ES8702356A1 - Procedimiento para la obtencion de derivados de la 3-nitrodihidropiridina - Google Patents

Procedimiento para la obtencion de derivados de la 3-nitrodihidropiridina

Info

Publication number
ES8702356A1
ES8702356A1 ES553085A ES553085A ES8702356A1 ES 8702356 A1 ES8702356 A1 ES 8702356A1 ES 553085 A ES553085 A ES 553085A ES 553085 A ES553085 A ES 553085A ES 8702356 A1 ES8702356 A1 ES 8702356A1
Authority
ES
Spain
Prior art keywords
atoms
nitro
hydrogen
image
radical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES553085A
Other languages
English (en)
Other versions
ES553085A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of ES553085A0 publication Critical patent/ES553085A0/es
Publication of ES8702356A1 publication Critical patent/ES8702356A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE LA 3-NITRO-DIHIDROPIRIDINA. CONSISTE EN HACER REACCIONAS ESTERES DEL ACIDO AMINOCROTONICO DE FORMULA (II) CON BENCILIDEN-NITROACETONAS DE FORMULA (III), PARA OBTENER DERIVADOS DE LA 3-NITRO-DIHIDROPIRIDINA DE FORMULA (I) EN LA QUE R1 Y R2 PUEDEN SER IGUALES O DIFERENTES U SIGNIFICAN H, ALQUILO CON C 1 A 4, ALCOXI CON C 1 A 2, HALOGENOALCOXI CON C 1 A 4, NITRO Y OTROS; X SIGNIFICA OXIGENO O AZUFRE; A SIGNIFICA UN RESTO HIDROCARBONADO DE CADENA LINEAL O RAMIFICADA, SATURADO O INSATURADO, CON HASTA 12 ATOMOS DE CARBONO, QUE EN CASO DADO CONTIENE UNO O DOS MIEMBROS DE CADENA IGUALES O DIFERENTES DEL GRUPO FORMADO POR O, S O CO; Y R3 SIGNIFICA UN RESTO DEL GRUPO FORMADO POR -O-COR6, -S-CO-R6, SH, OH Y OTROS. LA REACCION SE EFECTUA A UNA TEMPERATURA COMPRENDIDA ENTRE 10 Y 150JC. TIENEN UTILIDAD COMO MEDICAMENTOS INFLUENCIADORES DEL SISTEMA CIRCULATORIO.
ES553085A 1984-06-04 1986-03-17 Procedimiento para la obtencion de derivados de la 3-nitrodihidropiridina Expired ES8702356A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19843420784 DE3420784A1 (de) 1984-06-04 1984-06-04 3-nitro-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln

Publications (2)

Publication Number Publication Date
ES553085A0 ES553085A0 (es) 1987-01-01
ES8702356A1 true ES8702356A1 (es) 1987-01-01

Family

ID=6237588

Family Applications (6)

Application Number Title Priority Date Filing Date
ES543838A Expired ES8607239A1 (es) 1984-06-04 1985-06-03 Derivados de la 3-nitro-dihidropiridina
ES553088A Expired ES8702357A1 (es) 1984-06-04 1986-03-17 Procedimiento para la obtencion de derivados de la 3-nitrodihidropiridina
ES553087A Expired ES8702892A1 (es) 1984-06-04 1986-03-17 Procedimiento para la obtencion de derivados de la 3-nitrodihidropiridina
ES553089A Expired ES8702358A1 (es) 1984-06-04 1986-03-17 Procedimiento para la obtencion de derivados de la 3-nitrodihidropiridina
ES553085A Expired ES8702356A1 (es) 1984-06-04 1986-03-17 Procedimiento para la obtencion de derivados de la 3-nitrodihidropiridina
ES553086A Expired ES8702891A1 (es) 1984-06-04 1986-03-17 Procedimiento para la obtencion de derivados de la 3-nitrodihidropiridina

Family Applications Before (4)

Application Number Title Priority Date Filing Date
ES543838A Expired ES8607239A1 (es) 1984-06-04 1985-06-03 Derivados de la 3-nitro-dihidropiridina
ES553088A Expired ES8702357A1 (es) 1984-06-04 1986-03-17 Procedimiento para la obtencion de derivados de la 3-nitrodihidropiridina
ES553087A Expired ES8702892A1 (es) 1984-06-04 1986-03-17 Procedimiento para la obtencion de derivados de la 3-nitrodihidropiridina
ES553089A Expired ES8702358A1 (es) 1984-06-04 1986-03-17 Procedimiento para la obtencion de derivados de la 3-nitrodihidropiridina

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES553086A Expired ES8702891A1 (es) 1984-06-04 1986-03-17 Procedimiento para la obtencion de derivados de la 3-nitrodihidropiridina

Country Status (16)

Country Link
US (1) US4645775A (es)
EP (1) EP0164010B1 (es)
JP (1) JPH0670013B2 (es)
KR (1) KR860000262A (es)
AT (1) ATE40883T1 (es)
AU (1) AU4329485A (es)
DE (2) DE3420784A1 (es)
DK (1) DK248585A (es)
ES (6) ES8607239A1 (es)
FI (1) FI852204L (es)
GR (1) GR851313B (es)
HU (1) HU193986B (es)
IL (1) IL75364A0 (es)
NO (1) NO852024L (es)
PT (1) PT80579B (es)
ZA (1) ZA854163B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3617976A1 (de) * 1986-05-28 1988-01-14 Alter Sa 1,4-dihydropyridin, verfahren zu dessen herstellung und dessen verwendung in antithrombotischen medikamenten
DE3732380A1 (de) * 1987-09-25 1989-04-06 Bayer Ag Dihydropyridinether, verfahren zu ihrer herstellung und ihre verwendung
JPH02167262A (ja) * 1988-06-05 1990-06-27 Taisho Pharmaceut Co Ltd １，４―ジヒドロピリジン誘導体

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2752820A1 (de) * 1977-11-26 1979-05-31 Bayer Ag Neue nitrosubstituierte 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
NZ201395A (en) * 1981-07-30 1987-02-20 Bayer Ag Pharmaceutical compositions containing 1,4-dihydropyridines and certain of these dihydropyridines
DE3319956A1 (de) * 1983-06-01 1984-12-06 Bayer Ag, 5090 Leverkusen 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln
FR2554109A1 (fr) * 1983-11-01 1985-05-03 Sandoz Sa Nouveaux derives de la 1,4-dihydropyridine, leur preparation et leur utilisation en therapeutique comme medicaments

Also Published As

Publication number Publication date
JPS611660A (ja) 1986-01-07
ES8702357A1 (es) 1987-01-01
HUT38313A (en) 1986-05-28
JPH0670013B2 (ja) 1994-09-07
EP0164010A3 (en) 1987-08-05
GR851313B (es) 1985-11-25
ES553088A0 (es) 1987-01-01
KR860000262A (ko) 1986-01-27
NO852024L (no) 1985-12-05
ES553086A0 (es) 1987-01-16
PT80579B (en) 1987-04-28
PT80579A (en) 1985-07-01
DE3568330D1 (en) 1989-03-30
IL75364A0 (en) 1985-09-29
DK248585D0 (da) 1985-06-03
ATE40883T1 (de) 1989-03-15
DK248585A (da) 1985-12-05
EP0164010A2 (de) 1985-12-11
HU193986B (en) 1987-12-28
ES553085A0 (es) 1987-01-01
ZA854163B (en) 1986-01-29
DE3420784A1 (de) 1985-12-05
ES8702891A1 (es) 1987-01-16
FI852204L (fi) 1985-12-05
ES8702358A1 (es) 1987-01-01
FI852204A0 (fi) 1985-05-31
ES553087A0 (es) 1987-01-16
ES553089A0 (es) 1987-01-01
US4645775A (en) 1987-02-24
EP0164010B1 (de) 1989-02-22
ES8702892A1 (es) 1987-01-16
ES543838A0 (es) 1986-06-16
ES8607239A1 (es) 1986-06-16
AU4329485A (en) 1985-12-12

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