Critical Alcon Laboratories Inc
Publication of ES535798A0 publication Critical patent/ES535798A0/es
Publication of ES8900214A1 publication Critical patent/ES8900214A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/65—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by splitting-off hydrogen atoms or functional groups; by hydrogenolysis of functional groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/96—Spiro-condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/28—Halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/78—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D127/00—Coating compositions based on homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a halogen; Coating compositions based on derivatives of such polymers
    • C09D127/02—Coating compositions based on homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a halogen; Coating compositions based on derivatives of such polymers not modified by chemical after-treatment
    • C09D127/04—Coating compositions based on homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a halogen; Coating compositions based on derivatives of such polymers not modified by chemical after-treatment containing chlorine atoms
    • C09D127/06—Homopolymers or copolymers of vinyl chloride

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Materials Engineering (AREA)
  • Wood Science & Technology (AREA)
  • Diabetes (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pyrane Compounds (AREA)
  • Indole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

METODO DE FABRICAR COMPUESTOS DE ESPRIO-HIDANTOINA. N CONSISTE EN CONDENSAR UN TRICICLO DE ACETONA DE FORMULA (II) CON UN CIANURO DE METAL DE ALCALI Y CARBONATO AMONICO, EN PRESENCIA DE UNA ACETONA, SOLUBILIZANDO UN DISOLVENTE ORGANICO INERTE, A TEMPERATURA DESDE 60 A 180G, EN LA QUE LOS EXCESOS ESTEQUIOMETRICOS DE CIANURO DE METAL DE ALCALI Y EL CARBONATO AMONICO SON HECHOS REACCIONAR EN RELACION CON LA ACETONA, PARA OBTENER COMPUESTOS DE ESPIRO-HIDANTOINA DE FORMULA (I) DONDE A Y B SON ANILLOS AROMATICOS CONECTADOS A TRAVES DE DOS POSICIONES ADYACENTES A UN ANILLO CENTRAL DE CINCO MIEMBROS. TIENEN UTILIDADES FARMACEUTICAS PARA TRATAR LA DIABETES. *FORMULA*
ES535798A 1983-09-14 1984-09-10 Proceso para la fabricacion de compuestos de espiro-hidantoina. Expired ES8900214A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/532,168 US4537892A (en) 1983-09-14 1983-09-14 Spiro-tricyclicaromatic succinimide derivatives as inhibitors of aldose reductase

Publications (2)

Publication Number Publication Date
ES535798A0 ES535798A0 (es) 1989-04-01
ES8900214A1 true ES8900214A1 (es) 1989-04-01

Family

ID=24120635

Family Applications (4)

Application Number Title Priority Date Filing Date
ES535798A Expired ES8900214A1 (es) 1983-09-14 1984-09-10 Proceso para la fabricacion de compuestos de espiro-hidantoina.
ES551436A Expired ES8800570A1 (es) 1983-09-14 1986-01-30 Proceso para la fabricacion de compuestos de espiro-hidantoina
ES551434A Expired ES8800572A1 (es) 1983-09-14 1986-01-30 Proceso para la fabricacion de compuestos de espiro-hidantoina
ES551435A Expired ES8800915A1 (es) 1983-09-14 1986-01-30 Proceso para la fabricacion de compuestos de espiro-hidantoina

Family Applications After (3)

Application Number Title Priority Date Filing Date
ES551436A Expired ES8800570A1 (es) 1983-09-14 1986-01-30 Proceso para la fabricacion de compuestos de espiro-hidantoina
ES551434A Expired ES8800572A1 (es) 1983-09-14 1986-01-30 Proceso para la fabricacion de compuestos de espiro-hidantoina
ES551435A Expired ES8800915A1 (es) 1983-09-14 1986-01-30 Proceso para la fabricacion de compuestos de espiro-hidantoina

Country Status (13)

Country Link
US (1) US4537892A (es)
EP (1) EP0137333B1 (es)
JP (1) JPH0825877B2 (es)
AT (1) ATE84026T1 (es)
AU (1) AU579111B2 (es)
CA (1) CA1269661A (es)
DE (1) DE3486020T2 (es)
ES (4) ES8900214A1 (es)
IE (1) IE59949B1 (es)
IL (1) IL72900A (es)
NZ (1) NZ209199A (es)
PT (1) PT79207B (es)
ZA (1) ZA847277B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5153211A (en) * 1983-09-14 1992-10-06 Alcon Laboratories, Inc. Spiro-tricyclicaromatic succinimide derivatives as inhibitors of aldose reductase
US5070100A (en) * 1983-09-14 1991-12-03 Alcon Laboratories, Inc. Spiro-tricyclicaromatic succinimide derivatives
US4717725A (en) * 1984-04-11 1988-01-05 Alcon Laboratories, Inc. Ophthalmic wound healing with aldose reductase inhibitors
AU598366B2 (en) * 1987-03-20 1990-06-21 Alcon Laboratories, Inc. Use of aldose reductase inhibitors to enhance insulin sensitivity in diabetes
CA1322526C (en) * 1987-06-04 1993-09-28 John I. Clark Chemical prevention or reversal of cataract by phase separation inhibitors
US5401880A (en) * 1987-06-04 1995-03-28 Oculon Corporation Chemical prevention or reversal of cataract by phase separation inhibitors
US5091421A (en) * 1987-06-04 1992-02-25 Massachusetts Institute Of Technology Chemical prevention or reversal of cataract by phase separation inhibitors
US5338545A (en) * 1987-06-04 1994-08-16 Oculon Corporation Chemical prevention or reversal of cataract by phase separation inhibitors
US5290813A (en) * 1987-06-04 1994-03-01 Massachusetts Institute Of Technology Chemical prevention or reversal of cataract by phase separation inhibitors
US4968809A (en) * 1988-11-04 1990-11-06 Dupriest Mark T Spirofluoreneisothiazolidinone dioxides as aldose reductase inhibitors
US5221686A (en) * 1992-08-04 1993-06-22 American Home Products Corporation Spiro[1,2-benzisothiazole-3(2H),5'-oxazolidine]-2',4'-dione 1,1-dioxides as antihyperglycemic agents
US5760246A (en) * 1996-12-17 1998-06-02 Biller; Scott A. Conformationally restricted aromatic inhibitors of microsomal triglyceride transfer protein and method
GB2355264A (en) 1999-09-30 2001-04-18 Merck & Co Inc Spirohydantoin derivatives useful as alpha 1a adrenoceptor antagonists
AU2006314062A1 (en) * 2005-11-21 2007-05-24 Mordechai Sharir Succinimide derivatives as ocular hypotensive agents
US8853257B2 (en) 2005-11-21 2014-10-07 Mordechai Sharir Succinimide derivatives as ocular hypotensive agents

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3821383A (en) * 1972-07-10 1974-06-28 Ayerst Mckenna & Harrison Compositions for and a method of treating diabetic complications
US4117230A (en) * 1976-10-18 1978-09-26 Pfizer Inc. Hydantoin derivatives as therapeutic agents
US4209630A (en) * 1976-10-18 1980-06-24 Pfizer Inc. Hydantoin derivatives as therapeutic agents
US4130714A (en) * 1977-05-23 1978-12-19 Pfizer Inc. Hydantoin therapeutic agents
US4127665A (en) * 1978-01-18 1978-11-28 Pfizer Inc. Thienohydantoin derivatives
DE3262294D1 (en) * 1981-05-13 1985-03-28 Ici Plc Pharmaceutical compositions containing spiro succinimide derivatives
IL68314A0 (en) * 1982-04-15 1983-07-31 Alcon Lab Inc Method and composition for inhibiting aldose reductase activity and process for preparing spirofluorofluoren and spiro-difluorofluoren compounds
DK277484A (da) * 1983-06-23 1984-12-24 Hoffmann La Roche Thiazolidinderivater
WO1986002647A1 (en) * 1984-10-30 1986-05-09 Pfizer Inc. Spiro-heteroazolones for treatment of diabetes complications

Also Published As

Publication number Publication date
ES8800915A1 (es) 1987-12-01
JPH0825877B2 (ja) 1996-03-13
ES551435A0 (es) 1987-12-01
ES551434A0 (es) 1987-11-01
US4537892A (en) 1985-08-27
ES535798A0 (es) 1989-04-01
CA1269661A (en) 1990-05-29
ES8800572A1 (es) 1987-11-01
AU579111B2 (en) 1988-11-17
JPS6089469A (ja) 1985-05-20
ATE84026T1 (de) 1993-01-15
DE3486020T2 (de) 1993-05-19
EP0137333A2 (en) 1985-04-17
IE59949B1 (en) 1994-05-04
NZ209199A (en) 1988-04-29
IL72900A (en) 1989-01-31
DE3486020D1 (de) 1993-02-11
PT79207B (en) 1986-08-14
PT79207A (en) 1984-10-01
EP0137333A3 (en) 1986-03-05
ES551436A0 (es) 1987-11-01
IE842331L (en) 1985-03-14
EP0137333B1 (en) 1992-12-30
ES8800570A1 (es) 1987-11-01
ZA847277B (en) 1985-05-29
AU3254784A (en) 1985-10-03
IL72900A0 (en) 1984-12-31

Similar Documents

Publication Publication Date Title
AU579111B2 (en) Spiro-tricyclicaromatic succinimide derivatives as inhibitors of aldose reductase
ZA847731B (en) 2-amino-5-hydroxy-4-methylpyrimidine derivates
EP1026157A3 (en) Method for the synthesis of huperzine A and analogs thereof and compounds useful therein
ES8800679A1 (es) Un procedimiento para preparar derivados de piperiliden-dihidrodibenzo-(a,d)-cicloheptenos y derivados aza
PL288409A1 (en) Method of obtaining novel derivatives of 4-phenyl-4-piperidinecarboxyamide
ES8106892A1 (es) Un procedimiento para preparar derivados de fenilpiperidina
GB2005259A (en) Hexahydropyrrolo indole derivatives
IE38979L (en) Tetrazolyl - quinoxalinecarboxamide derivatives
ES480113A1 (es) Procedimiento para la preparacion de nuevos derivados de 2- iminoimidazolidina.
NZ220800A (en) Tetrahydrobenzothiazoles and pharmaceutical compositions
IT1210926B (it) Derivati della 1-metil-5-nitro-imidazolina e composizioni terapeutiche che li comprendono come principio attivo.
ES2046528T3 (es) Derivados heterotetraciclicos de lactamas, proceso para su preparacion y composiciones farmaceuticas a base de los mismos.
GB1498857A (en) Antidepressant composition
JPS5285163A (en) Preparation of malenimide derivatives
JPS5251362A (en) Preparation of optically active pyrrolidine derivatives
JPS5285164A (en) Preparatin of maleinimide compounds
JPS52111576A (en) Synthesis of 5,7,8-trimethyl-3,4-dehydrotocotrienol
JPS5675428A (en) Hypoglycemic agent containing procainamide hydrochloride
JPS57159711A (en) Low oxygen cell sensitizer for radiation
JPS5489040A (en) Anti-ulcer agent
JPS5248692A (en) Preparation of homo-pyriimidazole derivatives
JPS5210253A (en) Preparation of tetracyclo(5,4,1,13,10,07 13) tridecan-8-one
FR2379505A1 (fr) Nouveaux produits doues notamment de proprietes therapeutiques, leurs procedes de preparation, et medicaments a base de ces produits
GR79114B (es)
JPS5325558A (en) Novel pyrrole derivatives and their preparation

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20010301