ES8705389A1 - Un procedimiento para preparar una sal de quelato con heterociclo nitrogenado - Google Patents
Un procedimiento para preparar una sal de quelato con heterociclo nitrogenadoInfo
- Publication number
- ES8705389A1 ES8705389A1 ES552090A ES552090A ES8705389A1 ES 8705389 A1 ES8705389 A1 ES 8705389A1 ES 552090 A ES552090 A ES 552090A ES 552090 A ES552090 A ES 552090A ES 8705389 A1 ES8705389 A1 ES 8705389A1
- Authority
- ES
- Spain
- Prior art keywords
- radionuclide
- dihydropyridine
- brain
- pyridinium salt
- elimination
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000002738 chelating agent Substances 0.000 title abstract 2
- 239000012217 radiopharmaceutical Substances 0.000 title abstract 2
- 229940121896 radiopharmaceutical Drugs 0.000 title abstract 2
- 230000002799 radiopharmaceutical effect Effects 0.000 title abstract 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical class C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 3
- 210000004556 brain Anatomy 0.000 abstract 3
- 125000004925 dihydropyridyl group Chemical group N1(CC=CC=C1)* 0.000 abstract 3
- 230000008499 blood brain barrier function Effects 0.000 abstract 2
- 230000008030 elimination Effects 0.000 abstract 2
- 238000003379 elimination reaction Methods 0.000 abstract 2
- YNGDWRXWKFWCJY-UHFFFAOYSA-N 1,4-Dihydropyridine Chemical compound C1C=CNC=C1 YNGDWRXWKFWCJY-UHFFFAOYSA-N 0.000 abstract 1
- 210000001218 blood-brain barrier Anatomy 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000003647 oxidation Effects 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000000467 secondary amino group Chemical group [H]N([*:1])[*:2] 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 125000001302 tertiary amino group Chemical group 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/53—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
- C07F13/005—Compounds without a metal-carbon linkage
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Pharmacology & Pharmacy (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Genetics & Genomics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Conversion Of X-Rays Into Visible Images (AREA)
- Luminescent Compositions (AREA)
- Glass Compositions (AREA)
Abstract
PROCEDIMIENTO PARA PREPARAR UNA SAL DE QUELATO CON HETEROCICLO NITROGENADO. CONSISTE EN: A) HACER REACCIONAR UNCOMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA (III); B) SEPARAR LOS GRUPOS PROTECTORES DE LA SAL DE FORMULA (I); Y C) CAMBIAR EL ANION EN LA SAL RESULTANTE DE FORMULA (I), DONDEES EL RESTO DE AGENTE QUELANTE CAPAZ DE FORMAR QUELATO CON UNN RADIONUCLEIDO METALICO, TENIENDO DICHO AGENTE QUELANTE UN GRUPO FUNCIONAL AMINO PRIMARIO, SECUNDARIO O TERCIARIO. TIENE APLICACION EN LA PREPARACION DE AGENTES RADIOFARMACEUTICOS POR PERMITIR NIVELES INCREMENTADOS DE CONCENTRACION DE RADIONUCLEIDO EN EL CEREBRO.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63238384A | 1984-07-19 | 1984-07-19 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES552090A0 ES552090A0 (es) | 1987-05-01 |
| ES8705389A1 true ES8705389A1 (es) | 1987-05-01 |
Family
ID=24535323
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES545395A Expired ES8700236A1 (es) | 1984-07-19 | 1985-07-19 | Un procedimiento para preparar una sal de quelato con hete- rociclo nitrogenado |
| ES552090A Expired ES8705389A1 (es) | 1984-07-19 | 1986-02-17 | Un procedimiento para preparar una sal de quelato con heterociclo nitrogenado |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES545395A Expired ES8700236A1 (es) | 1984-07-19 | 1985-07-19 | Un procedimiento para preparar una sal de quelato con hete- rociclo nitrogenado |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP0191788A1 (es) |
| JP (1) | JPS61112054A (es) |
| KR (1) | KR900008168B1 (es) |
| AU (1) | AU4632085A (es) |
| CA (1) | CA1266864A (es) |
| DK (1) | DK124686A (es) |
| ES (2) | ES8700236A1 (es) |
| FI (1) | FI861119A0 (es) |
| GR (1) | GR851793B (es) |
| IL (1) | IL75845A0 (es) |
| NO (1) | NO860980L (es) |
| PT (1) | PT80842B (es) |
| WO (1) | WO1986000897A1 (es) |
| ZA (1) | ZA855477B (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5071636A (en) * | 1987-12-29 | 1991-12-10 | Nihon Medi-Physics Co., Ltd. | Chelating compounds and their use |
| SE526214C2 (sv) * | 2003-02-28 | 2005-07-26 | Amersham Biosciences Ab | Ett sätt att generera metallkelaterande affinitetsligander |
| KR101033209B1 (ko) * | 2004-12-31 | 2011-05-06 | 주식회사 효성 | 분사성을 향상시킨 폴리에스테르 분섬사의 제조방법 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4444690A (en) * | 1982-02-25 | 1984-04-24 | University Patents, Inc. | Technetium chelates |
| EP0110955B1 (en) * | 1982-05-18 | 1995-08-23 | University Of Florida | Brain-specific drug delivery |
-
1985
- 1985-07-15 AU AU46320/85A patent/AU4632085A/en not_active Abandoned
- 1985-07-15 EP EP85903750A patent/EP0191788A1/en not_active Withdrawn
- 1985-07-15 WO PCT/US1985/001333 patent/WO1986000897A1/en not_active Application Discontinuation
- 1985-07-18 GR GR851793A patent/GR851793B/el unknown
- 1985-07-18 KR KR8505136A patent/KR900008168B1/ko active IP Right Grant
- 1985-07-18 IL IL75845A patent/IL75845A0/xx unknown
- 1985-07-19 CA CA000487166A patent/CA1266864A/en not_active Expired - Lifetime
- 1985-07-19 ZA ZA855477A patent/ZA855477B/xx unknown
- 1985-07-19 PT PT80842A patent/PT80842B/pt unknown
- 1985-07-19 JP JP60160039A patent/JPS61112054A/ja active Pending
- 1985-07-19 ES ES545395A patent/ES8700236A1/es not_active Expired
-
1986
- 1986-02-17 ES ES552090A patent/ES8705389A1/es not_active Expired
- 1986-03-14 NO NO860980A patent/NO860980L/no unknown
- 1986-03-18 DK DK124686A patent/DK124686A/da not_active Application Discontinuation
- 1986-03-18 FI FI861119A patent/FI861119A0/fi not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CA1266864A (en) | 1990-03-20 |
| ES8700236A1 (es) | 1986-10-01 |
| KR870000935A (ko) | 1987-03-10 |
| KR900008168B1 (en) | 1990-11-05 |
| WO1986000897A1 (en) | 1986-02-13 |
| GR851793B (es) | 1985-11-26 |
| EP0191788A1 (en) | 1986-08-27 |
| FI861119A (fi) | 1986-03-18 |
| JPS61112054A (ja) | 1986-05-30 |
| IL75845A0 (en) | 1985-11-29 |
| FI861119A0 (fi) | 1986-03-18 |
| DK124686A (da) | 1986-05-20 |
| PT80842A (en) | 1985-08-01 |
| ZA855477B (en) | 1987-03-25 |
| DK124686D0 (da) | 1986-03-18 |
| AU4632085A (en) | 1986-02-25 |
| NO860980L (no) | 1986-05-06 |
| ES552090A0 (es) | 1987-05-01 |
| PT80842B (en) | 1987-05-27 |
| ES545395A0 (es) | 1986-10-01 |
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