ES8802321A1 - Procedimiento para preparar peptidos difluorcetonicos - Google Patents

Procedimiento para preparar peptidos difluorcetonicos

Info

Publication number
ES8802321A1
ES8802321A1 ES557735A ES557735A ES8802321A1 ES 8802321 A1 ES8802321 A1 ES 8802321A1 ES 557735 A ES557735 A ES 557735A ES 557735 A ES557735 A ES 557735A ES 8802321 A1 ES8802321 A1 ES 8802321A1
Authority
ES
Spain
Prior art keywords
derivatives
following examples
set out
pages following
formula set
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES557735A
Other languages
English (en)
Other versions
ES557735A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zeneca Inc
Original Assignee
ICI Americas Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB858514436A external-priority patent/GB8514436D0/en
Priority claimed from GB858514440A external-priority patent/GB8514440D0/en
Priority claimed from GB858514438A external-priority patent/GB8514438D0/en
Application filed by ICI Americas Inc filed Critical ICI Americas Inc
Publication of ES8802321A1 publication Critical patent/ES8802321A1/es
Publication of ES557735A0 publication Critical patent/ES557735A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/16—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/18—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by doubly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

LOS PEPTIDOS DIFLUORCETONICOS (I), (() O (III), DONDE NO EXCLUSIVAMENTE, R1 Y R2 SON ISOPROPILO, R3 ES (BENCENOSULFONILAMINOCARBONIL)FENILO; A CARBONILO U OXICARBONILO, R4 HIDROGENO Y RA ES -CH2RB, CON R3 ALQUILO C1-10; SE OBTIENEN HACIENDO REACCIONAR UN ACIDO CARBOXILICO, DE FORMULA (I), (II) O (III), CON UNA SULFONAMIDA C1-6 (ALCANO O BENCENOSULFONAMIDA), EN PRESENCIA DE UN DESHIDRATANTE, COMO UNA CARBODIIMIDA SOLUBLE EN AGUA O DISOLVENTE ADECUADO ENTRE 10 Y 30JC. SON INHIBIDORES DE LA ELASTASA DE LEUCOCITOS HUMANOS (HLE) POR LO QUE PUEDEN APLICARSE AL TRATAMIENTO DEL ENFISEMA PULMONAR, ATEROSCLEROSIS, ARTRITIS REUMATOIDE Y OSTEOARTRITIS.
ES557735A 1985-06-07 1987-09-16 Procedimiento para preparar peptidos difluorcetonicos Expired ES8802321A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB858514436A GB8514436D0 (en) 1985-06-07 1985-06-07 Selected difluoro derivatives
GB858514440A GB8514440D0 (en) 1985-06-07 1985-06-07 Difluoro ketone tripeptide derivatives
GB858514438A GB8514438D0 (en) 1985-06-07 1985-06-07 Selected difluoro ketone dipeptide derivatives

Publications (2)

Publication Number Publication Date
ES8802321A1 true ES8802321A1 (es) 1988-05-01
ES557735A0 ES557735A0 (es) 1988-05-01

Family

ID=27262698

Family Applications (4)

Application Number Title Priority Date Filing Date
ES555826A Expired ES8801305A1 (es) 1985-06-07 1986-06-06 Procedimiento para preparar peptidos difluorcetonicos
ES557735A Expired ES8802321A1 (es) 1985-06-07 1987-09-16 Procedimiento para preparar peptidos difluorcetonicos
ES557733A Expired ES8802619A1 (es) 1985-06-07 1987-09-16 Procedimiento para preparar peptidos difluorcetonicos
ES557734A Expired ES8900051A1 (es) 1985-06-07 1987-09-16 Procedimiento para preparar peptidos difluorcetonicos

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES555826A Expired ES8801305A1 (es) 1985-06-07 1986-06-06 Procedimiento para preparar peptidos difluorcetonicos

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES557733A Expired ES8802619A1 (es) 1985-06-07 1987-09-16 Procedimiento para preparar peptidos difluorcetonicos
ES557734A Expired ES8900051A1 (es) 1985-06-07 1987-09-16 Procedimiento para preparar peptidos difluorcetonicos

Country Status (16)

Country Link
US (1) US4880780A (es)
EP (1) EP0204571B1 (es)
JP (1) JPH07116159B2 (es)
AT (1) ATE71934T1 (es)
AU (1) AU594683B2 (es)
DE (1) DE3683541D1 (es)
DK (1) DK267686A (es)
ES (4) ES8801305A1 (es)
FI (1) FI86859C (es)
GR (1) GR861488B (es)
HU (1) HU208438B (es)
IE (1) IE59146B1 (es)
IL (1) IL79049A0 (es)
NO (1) NO170585C (es)
NZ (1) NZ216437A (es)
PT (1) PT82724B (es)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8600263D0 (en) * 1985-01-22 1986-02-12 Ici America Inc Peptide derivatives
US5496927A (en) * 1985-02-04 1996-03-05 Merrell Pharmaceuticals Inc. Peptidase inhibitors
ES2052560T3 (es) * 1986-06-05 1994-07-16 Ici America Inc Compuestos difluorcetonicos.
GB8613703D0 (en) * 1986-06-05 1986-07-09 Ici America Inc Difluoro peptide compounds
GB8809316D0 (en) * 1987-05-11 1988-05-25 Ici America Inc Heterocyclic ketones
EP0371179A1 (en) * 1988-10-28 1990-06-06 Merrell Dow Pharmaceuticals Inc. Novel analogs of peptidase substrates
EP0369391A3 (en) * 1988-11-15 1991-09-25 Boehringer Ingelheim Pharmaceuticals Inc. N-substituted amides
GB8910547D0 (en) * 1989-05-08 1989-06-21 Ici America Inc Substituted ketones
US5221665A (en) * 1989-10-27 1993-06-22 Boehringer Ingelheim Pharmaceuticals, Inc. N-substituted amides
US5391705A (en) * 1991-03-15 1995-02-21 Merrell Dow Pharmaceuticals Inc. Polyfluorinated tripeptide thrombin inhibitors
AU655301B2 (en) * 1991-05-23 1994-12-15 Merrell Pharmaceuticals Inc. Inhibitors of cathepsin G and elastase for preventing connective tissue degradation
US5478811A (en) * 1991-08-22 1995-12-26 Merrell Dow Pharmaceuticals Inc. Orally-active elastase inhibitors
US5714470A (en) 1991-08-22 1998-02-03 Merrell Pharmaceuticals, Inc. Orally-active elastase inhibitors
US5486529A (en) * 1992-04-16 1996-01-23 Zeneca Limited Certain pyridyl ketones for treating diseases involving leukocyte elastase
IL108031A0 (en) * 1992-12-22 1994-04-12 Procter & Gamble Difluoro pentapeptide derivatives and pharmaceutical compositions containing them
PT804465E (pt) * 1994-06-02 2003-12-31 Aventis Pharma Inc Novos inibidores da elastase
HU221310B1 (en) * 1994-06-02 2002-09-28 Merrell Pharma Inc Acylated enol di and tripeptide derivatives, their use and pharmaceutical compositions comprising thereof
HU221311B1 (en) * 1994-06-02 2002-09-28 Merrell Pharma Inc Perfluoroalkyl tripeptides inhibitors of elastase, pharmaceutical compositions comprising thereof and their use
US6069232A (en) * 1995-10-02 2000-05-30 Hoechst Marion Roussel, Inc. Polyfluoroalkyl tryptophan tripeptide thrombin inhibitors
US6172044B1 (en) 1995-12-01 2001-01-09 Aventis Pharmaceuticals Inc. Acylated enol derivative of α-ketoesters and α-ketoamides
US5948886A (en) * 1996-11-20 1999-09-07 Hoechst Marion Roussel, Inc. Acylated enol derivatives of α-ketoesters and α-ketoamides
US6673784B1 (en) 1996-03-19 2004-01-06 G. D. Searle & Co. Electrophilic ketones for the treatment of herpesvirus infections
US5739354A (en) * 1996-03-26 1998-04-14 Hoechst Marion Roussel, Inc. Process for the preparation of N-methyl-D-phenylalanyl-N- 1- 3- (aminoiminomethyl)amino!propyl!-3,3-difluoro-2-oxohexyl!-L-prolinamide
CZ298749B6 (cs) 1996-10-18 2008-01-16 Vertex Pharmaceuticals Incorporated Inhibitory serinových proteáz a farmaceutické prostředky s jejich obsahem
SV2003000617A (es) 2000-08-31 2003-01-13 Lilly Co Eli Inhibidores de la proteasa peptidomimetica ref. x-14912m
AR045596A1 (es) 2003-09-05 2005-11-02 Vertex Pharma Inhibidores de proteasas de serina en particular proteasa ns3-ns4a del vhc
US7964624B1 (en) 2005-08-26 2011-06-21 Vertex Pharmaceuticals Incorporated Inhibitors of serine proteases
AR055395A1 (es) 2005-08-26 2007-08-22 Vertex Pharma Compuestos inhibidores de la actividad de la serina proteasa ns3-ns4a del virus de la hepatitis c
JP5436864B2 (ja) 2006-02-27 2014-03-05 バーテックス ファーマシューティカルズ インコーポレイテッド Ｖｘ−９５０を含む共結晶体およびそれを含む医薬組成物
MX2008011868A (es) * 2006-03-16 2008-12-15 Vertex Pharma Inhibidores deuterados de la proteasa de la hepatitis c.
EP2099454A4 (en) * 2006-11-17 2010-11-10 Abbott Lab AMINOPYRROLIDINES AS CHEMOKINE RECEPTOR ANTAGONISTS
EA200970806A1 (ru) 2007-02-27 2010-08-30 Вертекс Фармасьютикалз Инкорпорейтед Сокристаллы и содержащие их фармацевтические композиции
CN101903392A (zh) 2007-02-27 2010-12-01 弗特克斯药品有限公司 丝氨酸蛋白酶的抑制剂
JP5443360B2 (ja) 2007-08-30 2014-03-19 バーテックス ファーマシューティカルズ インコーポレイテッド 共結晶体およびそれを含む医薬組成物
KR20120089659A (ko) 2009-08-29 2012-08-13 아보트 러보러터리즈 치료용 ｄｌｌ4 결합 단백질
MX348312B (es) 2010-03-02 2017-06-06 Abbvie Inc Proteínas terapéuticas de enlace dll4.
CN103298834A (zh) 2010-08-03 2013-09-11 Abbvie公司 双重可变结构域免疫球蛋白及其用途
RU2636043C2 (ru) 2012-11-01 2017-11-17 Эббви Инк. Анти-vegf/dll4-иммуноглобулины с двойными вариабельными доменами и их применения
WO2016094881A2 (en) 2014-12-11 2016-06-16 Abbvie Inc. Lrp-8 binding proteins
TW201710286A (zh) 2015-06-15 2017-03-16 艾伯維有限公司 抗ｖｅｇｆ、ｐｄｇｆ及／或其受體之結合蛋白
US20220267699A1 (en) * 2019-07-01 2022-08-25 Basf Se Peptide acetals for stabilising enzymes

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE787249A (fr) 1971-08-05 1973-02-05 Squibb & Sons Inc Derives amino d'acides pyrazolopyridine carboxyliques, leurs esters et les sels de ces composes, ainsi que leurs procedes de preparation
US3935280A (en) 1975-01-10 1976-01-27 Aldrich-Boranes, Inc. Reduction of amino acids in the presence of boron trifluoride
US4277395A (en) * 1980-06-16 1981-07-07 Richardson-Merrell Inc. Novel enzyme inhibitors
DE3481913D1 (de) 1983-04-27 1990-05-17 Ici America Inc Prolin-derivate.
US4518528A (en) * 1983-05-19 1985-05-21 Rasnick David W α Amino fluoro ketones
GB8600263D0 (en) * 1985-01-22 1986-02-12 Ici America Inc Peptide derivatives

Also Published As

Publication number Publication date
IE861513L (en) 1986-12-07
ES557734A0 (es) 1988-11-16
HUT40811A (en) 1987-02-27
JPS6253951A (ja) 1987-03-09
ES555826A0 (es) 1987-12-16
IE59146B1 (en) 1994-01-12
NO170585B (no) 1992-07-27
FI86859B (fi) 1992-07-15
ES557733A0 (es) 1988-09-01
ES8802619A1 (es) 1988-09-01
PT82724B (pt) 1988-12-15
JPH07116159B2 (ja) 1995-12-13
FI862434A (fi) 1986-12-08
EP0204571A2 (en) 1986-12-10
FI862434A0 (fi) 1986-06-06
ATE71934T1 (de) 1992-02-15
NO862269D0 (no) 1986-06-06
AU594683B2 (en) 1990-03-15
ES8900051A1 (es) 1988-11-16
DK267686A (da) 1986-12-08
GR861488B (en) 1986-09-05
ES557735A0 (es) 1988-05-01
IL79049A0 (en) 1986-09-30
ES8801305A1 (es) 1987-12-16
DK267686D0 (da) 1986-06-06
NO170585C (no) 1992-11-04
DE3683541D1 (de) 1992-03-05
NO862269L (no) 1986-12-08
PT82724A (en) 1986-07-01
EP0204571B1 (en) 1992-01-22
EP0204571A3 (en) 1988-09-21
HU208438B (en) 1993-10-28
US4880780A (en) 1989-11-14
AU5845486A (en) 1986-12-18
FI86859C (fi) 1992-10-26
NZ216437A (en) 1990-06-26

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20000201