ES8701145A1 - Un procedimiento para la preparacion de derivados de tetrahidronaftaleno. - Google Patents

Un procedimiento para la preparacion de derivados de tetrahidronaftaleno.

Info

Publication number
ES8701145A1
ES8701145A1 ES547756A ES547756A ES8701145A1 ES 8701145 A1 ES8701145 A1 ES 8701145A1 ES 547756 A ES547756 A ES 547756A ES 547756 A ES547756 A ES 547756A ES 8701145 A1 ES8701145 A1 ES 8701145A1
Authority
ES
Spain
Prior art keywords
formula
tetrahydronaphthalene
compounds
derivatives
intermediates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES547756A
Other languages
English (en)
Other versions
ES547756A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES547756A0 publication Critical patent/ES547756A0/es
Publication of ES8701145A1 publication Critical patent/ES8701145A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/02—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C211/03—Monoamines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE TETRAHIDRONAFTALENO DE FORMULA GENERAL (I). SE HACE REACCIONAR UN COMPUESTO DE FORMULA (II) CON UNA AMINA DE FORMULA GENERAL (III), POR METODOS COMUNES EN PRESENCIA O AUSENCIA DE UN DISOLVENTE ORGANICO INERTE EN LAS CONDICIONES DE REACCION Y A TEMPERATURA ENTRE 80 Y 120JC, EN PRESENCIA DE UN ACEPTOR DE ACIDO, Y A TEMPERATURA AMBIENTE. LOS NUEVOS COMPUESTOS OBTENIDOS EN FORMA DE RACEMATOS SE RESUELVE EN SUS ANTIODAS OPTICOS Y SE CONVIERTEN EN SUS SALES DE ADICION DE ACIDO QUE POSEEN ACTIVIDAD CALCIO-ANTAGONISTA Y POR TANTO PUEDEN UTILIZARSE PARA EL CONTROL O PREVENCION DE LA ANGINA DE PECHO, ISQUEMIA, ARRITMIAS E HIPERTENSION, EN FORMA DE PREPARADOS FARMACEUTICOS.
ES547756A 1984-10-11 1985-10-10 Un procedimiento para la preparacion de derivados de tetrahidronaftaleno. Expired ES8701145A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH487084 1984-10-11

Publications (2)

Publication Number Publication Date
ES547756A0 ES547756A0 (es) 1986-11-16
ES8701145A1 true ES8701145A1 (es) 1986-11-16

Family

ID=4283985

Family Applications (3)

Application Number Title Priority Date Filing Date
ES547756A Expired ES8701145A1 (es) 1984-10-11 1985-10-10 Un procedimiento para la preparacion de derivados de tetrahidronaftaleno.
ES554020A Expired ES8802359A1 (es) 1984-10-11 1986-04-16 Un procedimiento para la preparacion de derivados de tetrahidronaftaleno.
ES554021A Expired ES8801174A1 (es) 1984-10-11 1986-04-16 Un procedimiento para la preparacion de derivados de tetrahidronaftaleno.

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES554020A Expired ES8802359A1 (es) 1984-10-11 1986-04-16 Un procedimiento para la preparacion de derivados de tetrahidronaftaleno.
ES554021A Expired ES8801174A1 (es) 1984-10-11 1986-04-16 Un procedimiento para la preparacion de derivados de tetrahidronaftaleno.

Country Status (21)

Country Link
US (1) US4680310A (es)
EP (1) EP0177960B1 (es)
JP (1) JPS6191157A (es)
KR (1) KR860003200A (es)
CN (1) CN1007727B (es)
AT (1) ATE61791T1 (es)
AU (1) AU589375B2 (es)
CA (1) CA1287636C (es)
DE (1) DE3582217D1 (es)
DK (1) DK464885A (es)
ES (3) ES8701145A1 (es)
FI (1) FI83508C (es)
GR (1) GR852450B (es)
HU (1) HU199773B (es)
IL (1) IL76576A0 (es)
MC (1) MC1706A1 (es)
NO (1) NO161971C (es)
NZ (1) NZ213651A (es)
PH (1) PH23223A (es)
PT (1) PT81286B (es)
ZA (1) ZA857681B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU573828B2 (en) * 1984-05-17 1988-06-23 E.R. Squibb & Sons, Inc. Tetrahydronaphthalenols
DE3630903A1 (de) * 1986-09-11 1988-03-24 Thomae Gmbh Dr K Neue tetrahydronaphthalin- und indanderivate, verfahren zu deren herstellung sowie diese enthaltende arzneimittel
CA1319144C (en) * 1986-11-14 1993-06-15 Quirico Branca Tetrahydronaphthalene derivatives
PT87163B (pt) * 1987-04-09 1992-07-31 Lilly Co Eli Processo para a preparacao de 1-fenil-3-naftaleniloxi-propanaminas
IT1224405B (it) * 1987-12-23 1990-10-04 Simes Composti attivi sul sistema cardiovascolare
DE3807813A1 (de) * 1988-03-10 1989-09-21 Thomae Gmbh Dr K Neue benzocycloheptenderivate, diese verbindungen enthaltende arzneimittel und verfahren zu deren herstellung
CA2011461A1 (en) * 1989-03-20 1990-09-20 Urs Hengartner Tetrahydronaphthalene derivatives
US5202486A (en) * 1990-07-31 1993-04-13 E. R. Squibb & Sons, Inc. Tetrahydroethanonaphthaleneamine derivatives
US5204373A (en) * 1991-08-26 1993-04-20 Bristol-Myers Squibb Company Farnesylated tetrahydro-naphthalenols as hypolipidemic agents
US5811556A (en) * 1997-04-30 1998-09-22 Roche Colorado Corporation Preparation of mibefradil via a naphthalenylacetic acid
US5808088A (en) * 1997-04-30 1998-09-15 Roche Colorado Corporation Preparation of mibefradil via an acetamide anion
US5811557A (en) * 1997-04-30 1998-09-22 Roche Colorado Corporation Preparation of mibefradil via an acetonitrile anion
WO2010046729A2 (en) * 2008-10-23 2010-04-29 Actelion Pharmaceuticals Ltd Tetrahydronaphthalene compounds
US8575361B2 (en) 2010-03-02 2013-11-05 Concert Pharmaceuticals Inc. Tetrahydronaphthalene derivatives
EP3144296A1 (en) 2010-03-02 2017-03-22 Concert Pharmaceuticals, Inc. Deuterated tetrahydronaphthalene derivatives
EP3585376A4 (en) * 2017-02-15 2020-11-25 Cavion, Inc. CALCIUM CHANNELS INHIBITORS

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE913199C (de) * 1952-05-28 1954-06-10 Hartmann & Braun Ag Anzeigeinstrument zur Bestimmung von Polung und ungefaehrer Groesse des Strom- und Spannungsfehlers von Messwandlern in Verbindung mit Messwandler-Pruefeinrichtungen, die nach dem Differentialverfahren arbeiten
US3957845A (en) * 1962-04-27 1976-05-18 Knoll A.G. Chemische Fabriken Trifluoromethyl-substituted phenyl acetonitriles
GB1256753A (es) * 1969-05-30 1971-12-15
US4127588A (en) * 1976-10-01 1978-11-28 Hoffmann-La Roche Inc. Sulphur containing derivatives
JPS5896045A (ja) * 1981-11-30 1983-06-07 Sumitomo Chem Co Ltd 新規なジフエニルアルカノアミン誘導体およびその製造法

Also Published As

Publication number Publication date
EP0177960B1 (de) 1991-03-20
EP0177960A3 (en) 1988-01-13
PT81286A (en) 1985-11-01
NO161971B (no) 1989-07-10
FI853817L (fi) 1986-04-12
CN85107496A (zh) 1986-07-23
US4680310A (en) 1987-07-14
ZA857681B (en) 1986-05-28
DE3582217D1 (de) 1991-04-25
FI83508B (fi) 1991-04-15
AU589375B2 (en) 1989-10-12
ES8801174A1 (es) 1987-12-16
PH23223A (en) 1989-06-06
HUT38605A (en) 1986-06-30
DK464885A (da) 1986-04-12
MC1706A1 (fr) 1986-09-22
AU4830185A (en) 1986-04-17
KR860003200A (ko) 1986-05-21
CN1007727B (zh) 1990-04-25
ES554021A0 (es) 1987-12-16
ES547756A0 (es) 1986-11-16
DK464885D0 (da) 1985-10-10
NO854036L (no) 1986-04-14
HU199773B (en) 1990-03-28
ES8802359A1 (es) 1988-05-16
FI853817A0 (fi) 1985-10-02
ES554020A0 (es) 1988-05-16
IL76576A0 (en) 1986-02-28
GR852450B (es) 1986-02-11
ATE61791T1 (de) 1991-04-15
JPS6191157A (ja) 1986-05-09
FI83508C (fi) 1991-07-25
EP0177960A2 (de) 1986-04-16
PT81286B (pt) 1988-02-17
NO161971C (no) 1989-10-18
NZ213651A (en) 1989-07-27
CA1287636C (en) 1991-08-13

Similar Documents

Publication Publication Date Title
ES8802359A1 (es) Un procedimiento para la preparacion de derivados de tetrahidronaftaleno.
MY101268A (en) Naphthalene derivatives, process for the preparation thereof and pharmaceutical composition containing same
HUT42080A (en) Process for producing labdane derivatives and pharmaceutical compositions containing them
HUT55397A (en) Process for producing mevalonic acid derivatives comprising thienopyridine ring and pharmaceutical compositions containing such active ingredient
CA2011448A1 (en) 6-amino-6-desoxyfumagillols, production and use thereof
EP0181592A3 (en) Use of spergualin derivatives for the preparation of medicaments having immunosuppressive activity
DE3362260D1 (en) (-)-15-deoxyspergualin, a process for the preparation of the same, and a pharmaceutical composition containing the same
EP0155006A3 (en) Compounds having antibacterial activity, process for their preparation and pharmaceutical compositions containing them
ES8705457A1 (es) Procedimiento para producir nuevos derivados de antibioticosdel grupo de la pluramicina
ES8609253A1 (es) Un procedimiento para la preparacion de derivados de dihi- dropiridina
IL106934A (en) Heteroarenylpiperazines a process for their preparation and pharmaceutical compositions comprising them
PT81066A (en) Arphamine derivatives a process for their preparation and the pharmaceutical compositions therewith
MY101746A (en) 1,5-benzothiazepine derivatives, a process for preparing the same, pharmaceutical compositions as well as the use thereof.

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970303