ES8801246A1 - Procedimiento para preparar derivados de fenilpirazina - Google Patents

Procedimiento para preparar derivados de fenilpirazina

Info

Publication number
ES8801246A1
ES8801246A1 ES557313A ES557313A ES8801246A1 ES 8801246 A1 ES8801246 A1 ES 8801246A1 ES 557313 A ES557313 A ES 557313A ES 557313 A ES557313 A ES 557313A ES 8801246 A1 ES8801246 A1 ES 8801246A1
Authority
ES
Spain
Prior art keywords
substituted phenyl
piperazine derivatives
phenyl piperazine
aggression
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES557313A
Other languages
English (en)
Other versions
ES557313A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of ES8801246A1 publication Critical patent/ES8801246A1/es
Publication of ES557313A0 publication Critical patent/ES557313A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Anesthesiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE FENILPIPERAZINA Y DE SUS SALES FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I). COMPRENDE LA REACCION DE UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA (III), PARA FORMAR UN COMPUESTO DE FORMULA (I), EN LAS QUE HAL REPRESENTA UN ATOMO DE HALOGENO, R1 ES HIDROGENO O FENILO Y R2 ES ALQUILO C1-6. LA REACCION SE EFECTUA EN UN DISOLVENTE ORGANICO INERTE, EN PRESENCIA DE UNA BASE, A UNA TEMPERATURA COMPRENDIDA ENTRE 50JC Y 200JC. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL APACIGUAMIENTO Y LA INHIBICION DE LA AGRESION EN ANIMALES.
ES557313A 1984-11-22 1987-01-14 Procedimiento para preparar derivados de fenilpirazina Expired ES8801246A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19843442570 DE3442570A1 (de) 1984-11-22 1984-11-22 Neue substituierte phenylpiperazinderivate, verfahren zu deren herstellung und die verwendung substituierter phenylpiperazinderivate als aggressionshemmer fuer tiere

Publications (2)

Publication Number Publication Date
ES8801246A1 true ES8801246A1 (es) 1988-01-01
ES557313A0 ES557313A0 (es) 1988-01-01

Family

ID=6250865

Family Applications (2)

Application Number Title Priority Date Filing Date
ES549076A Expired ES8704935A1 (es) 1984-11-22 1985-11-20 Procedimiento para preparar derivados de fenilpiperazina
ES557313A Expired ES8801246A1 (es) 1984-11-22 1987-01-14 Procedimiento para preparar derivados de fenilpirazina

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES549076A Expired ES8704935A1 (es) 1984-11-22 1985-11-20 Procedimiento para preparar derivados de fenilpiperazina

Country Status (14)

Country Link
US (1) US4746661A (es)
EP (1) EP0182247A1 (es)
JP (1) JPS61129167A (es)
KR (1) KR860004051A (es)
CN (1) CN85108214A (es)
AU (1) AU5025285A (es)
DE (1) DE3442570A1 (es)
DK (1) DK538185A (es)
ES (2) ES8704935A1 (es)
GR (1) GR852799B (es)
HU (1) HU195803B (es)
IL (1) IL77113A0 (es)
PT (1) PT81529B (es)
ZA (1) ZA858936B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4803203A (en) * 1986-11-05 1989-02-07 Warner-Lambert Company Phenyl and heterocyclic piperazinyl alkoxy-benzheterocyclic compounds as antipsychotic agents
US5006528A (en) * 1988-10-31 1991-04-09 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives
EP2162135A4 (en) * 2007-05-21 2012-02-22 Reviva Pharmaceuticals Inc COMPOSITIONS, SYNTHESIS AND METHOD FOR THE APPLICATION OF ATTAINED CHINOLINONE-BASED ANTIPSYCHOTICS
CN103497114A (zh) * 2007-06-29 2014-01-08 埃莫里大学 用于神经保护的nmda受体拮抗剂
WO2009137843A2 (en) * 2008-05-09 2009-11-12 Emory University Nmda receptor antagonists for the treatment of neuropsychiatric disorders

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5089221A (es) * 1973-12-10 1975-07-17
JPS54130587A (en) * 1978-03-30 1979-10-09 Otsuka Pharmaceut Co Ltd Carbostyryl derivative
EP0005828B1 (de) * 1978-06-06 1981-03-11 Hoechst Aktiengesellschaft Neue substituierte Phenylpiperazinderivate, diese enthaltende Arzneimittel und Verfahren zu deren Herstellung
DE2853996A1 (de) * 1978-12-14 1980-07-03 Hoechst Ag Neue substituierte phenylpiperazinderivate und verfahren zu deren herstellung
DE2827566A1 (de) * 1978-06-23 1980-01-10 Boehringer Mannheim Gmbh 1,2-dihydro-chinolin-2-on-derivate und verfahren zu ihrer herstellung
JPS6122351A (ja) * 1984-07-10 1986-01-30 Toshiba Corp アモルフアスシリコン感光体
JPS6164186A (ja) * 1984-09-06 1986-04-02 三菱電機株式会社 電子部品リ−ドレスパツケ−ジの実装構造

Also Published As

Publication number Publication date
PT81529A (de) 1985-12-01
ES549076A0 (es) 1987-04-16
PT81529B (de) 1987-06-12
US4746661A (en) 1988-05-24
IL77113A0 (en) 1986-04-29
CN85108214A (zh) 1986-08-20
GR852799B (es) 1986-03-19
ES8704935A1 (es) 1987-04-16
DK538185D0 (da) 1985-11-21
HUT39742A (en) 1986-10-29
DE3442570A1 (de) 1986-05-22
JPS61129167A (ja) 1986-06-17
AU5025285A (en) 1986-05-29
ES557313A0 (es) 1988-01-01
KR860004051A (ko) 1986-06-16
EP0182247A1 (de) 1986-05-28
ZA858936B (en) 1986-07-30
DK538185A (da) 1986-05-23
HU195803B (en) 1988-07-28

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