FI852856L - Prostaglandinanaloger och foerfaranden foer framstaellning av dessa. - Google Patents
Prostaglandinanaloger och foerfaranden foer framstaellning av dessa.Info
- Publication number
- FI852856L FI852856L FI852856A FI852856A FI852856L FI 852856 L FI852856 L FI 852856L FI 852856 A FI852856 A FI 852856A FI 852856 A FI852856 A FI 852856A FI 852856 L FI852856 L FI 852856L
- Authority
- FI
- Finland
- Prior art keywords
- sub
- pgl
- prostaglandinanaloger
- dessa
- foer framstaellning
- Prior art date
Links
- 231100000252 nontoxic Toxicity 0.000 abstract 2
- 230000003000 nontoxic effect Effects 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 229920000858 Cyclodextrin Polymers 0.000 abstract 1
- 101150020741 Hpgds gene Proteins 0.000 abstract 1
- 229920000954 Polyglycolide Polymers 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000005907 alkyl ester group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 235000010409 propane-1,2-diol alginate Nutrition 0.000 abstract 1
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
- C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
- C07D307/937—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans with hydrocarbon or substituted hydrocarbon radicals directly attached in position 2, e.g. prostacyclins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/005—Analogues or derivatives having the five membered ring replaced by other rings
- C07C405/0075—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system
- C07C405/0083—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system which is only ortho or peri condensed, e.g. carbacyclins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
- C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
- C08B37/0015—Inclusion compounds, i.e. host-guest compounds, e.g. polyrotaxanes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Materials Engineering (AREA)
- Polymers & Plastics (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Silver Salt Photography Or Processing Solution Therefor (AREA)
- Emergency Protection Circuit Devices (AREA)
- Materials For Medical Uses (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Furan Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP59151369A JPS6130554A (ja) | 1984-07-23 | 1984-07-23 | プロスタグランジン類似化合物のある特定の立体配置を有する異性体及びそれらを有効成分として含有する治療剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FI852856A0 FI852856A0 (fi) | 1985-07-22 |
| FI852856L true FI852856L (fi) | 1986-01-24 |
Family
ID=15517042
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI852856A FI852856L (fi) | 1984-07-23 | 1985-07-22 | Prostaglandinanaloger och foerfaranden foer framstaellning av dessa. |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US4935446A (fi) |
| EP (1) | EP0196380B1 (fi) |
| JP (1) | JPS6130554A (fi) |
| KR (1) | KR860001119A (fi) |
| AT (1) | ATE67484T1 (fi) |
| AU (1) | AU596947B2 (fi) |
| CA (1) | CA1264320A (fi) |
| DE (1) | DE3584158D1 (fi) |
| DK (1) | DK333385A (fi) |
| ES (3) | ES8609232A1 (fi) |
| FI (1) | FI852856L (fi) |
| GR (1) | GR851812B (fi) |
| HU (1) | HU199781B (fi) |
| NO (1) | NO852916L (fi) |
| PT (1) | PT80848B (fi) |
| YU (3) | YU45985B (fi) |
| ZA (1) | ZA855533B (fi) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2192395B (en) * | 1986-07-08 | 1990-11-14 | Kotobuki Seiyaku Co Ltd | Carbacyclin derivatives |
| US5218139A (en) * | 1990-12-27 | 1993-06-08 | G. D. Searle & Co. | Method for inhibiting IgE production |
| US5148032A (en) * | 1991-06-28 | 1992-09-15 | Siemens Medical Laboratories, Inc. | Radiation emitting device with moveable aperture plate |
| US5235816A (en) * | 1991-10-10 | 1993-08-17 | Praxair Technology, Inc. | Cryogenic rectification system for producing high purity oxygen |
| MY145694A (en) * | 2005-04-11 | 2012-03-30 | Xenon Pharmaceuticals Inc | Spiroheterocyclic compounds and their uses as therapeutic agents |
| MY144968A (en) | 2005-04-11 | 2011-11-30 | Xenon Pharmaceuticals Inc | Spiro-oxindole compounds and their uses as therapeutic agents |
| EP3205644A1 (en) | 2005-12-29 | 2017-08-16 | Celtaxsys Inc. | Diamine derivatives as inhibitors of leukotriene a4 hydrolase |
| US20110294842A9 (en) * | 2006-10-12 | 2011-12-01 | Xenon Pharmaceuticals Inc. | Spiro (furo [3, 2-c] pyridine-3-3' -indol) -2' (1'h)-one derivatives and related compounds for the treatment of sodium-channel mediated diseases, such as pain |
| EP2073806B1 (en) | 2006-10-12 | 2012-02-15 | Xenon Pharmaceuticals Inc. | Use of spiro-oxindole compounds as therapeutic agents |
| EP2350091B1 (en) * | 2008-10-17 | 2015-06-03 | Xenon Pharmaceuticals Inc. | Spiro-oxindole compounds and their use as therapeutic agents |
| CN106928247A (zh) | 2008-10-17 | 2017-07-07 | 泽农医药公司 | 螺羟吲哚化合物及其作为治疗剂的用途 |
| AR077252A1 (es) | 2009-06-29 | 2011-08-10 | Xenon Pharmaceuticals Inc | Enantiomeros de compuestos de espirooxindol y sus usos como agentes terapeuticos |
| PE20170202A1 (es) * | 2009-10-14 | 2017-03-24 | Xenon Pharmaceuticals Inc | Metodos sinteticos para compuestos espiro-oxoindol |
| US20110086899A1 (en) * | 2009-10-14 | 2011-04-14 | Xenon Pharmaceuticals Inc. | Pharmaceutical compositions for oral administration |
| MA34083B1 (fr) | 2010-02-26 | 2013-03-05 | Xenon Pharmaceuticals Inc | Compositions pharmaceutques de composé spiro-oxindole pour administration topique et leur utilisation en tant qu'agents thérapeutiques |
| US9487535B2 (en) | 2012-04-12 | 2016-11-08 | Xenon Pharmaceuticals Inc. | Asymmetric syntheses for spiro-oxindole compounds useful as therapeutic agents |
| MX2015011677A (es) | 2013-03-14 | 2016-07-08 | Celtaxsys Inc | Inhibidores de leucotrieno a4 hidrolasa. |
| US9682033B2 (en) | 2015-02-05 | 2017-06-20 | Teva Pharmaceuticals International Gmbh | Methods of treating postherpetic neuralgia with a topical formulation of a spiro-oxindole compound |
| WO2017218920A1 (en) | 2016-06-16 | 2017-12-21 | Teva Pharmaceuticals International Gmbh | Asymmetric synthesis of funapide |
| WO2018107158A1 (en) | 2016-12-09 | 2018-06-14 | Celtaxsys, Inc. | Monamine and monoamine derivatives as inhibitors of leukotriene a4 hydrolase |
| CA3045887A1 (en) | 2016-12-09 | 2018-06-14 | Celtaxsys, Inc. | Pendant amines and derivatives as inhibitors of leukotriene a4 hydrolase |
| RU2019119652A (ru) | 2016-12-09 | 2021-01-11 | Селтакссис, Инк. | Ингибиторы лейкотриен-а4-гидролазы |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4087620A (en) * | 1975-07-17 | 1978-05-02 | Ono Pharmaceutical Company | 15-Cycloalkyl-prostaglandin derivatives |
| US4180675A (en) * | 1975-07-17 | 1979-12-25 | Warner-Lambert Company | 15-Cycloalkyl-prostaglandin derivatives |
| US4178367A (en) * | 1977-02-21 | 1979-12-11 | Ono Pharmaceutical Co. Ltd. | Prostaglandin I2 analogues |
| JPS53103464A (en) * | 1977-02-21 | 1978-09-08 | Ono Pharmaceut Co Ltd | Prostaglandin x analogues and process for their preparation |
| JPS53127441A (en) * | 1977-04-11 | 1978-11-07 | Ono Pharmaceut Co Ltd | Prostaglandin-like compounds and their preparation |
| GB1588196A (en) * | 1977-06-14 | 1981-04-15 | Ono Pharmaceutical Co | Prostaglandin analogues |
| JPS6022710B2 (ja) * | 1977-09-16 | 1985-06-03 | 小野薬品工業株式会社 | プロスタグランジン類似化合物 |
| JPS54125653A (en) * | 1978-03-18 | 1979-09-29 | Ono Pharmaceut Co Ltd | Prostaglandin i2 analog, its preparation, and drug composition comprising it as active constituent |
| IT1113341B (it) * | 1978-03-31 | 1986-01-20 | Ono Pharmaceutical Co | Analoghi della 6,9-metano-pgi2 |
| JPS54130543A (en) * | 1978-03-31 | 1979-10-09 | Ono Pharmaceut Co Ltd | Prostagladin i2 analog, and its preparation |
| US4220795A (en) * | 1978-08-14 | 1980-09-02 | Miles Laboratories, Inc. | Cyclobutyl substituted derivatives of prostaglandin analogs |
| DE2902809A1 (de) * | 1979-01-25 | 1980-08-07 | Hoechst Ag | Neue analoga von prostacyclin |
| DE3006865A1 (de) * | 1980-02-23 | 1981-09-10 | Hoechst Ag, 6000 Frankfurt | Hetero-imino-prostacycline |
| JPS58164512A (ja) * | 1982-03-25 | 1983-09-29 | Ono Pharmaceut Co Ltd | プロスタグランジン類似化合物を有効成分として含有する肝臓疾患治療剤 |
| JPS591463A (ja) * | 1982-06-28 | 1984-01-06 | Ono Pharmaceut Co Ltd | 新規なプロスタグランジンｄ類似化合物 |
| JPS5944340A (ja) * | 1982-09-08 | 1984-03-12 | Sankyo Co Ltd | メタノプロスタサイクリン誘導体の光学活性結晶性アミン塩およびその製法 |
| JPS59163365A (ja) * | 1983-03-08 | 1984-09-14 | Ono Pharmaceut Co Ltd | プロスタグランジン類似化合物 |
-
1984
- 1984-07-23 JP JP59151369A patent/JPS6130554A/ja active Pending
-
1985
- 1985-07-22 PT PT80848A patent/PT80848B/pt not_active IP Right Cessation
- 1985-07-22 DE DE8585305202T patent/DE3584158D1/de not_active Expired - Lifetime
- 1985-07-22 AT AT85305202T patent/ATE67484T1/de not_active IP Right Cessation
- 1985-07-22 HU HU852791A patent/HU199781B/hu unknown
- 1985-07-22 YU YU120185A patent/YU45985B/sh unknown
- 1985-07-22 ES ES545457A patent/ES8609232A1/es not_active Expired
- 1985-07-22 AU AU45232/85A patent/AU596947B2/en not_active Ceased
- 1985-07-22 NO NO852916A patent/NO852916L/no unknown
- 1985-07-22 EP EP85305202A patent/EP0196380B1/en not_active Expired - Lifetime
- 1985-07-22 GR GR851812A patent/GR851812B/el unknown
- 1985-07-22 FI FI852856A patent/FI852856L/fi not_active Application Discontinuation
- 1985-07-22 DK DK333385A patent/DK333385A/da unknown
- 1985-07-22 CA CA000487203A patent/CA1264320A/en not_active Expired - Lifetime
- 1985-07-22 KR KR1019850005225A patent/KR860001119A/ko not_active Application Discontinuation
- 1985-07-22 ZA ZA855533A patent/ZA855533B/xx unknown
-
1986
- 1986-02-28 ES ES552554A patent/ES8705385A1/es not_active Expired
- 1986-02-28 ES ES552553A patent/ES8705384A1/es not_active Expired
-
1987
- 1987-07-30 YU YU143387A patent/YU46220B/sh unknown
- 1987-07-30 YU YU143287A patent/YU46219B/sh unknown
-
1989
- 1989-03-30 US US07/331,011 patent/US4935446A/en not_active Expired - Fee Related
-
1990
- 1990-05-25 US US07/528,865 patent/US5109021A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| HUT39157A (en) | 1986-08-28 |
| PT80848B (pt) | 1987-11-30 |
| FI852856A0 (fi) | 1985-07-22 |
| EP0196380B1 (en) | 1991-09-18 |
| YU46220B (sh) | 1993-05-28 |
| YU46219B (sh) | 1993-05-28 |
| YU143287A (en) | 1988-04-30 |
| JPS6130554A (ja) | 1986-02-12 |
| EP0196380A3 (en) | 1987-07-01 |
| YU120185A (en) | 1988-04-30 |
| ES8609232A1 (es) | 1986-09-01 |
| DE3584158D1 (de) | 1991-10-24 |
| ES545457A0 (es) | 1986-09-01 |
| ATE67484T1 (de) | 1991-10-15 |
| DK333385A (da) | 1986-01-24 |
| AU4523285A (en) | 1986-01-30 |
| EP0196380A2 (en) | 1986-10-08 |
| KR860001119A (ko) | 1986-02-22 |
| ES552553A0 (es) | 1987-05-01 |
| US4935446A (en) | 1990-06-19 |
| GR851812B (fi) | 1985-11-26 |
| HU199781B (en) | 1990-03-28 |
| US5109021A (en) | 1992-04-28 |
| DK333385D0 (da) | 1985-07-22 |
| ES8705385A1 (es) | 1987-05-01 |
| ZA855533B (en) | 1986-03-26 |
| NO852916L (no) | 1986-01-24 |
| AU596947B2 (en) | 1990-05-24 |
| ES8705384A1 (es) | 1987-05-01 |
| YU45985B (sh) | 1992-12-21 |
| YU143387A (en) | 1988-04-30 |
| PT80848A (en) | 1985-08-01 |
| ES552554A0 (es) | 1987-05-01 |
| CA1264320A (en) | 1990-01-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application lapsed |
Owner name: ONO PHARMACEUTICAL CO LTD |