ES8706613A1 - Un procedimiento para preparar derivados de 3-oxobutanamido-acetato. - Google Patents

Un procedimiento para preparar derivados de 3-oxobutanamido-acetato.

Info

Publication number
ES8706613A1
ES8706613A1 ES555010A ES555010A ES8706613A1 ES 8706613 A1 ES8706613 A1 ES 8706613A1 ES 555010 A ES555010 A ES 555010A ES 555010 A ES555010 A ES 555010A ES 8706613 A1 ES8706613 A1 ES 8706613A1
Authority
ES
Spain
Prior art keywords
preparation
pyrrolidone derivatives
alkyl
image
protecting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES555010A
Other languages
English (en)
Other versions
ES555010A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ISF SpA
Original Assignee
ISF SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ISF SpA filed Critical ISF SpA
Publication of ES555010A0 publication Critical patent/ES555010A0/es
Publication of ES8706613A1 publication Critical patent/ES8706613A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

METODO DE PREPARAR DERIVADOS DE 3-OXOBUTANAMIDO-ACETATO. CONSISTE EN HACER REACCIONAR BROMURO DE GAMMA-BROMOACETOACETILO O CLORURO DE GAMMA-CLOROACETOACETILO CON UN DERIVADO DE GLICINA DE FORMULA (II), A TEMPERATURA COMPRENDIDA ENTRE -78 Y 10GC, EN UN DISOLVENTE TAL COMO CLORURO DE METILENO, CLOROFORMO, TETRAHIDROFURANO O TOLUENO, SIENDO PREPARADO EL BROMOACETOACETILO O EL CLORURO DE CLOROACETOACETILO IN SITU PARA OBTENER DERIVADOS DE 3-OXOBUTANAMIDO-ACETATO DE FORMULA (I) DONDE X ES CLORO O BROMO; E Y ES NR ELEVADO A 1 R ELEVADO A 2 O UR EN DONDE R ELEVADO A 1 Y R ELEVADO A 2, IGUALES O DIFERENTES SON H O ALQUILO DE C 1 A 3; Y R ES ALQUILO DE C 1 A 3. SON UTILES COMO PSICOTROPOS PARA RESTAURAR LA FUNCION COGNOSCITIVA EN ANIMALES Y SERES HUMANOS. *FORMULA*
ES555010A 1984-04-02 1986-05-16 Un procedimiento para preparar derivados de 3-oxobutanamido-acetato. Expired ES8706613A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT20358/84A IT1173768B (it) 1984-04-02 1984-04-02 Procedimento di preparazione di derivati 1-carbamoilmetilici di 4-idrossi-2-osso-pirrolidina nonche' di intermedi per ottenere tali composti

Publications (2)

Publication Number Publication Date
ES555010A0 ES555010A0 (es) 1987-07-01
ES8706613A1 true ES8706613A1 (es) 1987-07-01

Family

ID=11166012

Family Applications (4)

Application Number Title Priority Date Filing Date
ES541811A Expired ES8700655A1 (es) 1984-04-02 1985-04-01 Un procedimiento para preparar derivados de pirrolidona
ES555011A Expired ES8706601A1 (es) 1984-04-02 1986-05-16 Un procedimiento para preparar haluros de gamma haloacetilo.
ES555009A Expired ES8800136A1 (es) 1984-04-02 1986-05-16 Un procedimiento para preparar derivados de 3-hidroxibutanamido-acetato.
ES555010A Expired ES8706613A1 (es) 1984-04-02 1986-05-16 Un procedimiento para preparar derivados de 3-oxobutanamido-acetato.

Family Applications Before (3)

Application Number Title Priority Date Filing Date
ES541811A Expired ES8700655A1 (es) 1984-04-02 1985-04-01 Un procedimiento para preparar derivados de pirrolidona
ES555011A Expired ES8706601A1 (es) 1984-04-02 1986-05-16 Un procedimiento para preparar haluros de gamma haloacetilo.
ES555009A Expired ES8800136A1 (es) 1984-04-02 1986-05-16 Un procedimiento para preparar derivados de 3-hidroxibutanamido-acetato.

Country Status (20)

Country Link
US (2) US4629797A (es)
EP (1) EP0156655B1 (es)
JP (1) JPH0610191B2 (es)
KR (1) KR920000047B1 (es)
AR (1) AR240917A1 (es)
AT (1) ATE38832T1 (es)
AU (1) AU568274B2 (es)
CA (1) CA1241334A (es)
DE (1) DE3566403D1 (es)
DK (1) DK145485A (es)
ES (4) ES8700655A1 (es)
FI (1) FI82035C (es)
GR (1) GR850819B (es)
HU (1) HU193749B (es)
IL (2) IL74779A (es)
IT (1) IT1173768B (es)
NO (1) NO165676C (es)
NZ (1) NZ211705A (es)
PT (1) PT80202B (es)
ZA (1) ZA852263B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1206699B (it) * 1984-02-27 1989-04-27 Isf Spa Procedimento per preparare derivati di pirrolidone.
EP0223328B1 (en) 1985-07-26 1992-01-29 Denki Kagaku Kogyo Kabushiki Kaisha Process for producing oxiracetam
CH680293A5 (es) * 1990-06-26 1992-07-31 Lonza Ag
KR100498268B1 (ko) * 1997-12-09 2005-11-01 주식회사 엘지생활건강 피롤리돈계 양쪽성 계면활성제
US8904443B2 (en) * 2005-09-07 2014-12-02 Sony Corporation System and method for improving home network GUI response time and presentation
CN101704778B (zh) * 2009-09-30 2012-10-17 厦门市华兴化工有限公司 一种制备4-羟基吡咯烷酮-2-乙酰胺的方法
CN103739538B (zh) * 2011-01-21 2016-03-16 温州智创科技有限公司 一种（s）-奥拉西坦的制备方法
CN102603598B (zh) * 2011-01-21 2014-07-16 重庆润泽医药有限公司 （s）-4-羟基-2-氧代-1-吡咯烷乙酰胺的制备方法
CN102432516B (zh) * 2011-12-14 2013-10-09 山东阿如拉药物研究开发有限公司 奥拉西坦的精制方法
CN102627596B (zh) * 2012-03-16 2016-01-27 天津景寅医药生物技术发展有限公司 一种4-羟基-2-氧代-1-吡咯烷乙酰胺的制备方法
US9069141B2 (en) 2012-12-10 2015-06-30 Baker Hughes Incorporated Fiber optic termination arrangement and method of making the same

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1075564B (it) * 1977-02-11 1985-04-22 Isf Spa Procedimento per la preparazione di derivati pirrolidinici
IT1075280B (it) * 1977-02-11 1985-04-22 Isf Spa Procedimento per la preparazione di derivati pirrolidinici

Also Published As

Publication number Publication date
PT80202A (en) 1985-05-01
EP0156655A3 (en) 1986-02-05
ES8800136A1 (es) 1987-11-01
ES8700655A1 (es) 1986-10-16
CA1255326C (es) 1989-06-06
KR850007586A (ko) 1985-12-07
JPH0610191B2 (ja) 1994-02-09
IL74779A0 (en) 1985-07-31
AR240917A1 (es) 1991-03-27
NO851330L (no) 1985-10-03
ATE38832T1 (de) 1988-12-15
PT80202B (pt) 1987-06-17
US4788300A (en) 1988-11-29
ES555010A0 (es) 1987-07-01
EP0156655A2 (en) 1985-10-02
AU4070485A (en) 1985-10-10
ZA852263B (en) 1985-11-27
EP0156655B1 (en) 1988-11-23
FI82035B (fi) 1990-09-28
ES8706601A1 (es) 1987-07-01
DK145485A (da) 1985-10-03
JPS60231651A (ja) 1985-11-18
US4629797A (en) 1986-12-16
GR850819B (es) 1985-11-25
NO165676B (no) 1990-12-10
ES555009A0 (es) 1987-11-01
DK145485D0 (da) 1985-04-01
NZ211705A (en) 1990-07-26
DE3566403D1 (en) 1988-12-29
IT1173768B (it) 1987-06-24
HUT38310A (en) 1986-05-28
NO165676C (no) 1991-03-20
IL74779A (en) 1990-11-05
IT8420358A0 (it) 1984-04-02
FI82035C (fi) 1991-01-10
AR240917A2 (es) 1991-03-27
FI851244A0 (fi) 1985-03-28
HU193749B (en) 1987-11-30
IL84951A (en) 1990-11-05
ES541811A0 (es) 1986-10-16
FI851244L (fi) 1985-10-03
AU568274B2 (en) 1987-12-17
KR920000047B1 (ko) 1992-01-06
CA1241334A (en) 1988-08-30
ES555011A0 (es) 1987-07-01

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970203