JPS51138653A - Prostaglandin analogues their preparation a nd pharmaceutical compositions - Google Patents

Prostaglandin analogues their preparation a nd pharmaceutical compositions

Info

Publication number
JPS51138653A
JPS51138653A JP51057212A JP5721276A JPS51138653A JP S51138653 A JPS51138653 A JP S51138653A JP 51057212 A JP51057212 A JP 51057212A JP 5721276 A JP5721276 A JP 5721276A JP S51138653 A JPS51138653 A JP S51138653A
Authority
JP
Japan
Prior art keywords
preparation
pharmaceutical compositions
prostaglandin analogues
vinylene
ethylene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP51057212A
Other languages
Japanese (ja)
Inventor
Masaki Hayashi
Seiji Kori
Sadahiko Iguchi
Katsuichi Shimoji
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ono Pharmaceutical Co Ltd
Original Assignee
Ono Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ono Pharmaceutical Co Ltd filed Critical Ono Pharmaceutical Co Ltd
Publication of JPS51138653A publication Critical patent/JPS51138653A/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

PURPOSE: Prostaglandin analogues and their salts of formula I are new: [where A is group of formula II, III or IV; R is H or 1W12C alyl; n is 0, 1, 2 or 3; R1, R2, R3, R4 and R5 are H, methyl or ethyl; (1) X is ethylene or cis-vinylene and Y is trans-vinylene, or both of them are ethylene when more than one of R1, R2 and R3 are methyl or ethyl. (2) X is ethylene or cis-vinylene, Y is ethylene or trans-vinylene and n is 1, 2 or 3 when R1, R2 and R3 are H].
COPYRIGHT: (C)1976,JPO&Japio
JP51057212A 1975-05-22 1976-05-20 Prostaglandin analogues their preparation a nd pharmaceutical compositions Pending JPS51138653A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB22090/75A GB1554711A (en) 1975-05-22 1975-05-22 20-chloroprostaglandin analogues

Publications (1)

Publication Number Publication Date
JPS51138653A true JPS51138653A (en) 1976-11-30

Family

ID=10173760

Family Applications (1)

Application Number Title Priority Date Filing Date
JP51057212A Pending JPS51138653A (en) 1975-05-22 1976-05-20 Prostaglandin analogues their preparation a nd pharmaceutical compositions

Country Status (11)

Country Link
JP (1) JPS51138653A (en)
AU (1) AU1409976A (en)
BE (1) BE842113A (en)
CH (1) CH612179A5 (en)
DE (1) DE2622416A1 (en)
DK (1) DK219976A (en)
FR (1) FR2311534A1 (en)
GB (1) GB1554711A (en)
LU (1) LU74999A1 (en)
NL (1) NL7605348A (en)
ZA (1) ZA762983B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1525282A (en) * 1975-08-08 1978-09-20 Ono Pharmaceutical Co 16-chloroprostaglandin analogues

Also Published As

Publication number Publication date
FR2311534A1 (en) 1976-12-17
NL7605348A (en) 1976-11-24
BE842113A (en) 1976-11-22
ZA762983B (en) 1977-04-27
DE2622416A1 (en) 1976-12-09
LU74999A1 (en) 1977-02-14
DK219976A (en) 1976-11-23
GB1554711A (en) 1979-10-24
FR2311534B1 (en) 1980-10-10
AU1409976A (en) 1977-11-24
CH612179A5 (en) 1979-07-13

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