ES8705385A1 - Procedimiento para preparar isomeros de derivados de prostaglandina - Google Patents

Procedimiento para preparar isomeros de derivados de prostaglandina

Info

Publication number
ES8705385A1
ES8705385A1 ES552554A ES552554A ES8705385A1 ES 8705385 A1 ES8705385 A1 ES 8705385A1 ES 552554 A ES552554 A ES 552554A ES 552554 A ES552554 A ES 552554A ES 8705385 A1 ES8705385 A1 ES 8705385A1
Authority
ES
Spain
Prior art keywords
processes
preparation
pharmaceutical compositions
compositions containing
prostaglandin analogues
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES552554A
Other languages
English (en)
Other versions
ES552554A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ono Pharmaceutical Co Ltd
Original Assignee
Ono Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ono Pharmaceutical Co Ltd filed Critical Ono Pharmaceutical Co Ltd
Publication of ES8705385A1 publication Critical patent/ES8705385A1/es
Publication of ES552554A0 publication Critical patent/ES552554A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • C07D307/937—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans with hydrocarbon or substituted hydrocarbon radicals directly attached in position 2, e.g. prostacyclins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/005—Analogues or derivatives having the five membered ring replaced by other rings
    • C07C405/0075—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system
    • C07C405/0083—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system which is only ortho or peri condensed, e.g. carbacyclins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
    • C08B37/0015—Inclusion compounds, i.e. host-guest compounds, e.g. polyrotaxanes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Polymers & Plastics (AREA)
  • Materials Engineering (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Furan Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Emergency Protection Circuit Devices (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Silver Salt Photography Or Processing Solution Therefor (AREA)
  • Indole Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE PROSTAGLANDINA, DE FORMULA (I), DE SUS ISOMEROS, SALES NO TOXICAS Y CLATRATOS DE CICLODEXTRINA. COMPRENDE LA REACCION DE HIDROLISIS DE UN COMPUESTO DE FORMULA (II), (III) O (IV), PARA OBTENER UN COMPUESTO DE FORMULA (I), EN LA QUE A, B, R1, R1B, R11, R12, R13 Y R14 PUEDEN SER VARIOS TIPOS DE RADICALES Y N VALE 0-2. TAMBIEN SE PUEDE OBTENER POR FORMACION DEL GRUPO OH MEDIANTE REDUCCION DE UN GRUPO CETO EN UN COMPUESTO ADECUADO. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE HIPERTENSION, TROMBOSIS, ASMA, ULCERAS GASTRICAS Y COMO DIURETICOS.
ES552554A 1984-07-23 1986-02-28 Procedimiento para preparar isomeros de derivados de prostaglandina Expired ES8705385A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP59151369A JPS6130554A (ja) 1984-07-23 1984-07-23 プロスタグランジン類似化合物のある特定の立体配置を有する異性体及びそれらを有効成分として含有する治療剤

Publications (2)

Publication Number Publication Date
ES8705385A1 true ES8705385A1 (es) 1987-05-01
ES552554A0 ES552554A0 (es) 1987-05-01

Family

ID=15517042

Family Applications (3)

Application Number Title Priority Date Filing Date
ES545457A Expired ES8609232A1 (es) 1984-07-23 1985-07-22 Procedimiento para la preparacion de un analogo a la prosta-glandina
ES552553A Expired ES8705384A1 (es) 1984-07-23 1986-02-28 Procedimiento para preparar isomeros de derivados de prostaglandina
ES552554A Expired ES8705385A1 (es) 1984-07-23 1986-02-28 Procedimiento para preparar isomeros de derivados de prostaglandina

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES545457A Expired ES8609232A1 (es) 1984-07-23 1985-07-22 Procedimiento para la preparacion de un analogo a la prosta-glandina
ES552553A Expired ES8705384A1 (es) 1984-07-23 1986-02-28 Procedimiento para preparar isomeros de derivados de prostaglandina

Country Status (17)

Country Link
US (2) US4935446A (es)
EP (1) EP0196380B1 (es)
JP (1) JPS6130554A (es)
KR (1) KR860001119A (es)
AT (1) ATE67484T1 (es)
AU (1) AU596947B2 (es)
CA (1) CA1264320A (es)
DE (1) DE3584158D1 (es)
DK (1) DK333385A (es)
ES (3) ES8609232A1 (es)
FI (1) FI852856L (es)
GR (1) GR851812B (es)
HU (1) HU199781B (es)
NO (1) NO852916L (es)
PT (1) PT80848B (es)
YU (3) YU45985B (es)
ZA (1) ZA855533B (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2192395B (en) * 1986-07-08 1990-11-14 Kotobuki Seiyaku Co Ltd Carbacyclin derivatives
US5218139A (en) * 1990-12-27 1993-06-08 G. D. Searle & Co. Method for inhibiting IgE production
US5148032A (en) * 1991-06-28 1992-09-15 Siemens Medical Laboratories, Inc. Radiation emitting device with moveable aperture plate
US5235816A (en) * 1991-10-10 1993-08-17 Praxair Technology, Inc. Cryogenic rectification system for producing high purity oxygen
MY144968A (en) 2005-04-11 2011-11-30 Xenon Pharmaceuticals Inc Spiro-oxindole compounds and their uses as therapeutic agents
AR053710A1 (es) * 2005-04-11 2007-05-16 Xenon Pharmaceuticals Inc Compuestos espiroheterociclicos y sus usos como agentes terapeuticos
US7737145B2 (en) 2005-12-29 2010-06-15 Estrellita Pharmaceuticals, Llc Diamine derivatives as inhibitors of leukotriene A4 hydrolase
AU2007307638A1 (en) * 2006-10-12 2008-04-17 Xenon Pharmaceuticals Inc. Spiro (furo [3, 2-C] pyridine-3-3 ' -indol) -2' (1'H)-one derivatives and related compounds for the treatment of sodium-channel mediated diseases, such as pain
ATE545416T1 (de) 2006-10-12 2012-03-15 Xenon Pharmaceuticals Inc Verwendung von spiro-oxindol-verbindungen als therapeutika
CA2741029A1 (en) 2008-10-17 2010-04-22 Xenon Pharmaceuticals Inc. Spiro-oxindole compounds and their use as therapeutic agents
CA2741024A1 (en) * 2008-10-17 2010-04-22 Xenon Pharmaceuticals Inc. Spiro-oxindole compounds and their use as therapeutic agents
AR077252A1 (es) * 2009-06-29 2011-08-10 Xenon Pharmaceuticals Inc Enantiomeros de compuestos de espirooxindol y sus usos como agentes terapeuticos
US20110086899A1 (en) * 2009-10-14 2011-04-14 Xenon Pharmaceuticals Inc. Pharmaceutical compositions for oral administration
NZ712378A (en) 2009-10-14 2017-05-26 Xenon Pharmaceuticals Inc Synthetic methods for spiro-oxindole compounds
EP2538919B1 (en) 2010-02-26 2017-07-12 Xenon Pharmaceuticals Inc. Pharmaceutical compositions of spiro-oxindole compound for topical administration and their use as therapeutic agents
CA2869547A1 (en) 2012-04-12 2013-10-17 Xenon Pharmaceuticals Inc. Asymmetric syntheses for spiro-oxindole compounds useful as therapeutic agents
CA2906035A1 (en) 2013-03-14 2014-09-25 Celtaxsys, Inc. Inhibitors of leukotriene a4 hydrolase
TW201636017A (zh) 2015-02-05 2016-10-16 梯瓦製藥國際有限責任公司 以螺吲哚酮化合物之局部調配物治療帶狀疱疹後遺神經痛之方法
US10100060B2 (en) 2016-06-16 2018-10-16 Xenon Pharmaceuticals Inc. Asymmetric synthesis of funapide
CA3045954A1 (en) 2016-12-09 2018-06-14 Celtaxsys, Inc. Monamine and monoamine derivatives as inhibitors of leukotriene a4 hydrolase
EP3551608A1 (en) 2016-12-09 2019-10-16 Celtaxsys Inc. Pendant amines and derivatives as inhibitors of leukotriene a4 hydrolase
WO2018107153A1 (en) 2016-12-09 2018-06-14 Celtaxsys, Inc. Inhibitors of leukotriene a4 hydrolase

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4180675A (en) * 1975-07-17 1979-12-25 Warner-Lambert Company 15-Cycloalkyl-prostaglandin derivatives
US4087620A (en) * 1975-07-17 1978-05-02 Ono Pharmaceutical Company 15-Cycloalkyl-prostaglandin derivatives
US4178367A (en) * 1977-02-21 1979-12-11 Ono Pharmaceutical Co. Ltd. Prostaglandin I2 analogues
JPS53103464A (en) * 1977-02-21 1978-09-08 Ono Pharmaceut Co Ltd Prostaglandin x analogues and process for their preparation
JPS53127441A (en) * 1977-04-11 1978-11-07 Ono Pharmaceut Co Ltd Prostaglandin-like compounds and their preparation
GB1588196A (en) * 1977-06-14 1981-04-15 Ono Pharmaceutical Co Prostaglandin analogues
JPS6022710B2 (ja) * 1977-09-16 1985-06-03 小野薬品工業株式会社 プロスタグランジン類似化合物
JPS54125653A (en) * 1978-03-18 1979-09-29 Ono Pharmaceut Co Ltd Prostaglandin i2 analog, its preparation, and drug composition comprising it as active constituent
GB2017699B (en) * 1978-03-31 1983-01-12 Ono Pharmaceutical Co 6,9-methano-pgi2 analogues
JPS54130543A (en) * 1978-03-31 1979-10-09 Ono Pharmaceut Co Ltd Prostagladin i2 analog, and its preparation
US4220795A (en) * 1978-08-14 1980-09-02 Miles Laboratories, Inc. Cyclobutyl substituted derivatives of prostaglandin analogs
DE2902809A1 (de) * 1979-01-25 1980-08-07 Hoechst Ag Neue analoga von prostacyclin
DE3006865A1 (de) * 1980-02-23 1981-09-10 Hoechst Ag, 6000 Frankfurt Hetero-imino-prostacycline
JPS58164512A (ja) * 1982-03-25 1983-09-29 Ono Pharmaceut Co Ltd プロスタグランジン類似化合物を有効成分として含有する肝臓疾患治療剤
JPS591463A (ja) * 1982-06-28 1984-01-06 Ono Pharmaceut Co Ltd 新規なプロスタグランジンｄ類似化合物
JPS5944340A (ja) * 1982-09-08 1984-03-12 Sankyo Co Ltd メタノプロスタサイクリン誘導体の光学活性結晶性アミン塩およびその製法
JPS59163365A (ja) * 1983-03-08 1984-09-14 Ono Pharmaceut Co Ltd プロスタグランジン類似化合物

Also Published As

Publication number Publication date
AU4523285A (en) 1986-01-30
ES545457A0 (es) 1986-09-01
AU596947B2 (en) 1990-05-24
ES8705384A1 (es) 1987-05-01
ES8609232A1 (es) 1986-09-01
ES552553A0 (es) 1987-05-01
NO852916L (no) 1986-01-24
PT80848B (pt) 1987-11-30
ZA855533B (en) 1986-03-26
YU143387A (en) 1988-04-30
KR860001119A (ko) 1986-02-22
FI852856L (fi) 1986-01-24
EP0196380B1 (en) 1991-09-18
YU143287A (en) 1988-04-30
PT80848A (en) 1985-08-01
CA1264320A (en) 1990-01-09
DK333385D0 (da) 1985-07-22
YU46220B (sh) 1993-05-28
US5109021A (en) 1992-04-28
EP0196380A2 (en) 1986-10-08
HUT39157A (en) 1986-08-28
YU45985B (sh) 1992-12-21
ATE67484T1 (de) 1991-10-15
HU199781B (en) 1990-03-28
ES552554A0 (es) 1987-05-01
EP0196380A3 (en) 1987-07-01
US4935446A (en) 1990-06-19
YU46219B (sh) 1993-05-28
FI852856A0 (fi) 1985-07-22
DE3584158D1 (de) 1991-10-24
GR851812B (es) 1985-11-26
JPS6130554A (ja) 1986-02-12
YU120185A (en) 1988-04-30
DK333385A (da) 1986-01-24

Similar Documents

Publication Publication Date Title
ES8609232A1 (es) Procedimiento para la preparacion de un analogo a la prosta-glandina
IL75337A (en) Polyenoic acids omega-substituted by a 4,5-dimethoxy-2-methyl-quinone or a 4,5-dimethoxy-2-methyl-phenyl group,process for the preparation thereof and pharmaceutical compositions containing the same
HUT61989A (en) Process for producing 2-deoxy-2,3-didehydro-n-acetylneuraminic acid derivatives and analogs, as well as pharmaceutical compositions comprising same as active ingredient
MY103850A (en) Phenol substituted gem-diphosphonate derivatives, process for their preparation and pharmaceutical compositions containing them.
ES428889A1 (es) Procedimiento de preparacion de derivados de acido prosta- noico.
HUT43494A (en) Process for producing pharmaceutical composition containing interferone-alpha
HUT52775A (en) Process for producing spiro-isoquinoline-pyrrolidine-tetrones, theyr analogues anf pharmaceutical compositions containing them
ES8705763A1 (es) Procedimiento para preparar nuevas formulaciones de gel parafines terapeuticos y diagnosticos
HUT47216A (en) Process for producing aquous compositions containing hydroxy-alkadinyl-benzoquinone derivatives as active components
ZA834693B (en) Prostaglandin d analogues,process for their preparation and compositions containing them
ES8607986A1 (es) Derivados de androsteno nuevos
DE3068250D1 (en) 3-hydroxymethyldibenzo(b,f)thiepins and dibenzo(b,f)thiepin-3-carboxaldehydes as prostaglandin antagonists, process for their preparation and pharmaceutical compositions
ES8102563A1 (es) Procedimiento para la preparacion de nuevas sustancias analogas de prostaciclina
GB1460519A (en) Polyunsaturated prostaglandin derivatives and process
DE3467760D1 (en) Salts of 15,16-methylene-17-alpha-pregna-4,6-diene-21-carboxylic acids, pharmaceutical compositions containing them and process for their preparation
JPS51138653A (en) Prostaglandin analogues their preparation a nd pharmaceutical compositions
EP0241115A3 (en) Process for producing unsaturated phosphonic acid dichlorides
JPS5476554A (en) Intermediate of prostaglandin analog and its production
JPS53127816A (en) Stabilized composition containing prostaglandin e
JPS5476552A (en) Production of prostaglandin analog
JPS53103450A (en) Preparation of cis-jasmonic acid methylester
JPS53144563A (en) Preparation of steroid derivatives
JPS5476553A (en) Intermediate of prostaglandin analog and its production
EP0177673A3 (en) Derivative of cyclohexene-1,4-dimethanol having a mucosecretolytic activity, process for its preparation and pharmaceutical compositions thereof

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970203