ES8705759A1 - Procedimiento para producir un preparado de enzimas pancrea-ticas en forma comprimida - Google Patents

Procedimiento para producir un preparado de enzimas pancrea-ticas en forma comprimida

Info

Publication number
ES8705759A1
ES8705759A1 ES549757A ES549757A ES8705759A1 ES 8705759 A1 ES8705759 A1 ES 8705759A1 ES 549757 A ES549757 A ES 549757A ES 549757 A ES549757 A ES 549757A ES 8705759 A1 ES8705759 A1 ES 8705759A1
Authority
ES
Spain
Prior art keywords
preparation
enzyme compositions
pancreas enzyme
pancreas
core
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES549757A
Other languages
English (en)
Other versions
ES549757A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of ES8705759A1 publication Critical patent/ES8705759A1/es
Publication of ES549757A0 publication Critical patent/ES549757A0/es
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)

Abstract

METODO DE PRODUCIR UN PREPARADO DE ENZIMAS PANCREATICAS EN FORMA COMPRIMIDA. CONSISTE EN APLICAR EN ETAPAS CONSECUTIVAS, SOBRE LOS NUCLEOS QUE CONTIENEN SUSTANCIA ACTIVA, MOVIDOS EN DISPOSITIVOS GRAGEADORES ADECUADOS, UNA CAPA AISLANTE DE BASE ACUOSA, PARA LO CUAL SE MEZCLAN PRIMERO LOS NUCLEOS MOVIDOS CON UN JARABE CUBRIENTE CALENTADO DE BASE ACUOSA HASTA QUE ESTOS NUCLEOS COMIENZAN A PEGARSE Y A CONTINUACION AÑADIR UN POLVO ESPOLVOREABLE; DESPUES DE INTERCALAR FASES DE SECADO, SE REPITE ESTE PROCESO HASTA TRES VECES; Y LOS NUCLEOS OBTENIDOS DE ESTA MANERA SE PROVEEN DE UNA CAPA DE BARNIZ A BASE DE DISOLVENTES ORGANICOS. TIENE UTILIDAD PARA PREPARAR COMPOSICIONES FARMACEUTICAS.
ES549757A 1984-12-12 1985-12-10 Procedimiento para producir un preparado de enzimas pancrea-ticas en forma comprimida Expired ES8705759A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19843445301 DE3445301A1 (de) 1984-12-12 1984-12-12 Pankreasenzympraeparate und verfahren zu deren herstellung

Publications (2)

Publication Number Publication Date
ES8705759A1 true ES8705759A1 (es) 1987-05-16
ES549757A0 ES549757A0 (es) 1987-05-16

Family

ID=6252579

Family Applications (1)

Application Number Title Priority Date Filing Date
ES549757A Expired ES8705759A1 (es) 1984-12-12 1985-12-10 Procedimiento para producir un preparado de enzimas pancrea-ticas en forma comprimida

Country Status (14)

Country Link
US (1) US4859471A (es)
EP (1) EP0184754B1 (es)
JP (1) JPS61145124A (es)
KR (1) KR930001277B1 (es)
AT (1) ATE73669T1 (es)
AU (1) AU592325B2 (es)
CA (1) CA1247526A (es)
DE (2) DE3445301A1 (es)
DK (1) DK572985A (es)
ES (1) ES8705759A1 (es)
GR (1) GR852955B (es)
IE (1) IE58621B1 (es)
PT (1) PT81649B (es)
ZA (1) ZA859482B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3777658D1 (de) * 1986-08-28 1992-04-23 Enzacor Pty Ltd Tierwachstumserreger.
DE3642853A1 (de) * 1986-12-16 1988-06-23 Ulrich Von Dr Ing Pidoll Arzneimittel
US5026560A (en) * 1987-01-29 1991-06-25 Takeda Chemical Industries, Ltd. Spherical granules having core and their production
KR100229754B1 (ko) * 1989-11-24 1999-11-15 샬러 한스, 하우스 한스 루돌프 판크레아틴구형입자, 이의 제조방법 및 이를 함유하는 약제학적 조성물
US5175003A (en) * 1990-04-06 1992-12-29 Biosytes Usa, Inc. Dual mechanism controlled release system for drug dosage forms
US5302400A (en) * 1992-06-22 1994-04-12 Digestive Care Inc. Preparation of gastric acid-resistant microspheres containing digestive enzymes and buffered-bile acids
US5750104A (en) * 1996-05-29 1998-05-12 Digestive Care Inc. High buffer-containing enteric coating digestive enzyme bile acid compositions and method of treating digestive disorders therewith
IT1319655B1 (it) 2000-11-15 2003-10-23 Eurand Int Microsfere di enzimi pancreatici con elevata stabilita' e relativometodo di preparazione.
US9011843B2 (en) * 2006-12-14 2015-04-21 Master Supplements, Inc. Formulations including monovalent alginate to enhance effectiveness of administered digestive enzymes
SG186648A1 (en) * 2007-02-20 2013-01-30 Aptalis Pharma Ltd Stable digestive enzyme compositions
US10087493B2 (en) 2008-03-07 2018-10-02 Aptalis Pharma Canada Ulc Method for detecting infectious parvovirus in pharmaceutical preparations
KR101442069B1 (ko) * 2009-09-30 2014-09-18 가부시키가이샤 상기 난용성 물질의 수용해성 개선방법
UA111726C2 (uk) 2010-10-01 2016-06-10 Апталіс Фарма Лімітед Препарат панкреліпази низької сили з кишковорозчинним покриттям
EP2741766B1 (en) 2011-08-08 2015-10-07 Aptalis Pharma Limited Method for dissolution testing of solid compositions containing digestive enzymes
JP5909796B2 (ja) 2012-03-02 2016-04-27 株式会社サンギ 難溶性物質の水溶解性改善方法
US10993996B2 (en) 2013-08-09 2021-05-04 Allergan Pharmaceuticals International Limited Digestive enzyme composition suitable for enteral administration
CA2947998A1 (en) 2014-06-19 2015-12-23 Aptalis Pharma Ltd. Methods for removing viral contaminants from pancreatic extracts

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE163891C (es) *
CH163891A (de) * 1931-11-13 1933-09-15 Kalle & Co Ag Verfahren zur Herstellung von haltbaren Pankreasamylase-Trockenpräparaten.
DE1063758B (de) * 1955-03-23 1959-08-20 Upjohn Co Im Darmtrakt loesliche Arzneimittelschutzumhuellungen
FR1537651A (fr) * 1961-10-24 1968-09-07 Denver Chemical Mfg Company Procédé de préparation de composition solide à enduit entérique
GB986254A (en) * 1962-12-11 1965-03-17 Upjohn Co Coated tablets
DE2035739A1 (en) * 1970-07-18 1972-01-27 Röhm FmbH, 6100 Darmstadt Oral enzyme prepsn - consisting of granulate with gastric juices-resistant coating in tablet or capsule form

Also Published As

Publication number Publication date
PT81649A (de) 1986-01-01
DE3445301A1 (de) 1986-06-12
JPS61145124A (ja) 1986-07-02
GR852955B (es) 1986-04-01
AU592325B2 (en) 1990-01-11
DK572985D0 (da) 1985-12-11
US4859471A (en) 1989-08-22
ZA859482B (en) 1986-08-27
KR860004636A (ko) 1986-07-11
AU5117985A (en) 1986-06-19
EP0184754A2 (de) 1986-06-18
DK572985A (da) 1986-06-13
CA1247526A (en) 1988-12-28
EP0184754B1 (de) 1992-03-18
PT81649B (pt) 1988-02-17
ES549757A0 (es) 1987-05-16
EP0184754A3 (en) 1987-09-30
IE853130L (en) 1986-06-12
KR930001277B1 (ko) 1993-02-25
ATE73669T1 (de) 1992-04-15
IE58621B1 (en) 1993-10-20
DE3585672D1 (de) 1992-04-23

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