ES8706662A1 - Procedimiento para la obtencion del antipoda levogiro y dextrogiro del racemato del acido 5-cloro-6-(3-clorobencenosulfonil)-1,3-benzodioxol-2-carboxilico - Google Patents

Procedimiento para la obtencion del antipoda levogiro y dextrogiro del racemato del acido 5-cloro-6-(3-clorobencenosulfonil)-1,3-benzodioxol-2-carboxilico

Info

Publication number
ES8706662A1
ES8706662A1 ES555600A ES555600A ES8706662A1 ES 8706662 A1 ES8706662 A1 ES 8706662A1 ES 555600 A ES555600 A ES 555600A ES 555600 A ES555600 A ES 555600A ES 8706662 A1 ES8706662 A1 ES 8706662A1
Authority
ES
Spain
Prior art keywords
pharmaceutical compositions
preparation
racemate
salts
cases
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES555600A
Other languages
English (en)
Other versions
ES555600A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of ES555600A0 publication Critical patent/ES555600A0/es
Publication of ES8706662A1 publication Critical patent/ES8706662A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

METODO DE OBTENER ANTIPODA LEVOGIRO Y DEXTROGIRO DEL RACEMATO DEL ACIDO 5-CLORO-6-(3-CLORBENCENOSULFONIL)-1,3-BENZODIOXOL-2-CARBOXILICO. CONSISTE EN OXIDAR UN COMPUESTO DE FORMULA (II), PARA OBTENER EL COMPUESTO DESEADO DE FORMULA (I) Y SUS SALES CON BASE Y ESTERES DE ALQUILO INFERIOR DEL RACEMATO. LA OXIDACION SE REALIZA MEDIANTE PEROXIDO DE HIDROGENO, EN UN DISOLVENTE ORGANICO U ORGANICO-ACUOSO INERTE, TAL COMO ACETICO CONTENIENDO AGUA, A TEMPERATURAS ENTRE 60 Y 100GC, Y CON UNA CANTIDAD MAS DE DOS VECES MOLAR DE PEROXIDO DE HIDROGENO CUANDO COMO PRODUCTO DE OXIDACION SE HA DE OBTENER UN COMPUESTO SULFONILO. TIENE APLICACIONES FARMACEUTICAS POR SU EFECTO URICOSURICO. *FORMULA*
ES555600A 1984-04-06 1986-06-02 Procedimiento para la obtencion del antipoda levogiro y dextrogiro del racemato del acido 5-cloro-6-(3-clorobencenosulfonil)-1,3-benzodioxol-2-carboxilico Expired ES8706662A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH175284 1984-04-06

Publications (2)

Publication Number Publication Date
ES555600A0 ES555600A0 (es) 1987-07-01
ES8706662A1 true ES8706662A1 (es) 1987-07-01

Family

ID=4217732

Family Applications (4)

Application Number Title Priority Date Filing Date
ES541965A Expired ES8800192A1 (es) 1984-04-06 1985-04-03 Procedimiento para la obtencion del acido 5-cloro-6-(3-clorobencenosulfonil)-1,3-benzodioxol-2-carboxilico.
ES555600A Expired ES8706662A1 (es) 1984-04-06 1986-06-02 Procedimiento para la obtencion del antipoda levogiro y dextrogiro del racemato del acido 5-cloro-6-(3-clorobencenosulfonil)-1,3-benzodioxol-2-carboxilico
ES555599A Expired ES8800921A1 (es) 1984-04-06 1986-06-02 Procedimiento para la obtencion del antipoda levogiro y dextrogiro del racemato del acido 5-cloro-6-(3-clorobencenosulfonil)-1,3-benzodioxol-2-carboxilico
ES555601A Expired ES8800922A1 (es) 1984-04-06 1986-06-02 Procedimiento para la obtencion del antipoda levogiro y dextrogiro del racemato del acido 5-cloro-6-(3-clorobencenosulfonil)-1,3-benzodioxol-2-carboxilico

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES541965A Expired ES8800192A1 (es) 1984-04-06 1985-04-03 Procedimiento para la obtencion del acido 5-cloro-6-(3-clorobencenosulfonil)-1,3-benzodioxol-2-carboxilico.

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES555599A Expired ES8800921A1 (es) 1984-04-06 1986-06-02 Procedimiento para la obtencion del antipoda levogiro y dextrogiro del racemato del acido 5-cloro-6-(3-clorobencenosulfonil)-1,3-benzodioxol-2-carboxilico
ES555601A Expired ES8800922A1 (es) 1984-04-06 1986-06-02 Procedimiento para la obtencion del antipoda levogiro y dextrogiro del racemato del acido 5-cloro-6-(3-clorobencenosulfonil)-1,3-benzodioxol-2-carboxilico

Country Status (11)

Country Link
EP (1) EP0158596A3 (es)
JP (1) JPS60228473A (es)
AU (1) AU4089185A (es)
DK (1) DK153285A (es)
ES (4) ES8800192A1 (es)
FI (1) FI851335L (es)
GR (1) GR850845B (es)
IL (1) IL74780A0 (es)
NO (1) NO851385L (es)
PT (1) PT80222B (es)
ZA (1) ZA852554B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006055187A1 (en) 2004-10-29 2006-05-26 Kalypsys, Inc. Sulfonyl-substituted bicyclic compounds as modulators of ppar
JP5322650B2 (ja) * 2005-10-25 2013-10-23 カリプシス・インコーポレーテッド Ｐｐａｒ調節剤の塩および代謝障害の治療方法
US20080176861A1 (en) 2007-01-23 2008-07-24 Kalypsys, Inc. Sulfonyl-substituted bicyclic compounds as ppar modulators for the treatment of non-alcoholic steatohepatitis

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR75464B (es) * 1981-04-24 1984-07-20 Ciba Geigy
ATE30722T1 (de) * 1982-10-22 1987-11-15 Ciba Geigy Ag Neue benzodioxolderivate, verfahren zu deren herstellung und entsprechende pharmazeutische zusammensetzungen.

Also Published As

Publication number Publication date
ES8800922A1 (es) 1987-12-01
PT80222A (en) 1985-05-01
ZA852554B (en) 1985-11-27
GR850845B (es) 1985-11-25
PT80222B (en) 1987-04-13
ES8800192A1 (es) 1987-11-01
FI851335L (fi) 1985-10-07
NO851385L (no) 1985-10-07
FI851335A0 (fi) 1985-04-03
EP0158596A2 (de) 1985-10-16
ES541965A0 (es) 1987-11-01
JPS60228473A (ja) 1985-11-13
DK153285D0 (da) 1985-04-03
ES555599A0 (es) 1987-12-01
IL74780A0 (en) 1985-07-31
DK153285A (da) 1985-10-07
ES8800921A1 (es) 1987-12-01
AU4089185A (en) 1985-10-10
ES555601A0 (es) 1987-12-01
ES555600A0 (es) 1987-07-01
EP0158596A3 (de) 1986-08-13

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