ES8703931A1 - Procedimiento para preparar nuevos antibioticos policiclicos por fermentacion de una cepa de actinomadura melliaura. - Google Patents
Procedimiento para preparar nuevos antibioticos policiclicos por fermentacion de una cepa de actinomadura melliaura.Info
- Publication number
- ES8703931A1 ES8703931A1 ES546915A ES546915A ES8703931A1 ES 8703931 A1 ES8703931 A1 ES 8703931A1 ES 546915 A ES546915 A ES 546915A ES 546915 A ES546915 A ES 546915A ES 8703931 A1 ES8703931 A1 ES 8703931A1
- Authority
- ES
- Spain
- Prior art keywords
- chlorine
- compounds
- preparation
- pharmaceutical compositions
- compositions containing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
- C12P1/02—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using fungi
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/38—Nucleosides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/044—Pyrrole radicals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/58—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound through only acyclic carbon atoms to a non-saccharide heterocyclic ring, e.g. bleomycin, phleomycin
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Mycology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Compounds Of Unknown Constitution (AREA)
Abstract
PROCEDIMIENTO PARA PREPARAR ANTIBIOTICOS POLICICLICOS. CONSISTE EN CULTIVAR UNA CEPA DE ACTINOMADURA MELLIAURA CAPAZ DE PRODUCIR LOS COMPUESTOS EN UN MEDIO NUTRIENTE ACUOSO HASTA QUE SE IMPARTE ACTIVIDAD BACTERIANA SUSTANCIAL, Y AISLAR AL MENOS UNO DE LOS COMPUESTOS TAL CUAL O EN FORMA DE SUS SALES FARMACEUTICAMENTE ACEPTABLES, PARA OBTENER ANTIBIOTICOS POLICICLICOS DE FORMULA (I) EN LA QUE: A) X ES CLORO Y R ES CH3; O B) X ES CLORO Y R ES HIDROGENO; REPRESENTANDO LAS LINEAS ONDULADAS ENLACES A LOS DOS ANILLOS DE AZUCAR DE 6 MIEMBROS QUE SIGNIFICAN QUE LOS SUSTITUYENTES UNIDOS A CADA ANILLO DE AZUCAR PUEDEN ESTAR EN CUALQUIERA DE LAS CONFIGURACIONES ESTEREOQUIMICAS POSIBLES. TIENEN APLICACIONES FARMACEUTICAS COMO AGENTES ANTIBACTERIANOS Y ANTITUMORALES.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/651,498 US4743594A (en) | 1984-09-17 | 1984-09-17 | Antibiotic, antitumor compounds and their use |
Publications (2)
Publication Number | Publication Date |
---|---|
ES546915A0 ES546915A0 (es) | 1987-03-01 |
ES8703931A1 true ES8703931A1 (es) | 1987-03-01 |
Family
ID=24613073
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES546915A Expired ES8703931A1 (es) | 1984-09-17 | 1985-09-12 | Procedimiento para preparar nuevos antibioticos policiclicos por fermentacion de una cepa de actinomadura melliaura. |
Country Status (18)
Country | Link |
---|---|
US (1) | US4743594A (es) |
EP (1) | EP0175284B1 (es) |
JP (1) | JPS61106592A (es) |
KR (1) | KR860002574A (es) |
AT (1) | ATE42305T1 (es) |
AU (1) | AU4741785A (es) |
CA (1) | CA1315230C (es) |
DE (1) | DE3569538D1 (es) |
DK (1) | DK415185A (es) |
ES (1) | ES8703931A1 (es) |
FI (1) | FI853506L (es) |
GR (1) | GR852224B (es) |
HK (1) | HK4992A (es) |
HU (1) | HU194315B (es) |
NO (1) | NO853567L (es) |
PT (1) | PT81118B (es) |
YU (1) | YU147385A (es) |
ZA (1) | ZA857003B (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3835842A1 (de) * | 1988-10-21 | 1990-04-26 | Goedecke Ag | Indolocarbazol-derivate, verfahren zu deren herstellung und deren verwendung als arzneimittel |
US5015578A (en) * | 1989-03-23 | 1991-05-14 | Bristol-Myers Squibb Company | BMY-41950 antitumor antibiotic |
ES2125976T3 (es) * | 1992-03-20 | 1999-03-16 | Wellcome Found | Otros derivados de indol con accion antiviral. |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5918035A (ja) * | 1982-07-20 | 1984-01-30 | Katsuyuki Taniguchi | ダンプ車の荷箱の支点構造 |
US4487925A (en) * | 1983-01-28 | 1984-12-11 | Bristol-Myers Company | Rebeccamycin and process for its preparation |
US4524145A (en) * | 1984-09-04 | 1985-06-18 | Bristol-Myers Company | 4'-Deschlororebeccamycin pharmaceutical composition and method of use |
-
1984
- 1984-09-17 US US06/651,498 patent/US4743594A/en not_active Expired - Fee Related
-
1985
- 1985-09-12 EP EP85111531A patent/EP0175284B1/en not_active Expired
- 1985-09-12 ZA ZA857003A patent/ZA857003B/xx unknown
- 1985-09-12 CA CA000490525A patent/CA1315230C/en not_active Expired - Fee Related
- 1985-09-12 KR KR1019850006663A patent/KR860002574A/ko not_active Application Discontinuation
- 1985-09-12 DE DE8585111531T patent/DE3569538D1/de not_active Expired
- 1985-09-12 NO NO853567A patent/NO853567L/no unknown
- 1985-09-12 AU AU47417/85A patent/AU4741785A/en not_active Abandoned
- 1985-09-12 ES ES546915A patent/ES8703931A1/es not_active Expired
- 1985-09-12 GR GR852224A patent/GR852224B/el unknown
- 1985-09-12 PT PT81118A patent/PT81118B/pt unknown
- 1985-09-12 AT AT85111531T patent/ATE42305T1/de not_active IP Right Cessation
- 1985-09-12 DK DK415185A patent/DK415185A/da unknown
- 1985-09-13 JP JP60203198A patent/JPS61106592A/ja active Granted
- 1985-09-13 FI FI853506A patent/FI853506L/fi not_active Application Discontinuation
- 1985-09-16 HU HU853482A patent/HU194315B/hu not_active IP Right Cessation
- 1985-09-17 YU YU01473/85A patent/YU147385A/xx unknown
-
1992
- 1992-01-16 HK HK49/92A patent/HK4992A/xx unknown
Also Published As
Publication number | Publication date |
---|---|
DE3569538D1 (en) | 1989-05-24 |
ES546915A0 (es) | 1987-03-01 |
EP0175284A3 (en) | 1986-12-17 |
EP0175284A2 (en) | 1986-03-26 |
EP0175284B1 (en) | 1989-04-19 |
DK415185A (da) | 1986-03-18 |
JPH0558440B2 (es) | 1993-08-26 |
HU194315B (en) | 1988-01-28 |
JPS61106592A (ja) | 1986-05-24 |
ATE42305T1 (de) | 1989-05-15 |
CA1315230C (en) | 1993-03-30 |
US4743594A (en) | 1988-05-10 |
ZA857003B (en) | 1986-12-30 |
PT81118B (en) | 1987-07-06 |
HUT42527A (en) | 1987-07-28 |
KR860002574A (ko) | 1986-04-26 |
GR852224B (es) | 1986-01-13 |
FI853506A0 (fi) | 1985-09-13 |
FI853506L (fi) | 1986-03-18 |
YU147385A (en) | 1988-06-30 |
NO853567L (no) | 1986-03-18 |
DK415185D0 (da) | 1985-09-12 |
PT81118A (en) | 1985-10-01 |
AU4741785A (en) | 1986-04-24 |
HK4992A (en) | 1992-01-17 |
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